MA34512B1 - Formes solides amorphes du chlorhydrate de la 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine - Google Patents
Formes solides amorphes du chlorhydrate de la 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholineInfo
- Publication number
- MA34512B1 MA34512B1 MA35713A MA35713A MA34512B1 MA 34512 B1 MA34512 B1 MA 34512B1 MA 35713 A MA35713 A MA 35713A MA 35713 A MA35713 A MA 35713A MA 34512 B1 MA34512 B1 MA 34512B1
- Authority
- MA
- Morocco
- Prior art keywords
- naphthalenyl
- pyrazol
- ethyl
- methyl
- solid forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE DES FORMES SOLIDES PRÉSENTANT UN FAIBLE DEGRÉ DE CRISTALLINITÉ OU PRATIQUEMENT AMORPHES DU SEL DE CHLORHYDRATE DE LA 4-[2-[[5-MÉTHYL-1-(2-NAPHTALÉNYL)-1H-PYRAZOL-3-YL]OXY]ÉTHYL]MORPHOLINE (P027) ET DES PROCÉDÉS POUR LEUR PRÉPARATION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10382225A EP2426111A1 (fr) | 2010-08-09 | 2010-08-09 | Formes cristallines de chlorhydrate de 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
PCT/EP2011/063583 WO2012019984A1 (fr) | 2010-08-09 | 2011-08-08 | Formes solides amorphes du chlorhydrate de la 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34512B1 true MA34512B1 (fr) | 2013-09-02 |
Family
ID=43244877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35713A MA34512B1 (fr) | 2010-08-09 | 2011-08-08 | Formes solides amorphes du chlorhydrate de la 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
Country Status (19)
Country | Link |
---|---|
US (1) | US9428462B2 (fr) |
EP (2) | EP2426111A1 (fr) |
JP (1) | JP5899214B2 (fr) |
KR (1) | KR20130095751A (fr) |
CN (1) | CN103052626B (fr) |
AR (1) | AR082608A1 (fr) |
AU (1) | AU2011288550A1 (fr) |
BR (1) | BR112013002651A2 (fr) |
CA (1) | CA2807855C (fr) |
CO (1) | CO6670586A2 (fr) |
ES (1) | ES2543429T3 (fr) |
HK (1) | HK1186468A1 (fr) |
MA (1) | MA34512B1 (fr) |
MX (1) | MX341711B (fr) |
PT (1) | PT2603495E (fr) |
RU (1) | RU2013110313A (fr) |
SG (1) | SG187745A1 (fr) |
TW (1) | TW201219387A (fr) |
WO (1) | WO2012019984A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2116539A1 (fr) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles en tant que ligands améliorant les effets analgésiques des opioïdes et réduisant leur dépendance |
EP2353598A1 (fr) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour utilisation dans la prévention et/ou le traitement de la douleur post-opératoire |
EP2353591A1 (fr) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la potentialisation de l'effet analgésique d'opioïdes et d'opiacés dans la douleur post-opératoire et en atténuant la dépendance |
EP2388005A1 (fr) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la prévention et/ou le traitement du vomissement induit par la chimiothérapie ou la radiothérapie |
EP2415471A1 (fr) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma dans l'hyperalgie induite par opioïdes |
EP2524694A1 (fr) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma dans la douleur liée au diabète de type 2 |
EP2792352A1 (fr) | 2013-04-16 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Combinaisons comprenants un ligand de receptor Sigma et un ligand de réceptor adrénergic-alpha-2 |
US20160310501A1 (en) * | 2013-12-17 | 2016-10-27 | Laboratorios Del Dr. Esteve, S.A. | Gabapentinoids and sigma receptor ligands combinations |
AU2014364647A1 (en) | 2013-12-17 | 2016-06-23 | Laboratorios Del Dr. Esteve, S.A. | Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) and Sigma receptor ligands combinations |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04364129A (ja) | 1990-10-26 | 1992-12-16 | Asahi Chem Ind Co Ltd | 6−置換アルコキシキノキサリン誘導体含有医薬組成物およびその製造法 |
SE508669C2 (sv) | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
PL1781618T3 (pl) * | 2004-08-27 | 2013-03-29 | Esteve Labor Dr | Inhibitory receptora sigma |
EP1634872A1 (fr) * | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Dérivés de pyrazole en tant qu'inhibiteurs des récepteurs sigma |
DK1781618T3 (da) * | 2004-08-27 | 2012-10-29 | Esteve Labor Dr | Sigma-receptorinhibitorer |
EP2191830A4 (fr) | 2007-09-21 | 2011-11-23 | Shionogi & Co | Préparation solide comprenant un antagoniste du récepteur npyy5 |
EP2116539A1 (fr) * | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles en tant que ligands améliorant les effets analgésiques des opioïdes et réduisant leur dépendance |
