MA26513A1 - Derives du bis-indole ayant une activite antimetastasique, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents
Derives du bis-indole ayant une activite antimetastasique, procede pour leur preparation et compositions pharmaceutiques les contenantInfo
- Publication number
- MA26513A1 MA26513A1 MA25125A MA25125A MA26513A1 MA 26513 A1 MA26513 A1 MA 26513A1 MA 25125 A MA25125 A MA 25125A MA 25125 A MA25125 A MA 25125A MA 26513 A1 MA26513 A1 MA 26513A1
- Authority
- MA
- Morocco
- Prior art keywords
- antimetastastic
- bis
- activity
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97110336A EP0887348A1 (fr) | 1997-06-25 | 1997-06-25 | Dérivés de bisindole ayant une activité antimétastatique, leur procédé de préparation et compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA26513A1 true MA26513A1 (fr) | 2004-12-20 |
Family
ID=8226954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA25125A MA26513A1 (fr) | 1997-06-25 | 1998-06-19 | Derives du bis-indole ayant une activite antimetastasique, procede pour leur preparation et compositions pharmaceutiques les contenant |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP0887348A1 (fr) |
| JP (1) | JP2002507206A (fr) |
| KR (1) | KR20010014215A (fr) |
| CN (1) | CN1268134A (fr) |
| AR (1) | AR016283A1 (fr) |
| AU (1) | AU8629598A (fr) |
| BR (1) | BR9810947A (fr) |
| CA (1) | CA2294250A1 (fr) |
| CO (1) | CO4940464A1 (fr) |
| HR (1) | HRP980357A2 (fr) |
| MA (1) | MA26513A1 (fr) |
| TR (1) | TR199903218T2 (fr) |
| WO (1) | WO1999000381A1 (fr) |
| ZA (1) | ZA985482B (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE277010T1 (de) | 1998-07-08 | 2004-10-15 | Harbor Branch Oceanographic | Bis-indolederivate und ihre verwendung als entzündungshemmende mittel |
| US7709520B2 (en) * | 2000-10-06 | 2010-05-04 | The Texas A&M University System | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers |
| IT1317925B1 (it) * | 2000-11-03 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante. |
| GB2368843A (en) * | 2000-11-08 | 2002-05-15 | Leuven K U Res & Dev | Non-porphyrin multipurpose contrast agents |
| WO2002038546A1 (fr) | 2000-11-08 | 2002-05-16 | K.U. Leuven Research & Development | Derives de bis-indole substitue utilises comme agents de contraste, compositions pharmaceutiques contenant lesdits derives et intermediaires permettant de preparer ces derives |
| EP1438044A1 (fr) | 2001-10-19 | 2004-07-21 | Transtech Pharma, Inc. | Bis-heteroaryl alcanes utilises comme agents therapeutiques |
| US7652036B2 (en) | 2003-02-25 | 2010-01-26 | Topotarget Uk Limited | Carbamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors |
| JP4698671B2 (ja) | 2004-06-01 | 2011-06-08 | エフ．ホフマン−ラ ロシュ アーゲー | モノアミン再取り込み阻害剤としての３−アミノ−１−アリールプロピルインドール |
| CA2576094A1 (fr) * | 2004-08-23 | 2006-03-02 | The Texas A&M University System | Activation dependant des ligands de nur77 et ses applications |
| CN1332948C (zh) * | 2005-05-12 | 2007-08-22 | 苏州大学 | 双吲哚烷基衍生物的合成方法 |
| CN100412058C (zh) * | 2005-05-12 | 2008-08-20 | 苏州大学 | 一种双吲哚烷基化合物的合成方法 |
| TW200716545A (en) | 2005-06-10 | 2007-05-01 | Sigma Tau Ind Farmaceuti | Indole derivatives having anti-tumor activity |
| EP1957454B1 (fr) | 2005-11-30 | 2011-07-20 | F. Hoffmann-La Roche AG | Procede de synthese de 3-amino-1-arylpropyle indoles |
| CN101316818B (zh) | 2005-11-30 | 2011-08-31 | 弗·哈夫曼-拉罗切有限公司 | 3-氨基-1-芳基丙基吲哚类和氮杂取代的吲哚类 |
