LU85747A1 - Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives - Google Patents

Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives Download PDF

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Publication number
LU85747A1
LU85747A1 LU85747A LU85747A LU85747A1 LU 85747 A1 LU85747 A1 LU 85747A1 LU 85747 A LU85747 A LU 85747A LU 85747 A LU85747 A LU 85747A LU 85747 A1 LU85747 A1 LU 85747A1
Authority
LU
Luxembourg
Prior art keywords
group
formula
imidazole
derivative
derivatives
Prior art date
Application number
LU85747A
Other languages
English (en)
French (fr)
Inventor
Claude Gillet
Joseph Roba
Michel Snyers
Georges Lambelin
Piedad Calderon
Alexis Cordi
Hugo Gorissen
William Van Dorsser
Original Assignee
Continental Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma filed Critical Continental Pharma
Priority to LU85747A priority Critical patent/LU85747A1/fr
Priority to AU52696/86A priority patent/AU597239B2/en
Priority to FI860369A priority patent/FI860369A/fi
Priority to ZA86596A priority patent/ZA86596B/xx
Priority to DK39286A priority patent/DK39286A/da
Priority to JP61015570A priority patent/JPS61176571A/ja
Priority to US06/823,157 priority patent/US4738979A/en
Priority to IE860222A priority patent/IE860222L/xx
Priority to DE8686870010T priority patent/DE3670081D1/de
Priority to NO860285A priority patent/NO860285L/no
Priority to IL77717A priority patent/IL77717A/xx
Priority to GR860223A priority patent/GR860223B/el
Priority to PT81910A priority patent/PT81910B/pt
Priority to CA000500447A priority patent/CA1273942A/en
Priority to KR1019860000517A priority patent/KR890001972B1/ko
Priority to ES551274A priority patent/ES8802141A1/es
Priority to AT86870010T priority patent/ATE51618T1/de
Priority to EP86870010A priority patent/EP0194984B1/en
Publication of LU85747A1 publication Critical patent/LU85747A1/fr
Priority to ES557663A priority patent/ES8900137A1/es
Priority to ES557664A priority patent/ES8801216A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LU85747A 1985-01-28 1985-01-28 Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives LU85747A1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
LU85747A LU85747A1 (fr) 1985-01-28 1985-01-28 Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
AU52696/86A AU597239B2 (en) 1985-01-28 1986-01-24 Derivatives of imidazole, their preparation and utilisation, and pharmaceutical compositions containing these derivatives
NO860285A NO860285L (no) 1985-01-28 1986-01-27 Fremgangsmaate ved fremstilling av imidazolderivater.
GR860223A GR860223B (en) 1985-01-28 1986-01-27 Imidazole derivatives method for their preparation their use and pharmaceutical compositions containing said derivatives
DK39286A DK39286A (da) 1985-01-28 1986-01-27 Imidazolderivater, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende disse derivater
JP61015570A JPS61176571A (ja) 1985-01-28 1986-01-27 イミダゾール誘導体およびその製造方法
US06/823,157 US4738979A (en) 1985-01-28 1986-01-27 α2 -blocking derivatives of imidazole
IE860222A IE860222L (en) 1985-01-28 1986-01-27 Imidazole derivatives.
DE8686870010T DE3670081D1 (de) 1985-01-28 1986-01-27 Imidazolderivate, verfahren zu deren herstellung, deren anwendung und pharmazeutische zusammenstellungen.
FI860369A FI860369A (fi) 1985-01-28 1986-01-27 Imidazolderivat, deras framstaellning och anvaendning samt dessa derivat innehaollande farmaceutiska kompositioner.
IL77717A IL77717A (en) 1985-01-28 1986-01-27 Pharmaceutical compositions containing derivatives of imidazole,their preparation and some novel compounds of this type
ZA86596A ZA86596B (en) 1985-01-28 1986-01-27 Derivatives of imidazole,their preparation and utilisation,and pharmaceutical compositions containing these derivates
PT81910A PT81910B (en) 1985-01-28 1986-01-27 Process for preparing derivatives of imidazole and pharmaceutical compositions containing these derivatives
CA000500447A CA1273942A (en) 1985-01-28 1986-01-27 Derivatives of imidazole, their preparation and utilisation, and pharmaceutical compositions containing these derivatives
KR1019860000517A KR890001972B1 (ko) 1985-01-28 1986-01-27 이미다졸 유도체의 제조방법
ES551274A ES8802141A1 (es) 1985-01-28 1986-01-27 Un procedimiento para la sintesis de derivados de imidazol.
AT86870010T ATE51618T1 (de) 1985-01-28 1986-01-27 Imidazolderivate, verfahren zu deren herstellung, deren anwendung und pharmazeutische zusammenstellungen.
EP86870010A EP0194984B1 (en) 1985-01-28 1986-01-27 Derivatives of imidazole, their preparation and utilisation, and pharmaceutical compositions containing these derivatives
ES557663A ES8900137A1 (es) 1985-01-28 1987-08-13 Un procedimiento para la sintesis de derivados de imidazol.
ES557664A ES8801216A1 (es) 1985-01-28 1987-08-13 Un procedimiento para la sintesis de derivados de imidazol.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU85747A LU85747A1 (fr) 1985-01-28 1985-01-28 Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
LU85747 1985-01-28

