MA33326B1 - Procédé pour la production de benzofuranes - Google Patents
Procédé pour la production de benzofuranesInfo
- Publication number
- MA33326B1 MA33326B1 MA34361A MA34361A MA33326B1 MA 33326 B1 MA33326 B1 MA 33326B1 MA 34361 A MA34361 A MA 34361A MA 34361 A MA34361 A MA 34361A MA 33326 B1 MA33326 B1 MA 33326B1
- Authority
- MA
- Morocco
- Prior art keywords
- preparation
- benzofuran
- production
- dronedarone
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La présente invention concerne la préparation de 2-alkyl-3-aroyl-5-nitrobenzofuranes par acylation de 2-(2-hydroxy-5-nitrophényl)-1-aryl-éthanones et traitement ultérieur des esters avec des associations de bases et d'acides protoniques ou d'acides de Lewis. Ce procédé peut s'utiliser pour la préparation de Dronédarone. L'invention concerne également des nouveaux intermédiaires pour la préparation de Dronédarone.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09290395 | 2009-05-27 | ||
US24455009P | 2009-09-22 | 2009-09-22 | |
PCT/EP2010/057270 WO2010136500A1 (fr) | 2009-05-27 | 2010-05-26 | Procédé de préparation de benzofuranes |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33326B1 true MA33326B1 (fr) | 2012-06-01 |
Family
ID=41152122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34361A MA33326B1 (fr) | 2009-05-27 | 2010-05-26 | Procédé pour la production de benzofuranes |
Country Status (28)
Country | Link |
---|---|
US (1) | US8674121B2 (fr) |
EP (1) | EP2435398B1 (fr) |
JP (1) | JP2012528114A (fr) |
KR (1) | KR20120017459A (fr) |
CN (1) | CN102459146A (fr) |
AR (1) | AR076890A1 (fr) |
AU (1) | AU2010251974A1 (fr) |
BR (1) | BRPI1014547A2 (fr) |
CA (1) | CA2763472A1 (fr) |
CO (1) | CO6480944A2 (fr) |
DK (1) | DK2435398T3 (fr) |
ES (1) | ES2453977T3 (fr) |
HK (1) | HK1167851A1 (fr) |
HR (1) | HRP20140248T1 (fr) |
IL (1) | IL216321A0 (fr) |
MA (1) | MA33326B1 (fr) |
MX (1) | MX2011011994A (fr) |
MY (1) | MY155506A (fr) |
NZ (1) | NZ596624A (fr) |
PL (1) | PL2435398T3 (fr) |
PT (1) | PT2435398E (fr) |
RU (1) | RU2011153180A (fr) |
SG (1) | SG176211A1 (fr) |
SI (1) | SI2435398T1 (fr) |
TW (1) | TW201107303A (fr) |
UY (1) | UY32656A (fr) |
WO (1) | WO2010136500A1 (fr) |
ZA (1) | ZA201107655B (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY32657A (es) | 2009-05-27 | 2010-12-31 | Sanofi Aventis | Procedimiento para la fabricación de productos intermedios de dronedarona |
HUP0900759A2 (en) | 2009-12-08 | 2011-11-28 | Sanofi Aventis | Novel process for producing dronedarone |
HUP1000010A2 (en) | 2010-01-08 | 2011-11-28 | Sanofi Sa | Process for producing dronedarone |
FR2957079B1 (fr) | 2010-03-02 | 2012-07-27 | Sanofi Aventis | Procede de synthese de derives de cetobenzofurane |
FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
FR2958291B1 (fr) | 2010-04-01 | 2013-07-05 | Sanofi Aventis | Procede de preparation de derives d'amino-benzofurane |
HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
