MA27444A1 - Derives d'isothiazole et d'isoxazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (tgf) - Google Patents
Derives d'isothiazole et d'isoxazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (tgf)Info
- Publication number
- MA27444A1 MA27444A1 MA28158A MA28158A MA27444A1 MA 27444 A1 MA27444 A1 MA 27444A1 MA 28158 A MA28158 A MA 28158A MA 28158 A MA28158 A MA 28158A MA 27444 A1 MA27444 A1 MA 27444A1
- Authority
- MA
- Morocco
- Prior art keywords
- tgf
- growth factor
- inhibitors
- isoxazole derivatives
- transforming growth
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Société dite: PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 18 Septembre 2002 60/412,131 US 2 Juillet 2003 60/484,580 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés disothiazole et d'isoxazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (TGF) Des dérivés disothiazole et d'isoxazole nouveaux, y compris leurs dérivés, les intermédiaires utilisés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en médecine sont décrits. Les composés de la présente invention sont de puissants inhibiteurs de la voie de transmission de signal du facteur de croissance transformant ("TGF")-P. Ils sont utiles dans le traitement de divers états pathologiques en rapport avec le TGF, comprenant, par exemple, le cancer et des maladies fibrotiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41213102P | 2002-09-18 | 2002-09-18 | |
US48458003P | 2003-07-02 | 2003-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27444A1 true MA27444A1 (fr) | 2005-07-01 |
Family
ID=32033584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28158A MA27444A1 (fr) | 2002-09-18 | 2005-03-18 | Derives d'isothiazole et d'isoxazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (tgf) |
Country Status (25)
Country | Link |
---|---|
US (1) | US7030125B2 (fr) |
EP (1) | EP1542995A1 (fr) |
JP (1) | JP2006506443A (fr) |
KR (1) | KR20050057441A (fr) |
CN (1) | CN1681809A (fr) |
AP (1) | AP2005003262A0 (fr) |
AR (1) | AR041275A1 (fr) |
AU (1) | AU2003263431A1 (fr) |
BR (1) | BR0314286A (fr) |
CA (1) | CA2499332A1 (fr) |
CO (1) | CO5550458A2 (fr) |
EA (1) | EA200500286A1 (fr) |
EC (1) | ECSP055685A (fr) |
HR (1) | HRP20050246A2 (fr) |
IS (1) | IS7695A (fr) |
MA (1) | MA27444A1 (fr) |
MX (1) | MXPA05002378A (fr) |
NO (1) | NO20051852L (fr) |
OA (1) | OA12925A (fr) |
PA (1) | PA8583101A1 (fr) |
PE (1) | PE20050076A1 (fr) |
PL (1) | PL375973A1 (fr) |
TW (1) | TW200410954A (fr) |
UY (1) | UY27983A1 (fr) |
WO (1) | WO2004026865A1 (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003263404A1 (en) * | 2002-09-18 | 2004-04-08 | Pfizer Products Inc. | Novel imidazole compounds as transforming growth factor (tgf) inhibitors |
OA12926A (en) | 2002-09-18 | 2006-10-13 | Pfizer Prod Inc | Novel oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors. |
CA2496295C (fr) | 2002-09-18 | 2010-11-23 | Michael John Munchhof | Nouveaux composes de pyrazole utilises comme inhibiteurs du facteur de croissance transformant (tgf) |
PA8595001A1 (es) * | 2003-03-04 | 2004-09-28 | Pfizer Prod Inc | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) |
AR051202A1 (es) | 2004-09-20 | 2006-12-27 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
BRPI0515478A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase |
AU2005329423A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
EP2316458A1 (fr) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Derives de pyridazine destines a l'inhibition du desaturase-coa-stearoyl de l'humain |
US7777036B2 (en) | 2004-09-20 | 2010-08-17 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
MX2007003318A (es) | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
TW200626154A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
JP5123671B2 (ja) | 2005-02-17 | 2013-01-23 | シンタ ファーマシューティカルズ コーポレーション | 増殖性疾患の治療のための化合物 |
CN101208089A (zh) | 2005-06-03 | 2008-06-25 | 泽农医药公司 | 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂 |
AU2006325706B2 (en) * | 2005-12-16 | 2012-03-29 | Novartis Ag | Control of intraocular pressure using ALK5 modulation agents |
TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
CN105358677B (zh) | 2013-03-14 | 2018-06-15 | 布里格海姆妇女医院公司 | 用于上皮干细胞扩增和培养的组合物和方法 |
HUE050761T2 (hu) | 2014-01-01 | 2021-01-28 | Medivation Tech Llc | Vegyületek és alkalmazási eljárások |
WO2016037016A1 (fr) | 2014-09-03 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Compositions, systèmes et procédés pour la production de cellules ciliées de l'oreille interne pour le traitement de la perte auditive |
US10669528B2 (en) | 2015-06-25 | 2020-06-02 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
CA3010610A1 (fr) | 2016-01-08 | 2017-07-13 | The Brigham And Women's Hospital, Inc. | Production de cellules enteroendocrines differenciees et cellules produisant de l'insuline |
US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
EP4049665A1 (fr) | 2016-03-15 | 2022-08-31 | Children's Medical Center Corporation | Procédés et compositions associées à l'expansion de cellules souches hématopoïétiques |
