MA39959A - Procédé de production de cellules progénitrices de foie adulte - Google Patents

Procédé de production de cellules progénitrices de foie adulte

Info

Publication number
MA39959A
MA39959A MA039959A MA39959A MA39959A MA 39959 A MA39959 A MA 39959A MA 039959 A MA039959 A MA 039959A MA 39959 A MA39959 A MA 39959A MA 39959 A MA39959 A MA 39959A
Authority
MA
Morocco
Prior art keywords
cells
progenitor cells
adult liver
liver progenitor
producing
Prior art date
Application number
MA039959A
Other languages
English (en)
Inventor
Tuba Baran
Luca Falciola
Kris Gellynck
Sarah Snykers
Etienne Sokal
Original Assignee
Promethera Biosciences S A /N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2014/068317 external-priority patent/WO2015028577A1/fr
Application filed by Promethera Biosciences S A /N V filed Critical Promethera Biosciences S A /N V
Publication of MA39959A publication Critical patent/MA39959A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)

Abstract

De nouvelles cellules progénitrices de foie adulte (appelées cellules souches h2) ont été caractérisées sur la base d'une série d'activités et de marqueurs biologiques. Des procédés de production de cellules souches h2 permettent d'obtenir ces cellules sous la forme de cellules adhérentes et de grappes de cellules tridimensionnelles en suspension qui peuvent être différenciées en cellules présentant de fortes activités spécifiques au foie et/ou qui peuvent être utilisées pour traiter des maladies hépatiques ou pour évaluer l'efficacité, le métabolisme et/ou la toxicité d'un composé.
MA039959A 2014-08-28 2015-08-28 Procédé de production de cellules progénitrices de foie adulte MA39959A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2014/068317 WO2015028577A1 (fr) 2013-08-28 2014-08-28 Procédé de production de cellules progénitrices de foie adulte
EP15157664 2015-03-04

Publications (1)

Publication Number Publication Date
MA39959A true MA39959A (fr) 2017-03-15

Family

ID=52705967

Family Applications (1)

Application Number Title Priority Date Filing Date
MA039959A MA39959A (fr) 2014-08-28 2015-08-28 Procédé de production de cellules progénitrices de foie adulte

Country Status (21)

