LV11180B - Diamine salts of clavulanic acid - Google Patents
Diamine salts of clavulanic acid Download PDFInfo
- Publication number
- LV11180B LV11180B LVP-94-220A LV940220A LV11180B LV 11180 B LV11180 B LV 11180B LV 940220 A LV940220 A LV 940220A LV 11180 B LV11180 B LV 11180B
- Authority
- LV
- Latvia
- Prior art keywords
- clavulanic acid
- salt
- diamine
- pharmaceutically acceptable
- ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D503/10—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D503/12—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 unsubstituted in position 6
- C07D503/14—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 unsubstituted in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, other than a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, attached in position 3
- C07D503/16—Radicals substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical
- C07D503/18—Radicals substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (16)
- LV 11180 IZGUDROJUMA FORMULA KLAVULĀNSKĀBES SĀLI AR DIAMĪNU « 1. Klavulānskabes sals, kas atbilst formulai (lla) vai (llb):(llb) kur katrs no R-ļ un R2 ir (1-8C)alkil-, (3-8C)cikloalkil- vai (3-8C)cikloalkil (1-8C) alkilgrupa, vēlams ar vienu vai vairākiem inertiem aizvietotājiem, vai saistīti savā starpā un izveido gredzenu ar 4-7 atomiem ciklā; katrs no R3 un R4 ir (1-8C)alkil-, (3-8C)cikloalkil- vai (3-8C)cikloalkil (1-8C)alkilgrupa, vēlams ar vienu vai vairākiem inertiem aizvietotājiem, vai saistīti savā starpā un izveido gredzenu ar 4-7 atomiem ciklā; X ir ūdeņraža atoms vai grupa, kas veido ūdeņraža tiltiņu; un katrs no n un m ir 0-5, neatkarīgi viens no otra.
- 2. Klavulānskābes sāls, saskaņā ar 1. punktu, kas atšķiras ar to, ka R-ļ, R2, R3 un R4 ir metilgrupa. 2
- 3. Klavulānskābes sāls, saskaņa ar 1. vai 2. punktu, kas atšķiras arto, ka X ir ūdeņraža atoms, n ir 1 un m ir 0.
- 4. Klavulānskābes sāls, saskaņā ar 1. vai 2. punktu, kas atšķiras arto, ka X ir hidroksilgrupa, n ir 1 un m ir 1.
- 5. Formulas lla diamīna sāls ar vienu klavulānskābes molekulu, saskaņā ar 1. punktu, kas atšķiras ar to, ka R-ļ, R2, R3 un R4 ir metilgrupas, X ir ūdeņraža atoms, n ir 1 un m ir 0.
- 6. 1., 2., 3. vai 4. punktā aprakstītā sāls iegūšanas paņēmiens, kas atšķir a s arto, ka klavulānskābe reaģē ardiamīnu (III): R, V A \ I / N-(CHJn - C—(CHj)m-N X A R1, R2, R3, R4, X, m un n ir tādi kā norādīts 12., 3. vai 4 punktā, organiskā šķīdinātājā.
- 7. Paņēmiens, saskaņā ar 6. punktu, kas atšķiras ar to, ka diamīna molu daudzums ir lielāks nekā klavulānskābes molu daudzums.
- 8. Paņēmiens, saskaņā ar 6. punktu, kas atšķiras ar to, ka diamīna molu daudzums ir mazāks nekā klavulānskābes molu daudzums.
- 9. Sāls iegūšanas paņēmiens, saskaņā ar 5. punktu, kas atšķitras arto, ka klavulānskābe reaģē ar N, N, Ν', Ν' - tetrametil -1,2 - diaminoetānu un N, N, Ν’, Ν’ -tetrametil - 1,2 - diaminoetāna molu daudzums ir lielāks nekā klavulānskābes molu daudzums.
- 10. Klavulānskābes vai tās farmaceitiski pieņemama sāls vai estera sagatavošanas paņēmiens, kurā ietilpst mono-, vai diamīna sāls, kas aprakstīts 1., 2., 3., 4. un 5. punktā, pārvēršana par klavulānskābi vai tās farmaceitiski pieņemamu sāli vai esteri.
