MA40408A - Molécules ayant une spécificité pour cd79 et cd22 - Google Patents

Molécules ayant une spécificité pour cd79 et cd22

Info

Publication number
MA40408A
MA40408A MA040408A MA40408A MA40408A MA 40408 A MA40408 A MA 40408A MA 040408 A MA040408 A MA 040408A MA 40408 A MA40408 A MA 40408A MA 40408 A MA40408 A MA 40408A
Authority
MA
Morocco
Prior art keywords
specificity
molecules
binding domain
antigen
domain specific
Prior art date
Application number
MA040408A
Other languages
English (en)
Inventor
Helene Margaret Finney
Stephen Edward Rapecki
Kerry Tyson
Michael John Wright
Original Assignee
Kerry Tyson
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51454239&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40408(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kerry Tyson, Ucb Biopharma Sprl filed Critical Kerry Tyson
Publication of MA40408A publication Critical patent/MA40408A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des molécules multispécifiques comprenant un domaine de liaison spécifique à l'antigène cd22 et un domaine de liaison spécifique à l'antigène cd79a et/ou cd79b, des compositions les comprenant et l'utilisation des deux dans le traitement, par exemple, d'une maladie auto-immune.
MA040408A 2014-07-16 2015-07-16 Molécules ayant une spécificité pour cd79 et cd22 MA40408A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1412658.5A GB201412658D0 (en) 2014-07-16 2014-07-16 Molecules

Publications (1)

Publication Number Publication Date
MA40408A true MA40408A (fr) 2017-05-24

Family

ID=51454239

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040408A MA40408A (fr) 2014-07-16 2015-07-16 Molécules ayant une spécificité pour cd79 et cd22

Country Status (17)

Country Link
US (2) US10370447B2 (fr)
EP (1) EP3169705A2 (fr)
JP (2) JP2017522023A (fr)
KR (1) KR20170035954A (fr)
CN (1) CN106661122B (fr)
AU (1) AU2015289094A1 (fr)
BR (1) BR112017000671A2 (fr)
CA (1) CA2954567A1 (fr)
CL (1) CL2017000110A1 (fr)
CO (1) CO2017000228A2 (fr)
GB (1) GB201412658D0 (fr)
IL (1) IL249537A0 (fr)
MA (1) MA40408A (fr)
MX (1) MX2016017040A (fr)
RU (2) RU2743590C2 (fr)
SG (1) SG11201610641YA (fr)
WO (1) WO2016009030A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412658D0 (en) * 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
GB201601075D0 (en) * 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
GB201521383D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl And Ucb Celltech Method
GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521391D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521393D0 (en) * 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
WO2017214170A2 (fr) 2016-06-06 2017-12-14 City Of Hope Anticorps baff-r et utilisations de ceux-ci
KR102584944B1 (ko) * 2016-06-06 2023-10-05 시티 오브 호프 Baff-r 표적 키메라 항원 수용체-변형된 t 세포 및 그 용도
JP7459043B2 (ja) * 2018-07-12 2024-04-01 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 親和性成熟ｃｄ２２特異的モノクローナル抗体およびその使用
JP2022513338A (ja) 2018-10-03 2022-02-07 ネペンザ・バイオサイエンシズ・エルエルシー 抗ｃｄ７９抗体およびその使用
GB201817311D0 (en) 2018-10-24 2018-12-05 Ucb Biopharma Sprl Antibodies
GB201817309D0 (en) 2018-10-24 2018-12-05 Ucb Biopharma Sprl Antibodies
EP3998286A4 (fr) * 2019-07-11 2023-04-26 Wuhan Yzy Biopharma Co., Ltd. Anticorps bispécifique symétrique tétravalent
US20230192900A1 (en) 2020-02-13 2023-06-22 UCB Biopharma SRL Bispecific antibodies binding hvem and cd9
WO2021160268A1 (fr) 2020-02-13 2021-08-19 UCB Biopharma SRL Anticorps bispécifiques contre cd9
EP4103610A1 (fr) 2020-02-13 2022-12-21 UCB Biopharma SRL Anticorps bispécifiques anti-cd44-ctla4
US20230096030A1 (en) 2020-02-13 2023-03-30 UCB Biopharma SRL Bispecific antibodies against cd9 and cd7
WO2021160265A1 (fr) 2020-02-13 2021-08-19 UCB Biopharma SRL Anticorps bispécifiques contre cd9 et cd137
TW202304986A (zh) * 2021-03-24 2023-02-01 美商健生生物科技公司 靶向cd22及cd79b的抗體