FR2962731B1 (fr) | 2010-07-19 | 2012-08-17 | Sanofi Aventis | Procede de preparation de derives d'amino-benzoyl-benzofurane |
FR2963006B1 (fr) | 2010-07-21 | 2013-03-15 | Sanofi Aventis | Procede de preparation de derives de nitro-benzofurane |
HUP1000386A2 (en) | 2010-07-22 | 2012-05-29 | Sanofi Sa | Novel process for producing dronedarone |
HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
EP2617718A1 (fr) | 2012-01-20 | 2013-07-24 | Sanofi | Procédé de préparation de dronédarone à l'aide d'un réactif dibutylaminopropanol |
US9221778B2 (en) | 2012-02-13 | 2015-12-29 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
WO2013121234A1 (fr) | 2012-02-14 | 2013-08-22 | Sanofi | Procédé de préparation de dronédarone par oxydation d'un groupe sulphényle |
WO2013124745A1 (fr) | 2012-02-22 | 2013-08-29 | Sanofi | Procédé pour la préparation de dronédarone par l'oxydation d'un groupe hydroxyle |
WO2013178337A1 (fr) | 2012-05-31 | 2013-12-05 | Sanofi | Procédé pour la préparation de dronédarone par réaction de grignard |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3577441A (en) | 1967-03-07 | 1971-05-04 | Warner Lambert Pharmaceutical | Nitro substituted benzofurans |
US3657350A (en) | 1967-05-09 | 1972-04-18 | Sterling Drug Inc | Process and compositions |
FR2665444B1 (fr) | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
GB2344819A (en) * | 1998-12-18 | 2000-06-21 | Portela & Ca Sa | 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones |
FR2800067B1 (fr) | 1999-10-21 | 2004-12-17 | Rhodia Chimie Sa | Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations |
EP1222181B1 (fr) | 1999-10-21 | 2003-12-10 | Rhodia Chimie | Procede de preparation d'un compose de type benzofurane ou benzothiophene |
FR2809397B1 (fr) | 2000-05-24 | 2002-07-19 | Rhodia Chimie Sa | Procede de preparation d'un compose de type benzofuranne ou benzothiophene |
CN1133613C (zh) * | 1999-10-22 | 2004-01-07 | 河南省科学院化学研究所 | 一种合成多羟基去氧安息香及其衍生物的新方法 |
AU1412901A (en) * | 1999-11-16 | 2001-05-30 | Toray Industries, Inc. | Benzene derivatives and use thereof as drugs |
FR2817865B1 (fr) | 2000-12-11 | 2005-02-18 | Sanofi Synthelabo | Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese |
IL146389A0 (en) | 2001-11-08 | 2002-07-25 | Isp Finetech Ltd | Process for the preparation of dronedarone |
FR2833259B1 (fr) | 2001-12-10 | 2004-08-27 | Oreal | Procede de preparation de 2-arylbenzofuranes, composes intermediaires, 2-arylbenzofuranes et compositions les comprenant |
GB0313915D0 (en) * | 2003-06-16 | 2003-07-23 | Smithkline Beecham Corp | Compounds |
EP1784380A1 (fr) | 2004-08-24 | 2007-05-16 | Basf Aktiengesellschaft | Procede de production de composes d'ammonium quaternaires de grande purete |
GB0611210D0 (en) | 2006-06-07 | 2006-07-19 | Cambrex Karlskoga Ab | Process |
GB0719180D0 (en) | 2007-10-02 | 2007-11-14 | Cambrex Karlskoga Ab | New process |
UY32657A (es) | 2009-05-27 | 2010-12-31 | Sanofi Aventis | Procedimiento para la fabricación de productos intermedios de dronedarona |
-
2010