- 11. Klavulānskābes vai tās farmaceitiski pieņemama sāls vai estera attīrīšanas paņēmiens, kurā ietilpst: i) sāls veidošanās no neattīrītas klavulānskābes organiskā šķīdinātājā ar formulas III diamīnu; ii) stadijā i) iegūta sāls izdalīšana; un iii) izolētā sāls pārvēršana par klavulānskābi, tās farmaceitiski pieņemamu sāli vai esteri.
- 12. Farmaceitiska kompozīcija, kurā ietilpst klavulānskābes sāls, saskaņā ar 1., 2., 3., 4. vai 5. punktu un farmaceitiski pieņemama pildviela vai atšķaidītājs.
- 13. Sāls, saskaņā ar 1., 2., 3., 4. vai 5 punktu, izmantošana par starpproduktu klavulānskābes vai tās farmaceitiski pieņemama sāls vai estera iegūšanas procesā. LV 11180 3
- 14. Klavulānskābes sāls pēc būtības, kā aprakstīts jebkurā no 2. līdz 8. piemēram.
- 15. Klavulānskābes sāls ar diamīnu iegūšanas paņēmiens no klavulānskābes pēc būtības, kā aprakstīts jebkurā no piemēriem 2., 3., 4. un 5.
- 16. Klavulānskābes iegūšanas paņēmiens no tās sāls ar diamīnu pēc būtības, kā aprakstīts jebkurā no piemēriem 6., 7. un 8.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93200872 | 1993-03-26 | ||
PCT/EP1994/000919 WO1994022873A1 (en) | 1993-03-26 | 1994-03-22 | Diamine salts of clavulanic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
LV11180A LV11180A (lv) | 1996-04-20 |
LV11180B true LV11180B (en) | 1996-08-20 |
Family
ID=8213723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-94-220A LV11180B (en) | 1993-03-26 | 1994-11-22 | Diamine salts of clavulanic acid |
Country Status (8)
Country | Link |
---|---|
JP (1) | JP2839955B2 (lv) |
KR (1) | KR100187333B1 (lv) |
BG (1) | BG61948B1 (lv) |
BR (1) | BR9404743A (lv) |
GR (2) | GR950300030T1 (lv) |
LV (1) | LV11180B (lv) |
RU (1) | RU2135502C1 (lv) |
SI (1) | SI0647229T1 (lv) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
AT399155B (de) * | 1992-03-26 | 1995-03-27 | Lek Tovarna Farmacevtskih | Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung |
-
1994
- 1994-03-22 KR KR1019940704230A patent/KR100187333B1/ko not_active IP Right Cessation
- 1994-03-22 SI SI9430013T patent/SI0647229T1/xx unknown
- 1994-03-22 JP JP6521641A patent/JP2839955B2/ja not_active Expired - Lifetime
- 1994-03-22 RU RU94046014A patent/RU2135502C1/ru active
- 1994-03-22 BR BR9404743-0A patent/BR9404743A/pt not_active Application Discontinuation
- 1994-11-22 LV LVP-94-220A patent/LV11180B/en unknown
- 1994-11-25 BG BG99212A patent/BG61948B1/bg unknown
-
1995
- 1995-06-30 GR GR950300030T patent/GR950300030T1/el unknown
-
1996
- 1996-10-16 GR GR960402720T patent/GR3021347T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
SI0647229T1 (en) | 1997-10-31 |
JPH07507573A (ja) | 1995-08-24 |
RU2135502C1 (ru) | 1999-08-27 |
KR100187333B1 (ko) | 1999-05-01 |
GR950300030T1 (en) | 1995-06-30 |
BR9404743A (pt) | 1999-09-28 |
GR3021347T3 (en) | 1997-01-31 |
BG61948B1 (bg) | 1998-10-30 |
RU94046014A (ru) | 1996-10-10 |
LV11180A (lv) | 1996-04-20 |
BG99212A (bg) | 1995-12-29 |
KR950701635A (ko) | 1995-04-28 |
JP2839955B2 (ja) | 1998-12-24 |
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