LV10924B - Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease - Google Patents

Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease Download PDF

Info

Publication number
LV10924B
LV10924B LVP-95-158A LV950158A LV10924B LV 10924 B LV10924 B LV 10924B LV 950158 A LV950158 A LV 950158A LV 10924 B LV10924 B LV 10924B
Authority
LV
Latvia
Prior art keywords
salen
metal complex
group
antioxidant
antioxidant salen
Prior art date
Application number
LVP-95-158A
Other languages
English (en)
Latvian (lv)
Other versions
LV10924A (lv
Inventor
Bernard Malfroy-Camine
Michel Baudry
Original Assignee
Eukarion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eukarion Inc filed Critical Eukarion Inc
Publication of LV10924A publication Critical patent/LV10924A/xx
Publication of LV10924B publication Critical patent/LV10924B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005Compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Fats And Perfumes (AREA)
LVP-95-158A 1992-12-07 1995-06-06 Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease LV10924B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/987,474 US5403834A (en) 1992-12-07 1992-12-07 Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
PCT/US1993/011857 WO1994013300A1 (fr) 1992-12-07 1993-12-06 Piegeurs de radicaux libres catalytiques synthetiques utiles comme antioxydants dans la prevention et la therapie de maladies

Publications (2)

Publication Number Publication Date
LV10924A LV10924A (lv) 1995-12-20
LV10924B true LV10924B (en) 1996-10-20

Family

ID=25533292

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-95-158A LV10924B (en) 1992-12-07 1995-06-06 Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease

Country Status (20)

