AP2014007915A0 - Use of (RS)-S-cyclopropyl-S-(4-{[4-{[1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-YL]amino}phenyl)suloximide for treating specific tumours - Google Patents
Use of (RS)-S-cyclopropyl-S-(4-{[4-{[1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-YL]amino}phenyl)suloximide for treating specific tumoursInfo
- Publication number
- AP2014007915A0 AP2014007915A0 AP2014007915A AP2014007915A AP2014007915A0 AP 2014007915 A0 AP2014007915 A0 AP 2014007915A0 AP 2014007915 A AP2014007915 A AP 2014007915A AP 2014007915 A AP2014007915 A AP 2014007915A AP 2014007915 A0 AP2014007915 A0 AP 2014007915A0
- Authority
- AP
- ARIPO
- Prior art keywords
- suloximide
- methylpropyl
- pyrimidin
- cyclopropyl
- oxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102012204506 | 2012-03-21 | ||
PCT/EP2013/055561 WO2013139734A1 (de) | 2012-03-21 | 2013-03-18 | Verwendung von (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluormethyl)pyrimidin-2-yl]amino}phenyl)sulfoximid zur behandlung spezifischer tumore |
Publications (1)
Publication Number | Publication Date |
---|---|
AP2014007915A0 true AP2014007915A0 (en) | 2014-09-30 |
Family
ID=47891732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2014007915A AP2014007915A0 (en) | 2012-03-21 | 2013-03-18 | Use of (RS)-S-cyclopropyl-S-(4-{[4-{[1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-YL]amino}phenyl)suloximide for treating specific tumours |
Country Status (20)
Country | Link |
---|---|
US (1) | US20150051232A1 (xx) |
EP (1) | EP2827871A1 (xx) |
JP (1) | JP2015510910A (xx) |
KR (1) | KR20140135215A (xx) |
CN (1) | CN104220075A (xx) |
AP (1) | AP2014007915A0 (xx) |
AU (1) | AU2013234451A1 (xx) |
CA (1) | CA2867746A1 (xx) |
CL (1) | CL2014002472A1 (xx) |
EA (1) | EA201491732A1 (xx) |
HK (1) | HK1204294A1 (xx) |
MA (1) | MA35943B1 (xx) |
MX (1) | MX2014011240A (xx) |
PH (1) | PH12014502075A1 (xx) |
SA (1) | SA113340398B1 (xx) |
SG (1) | SG11201405386SA (xx) |
TN (1) | TN2014000391A1 (xx) |
TW (1) | TW201338779A (xx) |
WO (1) | WO2013139734A1 (xx) |
ZA (1) | ZA201406986B (xx) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015071231A1 (de) * | 2013-11-14 | 2015-05-21 | Bayer Pharma Aktiengesellschaft | Kombinationen von (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluormethyl)pyrimidin-2-yl]amino}phenyl)sulfoximid zur behandlung von tumoren |
CN113956325A (zh) | 2014-06-13 | 2022-01-21 | 塔夫茨大学信托人 | Fap激活的治疗剂以及其相关用途 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1307271A (en) | 1970-06-25 | 1973-02-14 | Shell Int Research | Sulphoximine derivatives and their use in herbicidal compositions |
DE4029650A1 (de) | 1990-09-19 | 1992-03-26 | Hoechst Ag | 2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide |
DE69832715T2 (de) | 1997-07-12 | 2007-01-11 | Cancer Research Technology Ltd. | Cyclin-abhängige-kinase inhibierende purinderivate |
US6440965B1 (en) | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
EP1107958B1 (en) | 1998-08-29 | 2006-08-16 | AstraZeneca AB | Pyrimidine compounds |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
JP4771576B2 (ja) * | 2000-06-12 | 2011-09-14 | 譲治 稲澤 | Gasc1遺伝子 |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
PL367130A1 (en) | 2001-05-29 | 2005-02-21 | Schering Aktiengesellschaft | Cdk inhibiting pyrimidines, production thereof and their use as medicaments |
WO2003076437A1 (de) | 2002-03-11 | 2003-09-18 | Schering Aktiengesellschaft | Cdk inhibitorische 2-heteroaryl-pyrimidine, deren herstellung und verwendung als arzneimittel |
AU2003276463A1 (en) * | 2002-11-06 | 2004-06-07 | Cyclacel Limited | Combination comprising a cdk inhibitor and cisplatin |
DE10349423A1 (de) | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
EP2179991A1 (de) * | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
JP2012509859A (ja) * | 2008-11-24 | 2012-04-26 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 中皮腫の治療のためのcdk阻害物質 |
BRPI1016190A2 (pt) * | 2009-04-30 | 2017-03-28 | Novartis Ag | compostos farmacêuticos. |
DE102010014427A1 (de) * | 2010-04-01 | 2011-10-06 | Bayer Schering Pharma Aktiengesellschaft | Kombinationen neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren |
DE102010014426A1 (de) * | 2010-04-01 | 2011-10-06 | Bayer Schering Pharma Aktiengesellschaft | Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren |
