MA35618B1 - Promédicament de l'adrénomédulline à base de polyéthylène glycol et son utilisation - Google Patents

Promédicament de l'adrénomédulline à base de polyéthylène glycol et son utilisation

Info

Publication number
MA35618B1
MA35618B1 MA36961A MA36961A MA35618B1 MA 35618 B1 MA35618 B1 MA 35618B1 MA 36961 A MA36961 A MA 36961A MA 36961 A MA36961 A MA 36961A MA 35618 B1 MA35618 B1 MA 35618B1
Authority
MA
Morocco
Prior art keywords
adrenomedullin
polyethylene glycol
prodrug based
diseases
prevention
Prior art date
Application number
MA36961A
Other languages
English (en)
Inventor
Ingo Flamme
Johannes Kobberling
Hans-Georg Lerchen
Nils Griebenow
Rudolf Schohe-Loop
Sven Wittrock
Maria Kollnberger
Frank Wunder
Gorden Redlich
Andreas Knorr
July Marley
Iain Pritchard
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MA35618B1 publication Critical patent/MA35618B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)

Abstract

La présente invention concerne un nouveau promédicament de l'adrénomédulline à base de polyéthylène glycol (peg), des procédés pour le préparer, son utilisation pour le traitement et/ou la prévention de maladies, et son utilisation pour la production de médicaments destinés au traitement et/ou à la prévention de maladies, notamment des troubles cardiovasculaires, œdémateux et/ou inflammatoires.
MA36961A 2011-11-03 2014-04-28 Promédicament de l'adrénomédulline à base de polyéthylène glycol et son utilisation MA35618B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11187735 2011-11-03
PCT/EP2012/071507 WO2013064508A1 (fr) 2011-11-03 2012-10-30 Promédicament de l'adrénomédulline à base de polyéthylène glycol et son utilisation

Publications (1)

Publication Number Publication Date
MA35618B1 true MA35618B1 (fr) 2014-11-01

Family

ID=47146369

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36961A MA35618B1 (fr) 2011-11-03 2014-04-28 Promédicament de l'adrénomédulline à base de polyéthylène glycol et son utilisation

Country Status (45)

Country Link
US (3) US9603936B2 (fr)
EP (2) EP3075395B1 (fr)
JP (2) JP5995984B2 (fr)
KR (2) KR101965467B1 (fr)
CN (2) CN103998063B (fr)
AR (2) AR088582A1 (fr)
AU (2) AU2012331244B2 (fr)
BR (1) BR112014010708B1 (fr)
CA (1) CA2854134C (fr)
CL (1) CL2014000948A1 (fr)
CO (1) CO7020863A2 (fr)
CR (1) CR20140184A (fr)
CU (1) CU24184B1 (fr)
CY (2) CY1117354T1 (fr)
DK (2) DK2773376T3 (fr)
DO (2) DOP2014000078A (fr)
EA (2) EA025631B1 (fr)
EC (2) ECSP14013326A (fr)
ES (2) ES2659195T3 (fr)
GT (1) GT201400085A (fr)
HK (1) HK1246147A1 (fr)
HR (2) HRP20160285T1 (fr)
HU (2) HUE027333T2 (fr)
IL (3) IL232037B (fr)
IN (1) IN2014CN03290A (fr)
JO (2) JOP20190001B1 (fr)
LT (1) LT3075395T (fr)
MA (1) MA35618B1 (fr)
ME (1) ME02379B (fr)
MX (2) MX361287B (fr)
MY (2) MY173372A (fr)
NO (1) NO3075395T3 (fr)
PE (2) PE20181493A1 (fr)
PL (2) PL3075395T3 (fr)
PT (1) PT3075395T (fr)
RS (2) RS54623B1 (fr)
SG (2) SG11201400924TA (fr)
SI (2) SI2773376T1 (fr)
TN (1) TN2014000185A1 (fr)
TR (1) TR201802124T4 (fr)
TW (2) TWI583396B (fr)
UA (1) UA111098C2 (fr)
UY (2) UY34419A (fr)
WO (1) WO2013064508A1 (fr)
ZA (1) ZA201600434B (fr)

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IN2014DN03213A (fr) * 2011-11-03 2015-05-22 Bayer Ip Gmbh
EP2896400A1 (fr) * 2014-01-17 2015-07-22 Université Catholique De Louvain Procédé pour augmenter la biodisponibilité de composés inhalés
EP3127914A4 (fr) 2014-03-20 2017-11-22 University of Miyazaki Dérivés d'adrénomédulline à action prolongée
EP3197481A1 (fr) * 2014-09-26 2017-08-02 Bayer Pharma Aktiengesellschaft Dérivés d'adrénomédulline stabilisés et leur utilisation
AU2016324119B2 (en) * 2015-09-18 2019-11-14 Himuka AM Australia Pty Ltd. Long-acting adrenomedullin derivative
WO2018181638A1 (fr) 2017-03-29 2018-10-04 国立大学法人宮崎大学 Dérivé d'adrénomédulline à durée d'action longue
GB201707938D0 (en) * 2017-05-17 2017-06-28 Univ Sheffield Compounds
EP3986918A1 (fr) 2019-06-18 2022-04-27 Bayer Aktiengesellschaft Analogues d'adrénomédulline pour stabilisation à long terme et leur utilisation
JPWO2021112220A1 (fr) * 2019-12-05 2021-06-10
US20230364245A1 (en) 2020-04-03 2023-11-16 Bayer Aktiengesellschaft Pharmaceutical formulations polyethylene glycol-based prodrugs of adrenomedullin and use
WO2021198327A1 (fr) * 2020-04-03 2021-10-07 Bayer Aktiengesellschaft Formulations pharmaceutiques liquides de promédicaments à base de polyéthylène glycol d'adrénomédulline et leur utilisation
AU2021341508A1 (en) 2020-09-10 2023-05-25 Precirix N.V. Antibody fragment against fap
CN112457218B (zh) * 2020-11-05 2022-08-09 宁夏医科大学 2,4-二氨基丁酸衍生物的合成方法
CN117957021A (zh) 2021-08-20 2024-04-30 拜耳公司 用于制备聚乙二醇化肾上腺髓质素的方法、它的中间体及其用途
WO2023203135A1 (fr) 2022-04-22 2023-10-26 Precirix N.V. Anticorps radiomarqué amélioré
WO2023213801A1 (fr) 2022-05-02 2023-11-09 Precirix N.V. Pré-ciblage