EP2113501A1 (fr) * | 2008-04-25 | 2009-11-04 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazoles de 5-Methyl-1-(naphthalen-2-YL)-1H- utiles en tant qu'inhibiteurs de récepteur sigma |
EP2292236A1 (fr) * | 2009-08-14 | 2011-03-09 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la prévention ou le traitement de douleurs induites par la chimiothérapie |
EP2361904A1 (fr) | 2010-02-04 | 2011-08-31 | Laboratorios Del. Dr. Esteve, S.A. | Chlorhydrate de 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine et formes cristallines correspondantes |
MY160018A (en) * | 2009-11-25 | 2017-02-15 | Esteve Labor Dr | 4-[2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine salts |
EP2335688A1 (fr) * | 2009-11-25 | 2011-06-22 | Laboratorios Del. Dr. Esteve, S.A. | Compositions pharmaceutiques comprenant des ligands du récepteur sigma |
EP2426112A1 (fr) | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | Polymorphes et solvates de chlorhydrate de 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
HUE029738T2 (en) * | 2010-02-04 | 2017-04-28 | Esteve Labor Dr | 4- [2 - [[5-Methyl-1- (2-naphthalenyl) -1H-pyrazol-3-yl] oxy] ethyl] morpholine hydrochloride polymorphs and solvates |
EP2353598A1 (fr) * | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour utilisation dans la prévention et/ou le traitement de la douleur post-opératoire |
EP2388005A1 (fr) * | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la prévention et/ou le traitement du vomissement induit par la chimiothérapie ou la radiothérapie |
EP2415471A1 (fr) * | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma dans l'hyperalgie induite par opioïdes |
EP2460519A1 (fr) * | 2010-12-03 | 2012-06-06 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma pour la douleur du cancer des os |
-
2010
- 2010-08-09 EP EP10382225A patent/EP2426111A1/fr not_active Withdrawn
-
2011
- 2011-08-08 PT PT117406751T patent/PT2603495E/pt unknown
- 2011-08-08 SG SG2013009220A patent/SG187745A1/en unknown
- 2011-08-08 US US13/816,194 patent/US9428462B2/en not_active Expired - Fee Related
- 2011-08-08 RU RU2013110313/04A patent/RU2013110313A/ru not_active Application Discontinuation
- 2011-08-08 KR KR1020137006090A patent/KR20130095751A/ko not_active Application Discontinuation
- 2011-08-08 CA CA2807855A patent/CA2807855C/fr not_active Expired - Fee Related
- 2011-08-08 MA MA35713A patent/MA34512B1/fr unknown
- 2011-08-08 AU AU2011288550A patent/AU2011288550A1/en not_active Abandoned
- 2011-08-08 ES ES11740675.1T patent/ES2543429T3/es active Active
- 2011-08-08 EP EP20110740675 patent/EP2603495B1/fr active Active
- 2011-08-08 TW TW100128160A patent/TW201219387A/zh unknown
- 2011-08-08 WO PCT/EP2011/063583 patent/WO2012019984A1/fr active Application Filing
- 2011-08-08 MX MX2013001559A patent/MX341711B/es active IP Right Grant
- 2011-08-08 JP JP2013523580A patent/JP5899214B2/ja not_active Expired - Fee Related
- 2011-08-08 BR BR112013002651A patent/BR112013002651A2/pt not_active Application Discontinuation
- 2011-08-08 CN CN201180038821.9A patent/CN103052626B/zh not_active Expired - Fee Related
- 2011-08-09 AR ARP110102890A patent/AR082608A1/es unknown
-
2013
- 2013-02-08 CO CO13026634A patent/CO6670586A2/es not_active Application Discontinuation
- 2013-12-16 HK HK13113963.1A patent/HK1186468A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP2603495A1 (fr) | 2013-06-19 |
US9428462B2 (en) | 2016-08-30 |
JP5899214B2 (ja) | 2016-04-06 |
CA2807855A1 (fr) | 2012-02-16 |
EP2603495B1 (fr) | 2015-05-06 |
JP2013533298A (ja) | 2013-08-22 |
RU2013110313A (ru) | 2014-09-20 |
PT2603495E (pt) | 2015-08-28 |
KR20130095751A (ko) | 2013-08-28 |
AU2011288550A1 (en) | 2013-02-21 |
US20130150575A1 (en) | 2013-06-13 |
CA2807855C (fr) | 2018-10-23 |
WO2012019984A1 (fr) | 2012-02-16 |
CN103052626B (zh) | 2017-06-06 |
AR082608A1 (es) | 2012-12-19 |
ES2543429T3 (es) | 2015-08-19 |
MX341711B (es) | 2016-08-31 |
CN103052626A (zh) | 2013-04-17 |
TW201219387A (en) | 2012-05-16 |
BR112013002651A2 (pt) | 2016-05-31 |
CO6670586A2 (es) | 2013-05-15 |
MX2013001559A (es) | 2013-03-07 |
HK1186468A1 (en) | 2014-03-14 |
SG187745A1 (en) | 2013-03-28 |
EP2426111A1 (fr) | 2012-03-07 |
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