US11066419B2 (en) | 2016-12-30 | 2021-07-20 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using same |
EP3768267A4 (fr) | 2018-03-20 | 2022-04-20 | Icahn School of Medicine at Mount Sinai | Composés inhibiteurs de kinase, compositions et procédés d'utilisation |
US20210254006A1 (en) | 2018-06-06 | 2021-08-19 | Ideaya Biosciences, Inc. | Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds |
WO2020037326A1 (fr) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions et méthodes pour produire des cellules ciliées par la régulation à la baisse de foxo |
WO2020037323A1 (fr) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions et méthodes pour générer des cellules ciliées par la régulation à la hausse de jag-1 |
AU2019419414A1 (en) | 2018-12-31 | 2023-04-06 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5095272A (fr) * | 1973-12-24 | 1975-07-29 | ||
JP2002502379A (ja) | 1997-05-22 | 2002-01-22 | ジー.ディー.サール アンド カンパニー | p38キナーゼインヒビターとしての3(5)−ヘテロアリール置換ピラゾール |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
EP1019394A1 (fr) | 1997-05-22 | 2000-07-19 | G.D. Searle & Co. | DERIVES DE PYRAZOLE COMME INHIBITEURS DE KINASE p38 |
DE60001229T2 (de) | 1999-04-09 | 2003-10-30 | Smithkline Beecham Corp., Philadelphia | Triarylimidazole |
CO5271680A1 (es) | 2000-02-21 | 2003-04-30 | Smithkline Beecham Corp | Compuestos |
GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
GB0027987D0 (en) * | 2000-11-16 | 2001-01-03 | Smithkline Beecham Plc | Compounds |
WO2002040468A1 (fr) | 2000-11-16 | 2002-05-23 | Smithkline Beecham Corporation | Composes |
GB0100762D0 (en) | 2001-01-11 | 2001-02-21 | Smithkline Beecham Plc | Novel use |
US20040087623A1 (en) * | 2001-02-02 | 2004-05-06 | Gellibert Francoise Jeanne | Pyrazole derivatives against tgf overexpression |
GB0102668D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
EP1363904A1 (fr) * | 2001-02-02 | 2003-11-26 | Glaxo Group Limited | Pyrazoles utilises comme inhibiteurs du tgf |
GB0102672D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
US6673818B2 (en) * | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
US20050245520A1 (en) | 2002-07-31 | 2005-11-03 | Nerina Dodic | 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors |
-
2003
- 2003-09-12 CA CA002499332A patent/CA2499332A1/fr not_active Abandoned
- 2003-09-12 JP JP2004568905A patent/JP2006506443A/ja not_active Withdrawn
- 2003-09-12 PL PL03375973A patent/PL375973A1/xx not_active Application Discontinuation
- 2003-09-12 EA EA200500286A patent/EA200500286A1/ru unknown
- 2003-09-12 AP AP2005003262A patent/AP2005003262A0/xx unknown
- 2003-09-12 OA OA1200500074A patent/OA12925A/en unknown
- 2003-09-12 CN CNA038222043A patent/CN1681809A/zh active Pending
- 2003-09-12 WO PCT/IB2003/004005 patent/WO2004026865A1/fr active Application Filing
- 2003-09-12 EP EP03797466A patent/EP1542995A1/fr not_active Withdrawn
- 2003-09-12 BR BR0314286-8A patent/BR0314286A/pt not_active IP Right Cessation
- 2003-09-12 MX MXPA05002378A patent/MXPA05002378A/es active IP Right Grant
- 2003-09-12 KR KR1020057004662A patent/KR20050057441A/ko not_active Application Discontinuation
- 2003-09-12 AU AU2003263431A patent/AU2003263431A1/en not_active Abandoned
- 2003-09-15 TW TW092125380A patent/TW200410954A/zh unknown
- 2003-09-16 UY UY27983A patent/UY27983A1/es not_active Application Discontinuation
- 2003-09-16 AR ARP030103359A patent/AR041275A1/es unknown
- 2003-09-17 PE PE2003000951A patent/PE20050076A1/es not_active Application Discontinuation
- 2003-09-17 PA PA20038583101A patent/PA8583101A1/es unknown
- 2003-09-17 US US10/667,167 patent/US7030125B2/en not_active Expired - Fee Related
-
2005
- 2005-02-14 IS IS7695A patent/IS7695A/is unknown
- 2005-03-16 HR HR20050246A patent/HRP20050246A2/hr not_active Application Discontinuation
- 2005-03-17 EC EC2005005685A patent/ECSP055685A/es unknown
- 2005-03-18 CO CO05025189A patent/CO5550458A2/es not_active Application Discontinuation
- 2005-03-18 MA MA28158A patent/MA27444A1/fr unknown
- 2005-04-15 NO NO20051852A patent/NO20051852L/no unknown
Also Published As
Publication number | Publication date |
---|---|
PL375973A1 (en) | 2005-12-12 |
CA2499332A1 (fr) | 2004-04-01 |
UY27983A1 (es) | 2004-04-30 |
US20040116473A1 (en) | 2004-06-17 |
AP2005003262A0 (en) | 2005-03-31 |
EA200500286A1 (ru) | 2005-08-25 |
NO20051852L (no) | 2005-06-16 |
PA8583101A1 (es) | 2004-04-23 |
AR041275A1 (es) | 2005-05-11 |
MXPA05002378A (es) | 2005-05-23 |
TW200410954A (en) | 2004-07-01 |
EP1542995A1 (fr) | 2005-06-22 |
BR0314286A (pt) | 2005-08-02 |
AU2003263431A1 (en) | 2004-04-08 |
IS7695A (is) | 2005-02-14 |
JP2006506443A (ja) | 2006-02-23 |
WO2004026865A1 (fr) | 2004-04-01 |
HRP20050246A2 (en) | 2005-10-31 |
OA12925A (en) | 2006-10-13 |
KR20050057441A (ko) | 2005-06-16 |
CN1681809A (zh) | 2005-10-12 |
ECSP055685A (es) | 2005-05-30 |
US7030125B2 (en) | 2006-04-18 |
CO5550458A2 (es) | 2005-08-31 |
PE20050076A1 (es) | 2005-03-26 |
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