US3784703A
(en)
*
|
1972-02-29 |
1974-01-08 |
Merck & Co Inc |
Method of treating hypertension
|
US5017566A
(en)
|
1987-12-30 |
1991-05-21 |
University Of Florida |
Redox systems for brain-targeted drug delivery
|
US4933324A
(en)
|
1988-02-26 |
1990-06-12 |
Shashoua Victor E |
Fatty acid-neuroactive drug conjugate as a prodrug
|
US5994392A
(en)
|
1988-02-26 |
1999-11-30 |
Neuromedica, Inc. |
Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid
|
US4939174A
(en)
|
1988-02-26 |
1990-07-03 |
Shashoua Victor E |
Appetite suppression with dopamine-fatty acid conjugates
|
US5344832A
(en)
*
|
1990-01-10 |
1994-09-06 |
The Board Of Supervisors Of Louisiana University And Agricultural And Mechanical College |
Method for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates
|
RU2104698C1
(ru)
*
|
1991-12-23 |
1998-02-20 |
Дзе Борд оф Сьюпервайзорз оф Луизиана Стейт Юниверсити энд Эгрикалчурал энд Мекэникал Колледж |
Способ лечения патологических отклонений при диабете типа ii
|
US5472954A
(en)
|
1992-07-14 |
1995-12-05 |
Cyclops H.F. |
Cyclodextrin complexation
|
US5324718A
(en)
|
1992-07-14 |
1994-06-28 |
Thorsteinn Loftsson |
Cyclodextrin/drug complexation
|
ATE215079T1
(de)
|
1992-07-24 |
2002-04-15 |
Univ California |
Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
|
US6274600B1
(en)
|
1995-06-05 |
2001-08-14 |
The Regents Of The University Of California |
Heteroatom substituted benzoyl derivatives that enhance synaptic responses mediated by AMPA receptors
|
US20020099050A1
(en)
|
1993-07-23 |
2002-07-25 |
Lynch Gary S. |
Drugs that enhance synaptic responses mediated by AMPA receptors
|
US5488049A
(en)
|
1993-12-10 |
1996-01-30 |
Fidia - Georgetown Institute For The Neuro-Sciences |
Method of treating learning and memory disorders using benzothiadiazide derivatives as nootropic agents
|
US5852008A
(en)
|
1995-01-24 |
1998-12-22 |
The Regents Of The University Of California |
Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors
|
US5650409A
(en)
|
1995-06-02 |
1997-07-22 |
Cortex Pharmaceuticals, Inc. |
Benzoyl piperidines/pyrrolidines for enhancing synaptic response
|
US5773434A
(en)
|
1995-08-30 |
1998-06-30 |
Gary A. Rogers |
Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia
|
US5686423A
(en)
*
|
1996-02-16 |
1997-11-11 |
Department Of Health, The Executive Yuan, Republic Of China |
Di-and tri-peptide mimetic compounds for Parkinson's disease
|
US5891871A
(en)
|
1996-03-21 |
1999-04-06 |
Cocensys, Inc. |
Substituted 2,3-benzodiazepin-4-ones and the use thereof
|
US5736543A
(en)
|
1996-04-03 |
1998-04-07 |
The Regents Of The University Of California |
Benzoxazines for enhancing synaptic response
|
AU4416197A
(en)
|
1996-09-17 |
1998-04-14 |
Regents Of The University Of California, The |
Positive ampa receptor modulation to enhance brain neurotrophic factor expression
|
AU4345297A
(en)
|
1996-09-17 |
1998-04-14 |
Regents Of The University Of California, The |
Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor
|
AU5106498A
(en)
*
|
1996-10-22 |
1998-05-15 |
Ergo Research Corporation |
Method for increasing blood insulin levels in mammals
|
GB9702194D0
(en)
|
1997-02-04 |
1997-03-26 |
Lilly Co Eli |
Sulphonide derivatives
|
US6110935A
(en)
|
1997-02-13 |
2000-08-29 |
The Regents Of The University Of California |
Benzofurazan compounds for enhancing glutamatergic synaptic responses
|
US6329368B1
(en)
|
1997-05-09 |
2001-12-11 |