| EP1957488B1 (fr) | 2005-11-30 | 2009-09-09 | F.Hoffmann-La Roche Ag | 3-amino-2-arylpropyl azaindoles et leurs utilisations |
| CN105669540A (zh) * | 2009-01-28 | 2016-06-15 | 卡鲁斯治疗有限公司 | Scriptaid电子等排体及其在治疗中的用途 |
| CN101585800B (zh) * | 2009-06-19 | 2011-06-15 | 中国科学院上海有机化学研究所 | 具有生物活性双吲哚甲烷类化合物 |
| CA2825599C (fr) | 2011-02-01 | 2021-07-13 | The Board Of Trustees Of The University Of Illinois | Composes 4-methyl-n-hydroxybenzamide comme inhibiteurs d'histone deacetylase (hdac) |
| NZ707366A (en) | 2012-11-07 | 2018-11-30 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors and their use in therapy |
| DK2994465T3 (en) | 2013-05-10 | 2018-10-08 | Karus Therapeutics Ltd | HISTONDEACETYLASE INHIBITORS UNKNOWN |
| CN103274987A (zh) * | 2013-06-07 | 2013-09-04 | 华东师范大学 | 3,3-二取代氧化吲哚衍生物及其合成方法和应用 |
| CN104030964B (zh) * | 2014-06-05 | 2016-06-29 | 天津科技大学 | 双吲哚类化合物及合成方法 |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| CN107698658B (zh) * | 2015-06-23 | 2021-02-12 | 首都医科大学 | 双[3-(乙酰-Lys-AA-OBzl)-吲哚-2-基]乙烷,其制备,活性和应用 |
| EP3664797A4 (fr) * | 2017-08-10 | 2021-02-17 | The Texas A&M University System | Ligands de nr4a1, compositions pharmaceutiques et procédés d'utilisation associés |
| EP3883564A4 (fr) * | 2018-11-21 | 2022-07-27 | The University of the West Indies | Composés et utilisations associées |
| AU2021225838A1 (en) * | 2020-02-25 | 2022-10-20 | The Texas A&M University System | Methods for treating endometriosis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4866084A (en) * | 1987-07-17 | 1989-09-12 | Harbor Branch Oceanographic Institution, Inc. | Topsentin compounds effective against viruses and certain tumors |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| GB9516943D0 (en) * | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
-
1997
- 1997-06-25 EP EP97110336A patent/EP0887348A1/fr not_active Withdrawn
-
1998
- 1998-06-19 MA MA25125A patent/MA26513A1/fr unknown
- 1998-06-23 KR KR1019997012300A patent/KR20010014215A/ko not_active Application Discontinuation
- 1998-06-23 CA CA002294250A patent/CA2294250A1/fr not_active Abandoned
- 1998-06-23 BR BR9810947-2A patent/BR9810947A/pt not_active Application Discontinuation
- 1998-06-23 JP JP50527199A patent/JP2002507206A/ja active Pending
- 1998-06-23 WO PCT/EP1998/003837 patent/WO1999000381A1/fr not_active Application Discontinuation
- 1998-06-23 AU AU86295/98A patent/AU8629598A/en not_active Abandoned
- 1998-06-23 CN CN98808565A patent/CN1268134A/zh active Pending
- 1998-06-23 EP EP98937539A patent/EP0991645A1/fr not_active Withdrawn
- 1998-06-23 TR TR1999/03218T patent/TR199903218T2/xx unknown
- 1998-06-24 ZA ZA9805482A patent/ZA985482B/xx unknown
- 1998-06-24 HR HR97110336.1A patent/HRP980357A2/hr not_active Application Discontinuation
- 1998-06-24 AR ARP980103029A patent/AR016283A1/es unknown
- 1998-06-25 CO CO98036361A patent/CO4940464A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TR199903218T2 (xx) | 2000-07-21 |
| JP2002507206A (ja) | 2002-03-05 |
| BR9810947A (pt) | 2000-09-26 |
| HRP980357A2 (en) | 1999-02-28 |
| CA2294250A1 (fr) | 1999-01-07 |
| ZA985482B (en) | 1999-12-24 |
| WO1999000381A1 (fr) | 1999-01-07 |
| CO4940464A1 (es) | 2000-07-24 |
| EP0887348A1 (fr) | 1998-12-30 |
| AR016283A1 (es) | 2001-07-04 |
| AU8629598A (en) | 1999-01-19 |
| CN1268134A (zh) | 2000-09-27 |
| KR20010014215A (ko) | 2001-02-26 |
| EP0991645A1 (fr) | 2000-04-12 |
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