Family Cites Families (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DK336987D0 (da) 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
US6010902A (en) 1988-04-04 2000-01-04 Bristol-Meyers Squibb Company Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
EP1892296A1 (fr) 1988-09-02 2008-02-27 Dyax Corporation Production et sélection de protéines de liaison diversifiées recombinantes
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
CA2069342A1 (fr) 1989-10-20 1991-04-21 Herman Waldmann Materiel et methodes pour le traitement de tissus etrangers
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
WO1991010737A1 (fr) 1990-01-11 1991-07-25 Molecular Affinities Corporation Production d'anticorps utilisant des librairies de genes
EP1690935A3 (fr) 1990-01-12 2008-07-30 Abgenix, Inc. Génération d'anticorps xenogéniques
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
EP0542810A1 (fr) 1990-08-02 1993-05-26 B.R. Centre Limited Procedes de production de proteines presentant une fonction souhaitee
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DK0546073T3 (da) 1990-08-29 1998-02-02 Genpharm Int Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
ATE164395T1 (de) 1990-12-03 1998-04-15 Genentech Inc Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
CA2108147C (fr) 1991-04-10 2009-01-06 Angray Kang Banques de recepteurs heterodimeriques construites a l'aide de phagemides
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
GB9120467D0 (en) 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
WO1993011236A1 (fr) 1991-12-02 1993-06-10 Medical Research Council Production d'anticorps anti-auto-antigenes a partir de repertoires de segments d'anticorps affiches sur phage
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US6129914A (en) 1992-03-27 2000-10-10 Protein Design Labs, Inc. Bispecific antibody effective to treat B-cell lymphoma and cell line
US6106834A (en) 1993-06-02 2000-08-22 Research Corporation Technologies, Inc. Use of anti-CD45 leukocyte antigen antibodies for immunomodulation
UA40577C2 (uk) 1993-08-02 2001-08-15 Мерк Патент Гмбх Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин
EP0733070A1 (fr) 1993-12-08 1996-09-25 Genzyme Corporation Procede de generation d'anticorps specifiques
DK0744958T3 (da) 1994-01-31 2003-10-20 Univ Boston Polyklonale antistofbiblioteker
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
JP2978435B2 (ja) 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
AU740904B2 (en) 1997-03-20 2001-11-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors
US6306393B1 (en) 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US6183744B1 (en) 1997-03-24 2001-02-06 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US20020062010A1 (en) 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
US6368596B1 (en) 1997-07-08 2002-04-09 Board Of Regents, The University Of Texas System Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
DK1049787T3 (da) 1998-01-23 2005-04-04 Vlaams Interuniv Inst Biotech Antistofderivater med flere anvendelsesmuligheder
US6818749B1 (en) 1998-10-31 2004-11-16 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti carcinoma monoclonal antibody cc49
AU766882B2 (en) 1999-02-25 2003-10-23 National Jewish Medical And Research Center Product and method for treatment of conditions associated with receptor-desensitization
EP1543839B1 (fr) 1999-06-09 2017-09-20 Immunomedics, Inc. Immunothérapie de troubles auto-immuns à l'aide d'anticorps ciblant les cellules B
EP1194167B1 (fr) 1999-06-09 2009-08-19 Immunomedics, Inc. Immunotherapie de troubles auto-immuns a l'aide d'anticorps ciblant les cellules b
DE19952956A1 (de) 1999-11-03 2001-05-17 Acgt Progenomics Ag Verfahren zur Verbindung von molekularen Substanzen
CA2396534C (fr) 1999-12-28 2012-10-02 Esbatech Ag Intracorps a charpente definie stable dans un environnement reducteur et leurs applications
