LT4099B - Oral pharmaceutical compositions, processes for preparation and use thereof - Google Patents
Oral pharmaceutical compositions, processes for preparation and use thereof Download PDFInfo
- Publication number
- LT4099B LT4099B LT96-039A LT96039A LT4099B LT 4099 B LT4099 B LT 4099B LT 96039 A LT96039 A LT 96039A LT 4099 B LT4099 B LT 4099B
- Authority
- LT
- Lithuania
- Prior art keywords
- hydroxybenzoate
- mofetil mycophenolate
- xanthan gum
- pharmaceutical composition
- purified water
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 13
- 238000000034 method Methods 0.000 title description 6
- 239000008203 oral pharmaceutical composition Substances 0.000 title 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims abstract description 88
- 239000000725 suspension Substances 0.000 claims abstract description 39
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims abstract description 35
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229960000951 mycophenolic acid Drugs 0.000 claims abstract description 26
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 24
- 239000000872 buffer Substances 0.000 claims abstract description 19
- 239000004599 antimicrobial Substances 0.000 claims abstract description 13
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 13
- 239000003765 sweetening agent Substances 0.000 claims abstract description 13
- 239000000796 flavoring agent Substances 0.000 claims abstract description 9
- 239000000080 wetting agent Substances 0.000 claims abstract description 8
- 235000019264 food flavour enhancer Nutrition 0.000 claims abstract description 7
- 235000019634 flavors Nutrition 0.000 claims abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 98
- 239000000203 mixture Substances 0.000 claims description 89
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 71
- 229920001285 xanthan gum Polymers 0.000 claims description 49
- 239000004615 ingredient Substances 0.000 claims description 48
- 239000000230 xanthan gum Substances 0.000 claims description 47
- 235000010493 xanthan gum Nutrition 0.000 claims description 47
- 229940082509 xanthan gum Drugs 0.000 claims description 47
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 45
- 239000000600 sorbitol Substances 0.000 claims description 45
- 235000010356 sorbitol Nutrition 0.000 claims description 45
- 239000008213 purified water Substances 0.000 claims description 43
- 108010011485 Aspartame Proteins 0.000 claims description 37
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- 239000000605 aspartame Substances 0.000 claims description 37
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- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 37
- 239000003973 paint Substances 0.000 claims description 30
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- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 25
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 25
- 229930006000 Sucrose Natural products 0.000 claims description 24
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 24
- 239000005720 sucrose Substances 0.000 claims description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 23
- 239000008119 colloidal silica Substances 0.000 claims description 23
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 23
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 23
- 235000019800 disodium phosphate Nutrition 0.000 claims description 23
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- 239000001488 sodium phosphate Substances 0.000 claims description 23
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- 235000020357 syrup Nutrition 0.000 claims description 21
- 239000006188 syrup Substances 0.000 claims description 21
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims description 20
- 239000000975 dye Substances 0.000 claims description 20
- KRCMKUNIILUXPF-UHFFFAOYSA-N methyl 4-hydroxybenzoate;sodium Chemical compound [Na].COC(=O)C1=CC=C(O)C=C1 KRCMKUNIILUXPF-UHFFFAOYSA-N 0.000 claims description 19
- 239000008194 pharmaceutical composition Substances 0.000 claims description 19
