MA30719B1 - Nouveaux derives d'aminopyridine ayant une action inhibitrice selective sur aurora a. - Google Patents
Nouveaux derives d'aminopyridine ayant une action inhibitrice selective sur aurora a.Info
- Publication number
- MA30719B1 MA30719B1 MA31731A MA31731A MA30719B1 MA 30719 B1 MA30719 B1 MA 30719B1 MA 31731 A MA31731 A MA 31731A MA 31731 A MA31731 A MA 31731A MA 30719 B1 MA30719 B1 MA 30719B1
- Authority
- MA
- Morocco
- Prior art keywords
- aurora
- inhibitory action
- selective inhibitory
- aminopyridine derivatives
- novel aminopyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C07D241/22—Benzenesulfonamido pyrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
LA PRÉSENTE INVENTION CONCERNE UN COMPOSÉ DE FORMULE GÉNÉRALE I : DANS LAQUELLE : R1 REPRÉSENTE UN ATOME D'HYDROGÈNE, F, CN, ETC. ; R2 REPRÉSENTE O, S, SO, SO2, ETC. ; R3 REPRÉSENTE UN PHÉNYLE QUI PEUT ÊTRE SUBSTITUÉ ; X2 REPRÉSENTE CH, N, ETC. ; W REPRÉSENTE LE RÉSIDU SUIVANT : DANS LEQUEL : W1, W2 ET W3 REPRÉSENTENT CHACUN INDÉPENDAMMENT CH, N, ETC., OU UN DE SES SELS OU ESTERS PHARMACEUTIQUEMENT ACCEPTABLES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006236472 | 2006-08-31 | ||
US92608607P | 2007-04-25 | 2007-04-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30719B1 true MA30719B1 (fr) | 2009-09-01 |
Family
ID=39136042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31731A MA30719B1 (fr) | 2006-08-31 | 2009-03-20 | Nouveaux derives d'aminopyridine ayant une action inhibitrice selective sur aurora a. |
Country Status (27)
Country | Link |
---|---|
US (2) | US7915263B2 (fr) |
EP (2) | EP2061782A4 (fr) |
JP (3) | JP2008081492A (fr) |
KR (1) | KR20090055562A (fr) |
CN (1) | CN101528731B (fr) |
AR (1) | AR062585A1 (fr) |
AU (1) | AU2007289609B2 (fr) |
CA (1) | CA2657469C (fr) |
CL (1) | CL2007002519A1 (fr) |
CO (1) | CO6190529A2 (fr) |
CR (1) | CR10553A (fr) |
EC (1) | ECSP099062A (fr) |
ES (1) | ES2389515T3 (fr) |
GT (1) | GT200900008A (fr) |
HN (1) | HN2009000113A (fr) |
IL (1) | IL196497A0 (fr) |
MA (1) | MA30719B1 (fr) |
MX (1) | MX2009000390A (fr) |
NO (1) | NO20091301L (fr) |
NZ (1) | NZ574081A (fr) |
PE (1) | PE20080835A1 (fr) |
RU (1) | RU2437880C2 (fr) |
SV (1) | SV2009003152A (fr) |
TW (1) | TW200817363A (fr) |
UA (1) | UA95972C2 (fr) |
WO (2) | WO2008026769A1 (fr) |
ZA (1) | ZA200900126B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009104802A1 (fr) * | 2008-02-22 | 2009-08-27 | Banyu Pharmaceutical Co., Ltd. | Nouveaux dérivés d'aminopyridine présentant une action inhibitrice sélective d'aurora a |
EP2262813A4 (fr) * | 2008-03-31 | 2011-10-12 | Sun Pharmaceutical Ind Ltd | Procédé perfectionné pour la préparation d'analogues de morphinane |
US20110129467A1 (en) * | 2008-07-24 | 2011-06-02 | Nerviano Medical Sciences S.R.L. | Therapeutic combination comprising an aurora kinase inhibitor and antiproliferative agents |
EP2467142B1 (fr) | 2009-08-17 | 2016-09-21 | Memorial Sloan-Kettering Cancer Center | Dérivés 2-(pyrimidin-5-yl)-thiopyrimidine en tant que modulateurs Hsp70 and Hsc70 pour le traitement de maladies proliferatives |
EP2762476A4 (fr) | 2011-09-30 | 2015-03-25 | Taiho Pharmaceutical Co Ltd | Dérivé de 1,2,4-triazine-6-carboxamide |
TWI485146B (zh) * | 2012-02-29 | 2015-05-21 | Taiho Pharmaceutical Co Ltd | Novel piperidine compounds or salts thereof |
US9630896B2 (en) | 2013-11-22 | 2017-04-25 | Tansna Therapeutics, Inc. | 2,5-dialkyl-4-H/halo/ether-phenol compounds |
