LV12559B - 1,3,4-OXADIAZOLINE DERIVATIVES - Google Patents
1,3,4-OXADIAZOLINE DERIVATIVES Download PDFInfo
- Publication number
- LV12559B LV12559B LVP-00-103A LV000103A LV12559B LV 12559 B LV12559 B LV 12559B LV 000103 A LV000103 A LV 000103A LV 12559 B LV12559 B LV 12559B
- Authority
- LV
- Latvia
- Prior art keywords
- chloro
- compound
- oxadiazol
- oxo
- methyl
- Prior art date
Links
- WTSXVIMLKCKWIW-UHFFFAOYSA-N 3h-1,3,4-oxadiazol-2-one Chemical class O=C1NN=CO1 WTSXVIMLKCKWIW-UHFFFAOYSA-N 0.000 title description 7
- 150000003839 salts Chemical class 0.000 claims abstract description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 26
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- 150000001875 compounds Chemical class 0.000 claims description 109
- -1 dimethylaminoacetic acid 4-chloro-2 - {[5- (4-trifluoromethylphenyl) -2,3-dihydro-2-oxo-1,3,4-oxadiazol-3-yl ] methyl} phenyl ester Chemical class 0.000 claims description 36
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 29
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 21
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- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 10
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- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7296698P | 1998-01-29 | 1998-01-29 | |
| US10227498P | 1998-09-29 | 1998-09-29 | |
| PCT/US1999/000910 WO1999038510A1 (en) | 1998-01-29 | 1999-01-15 | Derivatives of 1,3,4-oxadiazolone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LV12559A LV12559A (en) | 2000-11-20 |
| LV12559B true LV12559B (en) | 2001-04-20 |
Family
ID=26753969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LVP-00-103A LV12559B (en) | 1998-01-29 | 2000-08-03 | 1,3,4-OXADIAZOLINE DERIVATIVES |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6034113A (tr) |
| EP (1) | EP1051173A4 (tr) |
| JP (1) | JP2002527352A (tr) |
| KR (1) | KR20010077838A (tr) |
| CN (1) | CN1150175C (tr) |
| AR (1) | AR010712A1 (tr) |
| AU (1) | AU735704B2 (tr) |
| BG (1) | BG104706A (tr) |
| BR (1) | BR9913010A (tr) |
| CA (1) | CA2318830A1 (tr) |
| CO (1) | CO5090837A1 (tr) |
| EE (1) | EE04089B1 (tr) |
| GE (1) | GEP20032914B (tr) |
| HU (1) | HUP0102025A3 (tr) |
| ID (1) | ID26909A (tr) |
| IL (1) | IL137518A0 (tr) |
| LT (1) | LT4838B (tr) |
| LV (1) | LV12559B (tr) |
| NO (1) | NO317102B1 (tr) |
| NZ (1) | NZ505409A (tr) |
| PL (1) | PL342060A1 (tr) |
| RU (1) | RU2202548C2 (tr) |
| SK (1) | SK10852000A3 (tr) |
| TR (1) | TR200002019T2 (tr) |
| TW (1) | TW550075B (tr) |
| UA (1) | UA58579C2 (tr) |
| WO (1) | WO1999038510A1 (tr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999038853A1 (en) * | 1998-01-29 | 1999-08-05 | Bristol-Myers Squibb Company | Amino acid derivatives of daryl 1,3,4-oxadiazolone |
| US6297241B1 (en) | 1999-01-29 | 2001-10-02 | Bristol-Myers Squibb Company | Carbamate derivatives of diaryl 1,3,4-oxadiazolone |
| ID29269A (id) * | 1999-01-29 | 2001-08-16 | Bristol Myers Squibb Co | Turunan-turunan karbamat dari diaril 1,3,4,oksadiazolon |
| US6326388B1 (en) * | 1999-12-21 | 2001-12-04 | Celgene Corporation | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level |
| WO2002072088A2 (en) | 2001-02-20 | 2002-09-19 | Bristol-Myers Squibb Company | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
| BR0208956A (pt) * | 2001-04-16 | 2004-07-13 | Tanabe Seiyaku Co | Abridor de canais de k ativados por cálcio de grande condutância |