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- 239000004290 sodium methyl p-hydroxybenzoate Substances 0.000 claims description 19
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 18
- 239000000787 lecithin Substances 0.000 claims description 18
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 17
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 17
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- GVKCHTBDSMQENH-UHFFFAOYSA-L phloxine B Chemical compound [Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 GVKCHTBDSMQENH-UHFFFAOYSA-L 0.000 claims description 16
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- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 15
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 15
- 238000011282 treatment Methods 0.000 claims description 14
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 13
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 13
- 241000167854 Bourreria succulenta Species 0.000 claims description 12
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 claims description 12
- 235000019693 cherries Nutrition 0.000 claims description 12
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 claims description 12
- 235000012732 erythrosine Nutrition 0.000 claims description 12
- 239000004174 erythrosine Substances 0.000 claims description 12
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 11
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- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 claims description 11
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| US13034393A | 1993-10-01 | 1993-10-01 |
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| US6436425B1 (en) | 1988-11-16 | 2002-08-20 | Mdv Technologies, Inc. | Method and non-gelling composition for inhibiting post-surgical adhesions |
| US5346703A (en) | 1990-08-07 | 1994-09-13 | Mediventures, Inc. | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
| US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5843470A (en) | 1995-10-06 | 1998-12-01 | Mdv Technologies, Inc. | Method and composition for inhibiting post-surgical adhesions |
| ID18663A (id) * | 1996-04-12 | 1998-04-30 | Novartis Ag | Komposisi farmasi berlapis enterik |
| US5759579A (en) * | 1996-12-05 | 1998-06-02 | American Home Products Corporation | Pharmaceutical suspension systems |
| AU753206B2 (en) * | 1997-12-23 | 2002-10-10 | Alliance Pharmaceutical Corporation | Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions |
| EP1113794A2 (en) * | 1998-09-14 | 2001-07-11 | Vertex Pharmaceuticals Incorporated | Methods of treating viral disease |
| US6410255B1 (en) * | 1999-05-05 | 2002-06-25 | Aurora Biosciences Corporation | Optical probes and assays |
| NZ540001A (en) | 1999-05-14 | 2007-06-29 | Nereus Pharmaceuticals Inc | Novel interleukin-1 and tumor necrosis factor-alpha modulators syntheses of said modulators and methods of using said modulators |
| US6726922B1 (en) | 1999-06-28 | 2004-04-27 | Minu, L.L.C. | Process and composition for temporarily suppressing pain |
| HK1049185A1 (zh) * | 2000-02-23 | 2003-05-02 | Invitrogen Corporation | 可改萤光蛋白 |
| JP4395549B2 (ja) * | 2000-11-16 | 2010-01-13 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬物及び発酵生成物の発見のための海洋放線菌分類群 |
| FR2819721B1 (fr) * | 2001-01-19 | 2005-02-04 | L M D | Traitement des escarres avec sucre non metabolisable et un absorbant polymerique |
| ES2243457T3 (es) * | 2001-01-23 | 2005-12-01 | Gador S.A. | Composicion que comprende bifosfonatos para la prevencion y/o tratamiento de trastornos metabolicos de huesos, procedimiento de preparacion de dicha composicion y usos de la misma. |
| DE60120630T2 (de) * | 2001-02-14 | 2007-05-24 | Forte Iq B.V. | Pharmazeutische Zusammensetzung enthaltend Xanthangummi |
| DK1275377T3 (da) | 2001-07-11 | 2003-10-06 | Applied Pharma Res | Granulater, der indeholder fedtopløselige stoffer, og en fremgangsmåde til fremstilling deraf |
| WO2003028649A2 (en) * | 2001-10-02 | 2003-04-10 | Smithkline Beecham Corporation | Novel composition of carvedilol |