US20050069538A1 (en) 2003-09-18 2005-03-31 Gregorio Aversa Therapeutic binding molecules
GB0103389D0 (en) 2001-02-12 2001-03-28 Novartis Ag Organic compounds
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
US6833441B2 (en) 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
EP1448584B1 (fr) 2001-09-26 2010-05-19 The Government of the United States of America as represented by The Secretary of Health and Human Services Anticorps anti-cd22 mutes a forte affinite pour les cellules leucemiques exprimant des cd22
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
WO2003048327A2 (fr) 2001-12-03 2003-06-12 Abgenix, Inc. Anticorps anti-cd45rb s'utilisant dans le traitement de maladies auto-immunes et de rejet de greffon
CA2476776A1 (fr) 2002-02-21 2003-09-04 Duke University Reactifs et methodes therapeutiques de maladies auto-immunes
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
PL224001B1 (pl) 2002-05-02 2016-11-30 Wyeth Corp Sposób wytwarzania stabilnej liofilizowanej kompozycji obejmującej monomeryczne koniugaty pochodna kalicheamycyny/przeciwciało anty-CD22, kompozycja otrzymana tym sposobem oraz jej zastosowanie
GB0225279D0 (en) 2002-10-30 2002-12-11 Celltech R&D Ltd Biological products
ES2374068T3 (es) 2002-12-03 2012-02-13 Ucb Pharma, S.A. Ensayo para identificar células productoras de anticuerpos.
US8420086B2 (en) 2002-12-13 2013-04-16 Immunomedics, Inc. Camptothecin conjugates of anti-CD22 antibodies for treatment of B cell diseases
GB0305702D0 (en) 2003-03-12 2003-04-16 Univ Birmingham Bispecific antibodies
CN1326878C (zh) 2003-04-29 2007-07-18 中国抗体制药有限公司 抗人非何杰金淋巴瘤嵌合抗体及其衍生物与应用
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
US20050048578A1 (en) 2003-06-26 2005-03-03 Epitomics, Inc. Methods of screening for monoclonal antibodies with desirable activity
US20040268306A1 (en) 2003-06-30 2004-12-30 Cheng Ken Prayoon Methods, systems and computer program products for language independent data communication and display
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
PT1644412E (pt) 2003-07-01 2015-12-23 Ucb Biopharma Sprl Fragmentos de anticorpos fab modificados
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
WO2005016950A1 (fr) 2003-08-07 2005-02-24 Epitomics, Inc. Methodes destinees a humaniser des anticorps monoclonaux de lapin
TW200521231A (en) 2003-09-18 2005-07-01 Novartis Ag Therapeutic binding molecules
AU2003271174A1 (en) 2003-10-10 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
ES2472690T3 (es) 2003-11-17 2014-07-02 Genentech, Inc. Anticuerpo contra CD22 para el tratamiento de tumores de origen hematopoy�tico
ES2343965T3 (es) 2003-11-25 2010-08-13 The Government Of The United States, As Represented By The Secretary Of Health And Human Services Anticuerpos anti-cd22 e inmunocongujados mutados.
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
WO2005118642A2 (fr) * 2004-06-01 2005-12-15 Domantis Limited Compositions de medicaments, fusions et conjugues
WO2006004910A2 (fr) 2004-06-28 2006-01-12 Transtarget Inc. Anticorps bispecifiques ameliores
TW200621282A (en) 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
CN101258162A (zh) 2005-05-11 2008-09-03 菲罗根股份公司 抗纤连蛋白ed-b和白细胞介素12的抗体l19的融合蛋白
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US7745393B2 (en) 2005-11-03 2010-06-29 Jumi Shin Minimalist bZIP proteins and uses thereof
GB0523954D0 (en) 2005-11-24 2006-01-04 Ucb Celltech Bioassays
GB0601513D0 (en) 2006-01-25 2006-03-08 Univ Erasmus Medical Ct Binding molecules 3
WO2007092196A2 (fr) 2006-01-27 2007-08-16 Cellerant Therapeutics, Inc. Compositions et procedes de traitement du syndrome myeloproliferatif
US8389688B2 (en) 2006-03-06 2013-03-05 Aeres Biomedical, Ltd. Humanized anti-CD22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