The Regents Of The University Of California |
Endocrine modulation with positive modulators of AMPA type glutamate receptors
|
US20050245612A1
(en)
*
|
2004-05-03 |
2005-11-03 |
Blass John P |
Pharmaceutical compositions for metabolic insufficiencies
|
US5985871A
(en)
|
1997-12-24 |
1999-11-16 |
Cortex Pharmaceuticals, Inc. |
Benzoxazine compounds for enhancing synaptic response
|
US6943159B1
(en)
|
1998-02-18 |
2005-09-13 |
Neurosearch A/S |
Compounds and their use as positive AMPA receptor modulators
|
EP1071426A2
(en)
|
1998-02-18 |
2001-01-31 |
Neurosearch A/S |
Novel compounds and their use as positive ampa receptor modulators
|
BR9908199A
(pt)
|
1998-02-24 |
2001-04-03 |
Lilly Co Eli |
Derivados de sulfonamida
|
US6174922B1
(en)
|
1998-05-11 |
2001-01-16 |
Eli Lilly And Company |
Sulphonamide derivatives
|
JP2002505288A
(ja)
|
1998-03-02 |
2002-02-19 |
コセンシス,インコーポレイテッド |
置換キナゾリンおよびアナログならびにそれらの使用
|
US6107489A
(en)
|
1998-03-17 |
2000-08-22 |
Conjuchem, Inc. |
Extended lifetimes in vivo renin inhibitors
|
US6124278A
(en)
|
1998-04-03 |
2000-09-26 |
The Regents Of The University Of California |
Acylbenzoxazines for enhancing synaptic response
|
AU3879899A
(en)
*
|
1998-05-04 |
1999-11-23 |
Neotherapeutics, Inc. |
Novel dopamine-like 9-substituted hypoxanthine and methods of use
|
EP1115393A4
(en)
|
1998-07-31 |
2002-03-26 |
Lilly Co Eli |
Sulfonamide derivatives
|
US6521605B1
(en)
|
1998-07-31 |
2003-02-18 |
Eli Lilly And Company |
Amidophosphate derivatives
|
WO2000006158A1
(en)
|
1998-07-31 |
2000-02-10 |
Eli Lilly And Company |
Heterocyclyl sulphonamide derivatives
|
PE20000943A1
(es)
|
1998-07-31 |
2000-09-28 |
Lilly Co Eli |
Derivados de sulfonamida
|
US6617351B1
(en)
|
1998-07-31 |
2003-09-09 |
Eli Lilly And Company |
Amide, carbamate, and urea derivatives
|
PE20000944A1
(es)
|
1998-07-31 |
2000-09-20 |
Lilly Co Eli |
Derivados de sulfonamida
|
WO2000006537A1
(en)
|
1998-07-31 |
2000-02-10 |
Eli Lilly And Company |
N-substituted sulfonamide derivatives
|
WO2000006159A1
(en)
|
1998-07-31 |
2000-02-10 |
Eli Lilly And Company |
Heterocyclic sulphonamide derivatives
|
AU5235699A
(en)
|
1998-07-31 |
2000-02-21 |
Eli Lilly And Company |
Sulfonamide derivatives
|
PE20000942A1
(es)
|
1998-07-31 |
2000-09-28 |
Lilly Co Eli |
Derivados de amida, carbamato y urea
|
US6358981B1
(en)
|
1998-07-31 |
2002-03-19 |
Eli Lilly And Company |
Sulphonamide derivatives
|
US6387954B1
(en)
|
1998-07-31 |
2002-05-14 |
Eli Lilly And Company |
Alkenyl sulphonamide derivatives
|
HUP0201157A3
(en)
|
1999-04-30 |
2003-04-28 |
Lilly Co Eli |
Monofluoroalkyl derivatives
|
JP4761683B2
(ja)
|
1999-06-04 |
2011-08-31 |
ユーロ−セルティック エス. ア. |
置換5−オキソ−5,6,7,8−テトラヒドロ−4h−1−ベンゾピランおよびベンゾチオピランならびにそのampa増強剤としての使用
|
US6297226B1
(en)
|
1999-10-15 |
2001-10-02 |
Neotherapeutics, Inc. |
Synthesis and methods of use of 9-substituted guanine derivatives
|
WO2001042203A1
(en)
|
1999-12-08 |
2001-06-14 |
Eli Lilly And Company |
Cyclopentyl sulfonamide derivatives
|
US6639107B1
(en)
|
1999-12-08 |
2003-10-28 |
Eli Lilly And Company |
Cyclopentyl sulfonamide derivatives
|
DE10004572A1
(de)
|
2000-02-02 |
2001-08-09 |
Boehringer Ingelheim Pharma |
Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
WO2001068592A1
(en)
|
2000-03-13 |
2001-09-20 |
Eli Lilly And Company |
Sulfonamide derivatives
|
US7345031B2
(en)
*
|
2000-04-12 |
2008-03-18 |
International Medical Innovations, Inc. |
Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
