ATE302200T1 - Barbitursaure derivaten mit antimetastatischer und antitumorischer wirkung - Google Patents

Barbitursaure derivaten mit antimetastatischer und antitumorischer wirkung

Info

Publication number
ATE302200T1
ATE302200T1 AT98936361T AT98936361T ATE302200T1 AT E302200 T1 ATE302200 T1 AT E302200T1 AT 98936361 T AT98936361 T AT 98936361T AT 98936361 T AT98936361 T AT 98936361T AT E302200 T1 ATE302200 T1 AT E302200T1
Authority
AT
Austria
Prior art keywords
antimetastatic
acid derivatives
barbituric acid
tumor effect
tumor
Prior art date
Application number
AT98936361T
Other languages
English (en)
Inventor
Ambrogio Oliva
Cillis Gianpiero De
Frank Grams
Valeria Livi
Gerd Zimmermann
Ernesto Menta
Hans-Willi Krell
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Application granted granted Critical
Publication of ATE302200T1 publication Critical patent/ATE302200T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT98936361T 1997-06-21 1998-06-18 Barbitursaure derivaten mit antimetastatischer und antitumorischer wirkung ATE302200T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97110200 1997-06-21
PCT/EP1998/003677 WO1998058925A1 (en) 1997-06-21 1998-06-18 Barbituric acid derivatives with antimetastatic and antitumor activity

Publications (1)

Publication Number Publication Date
ATE302200T1 true ATE302200T1 (de) 2005-09-15

Family

ID=8226939

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98936361T ATE302200T1 (de) 1997-06-21 1998-06-18 Barbitursaure derivaten mit antimetastatischer und antitumorischer wirkung

Country Status (18)

Country Link
US (1) US6335332B1 (de)
EP (1) EP0989982B1 (de)
JP (1) JP2002504916A (de)
KR (1) KR20010014020A (de)
CN (1) CN1295227C (de)
AR (1) AR018997A1 (de)
AT (1) ATE302200T1 (de)
AU (1) AU746853B2 (de)
BR (1) BR9810450A (de)
CA (1) CA2294259A1 (de)
CO (1) CO4940451A1 (de)
DE (1) DE69831233T2 (de)
ES (1) ES2247707T3 (de)
HR (1) HRP980340A2 (de)
MA (1) MA24573A1 (de)
TR (1) TR199903148T2 (de)
WO (1) WO1998058925A1 (de)
ZA (1) ZA985352B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO190596A0 (en) 1996-08-26 1996-09-19 Alchemia Pty Ltd Oligosaccharide synthesis
AUPO937597A0 (en) * 1997-09-24 1997-10-16 Alchemia Pty Ltd Protecting and linking groups for organic synthesis
US6265578B1 (en) 1999-02-12 2001-07-24 Hoffmann-La Roche Inc. Pyrimidine-2,4,6-triones
PA8498701A1 (es) * 1999-08-12 2002-08-26 Pfizer Prod Inc Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas
AU5723001A (en) 2000-04-24 2001-11-07 Aryx Therapeutics Ultrashort acting hypnotic barbiturates
US6841671B2 (en) 2000-10-26 2005-01-11 Pfizer Inc. Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
EP1332146A2 (de) * 2000-10-26 2003-08-06 Pfizer Products Inc. Spiropyrimidin-2,4,6-trione als metalloproteinase inhibitoren
EE200300195A (et) * 2000-10-26 2003-10-15 Pfizer Products Inc. Pürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
ATE344041T1 (de) * 2001-05-03 2006-11-15 Hoffmann La Roche Kombination eines gelatinasehemmers und eines anti-tumor-agent, und deren verwendung
DE60302150D1 (en) 2002-04-26 2005-12-08 Pfizer Prod Inc N-substituiete heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trion metalloproteinase inhibitoren
JP2005529889A (ja) 2002-04-26 2005-10-06 ファイザー・プロダクツ・インク ピリミジン−２，４，６−トリオンメタロ−プロテイナーゼ阻害剤
ES2247527T3 (es) 2002-04-26 2006-03-01 Pfizer Prod Inc Inhibidores de metaloproteinasa de triaril-oxi-aril-espiro-pirimidina-2,4,6-triona.
NI200300045A (es) 2002-04-26 2005-07-08 Pfizer Prod Inc Inhibidores de triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa.
US20070225253A1 (en) * 2004-04-01 2007-09-27 Didier Cataldo Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases
KR100837137B1 (ko) * 2004-04-01 2008-06-11 에프. 호프만-라 로슈 아게 기관지 염증성 질환의 치료 및 예방을 위한트리옥소피리미딘의 용도
NZ596889A (en) 2006-04-07 2013-06-28 Vertex Pharma Use of amide indole derivatives as modulators of ATP-binding cassette transporters
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
KR100862969B1 (ko) 2007-03-05 2008-10-13 바이오스펙트럼 주식회사 바르비투르산을 유효성분으로 포함하는 피부 미백제
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2745977C2 (ru) 2010-04-22 2021-04-05 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
WO2015123003A1 (en) 2014-02-14 2015-08-20 Warrell Raymond P Bifunctional compounds and use for reducing uric acid levels
SG10201913575VA (en) 2014-04-15 2020-02-27 Vertex Pharma Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
WO2016118611A1 (en) 2015-01-22 2016-07-28 Warrell Raymond P Jr Bifunctional compounds and use for reducing uric acid levels
TWI771303B (zh) 2016-06-30 2022-07-21 美商艾克奎斯特有限責任公司 化合物及其於降低尿酸位準之用途(一)
TWI749024B (zh) 2016-07-06 2021-12-11 美商艾克奎斯特有限責任公司 化合物及其於降低尿酸位準之用途
LV15384B (lv) 2017-07-24 2019-05-20 Latvijas Organiskās Sintēzes Institūts 1-Acetil-5-nitro-4-fenil-3-pirolin-2-ons pielietošanai vēža ārstēšanā

