NO941799L - - Google Patents
Info
- Publication number
- NO941799L NO941799L NO941799A NO941799A NO941799L NO 941799 L NO941799 L NO 941799L NO 941799 A NO941799 A NO 941799A NO 941799 A NO941799 A NO 941799A NO 941799 L NO941799 L NO 941799L
- Authority
- NO
- Norway
- Prior art keywords
- compound
- het
- solvates
- proviso
- ortho
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9103397A SE9103397D0 (sv) | 1991-11-18 | 1991-11-18 | Nya substituerade salicylsyror |
| PCT/SE1992/000758 WO1993010094A1 (fr) | 1991-11-18 | 1992-11-04 | Nouveaux acides salicyliques substitues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO941799D0 NO941799D0 (no) | 1994-05-13 |
| NO941799L true NO941799L (fr) | 1994-06-22 |
| NO300805B1 NO300805B1 (no) | 1997-07-28 |
Family
ID=20384352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO941799A NO300805B1 (no) | 1991-11-18 | 1994-05-13 | Nye substituerte salicylsyrer |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US5302718A (fr) |
| EP (1) | EP0613468B1 (fr) |
| JP (1) | JP3259915B2 (fr) |
| KR (1) | KR100253748B1 (fr) |
| AT (1) | ATE194597T1 (fr) |
| AU (1) | AU668528B2 (fr) |
| CA (1) | CA2123697C (fr) |
| DE (1) | DE69231252T2 (fr) |
| DK (1) | DK0613468T3 (fr) |
| EE (1) | EE03026B1 (fr) |
| ES (1) | ES2149780T3 (fr) |
| FI (1) | FI106857B (fr) |
| GR (1) | GR3034585T3 (fr) |
| HU (2) | HU221476B (fr) |
| IL (1) | IL103665A (fr) |
| LT (1) | LT3182B (fr) |
| LV (1) | LV10246B (fr) |
| MX (1) | MX9206647A (fr) |
| MY (1) | MY130169A (fr) |
| NO (1) | NO300805B1 (fr) |
| NZ (1) | NZ244998A (fr) |
| PT (1) | PT101068B (fr) |
| RU (1) | RU2124501C1 (fr) |
| SE (1) | SE9103397D0 (fr) |
| SK (1) | SK282080B6 (fr) |
| TW (1) | TW304944B (fr) |
| UA (1) | UA42869C2 (fr) |
| WO (1) | WO1993010094A1 (fr) |
| ZA (1) | ZA928864B (fr) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
| GB9310095D0 (en) * | 1993-05-17 | 1993-06-30 | Zeneca Ltd | Therapeutic compounds |
| US5965732A (en) * | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
| US5405842A (en) * | 1994-01-28 | 1995-04-11 | Silverman; Bernard A. | Treatment of steroid dependent asthmatics |
| GB9504854D0 (en) * | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
| US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| AU7074496A (en) * | 1995-09-18 | 1997-04-09 | Ligand Pharmaceuticals Incorporated | Ppar gamma antagonists for treating obesity |
| JPH09124620A (ja) | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
| CN1211183A (zh) | 1996-02-20 | 1999-03-17 | 布里斯托尔-迈尔斯斯奎布公司 | 联苯基异噁唑磺酰胺的制备方法 |
| US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
| US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
| JP3814742B2 (ja) * | 1996-10-18 | 2006-08-30 | イハラケミカル工業株式会社 | ４−フルオロサリチル酸類 |
| TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| AU6187898A (en) * | 1997-01-30 | 1998-08-25 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
| GB9804648D0 (en) | 1998-03-06 | 1998-04-29 | Zeneca Ltd | Chemical compounds |
| GB9805520D0 (en) | 1998-03-17 | 1998-05-13 | Zeneca Ltd | Chemical compounds |
| GB9811427D0 (en) | 1998-05-29 | 1998-07-22 | Zeneca Ltd | Chemical compounds |
