MA35943B1 - Utilisation de (rs)-s-cyclopropyl-s-(4-{[4-{ [(1r, 2r)-2-hydroxy-1-méthylpropyl]oxy}-5-(trifluorméthyl) pyrimidin-2-yl]amino} - Google Patents

Utilisation de (rs)-s-cyclopropyl-s-(4-{[4-{ [(1r, 2r)-2-hydroxy-1-méthylpropyl]oxy}-5-(trifluorméthyl) pyrimidin-2-yl]amino}

Info

Publication number
MA35943B1
MA35943B1 MA37365A MA37365A MA35943B1 MA 35943 B1 MA35943 B1 MA 35943B1 MA 37365 A MA37365 A MA 37365A MA 37365 A MA37365 A MA 37365A MA 35943 B1 MA35943 B1 MA 35943B1
Authority
MA
Morocco
Prior art keywords
trifluormethyl
methylpropyl
cyclopropyl
oxy
hydroxy
Prior art date
Application number
MA37365A
Other languages
English (en)
Inventor
Martin Kornacker
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47891732&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35943(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MA35943B1 publication Critical patent/MA35943B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne l'utilisation de (r)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1- méthylpropyl]oxy}-5-(trifluorméthyl)pyrimidin-2-yl]
MA37365A 2012-03-21 2014-09-18 Utilisation de (rs)-s-cyclopropyl-s-(4-{[4-{ [(1r, 2r)-2-hydroxy-1-méthylpropyl]oxy}-5-(trifluorméthyl) pyrimidin-2-yl]amino} MA35943B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012204506 2012-03-21
PCT/EP2013/055561 WO2013139734A1 (fr) 2012-03-21 2013-03-18 Utilisation de (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-méthylpropyl]oxy}-5-(trifluorméthyl)pyrimidin-2-yl]amino}phényl)sulfoximide pour traiter des tumeurs spécifiques

Publications (1)

Publication Number Publication Date
MA35943B1 true MA35943B1 (fr) 2014-12-01

Family

ID=47891732

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37365A MA35943B1 (fr) 2012-03-21 2014-09-18 Utilisation de (rs)-s-cyclopropyl-s-(4-{[4-{ [(1r, 2r)-2-hydroxy-1-méthylpropyl]oxy}-5-(trifluorméthyl) pyrimidin-2-yl]amino}

Country Status (20)

Country Link
US (1) US20150051232A1 (fr)
EP (1) EP2827871A1 (fr)
JP (1) JP2015510910A (fr)
KR (1) KR20140135215A (fr)
CN (1) CN104220075A (fr)
AP (1) AP2014007915A0 (fr)
AU (1) AU2013234451A1 (fr)
CA (1) CA2867746A1 (fr)
CL (1) CL2014002472A1 (fr)
EA (1) EA201491732A1 (fr)
HK (1) HK1204294A1 (fr)
MA (1) MA35943B1 (fr)
MX (1) MX2014011240A (fr)
PH (1) PH12014502075A1 (fr)
SA (1) SA113340398B1 (fr)
SG (1) SG11201405386SA (fr)
TN (1) TN2014000391A1 (fr)
TW (1) TW201338779A (fr)
WO (1) WO2013139734A1 (fr)
ZA (1) ZA201406986B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015071231A1 (fr) * 2013-11-14 2015-05-21 Bayer Pharma Aktiengesellschaft Combinaisons de (rs)-s-cyclopropyl-s-(4-{[4-{[(1r,2r) -2-hydroxy-1-méthylpropyl]oxy}-5-(trifluorométhyl)pyrimidin-yl-2]amino}phenyl)sulfoximide pour le traitement de tumeurs
CN113956325A (zh) 2014-06-13 2022-01-21 塔夫茨大学信托人 Fap激活的治疗剂以及其相关用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1307271A (en) 1970-06-25 1973-02-14 Shell Int Research Sulphoximine derivatives and their use in herbicidal compositions
DE4029650A1 (de) 1990-09-19 1992-03-26 Hoechst Ag 2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide
AU744986B2 (en) 1997-07-12 2002-03-07 Cancer Research Technology Limited Cyclin dependent kinase inhibiting purine derivatives
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
ES2270612T3 (es) 1998-08-29 2007-04-01 Astrazeneca Ab Compuestos de pirimidina.
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
JP4771576B2 (ja) * 2000-06-12 2011-09-14 譲治 稲澤 Ｇａｓｃ１遺伝子
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
JP4291135B2 (ja) 2001-05-29 2009-07-08 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト Ｃｄｋ阻害性ピリミジン、それらの製造および薬剤としての使用
EP1483260A1 (fr) 2002-03-11 2004-12-08 Schering Aktiengesellschaft 2-heteroaryle-pyrimidines inhibitrices de la kinase dependante des cyclines, leur production et leur utilisation comme medicaments
MXPA05004920A (es) * 2002-11-06 2005-08-18 Cyclacel Ltd Combinacion que comprende un inhibidor cdk y cisplatin.
DE10349423A1 (de) 2003-10-16 2005-06-16 Schering Ag Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
EP2179991A1 (fr) * 2008-10-21 2010-04-28 Bayer Schering Pharma Aktiengesellschaft Dérivés d'anilino-pyrimidine substitués par sulfoximine en tant qu'inhibiteurs de CDK, leur fabrication et leur utilisation en tant que médicaments
WO2010058006A1 (fr) * 2008-11-24 2010-05-27 Nerviano Medical Sciences S.R.L. Inhibiteur de cdk (kinase cycline-dépendante) pour le traitement d'un mésothéliome
PT2424843E (pt) * 2009-04-30 2014-06-02 Novartis Ag Derivados de imidazol e seu uso como moduladores de quinases dependentes de ciclina
DE102010014427A1 (de) * 2010-04-01 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Kombinationen neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
DE102010014426A1 (de) * 2010-04-01 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren