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TW201332573A (zh) 2013-08-16
BR112014010708B1 (pt) 2021-03-02
JOP20190001B1 (ar) 2022-03-14
CL2014000948A1 (es) 2014-09-05
ECSP18071104A (es) 2018-10-31
RS54623B1 (en) 2016-08-31
KR20150000462A (ko) 2015-01-02
ME02379B (fr) 2016-06-20
CO7020863A2 (es) 2014-08-11
EP2773376B1 (fr) 2016-01-13
DK2773376T3 (en) 2016-04-18
IL252281A0 (en) 2017-08-31
US20170204137A1 (en) 2017-07-20
NO3075395T3 (fr) 2018-04-21
RS56819B1 (sr) 2018-04-30
TWI653051B (zh) 2019-03-11
SG10201607516SA (en) 2016-10-28
HK1246147A1 (zh) 2018-09-07
CN107412740B (zh) 2021-02-09
US9649363B2 (en) 2017-05-16
KR101965467B1 (ko) 2019-04-03
MX350341B (es) 2017-09-04
EP3075395A1 (fr) 2016-10-05
CR20140184A (es) 2014-05-27
JP2014532682A (ja) 2014-12-08
CY1117354T1 (el) 2017-04-26
IL232037B (en) 2018-12-31
TW201720467A (zh) 2017-06-16
JO3385B1 (ar) 2019-03-13
JOP20190001A1 (ar) 2017-06-16
IN2014CN03290A (fr) 2015-07-03
SI3075395T1 (en) 2018-03-30
KR20180108892A (ko) 2018-10-04
PL3075395T3 (pl) 2018-04-30
EA201400528A1 (ru) 2014-10-30
JP5995984B2 (ja) 2016-09-21
DOP2018000203A (es) 2018-10-15
ES2568063T3 (es) 2016-04-27
CA2854134C (fr) 2020-04-21
MX2014004384A (es) 2014-04-30
JP6177975B2 (ja) 2017-08-09
US10035818B2 (en) 2018-07-31
MX361287B (es) 2018-12-03
TN2014000185A1 (en) 2015-09-30
EA025631B1 (ru) 2017-01-30
DOP2014000078A (es) 2014-07-15
US9603936B2 (en) 2017-03-28
CN103998063B (zh) 2016-09-21
SI2773376T1 (sl) 2016-05-31
ECSP14013326A (es) 2014-05-31
MY194197A (en) 2022-11-21
GT201400085A (es) 2015-03-05
CY1119897T1 (el) 2018-06-27
EA201600495A1 (ru) 2016-10-31
UA111098C2 (uk) 2016-03-25
IL258229B (en) 2020-02-27
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IL258229A (en) 2018-06-28
UY37922A (es) 2018-11-30
PE20141219A1 (es) 2014-09-13
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DK3075395T3 (en) 2018-02-19
BR112014010708A2 (pt) 2017-04-25
PE20181493A1 (es) 2018-09-18
AU2017203423A1 (en) 2017-06-08
PL2773376T3 (pl) 2016-07-29
HRP20160285T1 (hr) 2016-04-22
IL252281B (en) 2021-01-31
EA029410B1 (ru) 2018-03-30
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AR088582A1 (es) 2014-06-18
HRP20180319T1 (hr) 2018-03-23
MY173372A (en) 2020-01-21
CA2854134A1 (fr) 2013-05-10
TWI583396B (zh) 2017-05-21
CU24184B1 (es) 2016-07-29
AU2012331244A1 (en) 2014-04-17
CN107412740A (zh) 2017-12-01
HUE036535T2 (hu) 2018-07-30
KR102004668B1 (ko) 2019-07-26
PT3075395T (pt) 2018-02-13
CU20140051A7 (es) 2014-10-02
TR201802124T4 (tr) 2018-03-21
AR113830A2 (es) 2020-06-17
AU2017203423B2 (en) 2019-01-31
AU2012331244B2 (en) 2017-06-15
UY34419A (es) 2013-05-31
IL232037A0 (en) 2014-05-28
WO2013064508A1 (fr) 2013-05-10
US20140287984A1 (en) 2014-09-25
ES2659195T3 (es) 2018-03-14
SG11201400924TA (en) 2014-09-26
EP3075395B1 (fr) 2017-11-22
ZA201600434B (en) 2017-05-31
LT3075395T (lt) 2018-02-26
EP2773376A1 (fr) 2014-09-10
US20160367636A1 (en) 2016-12-22

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