LT4838B - 1,3,4-oksadiazolono dariniai - Google Patents

1,3,4-oksadiazolono dariniai Download PDF

Info

Publication number
LT4838B
LT4838B LT2000068A LT2000068A LT4838B LT 4838 B LT4838 B LT 4838B LT 2000068 A LT2000068 A LT 2000068A LT 2000068 A LT2000068 A LT 2000068A LT 4838 B LT4838 B LT 4838B
Authority
LT
Lithuania
Prior art keywords
methyl
phenyl
chloro
trifluoromethyl
oxadiazol
Prior art date
Application number
LT2000068A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2000068A (en
Inventor
Piyasena Hewawasam
Min Ding
John E. Starrett
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of LT2000068A publication Critical patent/LT2000068A/xx
Publication of LT4838B publication Critical patent/LT4838B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
LT2000068A 1998-01-29 2000-07-14 1,3,4-oksadiazolono dariniai LT4838B (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7296698P 1998-01-29 1998-01-29
US10227498P 1998-09-29 1998-09-29

Publications (2)

Publication Number Publication Date
LT2000068A LT2000068A (en) 2001-03-26
LT4838B true LT4838B (lt) 2001-08-27

Family

ID=26753969

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2000068A LT4838B (lt) 1998-01-29 2000-07-14 1,3,4-oksadiazolono dariniai

Country Status (27)

Country Link
US (1) US6034113A (id)
EP (1) EP1051173A4 (id)
JP (1) JP2002527352A (id)
KR (1) KR20010077838A (id)
CN (1) CN1150175C (id)
AR (1) AR010712A1 (id)
AU (1) AU735704B2 (id)
BG (1) BG104706A (id)
BR (1) BR9913010A (id)
CA (1) CA2318830A1 (id)
CO (1) CO5090837A1 (id)
EE (1) EE04089B1 (id)
GE (1) GEP20032914B (id)
HU (1) HUP0102025A3 (id)
ID (1) ID26909A (id)
IL (1) IL137518A0 (id)
LT (1) LT4838B (id)
LV (1) LV12559B (id)
NO (1) NO317102B1 (id)
NZ (1) NZ505409A (id)
PL (1) PL342060A1 (id)
RU (1) RU2202548C2 (id)
SK (1) SK10852000A3 (id)
TR (1) TR200002019T2 (id)
TW (1) TW550075B (id)
UA (1) UA58579C2 (id)
WO (1) WO1999038510A1 (id)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999038853A1 (en) * 1998-01-29 1999-08-05 Bristol-Myers Squibb Company Amino acid derivatives of daryl 1,3,4-oxadiazolone
US6297241B1 (en) 1999-01-29 2001-10-02 Bristol-Myers Squibb Company Carbamate derivatives of diaryl 1,3,4-oxadiazolone
HUP0200089A3 (en) * 1999-01-29 2004-07-28 Bristol Myers Squibb Co Carbamate derivatives of diaryl 1,3,4-oxadiazolone
US6326388B1 (en) * 1999-12-21 2001-12-04 Celgene Corporation Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
JP2005507853A (ja) 2001-02-20 2005-03-24 ブリストル−マイヤーズ　スクイブ　カンパニー Ｋｃｎｑカリウムチャンネルモジュレーター並びに片頭痛および機構的に関連する疾患の治療におけるそれらの使用
EP1432690A2 (en) * 2001-04-16 2004-06-30 Tanabe Seiyaku Co., Ltd. Imidazole, thiazole and oxazole derivatives and their use for the manufacture of a medicament for the treatment and/or prevention of pollakiuria or urinary incontinence
US6909027B1 (en) * 2001-08-13 2005-06-21 Perry Robins Method of forming an in-situ film dressing and the composition of the film-forming material
US7119246B2 (en) * 2002-06-25 2006-10-10 Perry Robins Method of treating acne
CN107929743B (zh) 2012-01-18 2023-09-01 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
JP5855599B2 (ja) * 2013-04-30 2016-02-09 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ
CN104710379B (zh) * 2015-03-09 2017-01-18 华南理工大学 一种bms‑191011的合成方法
JP6165816B2 (ja) * 2015-10-01 2017-07-19 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ
US10265300B2 (en) * 2017-02-24 2019-04-23 Ovid Therapeutics Inc. Methods of treating seizure disorders
EP3870159B1 (en) 2018-10-26 2024-11-13 University of South Florida Drug for treating tinnitus
CN110987847B (zh) * 2019-12-11 2021-02-19 苏州今蓝纳米科技有限公司 1,3,4-噁二唑衍生物在检测酸以及数据加密和储存中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971803A (en) 1973-05-21 1976-07-27 Ciba-Geigy Corporation 3-Hydroxybenzyl-oxadiazolone and -thiadiazolone derivatives
WO1998004135A1 (en) 1996-07-31 1998-02-05 Bristol-Myers Squibb Company Diphenyl heterocycles as potassium channel modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251488B (it) * 1991-09-17 1995-05-15 Mini Ricerca Scient Tecnolog Ossa(tia)diazol- e triazol-oni(tioni) ad attivita' acaricida ed insetticida
US5234947A (en) * 1991-11-07 1993-08-10 New York University Potassium channel activating compounds and methods of use thereof
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
WO1999038853A1 (en) * 1998-01-29 1999-08-05 Bristol-Myers Squibb Company Amino acid derivatives of daryl 1,3,4-oxadiazolone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971803A (en) 1973-05-21 1976-07-27 Ciba-Geigy Corporation 3-Hydroxybenzyl-oxadiazolone and -thiadiazolone derivatives
WO1998004135A1 (en) 1996-07-31 1998-02-05 Bristol-Myers Squibb Company Diphenyl heterocycles as potassium channel modulators

