LV10246B - Novel substituted salicylic acids - Google Patents

Novel substituted salicylic acids

Info

Publication number
LV10246B
LV10246B LVP-92-202A LV920202A LV10246B LV 10246 B LV10246 B LV 10246B LV 920202 A LV920202 A LV 920202A LV 10246 B LV10246 B LV 10246B
Authority
LV
Latvia
Prior art keywords
compound
novel substituted
salicylic acids
substituted salicylic
het
Prior art date
Application number
LVP-92-202A
Other languages
English (en)
Other versions
LV10246A (lv
Inventor
Hubert Agback
Leif Ahrgren
Thomas Berglindh
Martin Haraldsson
Lars-Inge Olsson
G Ran Smedegard
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of LV10246A publication Critical patent/LV10246A/xx
Publication of LV10246B publication Critical patent/LV10246B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
LVP-92-202A 1991-11-18 1992-11-13 Novel substituted salicylic acids LV10246B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103397A SE9103397D0 (sv) 1991-11-18 1991-11-18 Nya substituerade salicylsyror

Publications (2)

Publication Number Publication Date
LV10246A LV10246A (lv) 1994-10-20
LV10246B true LV10246B (en) 1995-04-20

Family

ID=20384352

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-92-202A LV10246B (en) 1991-11-18 1992-11-13 Novel substituted salicylic acids

Country Status (29)

Country Link
US (3) US5302718A (fr)
EP (1) EP0613468B1 (fr)
JP (1) JP3259915B2 (fr)
KR (1) KR100253748B1 (fr)
AT (1) ATE194597T1 (fr)
AU (1) AU668528B2 (fr)
CA (1) CA2123697C (fr)
DE (1) DE69231252T2 (fr)
DK (1) DK0613468T3 (fr)
EE (1) EE03026B1 (fr)
ES (1) ES2149780T3 (fr)
FI (1) FI106857B (fr)
GR (1) GR3034585T3 (fr)
HU (2) HU221476B (fr)
IL (1) IL103665A (fr)
LT (1) LT3182B (fr)
LV (1) LV10246B (fr)
MX (1) MX9206647A (fr)
MY (1) MY130169A (fr)
NO (1) NO300805B1 (fr)
NZ (1) NZ244998A (fr)
PT (1) PT101068B (fr)
RU (1) RU2124501C1 (fr)
SE (1) SE9103397D0 (fr)
SK (1) SK282080B6 (fr)
TW (1) TW304944B (fr)
UA (1) UA42869C2 (fr)
WO (1) WO1993010094A1 (fr)
ZA (1) ZA928864B (fr)

