MA45148A - Composés de carfilzomib pégylés - Google Patents
Composés de carfilzomib pégylésInfo
- Publication number
- MA45148A MA45148A MA045148A MA45148A MA45148A MA 45148 A MA45148 A MA 45148A MA 045148 A MA045148 A MA 045148A MA 45148 A MA45148 A MA 45148A MA 45148 A MA45148 A MA 45148A
- Authority
- MA
- Morocco
- Prior art keywords
- carfilzomib compounds
- pegylated carfilzomib
- pegylated
- compounds
- carfilzomib
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2230/00—Compositions for preparing biodegradable polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
- Detergent Compositions (AREA)
- Polyesters Or Polycarbonates (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662340926P | 2016-05-24 | 2016-05-24 | |
US201762485812P | 2017-04-14 | 2017-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA45148A true MA45148A (fr) | 2019-04-10 |
Family
ID=59062074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA045148A MA45148A (fr) | 2016-05-24 | 2017-05-23 | Composés de carfilzomib pégylés |
Country Status (24)
Country | Link |
---|---|
US (3) | US10517954B2 (fr) |
EP (1) | EP3464277B1 (fr) |
JP (1) | JP7142578B2 (fr) |
KR (1) | KR102492135B1 (fr) |
CN (1) | CN109415353B (fr) |
AU (1) | AU2017272101B2 (fr) |
CA (1) | CA3025170A1 (fr) |
CL (1) | CL2018003352A1 (fr) |
CO (1) | CO2018013112A2 (fr) |
CR (1) | CR20180602A (fr) |
ES (1) | ES2939849T3 (fr) |
IL (1) | IL263147B (fr) |
MA (1) | MA45148A (fr) |
MX (1) | MX2018014498A (fr) |
NZ (1) | NZ748615A (fr) |
PE (1) | PE20190328A1 (fr) |
PH (1) | PH12018502473A1 (fr) |
SG (2) | SG10201912278TA (fr) |
TN (1) | TN2018000393A1 (fr) |
TW (1) | TWI759301B (fr) |
UA (1) | UA125254C2 (fr) |
UY (1) | UY37253A (fr) |
WO (1) | WO2017205392A1 (fr) |
ZA (1) | ZA201807890B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI759301B (zh) | 2016-05-24 | 2022-04-01 | 美商安美基公司 | 聚乙二醇化卡非佐米化合物 |
MX2020004936A (es) * | 2017-11-16 | 2020-08-27 | Amgen Inc | Composiciones estables de compuestos de carfilzomib pegilado. |
US20220370628A9 (en) * | 2018-04-13 | 2022-11-24 | Massachusetts Institute Of Technology | Brush prodrugs and uses thereof |
WO2020254602A1 (fr) | 2019-06-21 | 2020-12-24 | Ascendis Pharma A/S | Conjugués d'azote donneur d'électrons ou de composés comprenant une amine tertiaire |
WO2021222783A1 (fr) * | 2020-05-01 | 2021-11-04 | Angiex, Inc. | Conjugués anticorps anti-tm4sf-médicament et leurs procédés d'utilisation |
CN113979895B (zh) * | 2020-07-08 | 2023-03-24 | 中国科学技术大学 | 一种精确序列可控的自降解聚合物及其制备方法和应用 |
CN115873231A (zh) * | 2022-12-17 | 2023-03-31 | 华南理工大学 | 一种聚乙二醇修饰的氨基糖苷类分子及其制备方法和应用 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
EP0575545B1 (fr) * | 1991-03-15 | 2003-05-21 | Amgen Inc. | Pegylation de polypeptides |
US20040100225A1 (en) | 2002-11-20 | 2004-05-27 | Neil Robert Miles | Cooling and control system for battery charging |
WO2005063777A1 (fr) | 2003-12-23 | 2005-07-14 | Corus Pharma | Promedicaments de benzylphosphate et de benzylphosphate substitue utilises dans le traitement d'une inflammation pulmonaire |
US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
US20050256324A1 (en) | 2004-05-10 | 2005-11-17 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
JP4990155B2 (ja) | 2004-12-07 | 2012-08-01 | プロテオリックス, インコーポレイテッド | プロテアソームを阻害するための組成物 |
JP5073315B2 (ja) | 2006-03-24 | 2012-11-14 | 関西ペイント株式会社 | 缶用塗料組成物 |
CL2008002966A1 (es) | 2007-10-04 | 2010-06-25 | Onyx Therapeutics Inc | Compuesto tetrapeptido ceto-epoxido cristalino; sal citrato cristalina del compuesto; metodos de preparacion; compuesto intermediario cristalino; metodo de preparacion; y uso para tratar cancer, enfermedad autoinmune, afeccion relacionada con trasplante, enfermedad neurodegenerativa, afeccion asociada con fibrosis, entre otros. |
WO2009152160A1 (fr) | 2008-06-10 | 2009-12-17 | Gilead Sciences, Inc. | Promédicaments inhalés à base de carbaprostacyclines et de prostacyclines destinés au traitement de l'hypertension artérielle pulmonaire |
WO2010033240A2 (fr) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymères à base de glucide pour administration de médicaments et leurs conjugués |