CA2948621A1 (fr) | 2014-05-13 | 2015-11-19 | Memorial Sloan Kettering Cancer Center | Modulateurs de hsp70 et leur procedes de fabrication et leur utilisation |
TWI693218B (zh) | 2014-11-14 | 2020-05-11 | 美商美國禮來大藥廠 | 極光a激酶抑制劑 |
US10866838B2 (en) * | 2015-03-25 | 2020-12-15 | Intel Corporation | Cluster computing service assurance apparatus and method |
CN108250191B (zh) * | 2018-03-15 | 2020-10-20 | 兰州大学 | 一种3,5-二取代的2-氨基-吡嗪化合物及其制备工艺与应用 |
WO2020049208A1 (fr) | 2018-09-09 | 2020-03-12 | Fundacio Privada Institut De Recerca De La Sida - Caixa | Aurora cinasa comme cible pour traiter, prévenir ou soigner une infection par vih ou le sida |
CN112898292A (zh) * | 2019-12-03 | 2021-06-04 | 微境生物医药科技(上海)有限公司 | 新型极光激酶抑制剂及其用途 |
TWI785474B (zh) * | 2020-01-22 | 2022-12-01 | 大陸商北京加科思新藥研發有限公司 | 用作選擇性Aurora A抑制劑的新型雜環化合物 |
WO2023196887A1 (fr) | 2022-04-08 | 2023-10-12 | Eli Lilly And Company | Méthode de traitement comprenant des inhibiteurs de kras g12c et des inhibiteurs d'aurora a |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
OA07174A (fr) | 1981-08-24 | 1984-04-30 | May & Baker Ltd | Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent. |
JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
US5223608A (en) | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
WO1992005785A1 (fr) | 1990-09-28 | 1992-04-16 | Smithkline Beecham Corporation | Analogues de camptothecine solubles dans l'eau, procedes et methodes |
US5162532A (en) | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
US5200524A (en) | 1990-12-20 | 1993-04-06 | North Carolina State University | Camptothecin intermediates and method of making same |
US5191082A (en) | 1990-12-20 | 1993-03-02 | North Carolina State University | Camptothecin intermediate and method of making camptothecin intermediates |
US5247089A (en) | 1990-12-20 | 1993-09-21 | North Carolina State University | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs |
US5243050A (en) | 1990-12-20 | 1993-09-07 | North Carolina State University | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs |
CA2145985C (fr) | 1992-10-28 | 2003-09-16 | Napoleone Ferrara | Antagonistes du facteur de croissance des cellules endotheliales des vaisseaux |
JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス.アー. | 光学的に高純度なシス−オキザラート(トランス−l−1,2−シクロヘキサンジアミン)白金(II)錯体の製造方法 |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
CA2222231A1 (fr) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Anticorps et fragments d'anticorps inhibant la croissance des tumeurs |
JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス.アー. | 白金化合物の製造方法 |
PE92198A1 (es) | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
BR0013899A (pt) | 1999-09-10 | 2003-07-08 | Merck & Co Inc | Composto, composição farmacêutica, processos de tratamento ou prevenção de câncer, de uma doença em que a angiogênese esteja implicada, da vascularização retinal, da retinopatia diabética, da degeneração macular relacionada a idade, de doenças inflamatórias, de uma doença ou condições dependentes da tirosina quinase, de patologias associadas com ossos, e, processos para produzir uma composição farmacêutica, e de reduzir ou prevenir dano tecidual em seguida a um evento isquêmico cerebral |
WO2002030358A2 (fr) | 2000-10-11 | 2002-04-18 | Tularik Inc. | Modulation de fonction de ccr4 |
US20020137755A1 (en) | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
BR0116411A (pt) * | 2000-12-21 | 2003-11-11 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
