CY1119897T1 - Προφαρμακο αδρενομεδουλλινης βασιζομενο σε πολυαιθυλενογλυκολη και χρηση αυτου - Google Patents

Προφαρμακο αδρενομεδουλλινης βασιζομενο σε πολυαιθυλενογλυκολη και χρηση αυτου

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Publication number
CY1119897T1
CY1119897T1 CY20181100151T CY181100151T CY1119897T1 CY 1119897 T1 CY1119897 T1 CY 1119897T1 CY 20181100151 T CY20181100151 T CY 20181100151T CY 181100151 T CY181100151 T CY 181100151T CY 1119897 T1 CY1119897 T1 CY 1119897T1
Authority
CY
Cyprus
Prior art keywords
glycle
adrenomedouline
polythylene
product
prodrugs
Prior art date
Application number
CY20181100151T
Other languages
English (en)
Inventor
Ingo Flamme
Johannes KÖBBERLING
Hans-Georg Lerchen
Nils Griebenow
Rudolf Schohe-Loop
Sven WITTROCK
Maria KÖLLNBERGER
Frank Wunder
Gorden Redlich
Andreas Knorr
July MARLEY
Iain PRITCHARD
Original Assignee
Bayer Schering Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Aktiengesellschaft filed Critical Bayer Schering Pharma Aktiengesellschaft
Publication of CY1119897T1 publication Critical patent/CY1119897T1/el

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/402,5-Pyrrolidine-diones
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/23Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • AHUMAN NECESSITIES
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    • A61P31/04Antibacterial agents
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    • AHUMAN NECESSITIES
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    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic

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Abstract

Η εφεύρεση σχετίζεται με φάρμακα που περιλαμβάνουν νέα πολυαιθυλενο γλυκόλη (PEG), που βασίζεται σε προφάρμακα Αδρενομεδουλλίνης, ή ένα εκ των αλάτων αυτών, επιδιαλυτωμένων συμπλοκών αυτών ή επιδιαλυτωμένων συμπλοκών αλάτων αυτών, σε συνδυασμό με ένα αδρανές μη-τοξικό φαρμακευτικώς κατάλληλο έκδοχο, όπου το φάρμακο υφίσταται σε μία φαρμακευτική μορφή για εισπνοή, την χρήση του για την θεραπευτική αντιμετώπιση και/ή πρόληψη παθήσεων, ειδικότερα καρδιαγγειακών, οιδηματωδών και/ή φλεγμονωδών διαταραχών, σε ειδικά προφάρμακα PEG-αδρενομεδουλλίνης και ενδιαμέσων της σύνθεσης της.
CY20181100151T 2011-11-03 2018-02-07 Προφαρμακο αδρενομεδουλλινης βασιζομενο σε πολυαιθυλενογλυκολη και χρηση αυτου CY1119897T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11187735 2011-11-03
EP15192265.5A EP3075395B1 (en) 2011-11-03 2012-10-30 Polyethylene glycol based prodrug of adrenomedullin and use thereof
EP12783566.8A EP2773376B1 (en) 2011-11-03 2012-10-30 Polyethylene glycol based prodrug of adrenomedullin and use thereof

Publications (1)

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CY1119897T1 true CY1119897T1 (el) 2018-06-27

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CY20161100293T CY1117354T1 (el) 2011-11-03 2016-04-12 Προφαρμακο αδρενομεδουλλινης βασιζομενο σε πολυαιθυλενογλυκολη και χρηση αυτου
CY20181100151T CY1119897T1 (el) 2011-11-03 2018-02-07 Προφαρμακο αδρενομεδουλλινης βασιζομενο σε πολυαιθυλενογλυκολη και χρηση αυτου

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US (3) US9603936B2 (el)
EP (2) EP2773376B1 (el)
JP (2) JP5995984B2 (el)
KR (2) KR102004668B1 (el)
CN (2) CN107412740B (el)
AR (2) AR088582A1 (el)
AU (2) AU2012331244B2 (el)
BR (1) BR112014010708B1 (el)
CA (1) CA2854134C (el)
CL (1) CL2014000948A1 (el)
CO (1) CO7020863A2 (el)
CR (1) CR20140184A (el)
CU (1) CU24184B1 (el)
CY (2) CY1117354T1 (el)
DK (2) DK2773376T3 (el)
DO (2) DOP2014000078A (el)
EA (2) EA025631B1 (el)
EC (2) ECSP14013326A (el)
ES (2) ES2568063T3 (el)
GT (1) GT201400085A (el)
HK (1) HK1246147A1 (el)
HR (2) HRP20160285T1 (el)
HU (2) HUE036535T2 (el)
IL (3) IL232037B (el)
IN (1) IN2014CN03290A (el)
JO (2) JOP20190001B1 (el)
LT (1) LT3075395T (el)
MA (1) MA35618B1 (el)
ME (1) ME02379B (el)
MX (2) MX350341B (el)
MY (2) MY194197A (el)
NO (1) NO3075395T3 (el)
PE (2) PE20141219A1 (el)
PL (2) PL3075395T3 (el)
PT (1) PT3075395T (el)
RS (2) RS56819B1 (el)
SG (2) SG10201607516SA (el)
SI (2) SI2773376T1 (el)
TN (1) TN2014000185A1 (el)
TR (1) TR201802124T4 (el)
TW (2) TWI653051B (el)
UA (1) UA111098C2 (el)
UY (2) UY37922A (el)
WO (1) WO2013064508A1 (el)
ZA (1) ZA201600434B (el)

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