EP2639242A3 (fr) 2006-03-06 2013-10-16 MedImmune, Inc. Anticorps humanisés dirigés contre l'antigène CD22 et leur utilisation dans le traitement de l'oncologie, des transplantations et les maladies auto-immunes
CA2652945C (fr) 2006-05-30 2015-06-02 Genentech, Inc. Anticorps et immuno-conjugues, et leurs utilisations
KR101571027B1 (ko) * 2006-06-12 2015-11-23 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 효과기 기능을 갖는 단일쇄 다가 결합 단백질
CN101626782B (zh) 2006-12-01 2013-03-27 梅达雷克斯公司 结合cd22的人抗体及其用途
CN104497143B (zh) * 2007-03-29 2020-08-25 健玛保 双特异性抗体及其制造方法
WO2009012256A1 (fr) 2007-07-16 2009-01-22 Genentech, Inc. Anticorps anti-cd79b humanisés, immunoconjugués, et procédés d'utilisation
CL2008002085A1 (es) 2007-07-16 2008-11-21 Genentech Inc Anticuerpo humanizado anti-cd79b/igbeta/b29; polinucleotido codificacnte, vector, celula huesped; metodo de fabricacion; inmunoconjugado; composicion farmaceutica; uso para tratar cancer; metodo in vitro para determinar presencia de cd79b, oinhibir crecimiento de celulas quqe expresa cd79b; ensayo in vitro para detectar celulas b
CN101842387B (zh) 2007-09-26 2014-05-07 Ucb医药有限公司 双特异性抗体融合物
PL2247620T3 (pl) 2008-01-31 2017-08-31 Genentech, Inc. Przeciwciała anty-CD79B i immunokoniugaty i sposoby stosowania
EP2259795B1 (fr) 2008-03-26 2016-04-06 Epitomics, Inc. Anticorps dirigé contre le facteur de croissance de l'endothélium vasculaire
EP2252631B1 (fr) 2008-04-02 2016-04-13 MacroGenics, Inc. Anticorps spécifiques du complexe bcr et procédés pour les utiliser
US8591889B2 (en) 2008-04-04 2013-11-26 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human monoclonal antibodies specific for CD22
CA3020290A1 (fr) 2008-06-25 2009-12-30 Esbatech, An Alcon Biomedical Research Unit Llc Anticorps stables et solubles inhibant le vegf
US8540235B2 (en) 2008-09-05 2013-09-24 Peter Kern Conveying apparatus for envelopes and related methods
WO2010035012A1 (fr) 2008-09-26 2010-04-01 Ucb Pharma S.A. Produits biologiques
EP3470087A1 (fr) 2009-02-13 2019-04-17 Immunomedics, Inc. Compositions lyophilisées d'immunoconjugués comportant une liaison clivable au niveau intracellulaire
JP5740772B2 (ja) 2009-08-31 2015-07-01 アイビーシー ファーマスーティカルズ，インコーポレイテッド 二重特異性免疫サイトカインドック−アンド−ロック（ｄｎｌ）複合体及びその治療的使用
GB0920127D0 (en) 2009-11-17 2009-12-30 Ucb Pharma Sa Antibodies
GB201000467D0 (en) 2010-01-12 2010-02-24 Ucb Pharma Sa Antibodies
WO2011130305A2 (fr) 2010-04-12 2011-10-20 Sorrento Therapeutics Inc. Procédé pour afficher les anticorps
WO2011131746A2 (fr) 2010-04-20 2011-10-27 Genmab A/S Protéines contenant des anticorps fc hétérodimères et leurs procédés de production
US20130209463A1 (en) 2010-06-30 2013-08-15 Compugen Ltd. Polypeptides and uses thereof as a drug for treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders
MX342920B (es) 2010-07-30 2016-10-19 Medimmune Llc Metodo para purificar polipeptidos o inmunoconjugados activos.
CA2808482C (fr) 2010-08-16 2021-10-26 Novimmune S.A. Procede de production d'anticorps multispecifiques et multivalents
AU2012222833B2 (en) 2011-03-03 2017-03-16 Zymeworks Inc. Multivalent heteromultimer scaffold design and constructs
WO2012151199A1 (fr) * 2011-05-02 2012-11-08 Immunomedics, Inc. Concentration d'ultrafiltration d'anticorps à allotype sélectionné pour une administration de petit volume
CN106432506A (zh) * 2011-05-24 2017-02-22 泽恩格尼亚股份有限公司 多价和单价多特异性复合物及其用途
US8852599B2 (en) 2011-05-26 2014-10-07 Bristol-Myers Squibb Company Immunoconjugates, compositions for making them, and methods of making and use
CN103717236A (zh) 2011-06-08 2014-04-09 加利福尼亚大学董事会 治疗肺癌和前列腺癌的抗-cd22抗原结合分子
WO2013012733A1 (fr) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Régions fc hétérodimères, molécules de liaison les comprenant, et méthodes associées
SI2771364T1 (sl) 2011-10-27 2019-10-30 Genmab As Produkcija heterodimernih proteinov
