MA28664B1 - Indazoles substitues, compositions les contenant, procede de fabrication et utilisation - Google Patents
Indazoles substitues, compositions les contenant, procede de fabrication et utilisationInfo
- Publication number
- MA28664B1 MA28664B1 MA29532A MA29532A MA28664B1 MA 28664 B1 MA28664 B1 MA 28664B1 MA 29532 A MA29532 A MA 29532A MA 29532 A MA29532 A MA 29532A MA 28664 B1 MA28664 B1 MA 28664B1
- Authority
- MA
- Morocco
- Prior art keywords
- manufacture
- compositions containing
- substituted indazoles
- containing same
- indazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Indazoles substitués, compositions les contenant, procédé de fabrication et utilisation. La présente invention concerne en particulier de nouveaux indazoles substitués spécifiques présentant une activité inhibitrice de kinases, ayant une activité thérapeutique, en particulier en oncologie.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0406042A FR2871158A1 (fr) | 2004-06-04 | 2004-06-04 | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
MA28664B1 true MA28664B1 (fr) | 2007-06-01 |
Family
ID=34946329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA29532A MA28664B1 (fr) | 2004-06-04 | 2006-12-14 | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
Country Status (22)
Country | Link |
---|---|
US (1) | US7517902B2 (fr) |
EP (1) | EP1765813A1 (fr) |
JP (1) | JP2008501669A (fr) |
KR (1) | KR20070043769A (fr) |
CN (1) | CN1980918A (fr) |
AR (1) | AR049389A1 (fr) |
AU (1) | AU2005259139B2 (fr) |
BR (1) | BRPI0510777A (fr) |
CA (1) | CA2567744A1 (fr) |
CR (1) | CR8767A (fr) |
EA (1) | EA012702B1 (fr) |
EC (1) | ECSP067046A (fr) |
FR (1) | FR2871158A1 (fr) |
IL (1) | IL179595A0 (fr) |
MA (1) | MA28664B1 (fr) |
MX (1) | MXPA06013954A (fr) |
NO (1) | NO20066050L (fr) |
TN (1) | TNSN06384A1 (fr) |
TW (1) | TW200610756A (fr) |
UY (1) | UY28941A1 (fr) |
WO (1) | WO2006003276A1 (fr) |
ZA (1) | ZA200610040B (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20061119A1 (es) * | 2005-01-19 | 2006-11-27 | Aventis Pharma Sa | PIRAZOLO PIRIDINAS SUSTITUIDAS COMO INHIBIDORES DE CINASAS FAK, KDR Y Tie |
FR2889526B1 (fr) * | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
DE102006005179A1 (de) * | 2006-02-06 | 2007-08-09 | Merck Patent Gmbh | Aminoindazolderivate |
EP2223925A1 (fr) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Inhibiteurs de kinase |
JP2010505962A (ja) * | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
CA2673095C (fr) * | 2006-12-20 | 2016-03-15 | Nerviano Medical Sciences S.R.L. | Derives de l'indazole en tant qu'inhibiteurs des kinases pour le traitement du cancer |
CN103923072B (zh) | 2007-07-20 | 2017-05-31 | 内尔维阿诺医学科学有限公司 | 作为具有激酶抑制剂活性的取代的吲唑衍生物 |
KR101061599B1 (ko) | 2008-12-05 | 2011-09-02 | 한국과학기술연구원 | 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물 |
CA2784807C (fr) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinase raf de type ii |
CN103080093A (zh) * | 2010-03-16 | 2013-05-01 | 达纳-法伯癌症研究所公司 | 吲唑化合物及其应用 |
WO2013074986A1 (fr) | 2011-11-17 | 2013-05-23 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de la kinase c-jun-n-terminale (jnk) |