- 2010-05-25 UY UY0001032656A patent/UY32656A/es not_active Application Discontinuation
- 2010-05-25 TW TW099116587A patent/TW201107303A/zh unknown
- 2010-05-26 JP JP2012512363A patent/JP2012528114A/ja active Pending
- 2010-05-26 CA CA2763472A patent/CA2763472A1/fr not_active Abandoned
- 2010-05-26 ES ES10724024.4T patent/ES2453977T3/es active Active
- 2010-05-26 MX MX2011011994A patent/MX2011011994A/es not_active Application Discontinuation
- 2010-05-26 SG SG2011086659A patent/SG176211A1/en unknown
- 2010-05-26 US US13/321,754 patent/US8674121B2/en active Active
- 2010-05-26 NZ NZ596624A patent/NZ596624A/xx not_active IP Right Cessation
- 2010-05-26 MY MYPI2011005061A patent/MY155506A/en unknown
- 2010-05-26 WO PCT/EP2010/057270 patent/WO2010136500A1/fr active Application Filing
- 2010-05-26 PT PT107240244T patent/PT2435398E/pt unknown
- 2010-05-26 CN CN2010800231311A patent/CN102459146A/zh active Pending
- 2010-05-26 KR KR1020117031012A patent/KR20120017459A/ko not_active Application Discontinuation
- 2010-05-26 AU AU2010251974A patent/AU2010251974A1/en not_active Abandoned
- 2010-05-26 MA MA34361A patent/MA33326B1/fr unknown
- 2010-05-26 PL PL10724024T patent/PL2435398T3/pl unknown
- 2010-05-26 EP EP10724024.4A patent/EP2435398B1/fr active Active
- 2010-05-26 AR ARP100101810A patent/AR076890A1/es not_active Application Discontinuation
- 2010-05-26 DK DK10724024.4T patent/DK2435398T3/da active
- 2010-05-26 SI SI201030564T patent/SI2435398T1/sl unknown
- 2010-05-26 BR BRPI1014547A patent/BRPI1014547A2/pt not_active IP Right Cessation
- 2010-05-26 RU RU2011153180/04A patent/RU2011153180A/ru not_active Application Discontinuation
-
2011
- 2011-10-19 ZA ZA2011/07655A patent/ZA201107655B/en unknown
- 2011-11-13 IL IL216321A patent/IL216321A0/en unknown
- 2011-12-23 CO CO11177480A patent/CO6480944A2/es active IP Right Grant
-
2012
- 2012-08-30 HK HK12108483.3A patent/HK1167851A1/xx not_active IP Right Cessation
-
2014
- 2014-03-18 HR HRP20140248AT patent/HRP20140248T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20140248T1 (hr) | 2014-06-20 |
JP2012528114A (ja) | 2012-11-12 |
EP2435398B1 (fr) | 2014-01-22 |
AU2010251974A1 (en) | 2011-12-22 |
SG176211A1 (en) | 2012-01-30 |
ZA201107655B (en) | 2012-07-25 |
US20120065411A1 (en) | 2012-03-15 |
BRPI1014547A2 (pt) | 2016-04-05 |
UY32656A (es) | 2010-12-31 |
HK1167851A1 (en) | 2012-12-14 |
ES2453977T3 (es) | 2014-04-09 |
AR076890A1 (es) | 2011-07-13 |
PL2435398T3 (pl) | 2014-06-30 |
TW201107303A (en) | 2011-03-01 |
CO6480944A2 (es) | 2012-07-16 |
RU2011153180A (ru) | 2013-07-10 |
CA2763472A1 (fr) | 2010-12-02 |
IL216321A0 (en) | 2012-01-31 |
KR20120017459A (ko) | 2012-02-28 |
MY155506A (en) | 2015-10-30 |
NZ596624A (en) | 2013-04-26 |
SI2435398T1 (sl) | 2014-04-30 |
CN102459146A (zh) | 2012-05-16 |
MX2011011994A (es) | 2011-12-08 |
EP2435398A1 (fr) | 2012-04-04 |
WO2010136500A1 (fr) | 2010-12-02 |
PT2435398E (pt) | 2014-04-02 |
US8674121B2 (en) | 2014-03-18 |
DK2435398T3 (da) | 2014-04-14 |
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