US7144903B2 (en) | 2001-05-23 | 2006-12-05 | Amgen Inc. | CCR4 antagonists |
CN1956982A (zh) * | 2004-05-21 | 2007-05-02 | 万有制药株式会社 | 具有氨基噻唑骨架的Cdk4、6选择性抑制剂 |
US7491720B2 (en) * | 2004-10-29 | 2009-02-17 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives having Aurora A selective inhibitory action |
WO2006053109A1 (fr) | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Composes heteroaryle |
GB0428082D0 (en) | 2004-12-22 | 2005-01-26 | Welcome Trust The Ltd | Therapeutic compounds |
WO2006074262A1 (fr) | 2005-01-05 | 2006-07-13 | Rigel Pharmaceuticals, Inc. | Inhibiteurs d'ubiquitine-ligases |
CA2607727A1 (fr) * | 2005-04-28 | 2006-11-09 | Mitsubishi Tanabe Pharma Corporation | Derive de cyanopyridine et emploi dudit derive au titre de medicament |
WO2006124874A2 (fr) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Inhibiteurs de la b-raf kinase |
WO2006129842A1 (fr) * | 2005-06-01 | 2006-12-07 | Banyu Pharmaceutical Co., Ltd. | Nouveau derive aminopyridine ayant une activite d’inhibition selective de l’aurora-a |
US7572809B2 (en) * | 2005-12-19 | 2009-08-11 | Hoffmann-La Roche Inc. | Isoquinoline aminopyrazole derivatives |
-
2007
- 2007-04-26 JP JP2007116649A patent/JP2008081492A/ja not_active Withdrawn
- 2007-08-29 CL CL200702519A patent/CL2007002519A1/es unknown
- 2007-08-29 EP EP07806705A patent/EP2061782A4/fr not_active Withdrawn
- 2007-08-29 ES ES07806706T patent/ES2389515T3/es active Active
- 2007-08-29 AR ARP070103835A patent/AR062585A1/es unknown
- 2007-08-29 WO PCT/JP2007/067251 patent/WO2008026769A1/fr active Application Filing
- 2007-08-29 US US11/897,272 patent/US7915263B2/en active Active
- 2007-08-29 KR KR1020097004339A patent/KR20090055562A/ko not_active Application Discontinuation
- 2007-08-29 US US12/310,307 patent/US20100016335A1/en not_active Abandoned
- 2007-08-29 CN CN200780032242.7A patent/CN101528731B/zh not_active Expired - Fee Related
- 2007-08-29 WO PCT/JP2007/067250 patent/WO2008026768A1/fr active Application Filing
- 2007-08-29 AU AU2007289609A patent/AU2007289609B2/en not_active Ceased
- 2007-08-29 MX MX2009000390A patent/MX2009000390A/es active IP Right Grant
- 2007-08-29 TW TW096132117A patent/TW200817363A/zh unknown
- 2007-08-29 JP JP2008532150A patent/JP4466782B2/ja active Active
- 2007-08-29 CA CA2657469A patent/CA2657469C/fr not_active Expired - Fee Related
- 2007-08-29 RU RU2009111599/04A patent/RU2437880C2/ru not_active IP Right Cessation
- 2007-08-29 PE PE2007001171A patent/PE20080835A1/es not_active Application Discontinuation
- 2007-08-29 EP EP07806706A patent/EP2062887B1/fr active Active
- 2007-08-29 UA UAA200902851A patent/UA95972C2/ru unknown
- 2007-08-29 NZ NZ574081A patent/NZ574081A/en not_active IP Right Cessation
-
2009
- 2009-01-07 ZA ZA200900126A patent/ZA200900126B/xx unknown
- 2009-01-13 HN HN2009000113A patent/HN2009000113A/es unknown
- 2009-01-13 CR CR10553A patent/CR10553A/es not_active Application Discontinuation
- 2009-01-13 IL IL196497A patent/IL196497A0/en unknown
- 2009-01-13 EC EC2009009062A patent/ECSP099062A/es unknown
- 2009-01-13 GT GT200900008A patent/GT200900008A/es unknown
- 2009-01-14 CO CO09002429A patent/CO6190529A2/es not_active Application Discontinuation
- 2009-01-14 SV SV2009003152A patent/SV2009003152A/es unknown
- 2009-03-20 MA MA31731A patent/MA30719B1/fr unknown
- 2009-03-30 NO NO20091301A patent/NO20091301L/no not_active Application Discontinuation
- 2009-10-29 JP JP2009248400A patent/JP5256168B2/ja active Active
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