MA24573A1 - Derives de l'acide barbiturique avec une activite anti-metastasique et anti-tumorale - Google Patents

Derives de l'acide barbiturique avec une activite anti-metastasique et anti-tumorale

Info

Publication number
MA24573A1
MA24573A1 MA25126A MA25126A MA24573A1 MA 24573 A1 MA24573 A1 MA 24573A1 MA 25126 A MA25126 A MA 25126A MA 25126 A MA25126 A MA 25126A MA 24573 A1 MA24573 A1 MA 24573A1
Authority
MA
Morocco
Prior art keywords
metastasic
acid derivatives
tumor activity
barbituric acid
barbituric
Prior art date
Application number
MA25126A
Other languages
English (en)
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of MA24573A1 publication Critical patent/MA24573A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
MA25126A 1997-06-21 1998-06-19 Derives de l'acide barbiturique avec une activite anti-metastasique et anti-tumorale MA24573A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97110200 1997-06-21

Publications (1)

Publication Number Publication Date
MA24573A1 true MA24573A1 (fr) 1998-12-31

Family

ID=8226939

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25126A MA24573A1 (fr) 1997-06-21 1998-06-19 Derives de l'acide barbiturique avec une activite anti-metastasique et anti-tumorale

Country Status (18)

Country Link
US (1) US6335332B1 (fr)
EP (1) EP0989982B1 (fr)
JP (1) JP2002504916A (fr)
KR (1) KR20010014020A (fr)
CN (1) CN1295227C (fr)
AR (1) AR018997A1 (fr)
AT (1) ATE302200T1 (fr)
AU (1) AU746853B2 (fr)
BR (1) BR9810450A (fr)
CA (1) CA2294259A1 (fr)
CO (1) CO4940451A1 (fr)
DE (1) DE69831233T2 (fr)
ES (1) ES2247707T3 (fr)
HR (1) HRP980340A2 (fr)
MA (1) MA24573A1 (fr)
TR (1) TR199903148T2 (fr)
WO (1) WO1998058925A1 (fr)
ZA (1) ZA985352B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO190596A0 (en) 1996-08-26 1996-09-19 Alchemia Pty Ltd Oligosaccharide synthesis
AUPO937597A0 (en) * 1997-09-24 1997-10-16 Alchemia Pty Ltd Protecting and linking groups for organic synthesis
US6265578B1 (en) * 1999-02-12 2001-07-24 Hoffmann-La Roche Inc. Pyrimidine-2,4,6-triones
PA8498701A1 (es) 1999-08-12 2002-08-26 Pfizer Prod Inc Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas
JP2003531196A (ja) 2000-04-24 2003-10-21 アリックス セラピューティクス 超短時間作用型催眠性バルビツール酸塩
BR0114917A (pt) 2000-10-26 2003-07-01 Pfizer Prod Inc Inibidores de pirimidina-2,4,6-triona metaloproteinase
AP2001002318A0 (en) * 2000-10-26 2001-12-31 Pfizer Prod Inc Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
US6841671B2 (en) 2000-10-26 2005-01-11 Pfizer Inc. Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
DE60215793T2 (de) * 2001-05-03 2007-09-06 F. Hoffmann-La Roche Ag Kombination eines gelatinasehemmers und eines anti-tumor-agent, und deren verwendung
CA2483500A1 (fr) 2002-04-26 2003-11-06 Pfizer Products Inc. Inhibiteurs de metalloproteinase a base de pyrimidine-2, 4, 6-trione
CA2480092A1 (fr) 2002-04-26 2003-11-06 Pfizer Products Inc. Inhibiteurs de la metalloproteinase n-substitues-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione
CA2483075A1 (fr) 2002-04-26 2003-11-06 Pfizer Products Inc. Inhibiteurs de la triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase
NI200300045A (es) 2002-04-26 2005-07-08 Pfizer Prod Inc Inhibidores de triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa.
JP4584981B2 (ja) * 2004-04-01 2010-11-24 ユニベルシテ・ド・リエージュ 気管支炎症疾患の処置および予防のためのトリオキソピリミジンの使用
KR100837137B1 (ko) * 2004-04-01 2008-06-11 에프. 호프만-라 로슈 아게 기관지 염증성 질환의 치료 및 예방을 위한트리옥소피리미딘의 용도
PL2007756T3 (pl) 2006-04-07 2016-01-29 Vertex Pharma Modulatory transporterów posiadających kasetę wiążącą ATP
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
KR100862969B1 (ko) 2007-03-05 2008-10-13 바이오스펙트럼 주식회사 바르비투르산을 유효성분으로 포함하는 피부 미백제
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
SG184987A1 (en) * 2010-04-22 2012-11-29 Vertex Pharma Process of producing cycloalkylcarboxamido-indole compounds
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
WO2015123003A1 (fr) 2014-02-14 2015-08-20 Warrell Raymond P Composés bifonctionnels et leur utilisation pour réduire les taux d'acide urique
US10206877B2 (en) 2014-04-15 2019-02-19 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
EP3247704A4 (fr) 2015-01-22 2018-10-03 Acquist LLC Composés bifonctionnels et leur utilisation pour la réduction des niveaux de l'acide urique
TWI771303B (zh) 2016-06-30 2022-07-21 美商艾克奎斯特有限責任公司 化合物及其於降低尿酸位準之用途(一)
TWI749024B (zh) 2016-07-06 2021-12-11 美商艾克奎斯特有限責任公司 化合物及其於降低尿酸位準之用途
LV15384B (lv) 2017-07-24 2019-05-20 Latvijas Organiskās Sintēzes Institūts 1-Acetil-5-nitro-4-fenil-3-pirolin-2-ons pielietošanai vēža ārstēšanā

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0594577B1 (fr) * 1989-11-14 1998-12-30 Sloan-Kettering Institute For Cancer Research Nouveaux inducteurs puissants de differenciation de terminaisons et leur mode d'emploi
ATE155893T1 (de) * 1990-05-16 1997-08-15 Abbott Lab Test für barbiturate, tracer, immunogene, antikörper und testsatz dafür
DE19548624A1 (de) 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
US6335332B1 (en) 2002-01-01
CA2294259A1 (fr) 1998-12-30
CN1295227C (zh) 2007-01-17
ATE302200T1 (de) 2005-09-15
CO4940451A1 (es) 2000-07-24
DE69831233D1 (de) 2005-09-22
WO1998058925A1 (fr) 1998-12-30
AU746853B2 (en) 2002-05-02
DE69831233T2 (de) 2006-06-01
JP2002504916A (ja) 2002-02-12
AR018997A1 (es) 2001-12-26
AU8539198A (en) 1999-01-04
HRP980340A2 (en) 1999-02-28
KR20010014020A (ko) 2001-02-26
ZA985352B (en) 1999-12-20
TR199903148T2 (xx) 2000-04-21
BR9810450A (pt) 2000-09-05
EP0989982A1 (fr) 2000-04-05
ES2247707T3 (es) 2006-03-01
EP0989982B1 (fr) 2005-08-17
CN1267296A (zh) 2000-09-20

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