| AU4676999A (en) | 1998-06-12 | 1999-12-30 | Ligand Pharmaceuticals, Inc. | Treatment of anti-estrogen resistant breast cancer using rxr modulators |
| CA2367916A1 (fr) | 1999-03-19 | 2000-09-28 | Ambarish Singh | Procedes pour la preparation de diphenylisoxazolesulfonamides |
| ATE344237T1 (de) | 1999-09-04 | 2006-11-15 | Astrazeneca Ab | Hydroxyacetamidobenzolsulfonamidderivate |
| ATE262507T1 (de) | 1999-09-04 | 2004-04-15 | Astrazeneca Ab | Substituierte n-phenyl-2-hydroxy-2-methyl-3,3,3- trifluorpropanamid-derivative zur erhöhung der pyruvatdehydrogenaseaktivität |
| JP2003508509A (ja) | 1999-09-04 | 2003-03-04 | アストラゼネカ アクチボラグ | ピルビン酸デヒドロゲナーゼの阻害剤としてのアミド |
| CA2307278A1 (fr) * | 2000-04-28 | 2001-10-28 | University Of British Columbia | Utilisation d'acides salicyliques substitues comportant un heterocycle azote pour l'inhibition de l'assimilation cellulaire de la cystine |
| DE60115414D1 (de) * | 2000-04-28 | 2006-01-05 | Univ British Columbia | N-heterosubstituierten salicylaten zur behandlung von krebs |
| US6639082B2 (en) | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
| WO2005023771A1 (fr) * | 2003-09-05 | 2005-03-17 | Ono Pharmaceutical Co., Ltd. | Antagoniste du recepteur de la chimiokine et son utilisation a des fins medicales |
| JP2007514731A (ja) * | 2003-12-19 | 2007-06-07 | ファイザー インコーポレイテッド | 糖尿病及び肥満症の治療のための１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ１型（１１−β−ｈｓｄ−１）の阻害剤としてのベンゼンスルホニルアミノ−ピリジン−２−イル誘導体及び関連化合物 |
| EP1763353A1 (fr) * | 2004-06-29 | 2007-03-21 | Warner-Lambert Company LLC | THERAPIES COMBINATOIRES DANS LESQUELLES SONT UTILISES DES INHIBITEURS DE BENZAMIDE DU RECEPTEUR P2X<SB>7</SB> |
| GB2421947A (en) * | 2005-01-07 | 2006-07-12 | Univ Southampton | Sulphonamide compounds for use as inhibitors of NF-kB |
| JP2009527560A (ja) * | 2006-02-21 | 2009-07-30 | アムゲン インコーポレイティッド | ホスホジエステラーゼ１０阻害剤としてのシンノリン誘導体 |
| MX2010014232A (es) * | 2008-06-23 | 2011-03-25 | Astellas Pharma Inc | Compuesto de sulfamida o sal del mismo. |
| CA2828212A1 (fr) * | 2011-02-23 | 2012-08-30 | Shiraz Mujtaba | Inhibiteurs de bromodomaines comme modulateurs d'expression genique |
| PE20180529A1 (es) | 2015-05-20 | 2018-03-19 | Amgen Inc | Agonistas de triazol del receptor apj |
| CA3010615C (fr) | 2016-01-14 | 2024-02-20 | Beth Israel Deaconess Medical Center, Inc. | Modulateurs de mastocytes et leurs utilisations |
| EP3452466B1 (fr) | 2016-05-03 | 2020-08-12 | Amgen Inc. | Composés triazole hétérocycliques utilisés en tant qu'agonistes du récepteur apj |
| EP3541792B1 (fr) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Composés de triazole furane utilisés en tant qu'agonistes du récepteur apj |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| MA46827A (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc | Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj |
| EP3541810B1 (fr) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Composés phényle triazole en tant qu'agonistes du récepteur apj |
| EP3541802A1 (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc. | Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj |
| EP3541803B1 (fr) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Composés de triazole pyridyle en tant qu'agonistes du récepteur apj |