KR20130077390A (ko) * | 2011-12-29 | 2013-07-09 | 제이더블유중외제약 주식회사 | 단백질 키나아제 저해활성을 가지는 6-아미노-3-카복스아미도인다졸 유도체 |
US10112927B2 (en) | 2012-10-18 | 2018-10-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
WO2014063054A1 (fr) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinase moelle osseuse sur chromosome x (bmx) et leurs utilisations |
WO2014063061A1 (fr) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Petites molécules marquées de façon hydrophobe en tant qu'inducteurs de la dégradation de protéine |
ES2676734T3 (es) | 2013-10-18 | 2018-07-24 | Syros Pharmaceuticals, Inc. | Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas |
JP6491202B2 (ja) | 2013-10-18 | 2019-03-27 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | サイクリン依存性キナーゼ7(cdk7)の多環阻害剤 |
TWI672141B (zh) | 2014-02-20 | 2019-09-21 | 美商醫科泰生技 | 投予ros1突變癌細胞之分子 |
US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
US10017477B2 (en) | 2014-04-23 | 2018-07-10 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
KR102595599B1 (ko) | 2014-12-02 | 2023-11-02 | 이그니타, 인코포레이티드 | 신경모세포종의 치료를 위한 병용 |
US10336707B2 (en) | 2014-12-16 | 2019-07-02 | Eudendron S.R.L. | Heterocyclic derivatives modulating activity of certain protein kinases |
WO2016105528A2 (fr) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de la kinase cycline-dépendante 7 (cdk7) |
CN106032359B (zh) * | 2015-03-09 | 2018-07-20 | 复旦大学 | 吲唑类化合物及其制备方法和用途 |
CA2978518C (fr) | 2015-03-27 | 2023-11-21 | Nathanael S. Gray | Inhibiteurs de kinases cycline-dependantes |
EP3307728A4 (fr) | 2015-06-12 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | Thérapie d'association utilisant des inhibiteurs de transcription et des inhibiteurs de kinases |
EP4019515A1 (fr) | 2015-09-09 | 2022-06-29 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinases cycline-dépendantes |
KR20180096621A (ko) | 2015-12-18 | 2018-08-29 | 이그니타, 인코포레이티드 | 암의 치료용 조합물 |
WO2018055550A1 (fr) | 2016-09-23 | 2018-03-29 | Novartis Ag | Composés d'indazole destinés à être utilisés dans des lésions de tendon et/ou de ligament |
JOP20190053A1 (ar) | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
CA3050770C (fr) * | 2016-12-07 | 2023-09-12 | Nanjing Xin Shi Dai Meditech Co. Ltd. | Composes et compositions pharmaceutiques pour moduler l'activite sgk, et leurs procedes |
IL271759B2 (en) | 2017-07-19 | 2024-01-01 | Ignyta Inc | Pharmaceutical preparations that include anthraxtinib |
US11548867B2 (en) | 2017-07-19 | 2023-01-10 | Idea Ya Biosciences, Inc. | Amido compounds as AhR modulators |
JP7311498B2 (ja) | 2017-10-17 | 2023-07-19 | イグナイタ インコーポレイテッド | 薬学的組成物および剤形 |
CN109134451A (zh) * | 2018-09-10 | 2019-01-04 | 遵义医学院 | 1,3-二取代脲类与硫脲类衍生物及其应用 |
WO2020210828A1 (fr) * | 2019-04-12 | 2020-10-15 | Hibercell, Inc. | (aza) indazolyl-aryle sulfonamide et composés apparentés et leur utilisation dans le traitement d'états médicaux |
CN114276297A (zh) * | 2020-10-15 | 2022-04-05 | 兰州大学 | 一种1h-吲唑vegfr-2激酶抑制剂及其制备与应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2971842A (en) * | 1956-03-21 | 1961-02-14 | Gen Aniline & Film Corp | Light sensitive layers for photomechanical reproduction |
DE60037455T2 (de) | 1999-09-17 | 2008-11-27 | Abbott Gmbh & Co. Kg | Kinaseinhibitoren als arzneimittel |
