MA33283B1 - Procédé pour la production d'intermédiaires de dronédarone - Google Patents

Procédé pour la production d'intermédiaires de dronédarone

Info

Publication number
MA33283B1
MA33283B1 MA34362A MA34362A MA33283B1 MA 33283 B1 MA33283 B1 MA 33283B1 MA 34362 A MA34362 A MA 34362A MA 34362 A MA34362 A MA 34362A MA 33283 B1 MA33283 B1 MA 33283B1
Authority
MA
Morocco
Prior art keywords
dronedarone
production
intermediaries
subsequent
ethanone
Prior art date
Application number
MA34362A
Other languages
Arabic (ar)
English (en)
Inventor
Gerhard Kretzschmar
Volker Kraft
Kai Rossen
Joachim Gräser
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MA33283B1 publication Critical patent/MA33283B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Catalysts (AREA)

Abstract

La présente invention a pour objet un procédé de production d'intermédiaires de la dronédarone de formule (I), par acylation de la 2-(2-hydroxy-5-nitrophényl)-1-(4-méthoxyphényl)éthanone, traitement subséquent de l'ester avec des bases et un catalyseur à base de zéolite (aluminosilicate) et déméthylation subséquente éventuelle. Ce procédé peut être utilisé pour la production de dronédarone.
MA34362A 2009-05-27 2010-05-26 Procédé pour la production d'intermédiaires de dronédarone MA33283B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09290394 2009-05-27
US24454709P 2009-09-22 2009-09-22
PCT/EP2010/057272 WO2010136502A1 (fr) 2009-05-27 2010-05-26 Procédé de production d'intermédiaires de la dronédarone

Publications (1)

Publication Number Publication Date
MA33283B1 true MA33283B1 (fr) 2012-05-02

Family

ID=41055218

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34362A MA33283B1 (fr) 2009-05-27 2010-05-26 Procédé pour la production d'intermédiaires de dronédarone

Country Status (20)

Country Link
US (1) US8658808B2 (fr)
EP (1) EP2435413B1 (fr)
JP (1) JP2012528115A (fr)
KR (1) KR20120018371A (fr)
CN (1) CN102448947A (fr)
AR (1) AR076603A1 (fr)
AU (1) AU2010251976A1 (fr)
BR (1) BRPI1012018A2 (fr)
CA (1) CA2766077A1 (fr)
CO (1) CO6480942A2 (fr)
IL (1) IL216322A0 (fr)
MA (1) MA33283B1 (fr)
MX (1) MX2011011893A (fr)
MY (1) MY183448A (fr)
NZ (1) NZ596732A (fr)
RU (1) RU2011153309A (fr)
SG (1) SG176212A1 (fr)
TW (1) TW201111354A (fr)
UY (1) UY32657A (fr)
WO (1) WO2010136502A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32656A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para producir benzofuranos
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958291B1 (fr) 2010-04-01 2013-07-05 Sanofi Aventis Procede de preparation de derives d'amino-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (fr) 2012-01-20 2013-07-24 Sanofi Procédé de préparation de dronédarone à l'aide d'un réactif dibutylaminopropanol
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (fr) 2012-02-14 2013-08-22 Sanofi Procédé de préparation de dronédarone par oxydation d'un groupe sulphényle
WO2013124745A1 (fr) 2012-02-22 2013-08-29 Sanofi Procédé pour la préparation de dronédarone par l'oxydation d'un groupe hydroxyle
WO2013178337A1 (fr) 2012-05-31 2013-12-05 Sanofi Procédé pour la préparation de dronédarone par réaction de grignard

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577441A (en) 1967-03-07 1971-05-04 Warner Lambert Pharmaceutical Nitro substituted benzofurans
US3657350A (en) 1967-05-09 1972-04-18 Sterling Drug Inc Process and compositions
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
FR2809397B1 (fr) * 2000-05-24 2002-07-19 Rhodia Chimie Sa Procede de preparation d'un compose de type benzofuranne ou benzothiophene
FR2800067B1 (fr) 1999-10-21 2004-12-17 Rhodia Chimie Sa Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations
AU1033101A (en) 1999-10-21 2001-04-30 Rhodia Chimie Method for preparing a benzofuran or benzothiophene compound
FR2817865B1 (fr) 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
IL146389A0 (en) 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
FR2833259B1 (fr) 2001-12-10 2004-08-27 Oreal Procede de preparation de 2-arylbenzofuranes, composes intermediaires, 2-arylbenzofuranes et compositions les comprenant
KR20070053783A (ko) 2004-08-24 2007-05-25 바스프 악티엔게젤샤프트 고-순도 4차 암모늄 화합물의 제조 방법
GB0611210D0 (en) * 2006-06-07 2006-07-19 Cambrex Karlskoga Ab Process
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
UY32656A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para producir benzofuranos

Also Published As

Publication number Publication date
KR20120018371A (ko) 2012-03-02
IL216322A0 (en) 2012-01-31
SG176212A1 (en) 2012-01-30
US8658808B2 (en) 2014-02-25
MY183448A (en) 2021-02-18
US20120077995A1 (en) 2012-03-29
JP2012528115A (ja) 2012-11-12
CN102448947A (zh) 2012-05-09
EP2435413B1 (fr) 2014-05-07
MX2011011893A (es) 2011-12-08
BRPI1012018A2 (pt) 2015-09-22
AR076603A1 (es) 2011-06-22
EP2435413A1 (fr) 2012-04-04
WO2010136502A1 (fr) 2010-12-02
TW201111354A (en) 2011-04-01
RU2011153309A (ru) 2013-07-10
UY32657A (es) 2010-12-31
CA2766077A1 (fr) 2010-12-02
CO6480942A2 (es) 2012-07-16
NZ596732A (en) 2013-07-26
AU2010251976A1 (en) 2011-12-22

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