MA31310B1 - Nouveaux composes - Google Patents

Nouveaux composes

Info

Publication number
MA31310B1
MA31310B1 MA32279A MA32279A MA31310B1 MA 31310 B1 MA31310 B1 MA 31310B1 MA 32279 A MA32279 A MA 32279A MA 32279 A MA32279 A MA 32279A MA 31310 B1 MA31310 B1 MA 31310B1
Authority
MA
Morocco
Prior art keywords
new compounds
gro
present
antibody
ena
Prior art date
Application number
MA32279A
Other languages
Arabic (ar)
English (en)
Inventor
Stephanie Jane Clegg
Eric Dobrzynski
Jonathan H Ellis
Volker Germaschewski
Alexis Paul Godillot
Zdenka Ludmila Jonak
Alan P Lewis
John R White
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA31310B1 publication Critical patent/MA31310B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

La présente invention concerne un anticorps qui comprend de multiples spécificités. Notamment, l'anticorps selon la présente invention se lie (a une réaction croisée avec) il-8 humaine, gro-alpha, gro-bêta, gro-gamma et ena-78.
MA32279A 2007-04-17 2009-10-15 Nouveaux composes MA31310B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91222907P 2007-04-17 2007-04-17
US4413208P 2008-04-11 2008-04-11
PCT/US2008/060424 WO2008130969A2 (fr) 2007-04-17 2008-04-16 Nouveaux composés

Publications (1)

Publication Number Publication Date
MA31310B1 true MA31310B1 (fr) 2010-04-01

Family

ID=39872910

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32279A MA31310B1 (fr) 2007-04-17 2009-10-15 Nouveaux composes

Country Status (30)

Country Link
US (3) US20080262203A1 (fr)
EP (1) EP2146745B1 (fr)
JP (1) JP5441885B2 (fr)
KR (1) KR101560841B1 (fr)
CN (1) CN101687035B (fr)
AU (1) AU2008243049B2 (fr)
BR (1) BRPI0810250A8 (fr)
CA (1) CA2684626C (fr)
CL (1) CL2008001071A1 (fr)
CO (1) CO6251323A2 (fr)
CR (1) CR11116A (fr)
CY (1) CY1116671T1 (fr)
DK (1) DK2146745T3 (fr)
DO (1) DOP2009000236A (fr)
EA (1) EA024621B1 (fr)
ES (1) ES2547475T3 (fr)
HK (1) HK1136970A1 (fr)
HR (1) HRP20150937T1 (fr)
HU (1) HUE027584T2 (fr)
IL (1) IL201440A (fr)
MA (1) MA31310B1 (fr)
MX (1) MX2009011153A (fr)
MY (1) MY150525A (fr)
NZ (1) NZ580239A (fr)
PE (1) PE20090302A1 (fr)
PL (1) PL2146745T3 (fr)
PT (1) PT2146745E (fr)
SI (1) SI2146745T1 (fr)
TW (1) TWI473815B (fr)
WO (1) WO2008130969A2 (fr)