EP1403255A4 (fr) * | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | Inhibiteurs de rho kinase |
FR2827861B1 (fr) | 2001-07-27 | 2004-04-02 | Aventis Pharma Sa | Derives des indazoles ou des indoles, leur utilisation en medecine humaine et plus particulierement en cancerologie |
US20030187026A1 (en) * | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
AU2002353186A1 (en) * | 2001-12-19 | 2003-06-30 | Smithkline Beecham P.L.C. | (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors |
FR2836915B1 (fr) | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
ES2411655T3 (es) * | 2002-05-17 | 2013-07-08 | Pfizer Italia S.R.L. | Derivados de aminoindazol activos como inhibidores de quinasas, procedimiento para su preparación y composiciones farmacéuticas que los comprenden |
MXPA05001688A (es) | 2002-08-12 | 2005-04-19 | Sugen Inc | 3-pirrolil-piridopirazoles y 3-pirrolil-indazoles como inhibidores de cinasa novedosos. |
AU2003278249B8 (en) | 2002-09-05 | 2010-11-18 | Aventis Pharma S.A. | Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same |
BR0316606A (pt) * | 2002-12-12 | 2005-10-11 | Aventis Pharma Sa | Derivados de aminoindazóis e sua utilização como inibidores de quinases |
WO2004113304A1 (fr) * | 2003-05-22 | 2004-12-29 | Abbott Laboratories | Inhibiteurs de kinases de type indazole, benzisoxazole et benzisothiazole |
CA2532800C (fr) | 2003-07-23 | 2013-06-18 | Exelixis, Inc. | Modulateurs de la proteine alk (anaplastic lymphoma kinase) et leurs methodes d'utilisation |
WO2005110410A2 (fr) | 2004-05-14 | 2005-11-24 | Abbott Laboratories | Inhibiteurs de kinases en tant qu'agents therapeutiques |
PE20061119A1 (es) | 2005-01-19 | 2006-11-27 | Aventis Pharma Sa | PIRAZOLO PIRIDINAS SUSTITUIDAS COMO INHIBIDORES DE CINASAS FAK, KDR Y Tie |
BRPI0608252A2 (pt) | 2005-03-10 | 2010-04-06 | Cgi Pharmaceuticals Inc | entidades quìmicas, composições farmacêuticas compreendendo as mesmas, métodos utilizando as referidas entidades quìmicas e uso das referidas entidades quìmicas |
-
2004
- 2004-06-04 FR FR0406042A patent/FR2871158A1/fr not_active Withdrawn
-
2005
- 2005-06-01 KR KR1020077000131A patent/KR20070043769A/ko not_active Application Discontinuation
- 2005-06-01 EA EA200602241A patent/EA012702B1/ru not_active IP Right Cessation
- 2005-06-01 CN CNA2005800226007A patent/CN1980918A/zh active Pending
- 2005-06-01 AU AU2005259139A patent/AU2005259139B2/en not_active Ceased
- 2005-06-01 WO PCT/FR2005/001335 patent/WO2006003276A1/fr active Application Filing
- 2005-06-01 JP JP2007514025A patent/JP2008501669A/ja active Pending
- 2005-06-01 ZA ZA200610040A patent/ZA200610040B/xx unknown
- 2005-06-01 MX MXPA06013954A patent/MXPA06013954A/es active IP Right Grant
- 2005-06-01 BR BRPI0510777-6A patent/BRPI0510777A/pt not_active IP Right Cessation
- 2005-06-01 CA CA002567744A patent/CA2567744A1/fr not_active Abandoned
- 2005-06-01 EP EP05775644A patent/EP1765813A1/fr not_active Withdrawn
- 2005-06-02 AR ARP050102268A patent/AR049389A1/es unknown
- 2005-06-03 UY UY28941A patent/UY28941A1/es unknown
- 2005-06-03 TW TW094118279A patent/TW200610756A/zh unknown
-
2006
- 2006-11-23 CR CR8767A patent/CR8767A/es not_active Application Discontinuation