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GB9310095D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Therapeutic compounds
US5965732A (en) * 1993-08-30 1999-10-12 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
US5405842A (en) * 1994-01-28 1995-04-11 Silverman; Bernard A. Treatment of steroid dependent asthmatics
GB9504854D0 (en) * 1994-03-31 1995-04-26 Zeneca Ltd Nitrogen derivatives
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
AU7074496A (en) 1995-09-18 1997-04-09 Ligand Pharmaceuticals Incorporated Ppar gamma antagonists for treating obesity
JPH09124620A (ja) * 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
WO1997029747A1 (fr) 1996-02-20 1997-08-21 Bristol-Myers Squibb Company Procedes d'elaboration de biphenyl isoxazole sulfamides
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
JP3814742B2 (ja) * 1996-10-18 2006-08-30 イハラケミカル工業株式会社 ４−フルオロサリチル酸類
WO1998033781A1 (fr) * 1997-01-30 1998-08-06 Bristol-Myers Squibb Company Procede pour prevenir ou traiter l'hypertension due a une baisse de secretion de la renine, par l'administration d'un antagoniste de l'endotheline
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
GB9804648D0 (en) 1998-03-06 1998-04-29 Zeneca Ltd Chemical compounds
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
GB9811427D0 (en) 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds
EP1093362A1 (fr) 1998-06-12 2001-04-25 Ligand Pharmaceuticals Incorporated Traitement du cancer du sein resistant aux anti-oestrogenes avec des modulateurs de rxr
EP1165472A4 (fr) 1999-03-19 2002-11-20 Bristol Myers Squibb Co Procedes pour la preparation de diphenylisoxazolesulfonamides
US6878712B1 (en) 1999-09-04 2005-04-12 Astrazeneca Ab Amides as inhibitors for pyruvate dehydrogenase
SK286774B6 (sk) 1999-09-04 2009-05-07 Astrazeneca Ab Substituované N-fenyl-2-hydroxy-2-metyl-3,3,3- trifluórpropánamidové deriváty, spôsob ich prípravy a farmaceutický prostriedok, ktorý ich obsahuje
WO2001017955A2 (fr) 1999-09-04 2001-03-15 Astrazeneca Ab Composes chimiques
EP1278521B1 (fr) * 2000-04-28 2005-11-30 The University of British Columbia Des salicylates n-heterocycliques substitues destines au traitement du cancer
CA2307278A1 (fr) * 2000-04-28 2001-10-28 University Of British Columbia Utilisation d'acides salicyliques substitues comportant un heterocycle azote pour l'inhibition de l'assimilation cellulaire de la cystine
US6639082B2 (en) 2000-10-17 2003-10-28 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
WO2005023771A1 (fr) * 2003-09-05 2005-03-17 Ono Pharmaceutical Co., Ltd. Antagoniste du recepteur de la chimiokine et son utilisation a des fins medicales
JP2007514731A (ja) * 2003-12-19 2007-06-07 ファイザー インコーポレイテッド 糖尿病及び肥満症の治療のための１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ１型（１１−β−ｈｓｄ−１）の阻害剤としてのベンゼンスルホニルアミノ−ピリジン−２−イル誘導体及び関連化合物
EP1763353A1 (fr) * 2004-06-29 2007-03-21 Warner-Lambert Company LLC THERAPIES COMBINATOIRES DANS LESQUELLES SONT UTILISES DES INHIBITEURS DE BENZAMIDE DU RECEPTEUR P2X<SB>7</SB>
GB2421947A (en) * 2005-01-07 2006-07-12 Univ Southampton Sulphonamide compounds for use as inhibitors of NF-kB
JP2009527560A (ja) * 2006-02-21 2009-07-30 アムゲン インコーポレイティッド ホスホジエステラーゼ１０阻害剤としてのシンノリン誘導体
RU2481329C2 (ru) * 2008-06-23 2013-05-10 Астеллас Фарма Инк. Сульфонамидные соединения или их соли
EP2677865A4 (fr) * 2011-02-23 2015-04-22 Icahn School Med Mount Sinai Inhibiteurs de bromodomaines comme modulateurs d'expression génique
KR102653667B1 (ko) 2015-05-20 2024-04-03 암젠 인크 Apj 수용체의 트라이아졸 작용제
CN108602775B (zh) 2016-01-14 2022-04-29 贝思以色列女会吏医学中心公司 肥大细胞调节剂及其用途
US9988369B2 (en) 2016-05-03 2018-06-05 Amgen Inc. Heterocyclic triazole compounds as agonists of the APJ receptor
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
EP3541802A1 (fr) 2016-11-16 2019-09-25 Amgen Inc. Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
EP3541804A1 (fr) 2016-11-16 2019-09-25 Amgen Inc. Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj
WO2018093580A1 (fr) 2016-11-16 2018-05-24 Amgen Inc. Composés de triazole pyridyle en tant qu'agonistes du récepteur apj
US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
WO2018097945A1 (fr) 2016-11-16 2018-05-31 Amgen Inc. Triazoles substitués par hétéroaryle utilisés en tant qu'agonistes du récepteur apj
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WO2019213006A1 (fr) 2018-05-01 2019-11-07 Amgen Inc. Pyrimidinones substituées en tant qu'agonistes du récepteur apj
CN111056978B (zh) * 2019-12-13 2021-01-19 西安交通大学 一种磺酰胺类化合物及其制备方法和应用

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US4897397A (en) * 1988-12-16 1990-01-30 Schering Corporation Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents

Also Published As

Publication number Publication date
AU668528B2 (en) 1996-05-09
DK0613468T3 (da) 2000-10-23
NO941799D0 (no) 1994-05-13
CA2123697A1 (fr) 1993-05-27
LT3182B (en) 1995-03-27
NO941799L (fr) 1994-06-22
SE9103397D0 (sv) 1991-11-18
HU221476B (en) 2002-10-28
EP0613468A1 (fr) 1994-09-07
US5302718A (en) 1994-04-12
JPH07501330A (ja) 1995-02-09
MY130169A (en) 2007-06-29
FI942289A (fi) 1994-05-17
EE03026B1 (et) 1997-08-15
US5556855A (en) 1996-09-17
JP3259915B2 (ja) 2002-02-25
HU9401391D0 (en) 1994-08-29
PT101068B (pt) 1999-08-31
IL103665A (en) 1997-08-14
EP0613468B1 (fr) 2000-07-12
HUT69723A (en) 1995-09-28
UA42869C2 (uk) 2001-11-15
FI106857B (fi) 2001-04-30
DE69231252T2 (de) 2001-03-01
HU211163A9 (en) 1995-10-30
PT101068A (pt) 1994-02-28
AU2958992A (en) 1993-06-15
KR100253748B1 (ko) 2000-05-01
MX9206647A (es) 1993-05-01
IL103665A0 (en) 1993-04-04
ZA928864B (en) 1993-05-13
CA2123697C (fr) 2003-12-09
RU2124501C1 (ru) 1999-01-10
SK282080B6 (sk) 2001-10-08
LTIP229A (en) 1994-09-25
DE69231252D1 (de) 2000-08-17
NZ244998A (en) 1995-09-26
GR3034585T3 (en) 2001-01-31
LV10246A (lv) 1994-10-20
ES2149780T3 (es) 2000-11-16
WO1993010094A1 (fr) 1993-05-27
TW304944B (fr) 1997-05-11
FI942289A0 (fi) 1994-05-17
NO300805B1 (no) 1997-07-28
SK54794A3 (en) 1995-02-08
ATE194597T1 (de) 2000-07-15
US5403930A (en) 1995-04-04

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