| US6909027B1 (en) * | 2001-08-13 | 2005-06-21 | Perry Robins | Method of forming an in-situ film dressing and the composition of the film-forming material |
| US7119246B2 (en) * | 2002-06-25 | 2006-10-10 | Perry Robins | Method of treating acne |
| AU2013262320B2 (en) | 2012-05-16 | 2018-02-22 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
| JP5855599B2 (ja) * | 2013-04-30 | 2016-02-09 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ |
| CN104710379B (zh) * | 2015-03-09 | 2017-01-18 | 华南理工大学 | 一种bms‑191011的合成方法 |
| JP6165816B2 (ja) * | 2015-10-01 | 2017-07-19 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ |
| JP2020508328A (ja) * | 2017-02-24 | 2020-03-19 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 発作性障害の治療方法 |
| CN110987847B (zh) * | 2019-12-11 | 2021-02-19 | 苏州今蓝纳米科技有限公司 | 1,3,4-噁二唑衍生物在检测酸以及数据加密和储存中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH583213A5 (tr) * | 1973-05-21 | 1976-12-31 | Ciba Geigy Ag | |
| IT1251488B (it) * | 1991-09-17 | 1995-05-15 | Mini Ricerca Scient Tecnolog | Ossa(tia)diazol- e triazol-oni(tioni) ad attivita' acaricida ed insetticida |
| US5234947A (en) * | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
| US5547966A (en) * | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
| TW467902B (en) * | 1996-07-31 | 2001-12-11 | Bristol Myers Squibb Co | Diphenyl heterocycles as potassium channel modulators |
| WO1999038853A1 (en) * | 1998-01-29 | 1999-08-05 | Bristol-Myers Squibb Company | Amino acid derivatives of daryl 1,3,4-oxadiazolone |
-
1999
- 1999-01-15 UA UA2000085059A patent/UA58579C2/uk unknown
- 1999-01-15 KR KR1020007008227A patent/KR20010077838A/ko not_active Application Discontinuation
- 1999-01-15 GE GEAP19995472A patent/GEP20032914B/en unknown
- 1999-01-15 US US09/232,033 patent/US6034113A/en not_active Expired - Fee Related
- 1999-01-15 EP EP99902290A patent/EP1051173A4/en not_active Withdrawn
- 1999-01-15 HU HU0102025A patent/HUP0102025A3/hu unknown
- 1999-01-15 WO PCT/US1999/000910 patent/WO1999038510A1/en not_active Application Discontinuation
- 1999-01-15 TR TR2000/02019T patent/TR200002019T2/tr unknown
- 1999-01-15 CA CA002318830A patent/CA2318830A1/en not_active Abandoned
- 1999-01-15 ID IDW20001421A patent/ID26909A/id unknown
- 1999-01-15 PL PL99342060A patent/PL342060A1/xx unknown
- 1999-01-15 JP JP2000529243A patent/JP2002527352A/ja active Pending
- 1999-01-15 IL IL13751899A patent/IL137518A0/xx unknown
- 1999-01-15 RU RU2000122733/04A patent/RU2202548C2/ru not_active IP Right Cessation
- 1999-01-15 SK SK1085-2000A patent/SK10852000A3/sk unknown
- 1999-01-15 EE EEP200000447A patent/EE04089B1/xx not_active IP Right Cessation
- 1999-01-15 AU AU22308/99A patent/AU735704B2/en not_active Ceased
- 1999-01-15 CN CNB998024112A patent/CN1150175C/zh not_active Expired - Fee Related
- 1999-01-15 BR BR9913010-6A patent/BR9913010A/pt not_active IP Right Cessation
- 1999-01-15 NZ NZ505409A patent/NZ505409A/en unknown
- 1999-01-27 TW TW088101231A patent/TW550075B/zh not_active IP Right Cessation
- 1999-01-27 AR ARP990100312A patent/AR010712A1/es not_active Application Discontinuation
- 1999-01-28 CO CO99004746A patent/CO5090837A1/es unknown
-
2000
- 2000-07-14 LT LT2000068A patent/LT4838B/lt not_active IP Right Cessation
- 2000-07-26 NO NO20003825A patent/NO317102B1/no not_active IP Right Cessation
- 2000-08-03 LV LVP-00-103A patent/LV12559B/en unknown
- 2000-08-22 BG BG104706A patent/BG104706A/xx unknown
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