-
2013
- 2013-03-18 MX MX2014011240A patent/MX2014011240A/es unknown
- 2013-03-18 AP AP2014007915A patent/AP2014007915A0/xx unknown
- 2013-03-18 CN CN201380015167.9A patent/CN104220075A/zh active Pending
- 2013-03-18 KR KR1020147026273A patent/KR20140135215A/ko not_active Application Discontinuation
- 2013-03-18 CA CA2867746A patent/CA2867746A1/en not_active Abandoned
- 2013-03-18 EP EP13709923.0A patent/EP2827871A1/de not_active Withdrawn
- 2013-03-18 US US14/387,075 patent/US20150051232A1/en not_active Abandoned
- 2013-03-18 EA EA201491732A patent/EA201491732A1/ru unknown
- 2013-03-18 SG SG11201405386SA patent/SG11201405386SA/en unknown
- 2013-03-18 WO PCT/EP2013/055561 patent/WO2013139734A1/de active Application Filing
- 2013-03-18 JP JP2015500871A patent/JP2015510910A/ja active Pending
- 2013-03-18 AU AU2013234451A patent/AU2013234451A1/en not_active Abandoned
- 2013-03-19 TW TW102109754A patent/TW201338779A/zh unknown
- 2013-03-20 SA SA113340398A patent/SA113340398B1/ar unknown
-
2014
- 2014-09-17 CL CL2014002472A patent/CL2014002472A1/es unknown
- 2014-09-18 TN TNP2014000391A patent/TN2014000391A1/fr unknown
- 2014-09-18 PH PH12014502075A patent/PH12014502075A1/en unknown
- 2014-09-18 MA MA37365A patent/MA35943B1/fr unknown
- 2014-09-25 ZA ZA2014/06986A patent/ZA201406986B/en unknown
-
2015
- 2015-05-26 HK HK15104968.3A patent/HK1204294A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
TN2014000391A1 (en) | 2015-12-21 |
CN104220075A (zh) | 2014-12-17 |
SG11201405386SA (en) | 2014-11-27 |
HK1204294A1 (en) | 2015-11-13 |
CL2014002472A1 (es) | 2014-12-12 |
TW201338779A (zh) | 2013-10-01 |
WO2013139734A1 (de) | 2013-09-26 |
SA113340398B1 (ar) | 2016-04-04 |
US20150051232A1 (en) | 2015-02-19 |
CA2867746A1 (en) | 2013-09-26 |
MX2014011240A (es) | 2014-10-15 |
ZA201406986B (en) | 2016-08-31 |
PH12014502075A1 (en) | 2014-12-10 |
KR20140135215A (ko) | 2014-11-25 |
EA201491732A1 (ru) | 2015-08-31 |
MA35943B1 (fr) | 2014-12-01 |
AU2013234451A1 (en) | 2014-09-25 |
EP2827871A1 (de) | 2015-01-28 |
JP2015510910A (ja) | 2015-04-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL242278A0 (en) | Compounds 4)-n-fluoro-2-methoxy-5-nitrophenyl)pyrimidine-2-converted amine and their salts | |
SG2014008304A (en) | C10rf32 antibodies, and uses thereof for treatment of cancer | |
HK1249759A1 (zh) | 取代的嘧啶基和吡啶基吡咯並吡啶酮類、其製備方法及其作為激酶抑制劑的用途 | |
SG10201704992SA (en) | Lsr antibodies, and uses thereof for treatment of cancer | |
IL231591A0 (en) | Converted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases | |
HK1206338A1 (en) | Pyrimidine compounds for the treatment of cancer | |
ZA201406145B (en) | Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use | |
EP2725903A4 (en) | 3-ALKOXY, THIOALKYL AND AMINO-4-AMINO-6- (SUBSTITUTED) PICOLINATES AND THEIR USE AS HERBICIDES | |
EP2807551A4 (en) | ROAD CHARACTERISTICS OF NOTES | |
EP2731429A4 (en) | COMPOUNDS, METHODS OF PREPARATION AND METHODS OF USE | |
IL231444A0 (en) | Aniline derivatives, their preparation and medical application | |
UA108494C2 (xx) | Застосування (rs)-s-цикропропіл-s-(4-{$4-{$(1r,2r)-2-гідрокси-1-метилпропіл]окси}-5-(трифторметил)піримідин-2-іл]аміно}феніл)сульфоксіміду для лікування пухлин | |
EP2931043A4 (en) | PROCESS FOR PREPARING 4-AMINO-5-FLUORO-3-CHLOR-6- (SUBSTITUTED) PICOLINATES | |
EP2903979A4 (en) | Novel compounds, their preparation and use | |
EP2757092A4 (en) | SUBSTITUTED CYANANILIN COMPOUNDS, METHOD OF MANUFACTURING THEREOF AND USE THEREOF | |
ZA201406986B (en) | Use of (rs)-s-cyclopropyl-s-(4-{[4-{[1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide for treating specific tumours | |
HK1191942A1 (zh) | 新型六氫環戊二烯並吡咯酮,六氫吡咯並吡咯酮,八氫吡咯並吡啶酮和八氫吡啶酮化合物 | |
SG11201501289TA (en) | Preparation for preventing or treating type i diabetes | |
IL240977A0 (en) | Use of (sr)-s-cyclopropyl-s-(4-{[4-{[(r2,r1)-2-hydroxy-1-methylpropyl]-oxy}-5-(trifluoromethyl)pyrimidin-2-yl] Amino}phenyl)sulfoxide for the treatment of certain tumors | |
IL232339A0 (en) | 32rf10c antibodies, and their uses for cancer treatment | |
IL232340A0 (en) | lsr antibodies, and their uses for cancer treatment | |
GB201118482D0 (en) | Treating tumours | |
GB201116328D0 (en) | Treatment for tumours |