Publications (1)

Publication Number Publication Date
LU85747A1 true LU85747A1 (fr) 1986-08-04

Family

ID=19730397

Family Applications (1)

Application Number Title Priority Date Filing Date
LU85747A LU85747A1 (fr) 1985-01-28 1985-01-28 Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives

Country Status (18)

Country Link
US (1) US4738979A (pt)
EP (1) EP0194984B1 (pt)
JP (1) JPS61176571A (pt)
KR (1) KR890001972B1 (pt)
AT (1) ATE51618T1 (pt)
AU (1) AU597239B2 (pt)
CA (1) CA1273942A (pt)
DE (1) DE3670081D1 (pt)
DK (1) DK39286A (pt)
ES (3) ES8802141A1 (pt)
FI (1) FI860369A (pt)
GR (1) GR860223B (pt)
IE (1) IE860222L (pt)
IL (1) IL77717A (pt)
LU (1) LU85747A1 (pt)
NO (1) NO860285L (pt)
PT (1) PT81910B (pt)
ZA (1) ZA86596B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
GB2210875B (en) * 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
EP0378910B1 (en) * 1988-12-15 1994-08-31 Texaco Development Corporation Method for the preparation of imidazoles
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
JPH032168A (ja) * 1989-03-30 1991-01-08 Farmos Yhtymae Oy アロマターゼ阻害活性を有する新規な４（５）―イミダゾール
GB2229719B (en) * 1989-03-30 1992-04-29 Farmos Oy Novel aromatase inhibiting 4(5)-imidazoles
GB2248058B (en) * 1990-09-21 1994-09-14 Orion Yhtymae Oy Aromatase inhibiting 4(5)-imidazoles
GB2244431A (en) * 1990-05-31 1991-12-04 Farmos Oy Treatment of age related memory impairment and other cognitive disorders
GB9012469D0 (en) * 1990-06-05 1990-07-25 Glaxo Group Ltd Medicaments
FR2732017B1 (fr) * 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
US6329369B1 (en) 1997-12-04 2001-12-11 Allergan Sales, Inc. Methods of treating pain and other conditions
US6841684B2 (en) 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
RU2235092C2 (ru) * 1997-12-04 2004-08-27 Оллерган Инк. Замещенные производные имидазола, способ введения активного соединения и способ лечения на основе этих соединений
US20080207719A1 (en) * 2003-04-10 2008-08-28 Orion Corporation Treatment of Epilepsy
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
US11111210B2 (en) 2015-11-18 2021-09-07 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
US11827606B2 (en) 2015-11-18 2023-11-28 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
US4281141A (en) * 1980-05-30 1981-07-28 Eli Lilly And Company 3-(Imidazol-4-yl)-2-phenylpropanenitriles
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
CA1238640A (en) * 1984-06-18 1988-06-28 Kenneth S. Hirsch 4(5)-substituted imidazoles
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives

Also Published As

Publication number Publication date
ES8802141A1 (es) 1988-04-01
ES8900137A1 (es) 1989-01-16
DK39286A (da) 1986-07-29
CA1273942C (en) 1990-09-11
IL77717A (en) 1990-07-12
DK39286D0 (da) 1986-01-27
AU5269686A (en) 1986-07-31
EP0194984B1 (en) 1990-04-04
ZA86596B (en) 1986-09-24
GR860223B (en) 1986-04-24
NO860285L (no) 1986-07-29
PT81910B (en) 1987-05-13
IE860222L (en) 1986-07-28
ES557664A0 (es) 1987-12-16
US4738979A (en) 1988-04-19
KR890001972B1 (ko) 1989-06-05
KR860005794A (ko) 1986-08-13
EP0194984A1 (en) 1986-09-17
ATE51618T1 (de) 1990-04-15
JPS61176571A (ja) 1986-08-08
FI860369A0 (fi) 1986-01-27
ES551274A0 (es) 1988-04-01
CA1273942A (en) 1990-09-11
ES8801216A1 (es) 1987-12-16
PT81910A (en) 1986-02-01
AU597239B2 (en) 1990-05-31
FI860369A (fi) 1986-07-29
ES557663A0 (es) 1989-01-16
DE3670081D1 (de) 1990-05-10

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