Country Link
US (2) US10538741B2 (fr)
EP (1) EP3140393B1 (fr)
JP (2) JP2017530697A (fr)
KR (2) KR102101060B1 (fr)
CN (1) CN106795489B (fr)
AU (1) AU2015308341B2 (fr)
BR (1) BR112017003996A2 (fr)
CA (1) CA2958851C (fr)
DK (1) DK3140393T3 (fr)
EA (1) EA035214B1 (fr)
ES (1) ES2954834T3 (fr)
FI (1) FI3140393T3 (fr)
IL (1) IL249232B (fr)
LT (1) LT3140393T (fr)
MA (1) MA39959A (fr)
MX (1) MX2017002667A (fr)
PL (1) PL3140393T3 (fr)
PT (1) PT3140393T (fr)
SA (1) SA517380984B1 (fr)
SG (1) SG11201701109WA (fr)
WO (1) WO2016030525A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
PT3039123T (pt) 2013-08-28 2020-01-16 Promethera Biosciences S A / N V Método para produção de células progenitoras de fígado adulto
AU2015267148B2 (en) 2014-05-28 2021-07-29 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
CN106795489B (zh) * 2014-08-28 2021-07-06 信铭普罗米迪拉亚洲有限公司 用于生产成人肝脏祖细胞的方法
EP3207123A1 (fr) 2014-10-17 2017-08-23 Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center Modèle in vivo d'intestin grêle humain faisant intervenir des cellules souches pluripotentes et ses procédés de fabrication et d'utilisation
CN116790476A (zh) 2016-05-05 2023-09-22 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
CA3045145A1 (fr) 2016-12-05 2018-06-14 Children's Hospital Medical Center Organoides du colon et leurs procedes de preparation et d'utilisation
WO2019055345A1 (fr) * 2017-09-12 2019-03-21 Beth Israel Deaconess Medical Center, Inc. Compositions et méthodes permettant de traiter une maladie hépatique et un dysfonctionnement hépatique
CN112513252B (zh) * 2018-05-16 2024-07-12 国家健康科学研究所 培养增殖性肝细胞的方法
KR102107057B1 (ko) * 2018-09-21 2020-05-07 오가노이드사이언스 주식회사 간 유래 줄기세포를 포함하는 간 오가노이드의 제조방법 및 이의 용도
CN117802031A (zh) * 2018-09-30 2024-04-02 中国科学院分子细胞科学卓越创新中心 肝细胞的体外扩增培养方法及应用
TW202035682A (zh) 2018-12-14 2020-10-01 比利時商普羅米修亞生物科技股份有限公司 表現hla-g之肝先驅細胞及取得包含該等細胞之此等細胞組成物之方法與其用途
TW202043463A (zh) 2018-12-14 2020-12-01 比利時商普羅米修亞生物科技股份有限公司 包含表現hla-e之肝先驅細胞之細胞組成物
SG11202110476YA (en) * 2019-03-26 2021-10-28 Promethera Therapeutics Sa Adult liver progenitor cells for treating acute-on-chronic liver failure
US20220202874A1 (en) 2019-03-26 2022-06-30 Promethera Therapeutics Sa Adult Liver Progenitor Cells for Treating Non-Alcoholic Fatty Liver Disease
CN113939585A (zh) * 2019-04-30 2022-01-14 普罗米瑟拉疗法公司 人同种异体肝源性祖细胞的制备
TW202106874A (zh) 2019-04-30 2021-02-16 比利時商普羅米修亞生物科技股份有限公司 人類同種異體肝衍生前驅細胞的製備(一)
CN110179970A (zh) * 2019-07-05 2019-08-30 浙江大学 Il-1r2细胞因子在制备治疗肝功能衰竭药剂中的应用
US20230256027A1 (en) 2019-10-09 2023-08-17 Cellaïon SA Use of Liver Progenitor or Stem Cells, Lysates Thereof, and/or Conditioned Medium in Disorders Characterized by Vascular Hyperpermeability
CN111206013A (zh) * 2020-02-13 2020-05-29 上海交通大学医学院附属仁济医院 一种长时间维持人原代肝细胞的功能状态的培养方法
EP3881853A1 (fr) 2020-03-20 2021-09-22 Promethera Therapeutics Sa Cellules progénitrices allogéniques humaines dérivées du foie à utiliser dans le traitement des maladies pulmonaires inflammatoires et infectieuses et de l'inflammation systémique
US20220331502A1 (en) * 2020-06-26 2022-10-20 Ykrita Lifesciences Private Limited Bioengineered Artificial Lateral Liver (BALL) or Bioengineered Artificial Ectopic Liver (BAEL)
WO2023180122A1 (fr) 2022-03-24 2023-09-28 Université Catholique de Louvain Utilisation de cellules progénitrices allogéniques humaines dérivées du foie pour traiter et/ou prévenir la sénescence cellulaire

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US6872389B1 (en) 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
IL155249A0 (en) * 2000-10-03 2003-11-23 Univ North Carolina Methods of isolating bipotent hepatic progenitor cells
SE527491C2 (sv) 2003-12-19 2006-03-21 Cmc Contrast Ab Kontraktsmedelskomposition för magnetisk resonanstomografi för oral administration
ES2359874T5 (es) * 2005-12-21 2014-12-12 Universite Catholique De Louvain Células madre hepáticas aisladas
CA2634510C (fr) * 2005-12-21 2018-01-09 Universite Catholique De Louvain Cellules souches progenitrices hepatiques isolees
US8415149B2 (en) * 2010-05-06 2013-04-09 Gwo Xi Stem Cell Applied Technology Co., Ltd. Hepatic progenitor cells and uses thereof
EP3016665B1 (fr) * 2013-07-05 2019-09-18 Université Catholique de Louvain Milieu conditionné provenant de cellules souches de foie humain adulte et utilisation de ce milieu dans le traitement de maladies
PT3039123T (pt) 2013-08-28 2020-01-16 Promethera Biosciences S A / N V Método para produção de células progenitoras de fígado adulto
CN106795489B (zh) * 2014-08-28 2021-07-06 信铭普罗米迪拉亚洲有限公司 用于生产成人肝脏祖细胞的方法