- 2006-11-24 TN TNP2006000384A patent/TNSN06384A1/fr unknown
- 2006-11-26 IL IL179595A patent/IL179595A0/en unknown
- 2006-11-30 EC EC2006007046A patent/ECSP067046A/es unknown
- 2006-12-04 US US11/566,382 patent/US7517902B2/en not_active Expired - Fee Related
- 2006-12-14 MA MA29532A patent/MA28664B1/fr unknown
- 2006-12-28 NO NO20066050A patent/NO20066050L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CR8767A (es) | 2007-08-28 |
US20070161626A1 (en) | 2007-07-12 |
AU2005259139B2 (en) | 2011-09-08 |
ZA200610040B (en) | 2008-02-27 |
TW200610756A (en) | 2006-04-01 |
WO2006003276A1 (fr) | 2006-01-12 |
MXPA06013954A (es) | 2007-03-15 |
AR049389A1 (es) | 2006-07-26 |
ECSP067046A (es) | 2006-12-29 |
UY28941A1 (es) | 2005-12-30 |
JP2008501669A (ja) | 2008-01-24 |
EP1765813A1 (fr) | 2007-03-28 |
TNSN06384A1 (fr) | 2008-02-22 |
KR20070043769A (ko) | 2007-04-25 |
CA2567744A1 (fr) | 2006-01-12 |
US7517902B2 (en) | 2009-04-14 |
AU2005259139A1 (en) | 2006-01-12 |
CN1980918A (zh) | 2007-06-13 |
NO20066050L (no) | 2007-02-05 |
EA012702B1 (ru) | 2009-12-30 |
FR2871158A1 (fr) | 2005-12-09 |
EA200602241A1 (ru) | 2007-04-27 |
BRPI0510777A (pt) | 2007-11-20 |
IL179595A0 (en) | 2007-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA28664B1 (fr) | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation | |
TNSN04175A1 (fr) | Indazoles substitues avec une activite anticancereuse | |
NO20082476L (no) | Bicykliske forbindelser med kinaseinhiberende aktivitet | |
ATE378337T1 (de) | Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen | |
MXPA06011046A (es) | Ciertos compuestos basados en triazol, composiciones, y usos de los mismos. | |
ATE493401T1 (de) | Als proteinkinaseinhibitoren geeignete diaminotriazolverbindungen | |
TW200801008A (en) | Protein kinase inhibitors | |
FR2889526B1 (fr) | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation | |
BRPI0512547A (pt) | pirimidinas | |
WO2007067781A3 (fr) | Inhibiteurs de proteines kinases | |
BRPI0409367A (pt) | derivados de piperidina inibidores de renina | |
BRPI0616630B8 (pt) | compostos de pirazol substituídos | |
ATE419253T1 (de) | Inhibitoren von thienopyridin- und furopyridinkinase | |
DE60314603D1 (de) | Zusammensetzungen brauchbar als protein-kinase- inhibitoren | |
BRPI0513915A (pt) | compostos aminoeteroarila enantiomericamente puros como inibidores de proteìna quinase | |
EA200801301A1 (ru) | ИНГИБИТОРЫ АКТИВНОСТИ Akt | |
ATE532781T1 (de) | 5-(acylamino)indazol-derivate als kinase- inhibitoren | |
ATE420883T1 (de) | Pyrrolopyrimidine verwendbar als protein kinase inhibitoren | |
EA200970403A1 (ru) | Бициклические триазолы в качестве модуляторов протеинкиназы | |
MY140291A (en) | Sulfoximine-substituted pyrimidines for use as cd and/or vegf inhibitors, the production thereof and their use as drugs | |
ATE450530T1 (de) | Zusammensetzungen zur verwendung als protein- kinase-inhibitoren | |
DE60332433D1 (de) | Azolylaminoazine als proteinkinasehemmer | |
DE60332604D1 (de) | Azolylaminoazine als proteinkinasehemmer | |
NO20060985L (no) | Inhibitorer av Akt aktivitet | |
ATE548363T1 (de) | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen |