MA30327B1 - Derives de tetrahydroisoquinoleine pour renforcer la fonction de la memoire - Google Patents

Derives de tetrahydroisoquinoleine pour renforcer la fonction de la memoire

Info

Publication number
MA30327B1
MA30327B1 MA31273A MA31273A MA30327B1 MA 30327 B1 MA30327 B1 MA 30327B1 MA 31273 A MA31273 A MA 31273A MA 31273 A MA31273 A MA 31273A MA 30327 B1 MA30327 B1 MA 30327B1
Authority
MA
Morocco
Prior art keywords
memory
derivatives
tetrahydroisoquinoleine
strengthen
function
Prior art date
Application number
MA31273A
Other languages
English (en)
Inventor
Francois Jenck
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA30327B1 publication Critical patent/MA30327B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne l'utilisation de dérivés de tétrahydroisoquinoléine pour préparer un médicament destiné à renforcer, maintenir et/ou rétablir tous les stades et/ou types de mémoire à court, moyen et/ou long terme.
MA31273A 2006-03-15 2008-10-07 Derives de tetrahydroisoquinoleine pour renforcer la fonction de la memoire MA30327B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2006050812 2006-03-15

Publications (1)

Publication Number Publication Date
MA30327B1 true MA30327B1 (fr) 2009-04-01

Family

ID=38181192

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31273A MA30327B1 (fr) 2006-03-15 2008-10-07 Derives de tetrahydroisoquinoleine pour renforcer la fonction de la memoire

Country Status (16)

Country Link
US (1) US20090082394A1 (fr)
EP (1) EP1998774A1 (fr)
JP (3) JP4582722B2 (fr)
KR (1) KR101065239B1 (fr)
CN (1) CN101400348A (fr)
AU (1) AU2007226203A1 (fr)
BR (1) BRPI0708913A2 (fr)
CA (1) CA2644010A1 (fr)
CR (1) CR10260A (fr)
EA (1) EA015256B1 (fr)
IL (1) IL194044A0 (fr)
MA (1) MA30327B1 (fr)
MX (1) MX2008011647A (fr)
NO (1) NO20084253L (fr)
UA (1) UA93903C2 (fr)
WO (1) WO2007105177A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2557163C (fr) 2004-03-01 2011-08-16 Actelion Pharmaceuticals Ltd Derives de 1,2,3,4-tetrahydroisoquinoleine substitues
CN101400348A (zh) * 2006-03-15 2009-04-01 埃科特莱茵药品有限公司 用于提高记忆功能的四氢异喹啉衍生物
WO2007122591A2 (fr) * 2006-04-26 2007-11-01 Actelion Pharmaceuticals Ltd Nouveaux dérivés de pyrazolo-tétrahydropyridine
CN101568542B (zh) 2006-12-22 2013-03-27 埃科特莱茵药品有限公司 5,6,7,8-四氢-咪唑并[1,5-a]吡嗪衍生物
CA2681163A1 (fr) * 2007-04-04 2008-10-16 F. Hoffmann-La Roche Ag Composes heterocycliques en tant qu'antagonistes des recepteurs d'orexine
PE20091010A1 (es) 2007-10-10 2009-08-08 Actelion Pharmaceuticals Ltd Derivados de tetrahidroquinolina
EP2231155A4 (fr) 2007-12-18 2011-09-14 Concert Pharmaceuticals Inc Dérivés de tétrahydroisoquinoline
ATE528295T1 (de) 2007-12-28 2011-10-15 Actelion Pharmaceuticals Ltd Trisubstituierte 3,4-dihydro-1h-isochinolin- verbindung, verfahren zu ihrer herstellung und ihre anwendung
EP2307417A2 (fr) 2008-06-25 2011-04-13 Actelion Pharmaceuticals Ltd. Composés de 5,6,7,8-tétrahydro-imidazo[1,5-a]pyrazine
WO2010095106A1 (fr) 2009-02-20 2010-08-26 Actelion Pharmaceuticals Ltd Formes solides de chlorhydrate de( 2r)-2-{(is)-6, 7-diméthoxy- 1-[2- (4-trifluorométhyl-phényl)-éthyl]-3, 4-dihydro-1h-isoquinolin-2-yl}-n-méthyl-2-phényl acétamide
KR101802726B1 (ko) 2010-08-24 2017-11-29 액테리온 파마슈티칼 리미티드 오렉신 수용체 안타고니스트로서의 프롤린 술폰아미드 유도체
BR112013006594B1 (pt) 2010-09-22 2021-08-17 Eisai R&D Management Co., Ltd Composto ciclopropano antagonista de receptor da orexina e composição farmacêutica
CA2815179A1 (fr) 2010-11-10 2012-05-18 Actelion Pharmaceuticals Ltd Derives de lactame utiles en tant qu'antagonistes du recepteur de l'orexine
WO2012085857A1 (fr) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-3-ylamides
WO2012110986A1 (fr) 2011-02-18 2012-08-23 Actelion Pharmaceuticals Ltd Nouveaux dérivés de pyrazole et d'imidazole utiles à titre d'antagonistes d'orexine
WO2012114252A1 (fr) 2011-02-21 2012-08-30 Actelion Pharmaceuticals Ltd Nouveaux amides d'indole et de pyrrolopyridine
WO2013050938A1 (fr) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd Dérivés de 3,7-diazabicyclo[3.3.1]nonane et de 9-oxa-3,7- diazabicyclo[3.3.1]nonane
PL2776430T3 (pl) 2011-11-08 2016-09-30 Pochodne 2-(1,2,3-triazol-2-ilo)benzamidu i 3-(1,2,3-triazol-2-ilo)pikolinoamidu jako antagoniści receptora oreksynowego
NZ703448A (en) 2012-06-04 2017-07-28 Actelion Pharmaceuticals Ltd Benzimidazole-proline derivatives
CA2885180C (fr) 2012-10-10 2021-03-02 Actelion Pharmaceuticals Ltd Antagonistes des recepteurs de l'orexine, qui sont des derives [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone
CN105051040A (zh) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
PT3077389T (pt) 2013-12-03 2017-12-15 Idorsia Pharmaceuticals Ltd Forma cristalina de (s)-(2-(6-cloro-7-metil-1hbenzo[d]imidazol-2-il)-2-metilpirrolidin-1-il)(5-metoxi-2-(2h-1,2,3-triazol-2-il)fenil)metanona e a sua utilização como como antagonistas do receptor de orexina
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
MY179605A (en) 2013-12-04 2020-11-11 Idorsia Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
MX2017004950A (es) 2014-10-23 2018-01-16 Eisai R&D Man Co Ltd Composiciones y metodos para tratar el insomnio.
WO2020007964A1 (fr) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd Dérivés de 2-(2-azabicyclo [3.1.0] hexan-1-yl)-1h-benzimidazole
WO2020007977A1 (fr) 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd Dérivés de 7-trifluorométhyl-[1,4]diazépane
WO2020099511A1 (fr) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Dérivés de benzimidazole-2-méthyl-morpholine
AR129309A1 (es) 2022-05-13 2024-08-07 Idorsia Pharmaceuticals Ltd Derivados de hidrazina-n-carboxamida cíclica sustituida con tiazoloaril-metilo