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NIGEL S. COOK: "The pharmacology of potassium channels and their therapeutic potential", TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, pages 21 - 28
TRIVEDI S ET AL.: "Calcium dependent K-channels in guinea pig and human urinary bladder", BIOCHEM BIOPHYS RES COMMUN., 1995, pages 404 - 409
ULRICH QUAST , NIGEL S. COOK: "Moving together: K+ channel openersand ATP-sensitive K+ channels", TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, pages 431 - 435
WILDER SMITH, A.E.: "Preparation of Some New 4-Substituted Derivatives of p-Amino-o-hydroxy-phenyl-1,3,4-oxadiazolone-5 and Study of their Mycobacteriostatic Activity", ARZNEIM. FORSCH., 1967, pages 768 - 772

Also Published As

Publication number Publication date
NO20003825D0 (no) 2000-07-26
CO5090837A1 (es) 2001-10-30
EP1051173A1 (en) 2000-11-15
TR200002019T2 (tr) 2000-11-21
CN1150175C (zh) 2004-05-19
EE04089B1 (et) 2003-08-15
LT2000068A (en) 2001-03-26
HUP0102025A2 (hu) 2001-11-28
AU735704B2 (en) 2001-07-12
IL137518A0 (en) 2001-07-24
LV12559B (en) 2001-04-20
NO20003825L (no) 2000-07-26
LV12559A (en) 2000-11-20
EE200000447A (et) 2001-12-17
WO1999038510A1 (en) 1999-08-05
AR010712A1 (es) 2000-07-12
US6034113A (en) 2000-03-07
TW550075B (en) 2003-09-01
PL342060A1 (en) 2001-05-21
NZ505409A (en) 2003-08-29
GEP20032914B (en) 2003-03-25
SK10852000A3 (sk) 2002-02-05
EP1051173A4 (en) 2002-07-31
UA58579C2 (uk) 2003-08-15
CA2318830A1 (en) 1999-08-05
KR20010077838A (ko) 2001-08-20
RU2202548C2 (ru) 2003-04-20
CN1289249A (zh) 2001-03-28
HUP0102025A3 (en) 2002-01-28
JP2002527352A (ja) 2002-08-27
BG104706A (en) 2001-04-30
BR9913010A (pt) 2001-05-08
NO317102B1 (no) 2004-08-09
ID26909A (id) 2001-02-15
AU2230899A (en) 1999-08-16

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