|
BR0110871A
(pt)
|
2000-05-19 |
2003-02-11 |
Lilly Co Eli |
Derivados de sulfonamida
|
KR20030007644A
(ko)
|
2000-05-19 |
2003-01-23 |
일라이 릴리 앤드 캄파니 |
술폰아미드 유도체
|
AU2001262932A1
(en)
|
2000-06-06 |
2001-12-17 |
Eli Lilly And Company |
(bis)sulfonamide derivatives
|
EP1296945B1
(en)
|
2000-06-13 |
2004-08-04 |
Eli Lilly And Company |
Sulfonamide derivatives
|
WO2002014294A2
(en)
|
2000-08-11 |
2002-02-21 |
Eli Lilly And Company |
Heterocyclic sulfonamide derivatives and their use for potentiating glutamate receptor function
|
EP1313719A2
(en)
|
2000-08-11 |
2003-05-28 |
Eli Lilly And Company |
Heterocyclic sulfonamide derivatives and their use for potentiating glutamate receptor function
|
US20040198833A1
(en)
|
2000-08-31 |
2004-10-07 |
Bender David Michael |
Acetylenic sulfonamide derivatives
|
WO2002032858A1
(en)
|
2000-10-13 |
2002-04-25 |
Eli Lilly And Company |
Cycloalkylfluorosulfonamide derivatives
|
WO2002049636A1
(en)
*
|
2000-12-19 |
2002-06-27 |
Rajagopal Thiruvengadam |
An antidiabetic composition of amino acids
|
CA2446161A1
(en)
*
|
2001-05-04 |
2002-11-14 |
Emanuele Sher |
Use of an ampa receptor potentiator for the manufacture of a medicament for the treatment of type 2 diabetes
|
ITBO20010271A1
(it)
|
2001-05-08 |
2002-11-08 |
Giuseppe Cannazza |
Metodo per il trattamento e la prevenzione dei disturbi del sistema nervoso centrale associati ad una alterazione della neurotrasmissione gl
|
US20030100552A1
(en)
|
2001-05-17 |
2003-05-29 |
Boehringer Ingelheim Pharma Kg |
Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions
|
EP1395550B1
(en)
|
2001-05-30 |
2005-06-29 |
Eli Lilly And Company |
Cycloalkenylsulfonamide derivatives
|
CA2446716A1
(en)
|
2001-06-05 |
2002-12-12 |
Eli Lilly And Company |
Sulfonamide derivatives
|
TWI232863B
(en)
|
2001-06-11 |
2005-05-21 |
Akzo Nobel Nv |
Benzoxazepine derivatives
|
EP1414423A1
(de)
*
|
2001-07-31 |
2004-05-06 |
Lothar Saiger |
Mittel zur behandlung von depressionen enthaltend ein lokalanästhetikum
|
US7045543B2
(en)
*
|
2001-11-05 |
2006-05-16 |
Enzrel Inc. |
Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites
|
NZ532368A
(en)
|
2001-11-26 |
2006-10-27 |
Cortex Pharma Inc |
Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
|
AU2003263793A1
(en)
*
|
2002-07-19 |
2004-02-09 |
Lg Life Sciences |
Dendrimers as molecular translocators
|
US20080200453A1
(en)
*
|
2002-07-29 |
2008-08-21 |
Cincotta Anthony H |
Methods of treating metabolic syndrome using dopamine receptor agonists
|
US9655865B2
(en)
*
|
2002-07-29 |
2017-05-23 |
Veroscience, Llc |
Therapeutic treatment for metabolic syndrome, type 2 diabetes, obesity, or prediabetes
|
US20050054652A1
(en)
*
|
2002-07-29 |
2005-03-10 |
Cincotta Anthony H. |
Methods of treating metabolic syndrome using dopamine receptor agonists
|
FR2854634B1
(fr)
|
2003-05-05 |
2005-07-08 |
Servier Lab |
Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
US7625932B2
(en)
|
2003-10-08 |
2009-12-01 |
Eli Lilly And Company |
Pyrrole and pyrazole derivatives as potentiators of glutamate receptors
|
GB0407583D0
(en)
*
|
2004-04-05 |
2004-05-05 |
Arbab Tarig S M |
Diagnostic testing and related matters
|
EP1752146A4
(en)
*
|
2004-05-19 |
2007-10-10 |
Ajinomoto Kk |
THERAPEUTIC AGENT AGAINST DIABETES
|
PT1751087E
(pt)
|
2004-06-04 |
2012-09-10 |
Xenoport Inc |
Derivados de levodopa e as suas composições e utilizações
|
DE602005015119D1
(de)
|
2004-08-09 |