UA112203C2 (uk) 2011-11-11 2016-08-10 Юсб Фарма С.А. Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини
EP2783214A2 (fr) 2011-11-23 2014-10-01 The Board of Regents of The University of Texas System Identification protéomique d'anticorps
CA2853138A1 (fr) 2011-12-05 2013-06-13 Immunomedics, Inc. Utilisation therapeutique d'anticorps anti-cd22 pour induire une trogocytose
US20140212425A1 (en) 2011-12-05 2014-07-31 Immunomedics, Inc. Therapeutic use of anti-cd22 antibodies for inducing trogocytosis
CA2859089A1 (fr) 2011-12-16 2013-06-20 Pfizer Inc. Combinaison d'inotuzumab ozogamicine et de torisel pour le traitement du cancer
JP2015516984A (ja) 2012-04-26 2015-06-18 バイオアトラ、エルエルシー 抗ｃｄ２２抗体
EP2861622A4 (fr) 2012-06-15 2016-06-01 Sinomab Bioscience Ltd Anticorps anti-idiotypiques anti-cd22 et leurs utilisations
CA2871386A1 (fr) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Procede de selection et de production de molecules therapeutiques multi-specifiques, selectives et personnalisees comprenant au moins deux entites de ciblage differentes et leursutilisations
AR091700A1 (es) 2012-07-09 2015-02-25 Genentech Inc Anticuerpos e inmunoconjugados anti-cd79b
EP2869849A1 (fr) 2012-07-09 2015-05-13 Genentech, Inc. Immunoconjugués comprenant des anticorps anti-cd22
JP6297550B2 (ja) 2012-07-09 2018-03-20 ジェネンテック， インコーポレイテッド 抗ｃｄ７９ｂ抗体を含む免疫複合体
BR112015000439A2 (pt) 2012-07-09 2017-12-19 Genentech Inc imunoconjugado , formulação farmacêutica e métodos de tratamento de um indivíduo e de inibição da proliferação
CN104582717B (zh) 2012-07-19 2018-03-13 雷德伍德生物科技股份有限公司 对cd22有特异性的抗体及其使用方法
US9682143B2 (en) 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
KR101963231B1 (ko) 2012-09-11 2019-03-28 삼성전자주식회사 이중특이 항체의 제작을 위한 단백질 복합체 및 이를 이용한 이중특이 항체 제조 방법
WO2014066271A1 (fr) 2012-10-22 2014-05-01 Becton, Dickinson And Company Cellules de lignage non b capables de produire des anticorps
GB201223276D0 (en) 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
EP2961773B1 (fr) 2013-02-26 2019-03-20 Roche Glycart AG Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t
CN103214578B (zh) 2013-05-10 2014-05-28 北京东方百泰生物科技有限公司 一种新型的人源化抗cd22抗体
UA116479C2 (uk) 2013-08-09 2018-03-26 Макродженікс, Інк. БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ
EP3057994B1 (fr) 2013-10-15 2020-09-23 The Scripps Research Institute Commutateurs de cellules t à récepteur d'antigène chimère peptidique et leurs utilisations
MX2016008189A (es) 2014-01-03 2016-09-29 Hoffmann La Roche Conjugados helicoidales-anticuerpo anti-helicoidal unidos covalentemente y usos de los mismos.
US9139649B2 (en) 2014-02-25 2015-09-22 Immunomedics, Inc. Humanized anti-CD22 antibody
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct
GB201411420D0 (en) 2014-06-26 2014-08-13 Ucb Biopharma Sprl Antibody constructs
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412658D0 (en) * 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
TWI681971B (zh) 2014-08-06 2020-01-11 日商安斯泰來製藥股份有限公司 新穎抗人類Ｉｇβ抗體
JP6802158B2 (ja) 2014-12-05 2020-12-16 ジェネンテック， インコーポレイテッド 抗ＣＤ７９ｂ抗体及び使用方法
US11091546B2 (en) 2015-04-15 2021-08-17 The Scripps Research Institute Optimized PNE-based chimeric receptor T cell switches and uses thereof
US20160304611A1 (en) 2015-04-17 2016-10-20 Immunomedics, Inc. Combination therapy for treating adult patients with relapsed/refractory cd22+ b-cell acute lymphoblastic leukemia
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
GB201601075D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201521383D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl And Ucb Celltech Method
GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521391D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521393D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
CN110248668B (zh) 2016-12-15 2023-05-30 杜克大学 用于消耗调节性b10细胞的抗体和方法以及与免疫检查点抑制剂的联用