| GB0124953D0 (en) * | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| US20040127435A1 (en) * | 2002-08-02 | 2004-07-01 | Regents Of The University Of California | Uses for inhibitors of inosine monophosphate dehydrogenase |
| US7112581B2 (en) * | 2002-09-27 | 2006-09-26 | Nereus Pharmaceuticals, Inc. | Macrocyclic lactams |
| GB0307553D0 (en) * | 2003-04-01 | 2003-05-07 | Novartis Ag | Organic compounds |
| US20050187170A1 (en) * | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
| CN101791306A (zh) * | 2003-06-20 | 2010-08-04 | 加利福尼亚大学董事会 | 盐孢菌酰胺及其使用方法 |
| DE602004031614D1 (de) * | 2003-06-20 | 2011-04-14 | Nereus Pharmaceuticals Inc | Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebs |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| WO2005025622A1 (ja) * | 2003-09-12 | 2005-03-24 | Ryukakusan Co. Ltd. | 苦みマスキング粒状ゼリー飲料 |
| AR045957A1 (es) * | 2003-10-03 | 2005-11-16 | Novartis Ag | Composicion farmaceutica y combinacion |
| US7087369B2 (en) * | 2003-12-17 | 2006-08-08 | The Regents Of The University Of California | Cornea preservation medium |
| EP1711486B1 (en) * | 2004-01-23 | 2011-05-11 | Nereus Pharmaceuticals, Inc. | Bis-indole pyrroles useful as antimicrobial agents |
| TW200613294A (en) * | 2004-04-26 | 2006-05-01 | Teva Gyogyszergyar Reszvenytarsasag | Process for preparation of mycophenolic acid and ester derivatives thereof |
| WO2005105771A1 (en) * | 2004-04-27 | 2005-11-10 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| JP2007535559A (ja) | 2004-04-30 | 2007-12-06 | ネレアス ファーマシューティカルズ インコーポレイテッド | ［３．２．０］複素環式化合物及びその使用法 |
| US20050266031A1 (en) | 2004-05-25 | 2005-12-01 | Jay Dickerson | Pharmaceutical suspension composition |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| WO2006004795A2 (en) * | 2004-06-25 | 2006-01-12 | The Johns Hopkins University | Angiogenesis inhibitors |
| JP2008506783A (ja) * | 2004-07-20 | 2008-03-06 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | ミコフェノール酸ナトリウムの結晶形の調製方法 |
| US20060051428A1 (en) * | 2004-09-03 | 2006-03-09 | Nelson Ayala | Aspartame and citrate flavored phosphate salt laxative |
| US20060093629A1 (en) * | 2004-10-29 | 2006-05-04 | Buehler Gail K | Dye-free pharmaceutical suspensions and related methods |
| NZ555439A (en) * | 2004-12-03 | 2010-12-24 | Dana Farber Cancer Inst Inc | Use of salinosporamide A for treating neoplastic diseases which are resistant to the chemotherapeutic agents bortezomib, dexamethasone, doxorubicin or thalidomide |
| US20080280977A1 (en) * | 2005-04-26 | 2008-11-13 | Sandor Molnar | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
| EP2311795A3 (en) | 2005-07-21 | 2011-12-28 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators |
| US20070082061A1 (en) * | 2005-10-07 | 2007-04-12 | Nelson Ayala | Reduction of saltiness with sweeteners |
| AU2007214784A1 (en) * | 2006-02-13 | 2007-08-23 | Novartis Ag | High dosage of mycophenolic acid (MPA) |
| US7985429B2 (en) | 2006-03-03 | 2011-07-26 | C. B. Fleet Company, Inc. | Flavored colonic cleansing system |
| GB0612809D0 (en) * | 2006-06-28 | 2006-08-09 | Univ Sunderland | Formulation |
| US7998510B2 (en) | 2006-08-17 | 2011-08-16 | C. B. Fleet Company, Inc. | Low dose colonic cleansing system |
| FR2911506B1 (fr) * | 2007-01-18 | 2009-07-03 | Ceva Sante Animale Sa | Compositions pharmaceutiques destinees a une administration par voie orale sous forme de suspensions aqueuses stabilisees |
| WO2008095195A2 (en) * | 2007-02-02 | 2008-08-07 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of salinosporamide a |
| US8999395B2 (en) * | 2007-02-09 | 2015-04-07 | Ceva Sante Animale | Pharmaceutical compositions for oral administration in the form of stabilised aqueous suspensions |
| USD683210S1 (en) | 2007-03-01 | 2013-05-28 | C.B. Fleet Company, Inc. | Container for colonic cleansing kit |
| US20090017167A1 (en) * | 2007-07-11 | 2009-01-15 | Herbalife International Inc. | Mixture and beverage made therefrom for protecting cellular hydration |