2009-08-06 |
Glaxo Group Ltd |
Verbindungen, die den glutamatrezeptor verstärken und anwendungen davon in der medizin
|
GB0417709D0
(en)
|
2004-08-09 |
2004-09-08 |
Glaxo Group Ltd |
Compounds
|
JP2008509179A
(ja)
|
2004-08-09 |
2008-03-27 |
グラクソ グループ リミテッド |
グルタミン酸受容体を強化する化合物および医学におけるその使用
|
US20060167099A1
(en)
*
|
2004-11-09 |
2006-07-27 |
Anat Biegon |
Use of compositions that increase glutamate receptor activity in treatment of brain injury
|
WO2006087169A1
(en)
|
2005-02-15 |
2006-08-24 |
Glaxo Group Limited |
Compounds which potentiate glutamate receptor and uses thereof in medicine
|
WO2006087232A1
(en)
*
|
2005-02-17 |
2006-08-24 |
Instituto Del Metabolismo Celular, S.L. |
L-aspartic acid for the treatment of problems in connection with the fat or glucose metabolism
|
DE602006003661D1
(de)
|
2005-06-06 |
2008-12-24 |
Lilly Co Eli |
Ampa-rezeptoren-verstärker
|
US20090305225A1
(en)
*
|
2005-06-13 |
2009-12-10 |
Galbraith Richard A |
Inhibition of Creatine Uptake to Promote Weight Loss
|
WO2007060144A2
(en)
|
2005-11-22 |
2007-05-31 |
Neurosearch A/S |
Novel quinoxaline derivatives and their medical use
|
EP2135603B1
(en)
*
|
2005-11-22 |
2013-01-02 |
Orexigen Therapeutics, Inc. |
Compositions and methods for increasing insulin sensitivity
|
EP1981865A1
(en)
|
2006-02-08 |
2008-10-22 |
Glaxo Group Limited |
4-phenyl-3-(2-propylsulfonylamino) tetrahydrofuran derivatives which potentiate glutamate receptors and are useful in the treatment of schizophrenia
|
GB0602560D0
(en)
|
2006-02-08 |
2006-03-22 |
Glaxo Group Ltd |
Compounds
|
TW200843731A
(en)
|
2006-12-21 |
2008-11-16 |
Xenoport Inc |
Catechol protected levodopa diester prodrugs, compositions, and methods of use
|
US7709527B2
(en)
|
2006-12-21 |
2010-05-04 |
Xenoport, Inc. |
Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use
|
GB0711088D0
(en)
*
|
2007-06-08 |
2007-07-18 |
Glaxo Group Ltd |
Compounds
|
US8741918B2
(en)
*
|
2007-06-21 |
2014-06-03 |
Veroscience Llc |
Parenteral formulations of dopamine agonists
|
GB0721094D0
(en)
*
|
2007-10-26 |
2007-12-05 |
Glaxo Group Ltd |
Compounds
|
GB0721092D0
(en)
*
|
2007-10-26 |
2007-12-05 |
Glaxo Group Ltd |
Compounds
|
CN101990431B
(zh)
*
|
2008-03-12 |
2014-06-18 |
迈阿密大学 |
用于检测和治疗低血糖症的方法和测定法
|
WO2010015037A1
(en)
*
|
2008-08-08 |
2010-02-11 |
Howard Florey Institute |
Therapeutic methods and compositions
|
US8399513B2
(en)
|
2008-10-20 |
2013-03-19 |
Xenoport, Inc. |
Levodopa prodrug mesylate hydrate
|
GB0821166D0
(en)
*
|
2008-11-19 |
2008-12-24 |
Glaxo Group Ltd |
Compounds
|
GB0822425D0
(en)
*
|
2008-12-09 |
2009-01-14 |
Glaxo Group Ltd |
Compounds
|
WO2010121023A2
(en)
*
|
2009-04-15 |
2010-10-21 |
The Regents Of The University Of California |
Peptides and aptamers for targeting of neuron or nerves
|
US10206921B2
(en)
|
2009-06-03 |
2019-02-19 |
The Regents Of The University Of California |
Methods and compositions for treating a subject for central nervous system (CNS) injury
|
US20120283193A1
(en)
*
|
2009-10-31 |
2012-11-08 |
The Regents Of The University Of California |
Manipulation of brain in a circuit-specific manner
|
PE20131116A1
(es)
*
|
2010-08-10 |
2013-10-24 |
Takeda Pharmaceutical |
Compuestos heterociclicos potenciadores de ampa
|
US8697898B2
(en)
|
2011-11-23 |
2014-04-15 |
Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego PAN |
Medical application of lipid derivatives of dopamine and the methods of their production
|