Country Link
US (2) US5403834A (fr)
EP (2) EP1642583A2 (fr)
JP (1) JP3502099B2 (fr)
KR (1) KR20040004386A (fr)
AT (1) ATE290867T1 (fr)
AU (1) AU697399B2 (fr)
CA (1) CA2150937C (fr)
CZ (1) CZ296288B6 (fr)
DE (1) DE69333775T2 (fr)
GB (2) GB2277873B (fr)
HU (1) HU225109B1 (fr)
LV (1) LV10924B (fr)
NO (1) NO319454B1 (fr)
NZ (1) NZ259200A (fr)
OA (1) OA10165A (fr)
PL (1) PL175446B1 (fr)
RU (1) RU2157213C2 (fr)
SK (1) SK74595A3 (fr)
UA (1) UA27949C2 (fr)
WO (1) WO1994013300A1 (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5653685A (en) * 1990-10-10 1997-08-05 Lrt, Inc. Method of providing circulation via lung expansion and deflation
USRE36460E (en) * 1990-10-10 1999-12-21 Life Science Holdings, Inc. Method of providing circulation via lung expansion and deflation
US5403834A (en) * 1992-12-07 1995-04-04 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US5696109A (en) * 1992-12-07 1997-12-09 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US7582786B2 (en) * 1992-12-07 2009-09-01 Eukarion Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US5834509A (en) * 1992-12-07 1998-11-10 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US5686436A (en) * 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US6245758B1 (en) 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
CA2189528A1 (fr) * 1994-05-13 1995-11-23 Michael Keith Stern Procedes d'utilisation de catalyseurs de decomposition deperoxynitrite et compositions pharmaceutiques a cet effet
US5681278A (en) * 1994-06-23 1997-10-28 Cormedics Corp. Coronary vasculature treatment method
WO1996004311A1 (fr) * 1994-08-03 1996-02-15 University Of Alabama At Birmingham Research Foundation Anticorps monoclonal dirige contre la nitrotyrosine, procedes de diagnostic et procedes therapeutiques
US5900433A (en) * 1995-06-23 1999-05-04 Cormedics Corp. Vascular treatment method and apparatus
CA2247876A1 (fr) * 1996-03-08 1997-09-12 Ronald M. Klatz Procede et dispositif de ventilation liquide
AU4258097A (en) 1996-09-06 1998-03-26 Duke University Methods for testing compounds for use as therapeutic antioxidants
US6369106B1 (en) * 1996-12-26 2002-04-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Treatment of ischemic brain injuries with brain targeted anti oxidant compounds
US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US5834178C1 (en) * 1997-07-09 2002-04-23 Univ Wayne State Flush-storage solution for donor organs
US5829449A (en) * 1997-09-19 1998-11-03 Thione International, Inc. Smoking products containing antioxidants
AT409306B (de) * 1997-10-03 2002-07-25 Hoffmann La Roche Optisch chemischer sensor
ATE238307T1 (de) 1997-11-03 2003-05-15 Univ Duke Substituierte porphyrinen
CA2249778A1 (fr) * 1997-12-15 1999-06-15 Bayer Corporation Dosage competitif d'apo-peroxydase
GB9817845D0 (en) 1998-08-17 1998-10-14 Glaxo Group Ltd Chemical compounds
US7816403B2 (en) * 1998-09-08 2010-10-19 University Of Utah Research Foundation Method of inhibiting ATF/CREB and cancer cell growth and pharmaceutical compositions for same
US6703384B2 (en) 1998-09-23 2004-03-09 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
CA2359116C (fr) * 1999-01-25 2009-03-17 National Jewish Medical And Research Center Porphyrines substituees
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
ATE291446T1 (de) 1999-05-27 2005-04-15 Monsanto Co Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
US20040110722A1 (en) * 1999-05-27 2004-06-10 Ornberg Richard L. Modified hyaluronic acid polymers
US6179804B1 (en) * 1999-08-18 2001-01-30 Oxypatch, Llc Treatment apparatus for wounds
AU3680501A (en) * 2000-02-11 2001-08-20 Res Dev Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US20040047852A1 (en) * 2001-03-02 2004-03-11 Kennedy Thomas Preston Method of treating cancer
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
WO2002043514A1 (fr) * 2000-11-28 2002-06-06 Lorillard Licensing Company, Llc Article pour fumeur comportant une pompe sélective à co
US6481442B1 (en) 2000-11-28 2002-11-19 Lorillard Licensing Company, Llc Smoking article including a filter for selectively removing carbonyls
US6589948B1 (en) 2000-11-28 2003-07-08 Eukarion, Inc. Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases
US6692458B2 (en) * 2000-12-19 2004-02-17 Edwards Lifesciences Corporation Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis
US20030050297A1 (en) * 2001-01-19 2003-03-13 Crapo James D. Cancer therapy
ITPI20010014A1 (it) * 2001-03-05 2002-09-05 Ivo Pera Composto per filtri per sigarette,o altri articoli da fumo,a base di sostanze antiossidanti ed il filtro cosi'ottenuto
KR100681326B1 (ko) * 2001-04-20 2007-02-15 주식회사 중외제약 신규한 망간-키랄성 화합물 및 그의 이용방법
CA2449024A1 (fr) * 2001-06-01 2002-12-12 National Jewish Medical And Research Center Capteurs oxydants destines au traitement du diabete ou a etre utilises dans une transplantation ou a induire une tolerance immunitaire
WO2003010154A1 (fr) 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Composes seleno contenant un groupe fonctionnel nitron, leur preparation et leurs applications therapeutiques
WO2003010143A1 (fr) 2001-07-26 2003-02-06 Samsung Electronics Co., Ltd. Derives de l'acide dialkylhydroxybenzoique contenant des groupes chelateurs de metaux et leurs utilisations therapeutiques
WO2003010153A1 (fr) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Composes de n-alkyl-n-phenylhydroxylamine contenant des groupes chelateurs de metaux, leur preparation et leurs applications therapeutiques
US20030236301A1 (en) * 2001-12-19 2003-12-25 Bob Sanders Liposomal delivery of vitamin E based compounds
IL162614A0 (en) * 2001-12-19 2005-11-20 Res Dev Foundation Liposomal delivery of vitamin e based compounds
CA2488500A1 (fr) * 2002-06-07 2003-12-18 Duke University Porphyrines substituees
US6835387B2 (en) 2002-06-11 2004-12-28 Scimed Life Systems, Inc. Sustained release of superoxide dismutase mimics from implantable or insertable medical devices
US20040132789A1 (en) * 2002-08-22 2004-07-08 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US20040044220A1 (en) * 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US20050004002A1 (en) 2002-12-09 2005-01-06 American Bioscience, Inc. Compositions and methods of delivery of pharmacological agents
RU2361615C2 (ru) * 2002-12-09 2009-07-20 Абраксис Байосайенс, Ллс. Композиции и способы доставки фармакологических агентов
WO2004052098A1 (fr) * 2002-12-11 2004-06-24 Cryolife, Inc. Solutions de cryoconservation anti-radicaux
WO2005030137A2 (fr) * 2003-09-24 2005-04-07 The University Of Toledo, A University Instrumentality Of The State Of Ohio Procede ameliorer la performance biomecanique de matieres biologiques irradiees et matieres formees au moyen de ce procede
US20050100537A1 (en) * 2003-11-10 2005-05-12 Evans Gregory S. Methods and kits for reducing cellular damage, inhibiting free radical production, and scavenging free radicals in mammals
US20090099150A1 (en) * 2005-01-19 2009-04-16 Daniela Salvemini Methotrexate Combinations For Treating Inflammatory Diseases
CA2607237C (fr) * 2005-05-04 2010-03-23 Coty Prestige Lancaster Group Gmbh Utilisation de piegeurs de radicaux libres dans la protection de la peau et des cheveux et le traitement des dommages causes a la peau et aux cheveux par la chimiotherapie
CN103705947A (zh) * 2006-06-28 2014-04-09 株式会社Ihi 药物、药物引导装置、磁性检测装置和药物设计方法
WO2008070557A2 (fr) * 2006-12-01 2008-06-12 Women & Infants Hospital Complexes organométalliques en tant qu'agents thérapeutiques
US20090169484A1 (en) 2007-12-28 2009-07-02 Ihi Corporation Iron-salen complex
ES2600469T3 (es) 2008-05-23 2017-02-09 National Jewish Health Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro
WO2010058280A1 (fr) 2008-11-20 2010-05-27 株式会社Ihi Composé complexe de métal-salène auto-magnétique
KR101050273B1 (ko) * 2008-11-21 2011-07-19 세종대학교산학협력단 살렌 전이금속 착화합물, 및 그 제조 방법
JP5736367B2 (ja) * 2010-04-06 2015-06-17 株式会社Ihi 金属サレン錯体誘導体及びその製造方法
US8933118B2 (en) 2010-04-28 2015-01-13 Ihi Corporation Anti-brain-tumor drug
US9282923B2 (en) * 2010-06-01 2016-03-15 Ihi Corporation Fluorochrome material and method for using the same
CN103517895A (zh) * 2010-12-21 2014-01-15 株式会社Ihi 金属沙仑配位化合物及其制造方法
JP5873656B2 (ja) * 2011-06-13 2016-03-01 株式会社Ihi 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤
JP6017766B2 (ja) * 2011-07-26 2016-11-02 株式会社Ihi 新規な金属サレン錯体化合物の抗がん剤
JP6155190B2 (ja) * 2011-10-04 2017-06-28 株式会社Ihi 金属サレン錯体化合物応答性薬剤及び金属サレン錯体化合物の体内挙動制御システム
JP6046338B2 (ja) 2011-10-27 2016-12-14 株式会社Ihi ラジカル抑制剤
JP6131271B2 (ja) * 2012-01-05 2017-05-17 プレッドファルマ・アーベー カルマンガホジピル、新たな化学実体、および他の混合金属錯体、調製の方法、組成物、および処置の方法
CN108030926B (zh) * 2017-12-15 2021-07-13 武汉工程大学 一种具有高的SOD酶活性的Salen型锰配合物-壳聚糖复合材料及其制备方法
RU2699040C1 (ru) * 2018-07-23 2019-09-03 Федеральное государственное бюджетное учреждение науки "Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства" (ФГБУН УНПЦ РМ ФМБА России) Способ экстренной профилактики и лечения острой лучевой болезни (варианты)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US5106841A (en) * 1986-05-13 1992-04-21 Chai-Tech Corporation Antiviral compositions and method for their use
US5223538A (en) * 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
CA2116335C (fr) * 1991-08-26 1999-08-24 Eric N. Jacobsen Catalyseurs chiraux, reactions d'oxydation catalytique et de dismutation et methodes d'obtention d'epoxychromanes et de taxol
US5403834A (en) * 1992-12-07 1995-04-04 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease