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2703050B1 (fr) * 1993-03-24 1995-04-28 Adir Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GB9319732D0 (en) * 1993-09-24 1993-11-10 Ucb Sa Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety
JP3942207B2 (ja) * 1995-02-17 2007-07-11 武田薬品工業株式会社 うつ性症状改善剤
ES2234840T3 (es) * 2000-03-14 2005-07-01 Actelion Pharmaceuticals Ltd. Derivados de 1,2,3,4- tetrahidroisoquinolina.
AU779266B2 (en) * 2000-05-11 2005-01-13 Banyu Pharmaceutical Co., Ltd. N-acyltetrahydroisoquinoline derivatives
WO2002051232A2 (fr) * 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Nouvelles benzazepines et derives heterocycliques associes
PL373697A1 (en) * 2002-04-26 2005-09-05 F.Hoffmann-La Roche Ag Isoquinoline derivatives
CN100432056C (zh) * 2003-03-26 2008-11-12 埃科特莱茵药品有限公司 四氢异喹啉基乙酰胺衍生物作为阿立新受体拮抗剂的应用
CA2557163C (fr) * 2004-03-01 2011-08-16 Actelion Pharmaceuticals Ltd Derives de 1,2,3,4-tetrahydroisoquinoleine substitues
FR2874011B1 (fr) * 2004-08-03 2007-06-15 Sanofi Synthelabo Derives de sulfonamides, leur preparation et leur application en therapeutique
CN101400348A (zh) * 2006-03-15 2009-04-01 埃科特莱茵药品有限公司 用于提高记忆功能的四氢异喹啉衍生物

Also Published As

Publication number Publication date
KR101065239B1 (ko) 2011-09-16
MX2008011647A (es) 2008-09-22
KR20080103597A (ko) 2008-11-27
NO20084253L (no) 2008-10-10
JP2009530265A (ja) 2009-08-27
JP2010248237A (ja) 2010-11-04
CA2644010A1 (fr) 2007-09-20
JP4582722B2 (ja) 2010-11-17
EP1998774A1 (fr) 2008-12-10
EA200870357A1 (ru) 2009-02-27
BRPI0708913A2 (pt) 2011-06-14
EA015256B1 (ru) 2011-06-30
CR10260A (fr) 2008-10-03
WO2007105177A1 (fr) 2007-09-20
JP2010270127A (ja) 2010-12-02
CN101400348A (zh) 2009-04-01
UA93903C2 (ru) 2011-03-25
US20090082394A1 (en) 2009-03-26
IL194044A0 (en) 2009-09-22
AU2007226203A1 (en) 2007-09-20

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