| KR101465836B1 (ko) * | 2007-10-12 | 2014-11-26 | 류가쿠산 가부시키가이샤 | 약복용 입상 젤리 음료 및 그 제조 방법 |
| TW200932240A (en) * | 2007-10-25 | 2009-08-01 | Astellas Pharma Inc | Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production |
| US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| CA2723465A1 (en) | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Proteasome inhibitors |
| CN102099029A (zh) * | 2008-07-09 | 2011-06-15 | 阿斯普瑞瓦国际公司 | 治疗眼部病症的霉酚酸钠的pH值特定溶液 |
| CN101671706B (zh) * | 2009-09-05 | 2013-09-18 | 山东新时代药业有限公司 | 一种霉酚酸发酵过程中补糖方法 |
| MX2012002831A (es) * | 2009-09-10 | 2012-05-08 | Bial Portela & Ca Sa | Formulaciones para suspension oral de acetato de esclicarbazepina. |
| WO2011117883A1 (en) * | 2010-03-23 | 2011-09-29 | Alkem Laboratories Ltd. | Pharmaceutical composition of mycophenolate mofetil and process for preparing thereof |
| SG10201710567SA (en) | 2013-03-14 | 2018-01-30 | Alkermes Pharma Ireland Ltd | Prodrugs of fumarates and their use in treating various diseases |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| US9168246B2 (en) | 2013-06-27 | 2015-10-27 | Veloxis Pharmaceutical A/S | Regimen for suppressing organ rejection |
| NZ723269A (en) | 2014-02-24 | 2017-04-28 | Alkermes Pharma Ireland Ltd | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| EP3628640B1 (en) | 2014-09-02 | 2023-08-09 | Hub Therapeutics | Methods of making a deuterated or a non-deuterated molecule and pharmaceutical formulations for treatment |
| EP3204120B1 (en) | 2014-10-08 | 2021-05-26 | Pacific Northwest Research Institute | Methods and compositions for increasing the potency of antifungal agents |
| TW201615186A (zh) * | 2014-10-24 | 2016-05-01 | 朗齊生物醫學股份有限公司 | 脫克鈣藥物應用於癌症治療 |
| US12011429B2 (en) | 2016-06-02 | 2024-06-18 | Steven Baranowitz | Prevention and treatment of viral infections |
| WO2017210262A1 (en) | 2016-06-02 | 2017-12-07 | Steven Baranowitz | Prevention and treatment of viral infections |
| US10603299B2 (en) | 2016-06-02 | 2020-03-31 | Steven Baranowitz | Prevention and treatment of viral infections |
| WO2018167628A1 (en) * | 2017-03-13 | 2018-09-20 | Ftf Pharma Private Limited | Pharmaceutical composition of oral suspension of immunosuppressive agents |
| CN112533614A (zh) | 2018-03-28 | 2021-03-19 | 美国康宝莱国际公司 | 多糖的乙酰化 |
| GB2591396B (en) | 2018-08-18 | 2023-06-07 | Ftf Pharma Private Ltd | Pharmaceutical suspension for oral dosage |
| CN112315962B (zh) * | 2020-11-17 | 2022-03-29 | 北京化工大学 | 霉酚酸在治疗和预防柯萨奇病毒感染中的应用 |
| CN117883379A (zh) * | 2021-02-12 | 2024-04-16 | 浙江贝灵生物医药有限公司 | 一种口服碱性溶媒组合物及其制备方法与应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3880995A (en) | 1973-05-14 | 1975-04-29 | Lilly Co Eli | Treatment of arthritis with mycophenolic acid and derivatives |
| US4727069A (en) | 1987-01-30 | 1988-02-23 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions |
| US4753935A (en) | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US5247083A (en) | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1157100A (en) * | 1966-09-27 | 1969-07-02 | Ici Ltd | Pharmaceutical Compositions |
| ZA717826B (en) * | 1970-11-27 | 1973-06-27 | Lilly Co Eli | Psoriasis treatment with mycophenolic acid |
| CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| CH653550A5 (de) * | 1981-10-20 | 1986-01-15 | Sandoz Ag | Pharmazeutische zusammensetzung zur verzoegerten freigabe eines medikamentes im mundbereich. |
| KR100215167B1 (ko) * | 1990-08-10 | 1999-08-16 | 위샤르트 아이 시 | 면역 억제 조성물 |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3880995A (en) | 1973-05-14 | 1975-04-29 | Lilly Co Eli | Treatment of arthritis with mycophenolic acid and derivatives |
| US4727069A (en) | 1987-01-30 | 1988-02-23 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions |
| US4753935A (en) | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US4786637A (en) | 1987-01-30 | 1988-11-22 | Syntex (U.S.A.) Inc. | Treatment of allograft rejection with mycophenolic acid morpholinoethylester and derivatives thereof |
| US5247083A (en) | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
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