EA035100B1 (ru) | 2008-10-21 | 2020-04-28 | Оникс Терапьютикс, Инк. | Комбинированная терапия с применением пептид эпоксикетонов |
ES2647361T3 (es) | 2010-01-07 | 2017-12-21 | Alkermes Pharma Ireland Limited | Profármacos de sales de amonio cuaternario |
WO2013169282A1 (fr) | 2012-05-08 | 2013-11-14 | Onyx Therapeutics, Inc. | Procédés de complexation de cyclodextrine pour la formulation d'inhibiteurs peptidiques du protéasome |
UY34897A (es) | 2012-07-09 | 2014-01-31 | Onyx Therapeutics Inc | Profarmacos de inhibidores peptidicos de expoxi cetona proteasa |
CA2879139C (fr) | 2012-07-18 | 2021-05-11 | Onyx Therapeutics, Inc. | Compositions liposomales d'inhibiteurs du proteasome a base d'epoxycetone |
DE102013104003B3 (de) | 2013-04-19 | 2014-03-13 | Glatt Systemtechnik Gmbh | Vorrichtung zum Einbringen einer definierten Menge eines zweiten Pulvers in einen Prozessbehälter |
WO2016004221A1 (fr) | 2014-07-01 | 2016-01-07 | Mayo Foundation For Medical Education And Research | Procédés et matériaux d'identification et de traitement de mammifères résistants aux traitements par inhibiteur de protéasome |
CN104530413B (zh) * | 2014-10-01 | 2017-08-25 | 厦门赛诺邦格生物科技股份有限公司 | 一种多官能化h型聚乙二醇衍生物修饰的生物相关物质 |
CN106310289B (zh) | 2015-06-24 | 2020-10-13 | 天津键凯科技有限公司 | 一种聚乙二醇和麻醉药的结合物及其制备方法 |
US9815850B2 (en) | 2016-02-05 | 2017-11-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
ES2643856B1 (es) | 2016-05-24 | 2018-08-03 | Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea | Triazoles para la regulación de la homeostasis de calcio intracelular |
TWI759301B (zh) | 2016-05-24 | 2022-04-01 | 美商安美基公司 | 聚乙二醇化卡非佐米化合物 |
MX2018014455A (es) | 2016-05-24 | 2019-01-24 | Basf Se | Uracilpiridinas herbicidas. |
BR112018072034A2 (pt) | 2016-05-24 | 2019-02-12 | Novo Nordisk A/S | compostos mic-1 e usos dos mesmos |
MX2018014443A (es) | 2016-05-25 | 2019-04-15 | Bayer Pharma AG | 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas. |
MA45493A (fr) | 2016-06-27 | 2019-05-01 | Aicuris Anti Infective Cures Gmbh | Inhibiteurs d'entrée de hcmv. |
JP6631420B2 (ja) | 2016-06-28 | 2020-01-15 | 株式会社デンソー | 光センサ |
WO2018003319A1 (fr) | 2016-06-30 | 2018-01-04 | パナソニックIpマネジメント株式会社 | Procédé de fonctionnement d'un dispositif de lavage du linge, et programme associé |
JP6512183B2 (ja) | 2016-06-30 | 2019-05-15 | 株式会社Soken | 乗員検知システム及び乗員検知装置 |
JP6851640B2 (ja) | 2016-06-30 | 2021-03-31 | Fsテクニカル株式会社 | 供試体、アンカー試験装置およびアンカー試験方法 |
-
2017
- 2017-05-22 TW TW106116802A patent/TWI759301B/zh active
- 2017-05-23 JP JP2018561676A patent/JP7142578B2/ja active Active
- 2017-05-23 NZ NZ748615A patent/NZ748615A/en unknown
- 2017-05-23 ES ES17730293T patent/ES2939849T3/es active Active
- 2017-05-23 UA UAA201811668A patent/UA125254C2/uk unknown
- 2017-05-23 EP EP17730293.2A patent/EP3464277B1/fr active Active
- 2017-05-23 KR KR1020187037437A patent/KR102492135B1/ko active IP Right Grant
- 2017-05-23 CA CA3025170A patent/CA3025170A1/fr active Pending
- 2017-05-23 TN TNP/2018/000393A patent/TN2018000393A1/en unknown
- 2017-05-23 SG SG10201912278TA patent/SG10201912278TA/en unknown
- 2017-05-23 MX MX2018014498A patent/MX2018014498A/es unknown
- 2017-05-23 PE PE2018003110A patent/PE20190328A1/es unknown
- 2017-05-23 US US15/602,823 patent/US10517954B2/en active Active
- 2017-05-23 UY UY0001037253A patent/UY37253A/es not_active Application Discontinuation
- 2017-05-23 SG SG11201810396QA patent/SG11201810396QA/en unknown
- 2017-05-23 CR CR20180602A patent/CR20180602A/es unknown
- 2017-05-23 CN CN201780040664.2A patent/CN109415353B/zh active Active
- 2017-05-23 MA MA045148A patent/MA45148A/fr unknown
- 2017-05-23 AU AU2017272101A patent/AU2017272101B2/en active Active
- 2017-05-23 WO PCT/US2017/034029 patent/WO2017205392A1/fr unknown
-
2018
- 2018-11-20 IL IL263147A patent/IL263147B/en unknown
- 2018-11-22 ZA ZA2018/07890A patent/ZA201807890B/en unknown
- 2018-11-23 CL CL2018003352A patent/CL2018003352A1/es unknown
- 2018-11-23 PH PH12018502473A patent/PH12018502473A1/en unknown
- 2018-12-04 CO CONC2018/0013112A patent/CO2018013112A2/es unknown
-
2019
- 2019-11-05 US US16/675,134 patent/US10675353B2/en active Active
-
2020
- 2020-04-23 US US16/857,111 patent/US11077198B2/en active Active
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