Also Published As

Publication number Publication date
RU2743590C2 (ru) 2021-02-20
WO2016009030A2 (fr) 2016-01-21
CN106661122A (zh) 2017-05-10
CA2954567A1 (fr) 2016-01-21
KR20170035954A (ko) 2017-03-31
EP3169705A2 (fr) 2017-05-24
CN106661122B (zh) 2021-04-02
AU2015289094A1 (en) 2017-01-12
WO2016009030A3 (fr) 2016-03-24
US10370447B2 (en) 2019-08-06
US20170204178A1 (en) 2017-07-20
CO2017000228A2 (es) 2017-04-10
MX2016017040A (es) 2017-05-01
BR112017000671A2 (pt) 2018-01-09
US11261252B2 (en) 2022-03-01
IL249537A0 (en) 2017-02-28
CL2017000110A1 (es) 2017-10-30
JP2017522023A (ja) 2017-08-10
RU2021103288A (ru) 2021-03-04
RU2017104815A (ru) 2018-08-16
GB201412658D0 (en) 2014-08-27
JP2021129568A (ja) 2021-09-09
US20200024346A1 (en) 2020-01-23
RU2017104815A3 (fr) 2019-02-18
SG11201610641YA (en) 2017-01-27

Similar Documents

Publication Publication Date Title
MA40408A (fr) Molécules ayant une spécificité pour cd79 et cd22
MX2016017271A (es) Moleculas con especificidad para cd45 y cd79.
CO2018000211A2 (es) Moléculas de anticuerpo que se unen a cd45
EA201890315A1 (ru) Молекулы антител, связывающие cd22
PH12018501206A1 (en) Antibody molecules to pd-1 and uses thereof
TN2017000246A1 (en) Anti-c10orf54 antibodies and uses thereof
MX2018000590A (es) Moleculas de anticuerpo que se unen a agrupacion de diferenciacion 79 (cd79).
MX2017008819A (es) Anticuerpos anti-cd47 y usos de los mismos.
JOP20150048B1 (ar) جزيئات جسم مضاد لـ lag-3 واستخداماتها
PH12014502826A1 (en) Immunoconjugates comprising anti-cd79b antibodies
CA2900335C (fr) Analogues synthetiques d'epipolythiodioxopiperazines et leurs utilisations
MX2016003129A (es) Terapia de combinacion de anticuerpos contra el csf-1r humano y anticuerpos contralel pd-l1 humano.
IN2015DN02634A (fr)
EA201491947A1 (ru) Антитела и иммуноконъюгаты к ly6e и способы применения
BR112015023557A2 (pt) proteínas de ligações dual específicas direcionadas contra tnfa
MX2016002574A (es) Nuevos moduladores del homologo 6 (sez6) y metodos de uso.
MX2014014376A (es) Anticuerpos de anti-biotina y metodos de uso.
IN2015DN00634A (fr)
MX2020003219A (es) Anticuerpos que tienen especificidad para btn2 y usos de los mismos.
MX357675B (es) Anticuerpos anti-jagged y métodos de uso.
UA112760C2 (uk) Теобромін у комбінації з гвайфенезином для лікування кашлю
TWD180565S (zh) 塗抹器
MX2016014416A (es) Anticuerpos anti-her3 que se unen a la horquilla beta de her3.
MX2018011244A (es) Anticuerpos monoclonales neutralizantes para il-25 y usos de estos.
UA70205U (ru) Применение растительного препарата трипсидан в качестве лекарственного средства для комплексного лечения постинфекционного астенического синдрома и высокой тревожности у детей школьного возраста в условиях организованных коллективов