Also Published As

Publication number Publication date
JP2020127423A (ja) 2020-08-27
ES2954834T3 (es) 2023-11-27
SA517380984B1 (ar) 2022-02-14
US11339373B2 (en) 2022-05-24
LT3140393T (lt) 2023-09-11
CN106795489A (zh) 2017-05-31
JP2017530697A (ja) 2017-10-19
CA2958851C (fr) 2023-05-09
WO2016030525A1 (fr) 2016-03-03
FI3140393T3 (fi) 2023-09-07
AU2015308341B2 (en) 2021-09-16
IL249232B (en) 2020-04-30
US20200095554A1 (en) 2020-03-26
EP3140393A1 (fr) 2017-03-15
IL249232A0 (en) 2017-02-28
EA201790357A1 (ru) 2017-08-31
MX2017002667A (es) 2017-10-02
DK3140393T3 (da) 2023-09-18
PT3140393T (pt) 2023-09-04
KR102101060B1 (ko) 2020-04-16
CN106795489B (zh) 2021-07-06
PL3140393T3 (pl) 2023-11-06
US20170240863A1 (en) 2017-08-24
KR20190003833A (ko) 2019-01-09
BR112017003996A2 (pt) 2017-12-12
EP3140393B1 (fr) 2023-06-14
SG11201701109WA (en) 2017-03-30
KR20170002664A (ko) 2017-01-06
US10538741B2 (en) 2020-01-21
EA035214B1 (ru) 2020-05-18
AU2015308341A1 (en) 2017-03-02
CA2958851A1 (fr) 2016-03-03

Similar Documents

Publication Publication Date Title
SA517380984B1 (ar) طريقة لإنتاج خلايا سليفة في كبد بالغ
MX369514B (es) Metodo para producir celulas progenitoras hepaticas adultas.
IL291373A (en) Methods and systems for growing cells in culture
EP3523419A4 (fr) Compositions et méthodes pour déterminer une viabilité cellulaire
IL249828A0 (en) Limbal stem cells of cultured mammals, methods of their creation and uses thereof
MX2017004890A (es) Metodos y composiciones para la generación o el mantenimiento de células pluripotentes.
HK1210222A1 (en) A culture medium for hematopoietic stem cells and the applications thereof as well as the stem cells culture method
MX2017008416A (es) Formas solidas de un inhibidor de ask1.
WO2015134787A3 (fr) Procédés dans lesquels on utilise des molécules synthétiques contenant des randomères
PH12016500783A1 (en) Suspension and clustering of human pluripotent stem cells for differentation into pancreatic endocrine cells
SG10201810723VA (en) Improved t cell compositions
EP3426772A4 (fr) Cultures en suspension de cellules tumorales et procédés associés
EP3443608A4 (fr) Cellules électrochimiques à champs d'écoulement conçus et leurs procédés de fabrication
HK1208144A1 (en) Artificial biological heart valve and the production methods thereof
EP3325608A4 (fr) Procédés et micro-organismes de production de 1,3-butanediol
GB201602974D0 (en) Engineered cells & methods (1)
MX2021007613A (es) Metodos de establecimiento de bancos de celulas de densidad ultra-alta.
MX2015017253A (es) Composiciones y metodos para tratar trastornos metabolicos.
MX2017008414A (es) Composiciones inhibidoras de nitrificacion y metodos para preparar las mismas.
EP3464569A4 (fr) Procédés in vitro de différenciation de cellules souches en neurones et neurones générés utilisant lesdits procédés in vitro de différenciation de cellules souches en neurones
IL266831B (en) A population of cells for transplantation and a method for its production
HK1221604A1 (zh) 豬苓菌與蜜環菌屬的種的共生方法及使用該方法的豬苓菌的栽培方法
MX2015017414A (es) Bacteria acetogenica.
EP3303570A4 (fr) Méthodes pour cultiver et/ou différencier des cellules souches hématopoïétiques en progéniteurs, et utilisations correspondantes
EP3460050A4 (fr) Procédé de culture cellulaire, milieu de culture et kit de milieu de culture