Also Published As

Publication number Publication date
GB2305107A (en) 1997-04-02
UA27949C2 (uk) 2000-10-16
HU9501644D0 (en) 1995-08-28
SK74595A3 (en) 1996-05-08
AU5741994A (en) 1994-07-04
RU2157213C2 (ru) 2000-10-10
LV10924A (lv) 1995-12-20
KR20040004386A (ko) 2004-01-13
GB2277873B (en) 1997-05-14
GB9415050D0 (en) 1994-09-14
GB2305107B (en) 1997-05-14
AU697399B2 (en) 1998-10-08
CA2150937C (fr) 2007-08-14
EP0746321A4 (fr) 2001-05-09
US5827880A (en) 1998-10-27
EP1642583A2 (fr) 2006-04-05
NO952237L (no) 1995-08-01
NO319454B1 (no) 2005-08-15
GB9621087D0 (en) 1996-11-27
CZ296288B6 (cs) 2006-02-15
PL309334A1 (en) 1995-10-02
HUT72967A (en) 1996-06-28
US5403834A (en) 1995-04-04
JPH08504211A (ja) 1996-05-07
NO952237D0 (no) 1995-06-06
EP0746321A1 (fr) 1996-12-11
CZ144295A3 (en) 1996-10-16
HU225109B1 (en) 2006-06-28
DE69333775T2 (de) 2006-04-06
ATE290867T1 (de) 2005-04-15
WO1994013300A1 (fr) 1994-06-23
EP0746321B1 (fr) 2005-03-16
GB2277873A (en) 1994-11-16
PL175446B1 (pl) 1998-12-31
DE69333775D1 (de) 2005-04-21
NZ259200A (en) 1997-06-24
CA2150937A1 (fr) 1994-06-23
OA10165A (en) 1996-12-18
JP3502099B2 (ja) 2004-03-02

Similar Documents

Publication Publication Date Title
EP0746321B1 (fr) Piegeurs de radicaux libres catalytiques synthetiques utiles comme antioxydants dans la prevention et la therapie de maladies
WO1994013300A9 (fr) Piegeurs de radicaux libres catalytiques synthetiques utiles comme antioxydants dans la prevention et la therapie de maladies
US6900198B2 (en) Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US6589948B1 (en) Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases
US7582786B2 (en) Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US5834509A (en) Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
AU2002239381A1 (en) Cyclic salen-metal compounds as scavengers for oxygen radicals and useful as antioxidants in the treatment and prevention of diseases