MA32290B1 - Nouvelle classe de spiro pipéridines pour le traitement de maladies neurodégénératives - Google Patents
Nouvelle classe de spiro pipéridines pour le traitement de maladies neurodégénérativesInfo
- Publication number
- MA32290B1 MA32290B1 MA33328A MA33328A MA32290B1 MA 32290 B1 MA32290 B1 MA 32290B1 MA 33328 A MA33328 A MA 33328A MA 33328 A MA33328 A MA 33328A MA 32290 B1 MA32290 B1 MA 32290B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- biperidenate
- spiro
- new class
- neurological diseases
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 208000025966 Neurological disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5042308P | 2008-05-05 | 2008-05-05 | |
| PCT/IB2009/051815 WO2009136350A1 (en) | 2008-05-05 | 2009-05-04 | Novel class of spiro piperidines for the treatment of neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32290B1 true MA32290B1 (fr) | 2011-05-02 |
Family
ID=40902870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA33328A MA32290B1 (fr) | 2008-05-05 | 2010-11-05 | Nouvelle classe de spiro pipéridines pour le traitement de maladies neurodégénératives |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20110046160A1 (enExample) |
| EP (1) | EP2300484B1 (enExample) |
| JP (1) | JP2011519913A (enExample) |
| KR (1) | KR20110000749A (enExample) |
| CN (1) | CN102083841A (enExample) |
| AP (1) | AP2010005456A0 (enExample) |
| AT (1) | ATE537178T1 (enExample) |
| AU (1) | AU2009245322B2 (enExample) |
| BR (1) | BRPI0912433A2 (enExample) |
| CA (1) | CA2721786A1 (enExample) |
| CO (1) | CO6321280A2 (enExample) |
| CR (1) | CR11759A (enExample) |
| DO (1) | DOP2010000317A (enExample) |
| EA (1) | EA201001566A1 (enExample) |
| EC (1) | ECSP10010597A (enExample) |
| ES (1) | ES2375913T3 (enExample) |
| IL (1) | IL208793A0 (enExample) |
| MA (1) | MA32290B1 (enExample) |
| MX (1) | MX2010012066A (enExample) |
| NZ (1) | NZ588589A (enExample) |
| SV (1) | SV2010003725A (enExample) |
| WO (1) | WO2009136350A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| EP2556076A2 (en) * | 2010-04-09 | 2013-02-13 | Pfizer Inc. | Novel sultam compounds |
| EP2694489B1 (en) | 2011-04-07 | 2017-09-06 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| WO2012138590A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| KR20140054295A (ko) | 2011-08-22 | 2014-05-08 | 머크 샤프 앤드 돔 코포레이션 | Bace 억제제로서의 2-스피로-치환된 이미노티아진 및 그의 모노- 및 디옥시드, 조성물 및 그의 용도 |
| EP3233077A4 (en) | 2014-12-19 | 2018-08-08 | The Broad Institute Inc. | Dopamine d2 receptor ligands |
| EP3233799B1 (en) | 2014-12-19 | 2021-05-19 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004313693B2 (en) * | 2004-01-08 | 2010-08-26 | F. Hoffmann-La Roche Ag | Diaza-spiropiperidine derivatives |
| JP2006044497A (ja) * | 2004-08-05 | 2006-02-16 | Toyota Motor Corp | 車輪情報処理装置 |
| JP2008515989A (ja) * | 2004-10-13 | 2008-05-15 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病を治療するためのβ−セクレターゼ阻害薬として有用なスピロピペリジン化合物 |
| WO2007011810A1 (en) * | 2005-07-18 | 2007-01-25 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| WO2008030412A2 (en) * | 2006-09-07 | 2008-03-13 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| AU2007342368A1 (en) * | 2007-01-04 | 2008-07-17 | Merck & Co., Inc. | Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
-
2009
- 2009-05-04 US US12/990,739 patent/US20110046160A1/en not_active Abandoned
- 2009-05-04 MX MX2010012066A patent/MX2010012066A/es not_active Application Discontinuation
- 2009-05-04 ES ES09742523T patent/ES2375913T3/es active Active
- 2009-05-04 AP AP2010005456A patent/AP2010005456A0/xx unknown
- 2009-05-04 KR KR1020107024794A patent/KR20110000749A/ko not_active Ceased
- 2009-05-04 JP JP2011508035A patent/JP2011519913A/ja not_active Withdrawn
- 2009-05-04 AT AT09742523T patent/ATE537178T1/de active
- 2009-05-04 CA CA2721786A patent/CA2721786A1/en not_active Abandoned
- 2009-05-04 CN CN2009801261947A patent/CN102083841A/zh active Pending
- 2009-05-04 EP EP09742523A patent/EP2300484B1/en active Active
- 2009-05-04 NZ NZ588589A patent/NZ588589A/en not_active IP Right Cessation
- 2009-05-04 AU AU2009245322A patent/AU2009245322B2/en not_active Ceased
- 2009-05-04 BR BRPI0912433A patent/BRPI0912433A2/pt not_active Application Discontinuation
- 2009-05-04 WO PCT/IB2009/051815 patent/WO2009136350A1/en not_active Ceased
- 2009-05-04 EA EA201001566A patent/EA201001566A1/ru unknown
-
2010
- 2010-10-18 IL IL208793A patent/IL208793A0/en unknown
- 2010-10-21 DO DO2010000317A patent/DOP2010000317A/es unknown
- 2010-10-26 CR CR11759A patent/CR11759A/es not_active Application Discontinuation
- 2010-11-05 MA MA33328A patent/MA32290B1/fr unknown
- 2010-11-05 SV SV2010003725A patent/SV2010003725A/es not_active Application Discontinuation
- 2010-11-09 EC EC2010010597A patent/ECSP10010597A/es unknown
- 2010-11-11 CO CO10141834A patent/CO6321280A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0912433A2 (pt) | 2015-12-22 |
| US20110046160A1 (en) | 2011-02-24 |
| AP2010005456A0 (en) | 2010-12-31 |
| EA201001566A1 (ru) | 2011-04-29 |
| JP2011519913A (ja) | 2011-07-14 |
| ATE537178T1 (de) | 2011-12-15 |
| SV2010003725A (es) | 2011-07-05 |
| KR20110000749A (ko) | 2011-01-05 |
| CN102083841A (zh) | 2011-06-01 |
| WO2009136350A1 (en) | 2009-11-12 |
| CO6321280A2 (es) | 2011-09-20 |
| ECSP10010597A (es) | 2010-12-30 |
| AU2009245322B2 (en) | 2011-07-14 |
| MX2010012066A (es) | 2010-12-06 |
| CA2721786A1 (en) | 2009-11-12 |
| IL208793A0 (en) | 2010-12-30 |
| AU2009245322A1 (en) | 2009-11-12 |
| CR11759A (es) | 2010-11-22 |
| EP2300484B1 (en) | 2011-12-14 |
| DOP2010000317A (es) | 2010-11-15 |
| NZ588589A (en) | 2012-07-27 |
| ES2375913T3 (es) | 2012-03-07 |
| EP2300484A1 (en) | 2011-03-30 |
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