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643248B2 (en) * 1989-11-14 1993-11-11 Sloan-Kettering Institute For Cancer Research Novel potent inducers of terminal differentiation and method of use thereof
EP0457213B1 (de) * 1990-05-16 1997-07-23 Abbott Laboratories Test für Barbiturate, Tracer, Immunogene, Antikörper und Testsatz dafür
DE19548624A1 (de) 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
JP2002504916A (ja) 2002-02-12
AU746853B2 (en) 2002-05-02
TR199903148T2 (xx) 2000-04-21
CN1295227C (zh) 2007-01-17
CA2294259A1 (en) 1998-12-30
WO1998058925A1 (en) 1998-12-30
ZA985352B (en) 1999-12-20
HRP980340A2 (en) 1999-02-28
CO4940451A1 (es) 2000-07-24
BR9810450A (pt) 2000-09-05
AU8539198A (en) 1999-01-04
EP0989982B1 (de) 2005-08-17
DE69831233D1 (de) 2005-09-22
EP0989982A1 (de) 2000-04-05
US6335332B1 (en) 2002-01-01
CN1267296A (zh) 2000-09-20
DE69831233T2 (de) 2006-06-01
MA24573A1 (fr) 1998-12-31
KR20010014020A (ko) 2001-02-26
ES2247707T3 (es) 2006-03-01
AR018997A1 (es) 2001-12-26

Similar Documents

Publication Publication Date Title
ATE302200T1 (de) Barbitursaure derivaten mit antimetastatischer und antitumorischer wirkung
EE9800329A (et) Arüülaminorühmaga liidetud püridiinid ja pürimidiinid
DE69738197D1 (de) Azolotriazine und pyrimidine
ATE237580T1 (de) 5-alkyl-2-arylaminophenylessigsäure und derivative
FI972087A0 (fi) Dihydropyrimidiineja ja niiden käyttöjä
ATE288903T1 (de) Heterocyclische azahexan-derivate mit antiviraler wirkung
LT97145A (lt) Pirazol-4-il-benzoilo dariniai ir herbicidinė priemonė
ATE205483T1 (de) Chinazolinderivate
ATE198329T1 (de) Chinazolin-derivate
ID17948A (id) Piridine bersumbu heterosiklik
NO20001242L (no) April - et nytt protein med veksteffekter
FI20000516A7 (fi) Bis-indolyylimaleimidijohdannaiset ja niiden valmistus
FI914826A7 (fi) Kinatsoliinijohdokset ja niiden valmistus
FI972629A7 (fi) Aryyli- ja heteroaryylisulfonamidijohdoksia, niiden valmistus ja niiden käyttö endoteliinin antagonisteina
BR9507666A (pt) Novos derivados de pirimidina
NO982473L (no) 5'-Deoksy-cytidin derivater
DE69524611D1 (de) Pyrimidon-derivate
DE69606165D1 (de) Bizyclische isothioharnstoff-derivate mit therapeutischer wirkung
FI972795A7 (fi) Pyrimidiinijohdannaisia
NO315610B3 (no) Azolotriaziner og -pyrimidiner
FI965238L (fi) Aryyli- ja heteroaryylialkoksinaftaleenijohdannaiset
BR9508728A (pt) Derivados de naftolactama e uso dos mesmos
FIU950030U0 (fi) Med en stol hopkopplingsbart underlag foer en dators tangentbord
DE59706183D1 (de) Tetrahydropyrimidin-derivate
IT1297660B1 (it) Cardine (o cerniera) autobloccante regolabile

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0989982

Country of ref document: EP

REN Ceased due to non-payment of the annual fee