| WO2019089335A1 (fr) | 2017-11-03 | 2019-05-09 | Amgen Inc. | Agonistes de triazole fusionnés du récepteur apj |
| MA52487A (fr) | 2018-05-01 | 2021-03-10 | Amgen Inc | Pyrimidinones substituées en tant qu'agonistes du récepteur apj |
| CN111056978B (zh) * | 2019-12-13 | 2021-01-19 | 西安交通大学 | 一种磺酰胺类化合物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2396145A (en) * | 1940-12-14 | 1946-03-05 | Pharmscia Ab | Heterocyclic sulphonamido azo compounds |
| BE791889A (fr) * | 1971-11-26 | 1973-05-24 | Pharmacia Ab | Nouveaux derives de la pyridine |
| US4663334A (en) * | 1985-12-11 | 1987-05-05 | Mcneilab, Inc. | Heteroaromatic acetylenes useful as antihypertensive agents |
| US4897397A (en) * | 1988-12-16 | 1990-01-30 | Schering Corporation | Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents |
-
1991
- 1991-11-18 SE SE9103397A patent/SE9103397D0/xx unknown
-
1992
- 1992-11-03 NZ NZ244998A patent/NZ244998A/en not_active IP Right Cessation
- 1992-11-04 EP EP92924067A patent/EP0613468B1/fr not_active Expired - Lifetime
- 1992-11-04 WO PCT/SE1992/000758 patent/WO1993010094A1/fr active IP Right Grant
- 1992-11-04 SK SK547-94A patent/SK282080B6/sk unknown
- 1992-11-04 HU HU9401391A patent/HU221476B/hu not_active IP Right Cessation
- 1992-11-04 CA CA002123697A patent/CA2123697C/fr not_active Expired - Fee Related
- 1992-11-04 AT AT92924067T patent/ATE194597T1/de not_active IP Right Cessation
- 1992-11-04 KR KR1019940701664A patent/KR100253748B1/ko not_active IP Right Cessation
- 1992-11-04 AU AU29589/92A patent/AU668528B2/en not_active Ceased
- 1992-11-04 DK DK92924067T patent/DK0613468T3/da active
- 1992-11-04 RU RU94028109A patent/RU2124501C1/ru not_active IP Right Cessation
- 1992-11-04 JP JP50919193A patent/JP3259915B2/ja not_active Expired - Fee Related
- 1992-11-04 UA UA94005499A patent/UA42869C2/uk unknown
- 1992-11-04 ES ES92924067T patent/ES2149780T3/es not_active Expired - Lifetime
- 1992-11-04 DE DE69231252T patent/DE69231252T2/de not_active Expired - Fee Related
- 1992-11-06 IL IL10366592A patent/IL103665A/xx not_active IP Right Cessation
- 1992-11-09 US US07/973,753 patent/US5302718A/en not_active Expired - Lifetime
- 1992-11-13 LV LVP-92-202A patent/LV10246B/xx unknown
- 1992-11-17 LT LTIP229A patent/LT3182B/lt not_active IP Right Cessation
- 1992-11-17 MY MYPI92002100A patent/MY130169A/en unknown
- 1992-11-17 PT PT101068A patent/PT101068B/pt not_active IP Right Cessation
- 1992-11-17 ZA ZA928864A patent/ZA928864B/xx unknown
- 1992-11-18 MX MX9206647A patent/MX9206647A/es not_active IP Right Cessation
- 1992-11-27 TW TW081109532A patent/TW304944B/zh active
-
1993
- 1993-10-07 US US08/132,874 patent/US5403930A/en not_active Expired - Fee Related
-
1994
- 1994-05-13 NO NO941799A patent/NO300805B1/no unknown
- 1994-05-17 FI FI942289A patent/FI106857B/fi not_active IP Right Cessation
- 1994-11-02 EE EE9400111A patent/EE03026B1/xx not_active IP Right Cessation
- 1994-12-29 US US08/365,869 patent/US5556855A/en not_active Expired - Fee Related
-
1995
- 1995-06-28 HU HU95P/P00492P patent/HU211163A9/hu unknown
-
2000
- 2000-10-09 GR GR20000402274T patent/GR3034585T3/el not_active IP Right Cessation
Also Published As
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