ES2375913T3 - Nueva clase de espiropiperidinas para el tratamiento de enfermedades neurodegenerativas. - Google Patents
Nueva clase de espiropiperidinas para el tratamiento de enfermedades neurodegenerativas. Download PDFInfo
- Publication number
- ES2375913T3 ES2375913T3 ES09742523T ES09742523T ES2375913T3 ES 2375913 T3 ES2375913 T3 ES 2375913T3 ES 09742523 T ES09742523 T ES 09742523T ES 09742523 T ES09742523 T ES 09742523T ES 2375913 T3 ES2375913 T3 ES 2375913T3
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- Prior art keywords
- methyl
- alkyl
- fluorophenyl
- aunt
- cycloalkyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5042308P | 2008-05-05 | 2008-05-05 | |
| US50423P | 2008-05-05 | ||
| PCT/IB2009/051815 WO2009136350A1 (en) | 2008-05-05 | 2009-05-04 | Novel class of spiro piperidines for the treatment of neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2375913T3 true ES2375913T3 (es) | 2012-03-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09742523T Active ES2375913T3 (es) | 2008-05-05 | 2009-05-04 | Nueva clase de espiropiperidinas para el tratamiento de enfermedades neurodegenerativas. |
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|---|---|
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| EP (1) | EP2300484B1 (enExample) |
| JP (1) | JP2011519913A (enExample) |
| KR (1) | KR20110000749A (enExample) |
| CN (1) | CN102083841A (enExample) |
| AP (1) | AP2010005456A0 (enExample) |
| AT (1) | ATE537178T1 (enExample) |
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| BR (1) | BRPI0912433A2 (enExample) |
| CA (1) | CA2721786A1 (enExample) |
| CO (1) | CO6321280A2 (enExample) |
| CR (1) | CR11759A (enExample) |
| DO (1) | DOP2010000317A (enExample) |
| EA (1) | EA201001566A1 (enExample) |
| EC (1) | ECSP10010597A (enExample) |
| ES (1) | ES2375913T3 (enExample) |
| IL (1) | IL208793A0 (enExample) |
| MA (1) | MA32290B1 (enExample) |
| MX (1) | MX2010012066A (enExample) |
| NZ (1) | NZ588589A (enExample) |
| SV (1) | SV2010003725A (enExample) |
| WO (1) | WO2009136350A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| WO2011125006A2 (en) * | 2010-04-09 | 2011-10-13 | Pfizer Inc. | Novel sultam compounds |
| EP2694521B1 (en) | 2011-04-07 | 2015-11-25 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| US9221839B2 (en) | 2011-04-07 | 2015-12-29 | Merck Sharp & Dohme Corp. | C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
| AU2012298983A1 (en) | 2011-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as BACE inhibitors, compositions and their use |
| EP3233077A4 (en) | 2014-12-19 | 2018-08-08 | The Broad Institute Inc. | Dopamine d2 receptor ligands |
| EP3233799B1 (en) | 2014-12-19 | 2021-05-19 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
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| JP4762155B2 (ja) * | 2004-01-08 | 2011-08-31 | エフ．ホフマン−ラ ロシュ アーゲー | ジアザ−スピロピペリジン誘導体 |
| JP2006044497A (ja) * | 2004-08-05 | 2006-02-16 | Toyota Motor Corp | 車輪情報処理装置 |
| CA2583342A1 (en) * | 2004-10-13 | 2006-04-27 | Merck And Co., Inc. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer's disease |
| AU2006270084B2 (en) * | 2005-07-18 | 2011-08-25 | Merck Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
| JP2010502705A (ja) * | 2006-09-07 | 2010-01-28 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病の治療用としてのスピロピペリジンベータセクレターゼ阻害剤 |
| US8377954B2 (en) * | 2007-01-04 | 2013-02-19 | Merck, Sharp & Dohme, Corp | Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
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2009
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- 2009-05-04 AT AT09742523T patent/ATE537178T1/de active
- 2009-05-04 JP JP2011508035A patent/JP2011519913A/ja not_active Withdrawn
- 2009-05-04 CN CN2009801261947A patent/CN102083841A/zh active Pending
- 2009-05-04 US US12/990,739 patent/US20110046160A1/en not_active Abandoned
- 2009-05-04 CA CA2721786A patent/CA2721786A1/en not_active Abandoned
- 2009-05-04 EP EP09742523A patent/EP2300484B1/en active Active
- 2009-05-04 EA EA201001566A patent/EA201001566A1/ru unknown
- 2009-05-04 NZ NZ588589A patent/NZ588589A/en not_active IP Right Cessation
- 2009-05-04 KR KR1020107024794A patent/KR20110000749A/ko not_active Ceased
- 2009-05-04 ES ES09742523T patent/ES2375913T3/es active Active
- 2009-05-04 BR BRPI0912433A patent/BRPI0912433A2/pt not_active Application Discontinuation
- 2009-05-04 AP AP2010005456A patent/AP2010005456A0/xx unknown
- 2009-05-04 AU AU2009245322A patent/AU2009245322B2/en not_active Ceased
- 2009-05-04 WO PCT/IB2009/051815 patent/WO2009136350A1/en not_active Ceased
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2010
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- 2010-10-26 CR CR11759A patent/CR11759A/es not_active Application Discontinuation
- 2010-11-05 SV SV2010003725A patent/SV2010003725A/es not_active Application Discontinuation
- 2010-11-05 MA MA33328A patent/MA32290B1/fr unknown
- 2010-11-09 EC EC2010010597A patent/ECSP10010597A/es unknown
- 2010-11-11 CO CO10141834A patent/CO6321280A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN102083841A (zh) | 2011-06-01 |
| CR11759A (es) | 2010-11-22 |
| AU2009245322B2 (en) | 2011-07-14 |
| DOP2010000317A (es) | 2010-11-15 |
| CO6321280A2 (es) | 2011-09-20 |
| SV2010003725A (es) | 2011-07-05 |
| MA32290B1 (fr) | 2011-05-02 |
| US20110046160A1 (en) | 2011-02-24 |
| WO2009136350A1 (en) | 2009-11-12 |
| EP2300484A1 (en) | 2011-03-30 |
| ECSP10010597A (es) | 2010-12-30 |
| EP2300484B1 (en) | 2011-12-14 |
| AU2009245322A1 (en) | 2009-11-12 |
| NZ588589A (en) | 2012-07-27 |
| JP2011519913A (ja) | 2011-07-14 |
| BRPI0912433A2 (pt) | 2015-12-22 |
| EA201001566A1 (ru) | 2011-04-29 |
| KR20110000749A (ko) | 2011-01-05 |
| CA2721786A1 (en) | 2009-11-12 |
| IL208793A0 (en) | 2010-12-30 |
| MX2010012066A (es) | 2010-12-06 |
| ATE537178T1 (de) | 2011-12-15 |
| AP2010005456A0 (en) | 2010-12-31 |
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