Also Published As

Publication number Publication date
US20150051232A1 (en) 2015-02-19
AP2014007915A0 (en) 2014-09-30
KR20140135215A (ko) 2014-11-25
TW201338779A (zh) 2013-10-01
CA2867746A1 (fr) 2013-09-26
CL2014002472A1 (es) 2014-12-12
WO2013139734A1 (fr) 2013-09-26
SA113340398B1 (ar) 2016-04-04
JP2015510910A (ja) 2015-04-13
AU2013234451A1 (en) 2014-09-25
CN104220075A (zh) 2014-12-17
TN2014000391A1 (en) 2015-12-21
EP2827871A1 (fr) 2015-01-28
MX2014011240A (es) 2014-10-15
SG11201405386SA (en) 2014-11-27
HK1204294A1 (en) 2015-11-13
ZA201406986B (en) 2016-08-31
PH12014502075A1 (en) 2014-12-10
EA201491732A1 (ru) 2015-08-31

Similar Documents

Publication Publication Date Title
DOP2016000327A (es) (2r,5s,13ar)-7,9-dioxo-10-((2,4,6-trifluorobencil)carbamoil)-2,3,4,5,7,9,13,13a-octahidro-2,5-metanopirido[1’,2’:4,5]pirazino[2,1-b][1,3]oxazepin-8-olato de sodio
UY34824A (es) Nucleósidos de espirooxetano de uracilo
UY34778A (es) ?COMPUESTOS DE HEXAHIDROPIRANO[3,4-d][1,3]TIAZIN-2-AMINA HETEROCÍCLICOS SUSTITUÍDOS?.
UY34302A (es) COMPUESTOS DE HEXAHIDROPIRANO[3,4-d][1,3]TIAZIN-2- AMINA
EA201491811A1 (ru) АНТИ-LgR5 АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ
PH12014502398B1 (en) Pesticidal compositions and processes related thereto
UA110880C2 (uk) Заміщені амідином бета-лактами, їх одержання та застосування як антибактеріальних засобів
EA201690461A1 (ru) Полиморфные формы (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она
UY34765A (es) Compuestos novedosos.
EA201590993A1 (ru) Гетеродимерные иммуноглобулины
UY34885A (es) Proteínas de unión anti-mesotelina
MA37506B1 (fr) Utilisations thérapeutiques de protéines de facteur de croissance des fibroblastes 21
EA201592082A1 (ru) 3,4-дигидроизохинолин-2(1h)-ильные соединения
MA35898B1 (fr) Anticorps anti-lrp5 et leurs procédés d'utilisation
EA201590962A1 (ru) Новые соединения
BR112015000329A2 (pt) formulações de diclofenac
UY34329A (es) Compuestos de triazolopiridina
EA201590503A1 (ru) Альфа-1-микроглобулин для применения в лечении заболеваний, связанных с митохондриями
UY34553A (es) Procedimiento de preparación de la sal de l-arginina de perindoprilo
UY34191A (es) ?N-(6-((2R,3S)-3,4-Dihidroxibutan-2-iloxi)-2-(4-fluorobenciltio)pirimidin-4-il)-3-metilazetidina-1-sulfonamida y sales farmacéuticamente aceptables de lamisma?.
CO6821958A2 (es) Tetrahidroquinolinas condensadas con cicloalquilo como moduladores de receptores de crth2
UY34677A (es) Imidazopiridazinas sustituidas
EA201400881A1 (ru) Полиморфы n-(2-метоксибензоил)-4-[(метиламинокарбонил)амино]бензолсульфонамида
UY34223A (es) Formulaciones de (trimetoxifenilamino)pirimidinilo nuevas
MA35943B1 (fr) Utilisation de (rs)-s-cyclopropyl-s-(4-{[4-{ [(1r, 2r)-2-hydroxy-1-méthylpropyl]oxy}-5-(trifluorméthyl) pyrimidin-2-yl]amino}