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CN104761637B (zh) 2006-03-31 2021-10-15 中外制药株式会社 调控抗体血液动力学的方法
EP3127921A1 (fr) 2007-09-26 2017-02-08 Chugai Seiyaku Kabushiki Kaisha Procédé de modification d'un anticorps par point isoélectrique par substitution d'acide aminé dans cdr
TWI564021B (zh) 2008-04-11 2017-01-01 Chugai Pharmaceutical Co Ltd Repeated binding of antigen to antigen binding molecules
CA2783563A1 (fr) * 2009-12-07 2011-06-16 Decimmune Therapeutics, Inc. Anticorps anti-inflammatoires et leurs utilisations
US20120315267A1 (en) * 2010-02-09 2012-12-13 Glaxosmithkline Llc Novel uses
TWI761912B (zh) 2010-11-30 2022-04-21 日商中外製藥股份有限公司 具有鈣依存性的抗原結合能力之抗體
WO2013166099A1 (fr) * 2012-05-01 2013-11-07 Glaxosmithkline Llc Nouveaux anticorps
WO2014030750A1 (fr) 2012-08-24 2014-02-27 中外製薬株式会社 ANTICORPS Fc SPÉCIFIQUE À FcyRII DE SOURIS
CN113831406A (zh) 2012-08-24 2021-12-24 中外制药株式会社 FcγRIIb特异性Fc区变体
EP2970445A4 (fr) 2013-03-12 2017-02-22 Decimmune Therapeutics Inc. Anticorps humanisés anti-n2
US9290570B2 (en) 2013-03-15 2016-03-22 Eli Lilly And Company Pan-ELR+ CXC Chemokine Antibodies
JO3580B1 (ar) 2013-03-15 2020-07-05 Lilly Co Eli أجسام مضادة لكيموكين elr+ cxc شامل
CA2908350C (fr) 2013-04-02 2023-08-08 Futa Mimoto Variant de region fc
EP2796875B8 (fr) * 2013-04-23 2020-11-25 Albert-Ludwigs-Universität Freiburg Inhibiteurs de protéines spécifiques de sécrétome d'un chondrocyte pour utilisation dans le traitement de la métastase du cancer du sein
KR20160021125A (ko) * 2013-05-17 2016-02-24 쌩뜨레 나티오날 데 라 르세르쉬 생띠끄 (씨. 엔. 알. 에스) 항-cxcl1, cxcl7 및 cxcl8 항체 및 이들의 용도
PE20171111A1 (es) 2014-12-19 2017-08-07 Chugai Pharmaceutical Co Ltd Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso
EA201791754A1 (ru) 2015-02-05 2019-01-31 Чугаи Сейяку Кабусики Кайся АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
WO2018025982A1 (fr) 2016-08-05 2018-02-08 中外製薬株式会社 Composition pour la prophylaxie ou le traitement de maladies liées à il-8
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
WO2019036605A2 (fr) * 2017-08-17 2019-02-21 Massachusetts Institute Of Technology Agents de liaison à spécificité multiple de chimiokines cxc et leurs utilisations
EP3694545A4 (fr) 2017-10-11 2021-12-01 Board Of Regents, The University Of Texas System Anticorps pd-l1 humains et leurs procédés d'utilisation
CN116327926A (zh) 2018-03-15 2023-06-27 中外制药株式会社 对寨卡病毒具有交叉反应性的抗登革热病毒抗体及使用方法
AU2019239568A1 (en) * 2018-03-23 2020-09-17 Board Of Regents, The University Of Texas System Dual specificity antibodies to human PD-L1 and PD-L2 and methods of use therefor
WO2021113697A1 (fr) * 2019-12-05 2021-06-10 Seagen Inc. Anticorps anti-avb6 et conjugués anticorps-médicament
US20220080044A1 (en) * 2020-09-14 2022-03-17 National Yang-Ming University Method for preventing or treating peripheral arterial occlusive disease

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Also Published As

Publication number Publication date
TWI473815B (zh) 2015-02-21
IL201440A (en) 2016-08-31
WO2008130969A3 (fr) 2008-12-18
TW200906855A (en) 2009-02-16
PE20090302A1 (es) 2009-04-03
EP2146745A4 (fr) 2011-11-30
IL201440A0 (en) 2010-06-16
WO2008130969A2 (fr) 2008-10-30
CA2684626A1 (fr) 2008-10-30
HK1136970A1 (en) 2010-07-16
EP2146745A2 (fr) 2010-01-27
EA200970954A1 (ru) 2010-08-30
CR11116A (es) 2010-03-22
CA2684626C (fr) 2014-11-04
CN101687035B (zh) 2013-06-12
MY150525A (en) 2014-01-30
JP2010524469A (ja) 2010-07-22
PT2146745E (pt) 2015-10-14
ES2547475T3 (es) 2015-10-06
BRPI0810250A2 (pt) 2014-10-14
US8828384B2 (en) 2014-09-09
BRPI0810250A8 (pt) 2017-02-21
AU2008243049A1 (en) 2008-10-30
CY1116671T1 (el) 2017-03-15
SI2146745T1 (sl) 2015-10-30
HRP20150937T1 (hr) 2015-10-09
US20140010807A1 (en) 2014-01-09
DK2146745T3 (en) 2015-09-14
HUE027584T2 (en) 2016-11-28
CL2008001071A1 (es) 2009-05-22
EP2146745B1 (fr) 2015-06-17
CO6251323A2 (es) 2011-02-21
KR20100020946A (ko) 2010-02-23
EA024621B1 (ru) 2016-10-31
MX2009011153A (es) 2009-10-30
JP5441885B2 (ja) 2014-03-12
PL2146745T3 (pl) 2015-11-30
US20080262203A1 (en) 2008-10-23
US8496932B2 (en) 2013-07-30
NZ580239A (en) 2012-07-27
CN101687035A (zh) 2010-03-31
KR101560841B1 (ko) 2015-11-11
AU2008243049B2 (en) 2011-04-21
US20110229475A1 (en) 2011-09-22
DOP2009000236A (es) 2009-11-15

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