LT3675B - Indenoindole copounds ii, process for preraring them and pharmaceutical composition containing them - Google Patents

Indenoindole copounds ii, process for preraring them and pharmaceutical composition containing them Download PDF

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Publication number
LT3675B
LT3675B LTIP912A LTIP912A LT3675B LT 3675 B LT3675 B LT 3675B LT IP912 A LTIP912 A LT IP912A LT IP912 A LTIP912 A LT IP912A LT 3675 B LT3675 B LT 3675B
Authority
LT
Lithuania
Prior art keywords
tetrahydro
indole
cis
formula
thii
Prior art date
Application number
LTIP912A
Other languages
English (en)
Lithuanian (lt)
Inventor
Malcolm Sainsbury
Howard G Shertzer
Original Assignee
Univ Bath
Univ Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bath, Univ Cincinnati filed Critical Univ Bath
Publication of LTIP912A publication Critical patent/LTIP912A/xx
Publication of LT3675B publication Critical patent/LT3675B/lt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/70[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/94[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
LTIP912A 1989-06-22 1993-08-30 Indenoindole copounds ii, process for preraring them and pharmaceutical composition containing them LT3675B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8902274A SE8902274D0 (sv) 1989-06-22 1989-06-22 Indenoidole compounds ii

Publications (2)

Publication Number Publication Date
LTIP912A LTIP912A (en) 1995-03-27
LT3675B true LT3675B (en) 1996-01-25

Family

ID=20376370

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP912A LT3675B (en) 1989-06-22 1993-08-30 Indenoindole copounds ii, process for preraring them and pharmaceutical composition containing them

Country Status (34)

Country Link
EP (1) EP0409410B1 (fi)
JP (1) JP3064411B2 (fi)
KR (1) KR920702679A (fi)
CN (1) CN1033029C (fi)
AT (1) ATE135688T1 (fi)
BG (1) BG60317B2 (fi)
CA (1) CA2060897A1 (fi)
DD (1) DD297960A5 (fi)
DE (1) DE69025998T2 (fi)
DK (1) DK0409410T3 (fi)
DZ (1) DZ1428A1 (fi)
ES (1) ES2084660T3 (fi)
FI (1) FI100800B (fi)
GR (1) GR3019779T3 (fi)
HR (1) HRP920903B1 (fi)
HU (1) HUT59097A (fi)
IE (1) IE74682B1 (fi)
IL (1) IL94830A (fi)
IS (1) IS3590A7 (fi)
LT (1) LT3675B (fi)
LV (1) LV10253B (fi)
MX (1) MX21244A (fi)
MY (1) MY107311A (fi)
NO (1) NO177932C (fi)
NZ (1) NZ234175A (fi)
PL (1) PL167761B1 (fi)
PT (1) PT94468B (fi)
RO (1) RO111573B1 (fi)
RU (1) RU2104270C1 (fi)
SE (1) SE8902274D0 (fi)
SI (1) SI9011223B (fi)
WO (1) WO1990015799A1 (fi)
YU (1) YU122390A (fi)
ZA (1) ZA904827B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ240232A (en) * 1990-10-16 1994-05-26 Univ Bath Indenoindole derivatives and compositions thereof
JPH0656669A (ja) * 1992-06-11 1994-03-01 Asahi Breweries Ltd 活性酸素消去作用を持つプテリン誘導体製剤
SE9302431D0 (sv) * 1993-07-16 1993-07-16 Ab Astra Use of indenoindole compounds
CA2128283A1 (fr) * 1993-07-20 1995-01-21 Paul Caubere (thia)cycloalkyl¬b|indoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6288099B1 (en) 1998-12-04 2001-09-11 American Home Products Corporation Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
JP2002531569A (ja) * 1998-12-04 2002-09-24 ワイス 新規なカリウムチャンネル開放物質としての置換ベンゾフラノインドール及びインデノインドール
FR2826009B1 (fr) * 2001-06-13 2003-08-15 Servier Lab Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PL1910338T3 (pl) 2005-07-14 2011-02-28 Irm Llc Związki heterotetracykliczne jako mimetyki TPO
DE102006047231B4 (de) * 2006-10-04 2009-02-12 Hemmerling, Hans-Jörg, Dr. Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
AU2012270311B2 (en) * 2011-06-16 2016-04-21 Katholieke Universiteit Leuven K.U. Leuven R & D Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
CN105121433B (zh) 2012-12-14 2018-01-23 韩国化学研究院 抗病毒化合物、其药学上可接受的盐或光学异构体、用于制备它们的方法以及包含它们作为有效成分的用于预防或治疗病毒性疾病的药物组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A.G. ANASTASSIOU ET AL.: "Generation and thermal reorganization of a linearly-fused N-methyldibenzoazocinyl anion", J. CHEM. SOC., CHEM. COMMUN., 1981, pages 647 - 648

Also Published As

Publication number Publication date
SE8902274D0 (sv) 1989-06-22
MX21244A (es) 1994-03-31
HU904825D0 (en) 1992-03-30
LV10253A (lv) 1994-10-20
DD297960A5 (de) 1992-01-30
CN1051554A (zh) 1991-05-22
DZ1428A1 (fr) 2004-09-13
SI9011223B (sl) 1998-08-31
IL94830A0 (en) 1991-04-15
HRP920903B1 (en) 1998-06-30
GR3019779T3 (en) 1996-07-31
MY107311A (en) 1995-11-30
CN1033029C (zh) 1996-10-16
YU122390A (sh) 1992-09-07
ZA904827B (en) 1991-04-24
HUT59097A (en) 1992-04-28
NO915049D0 (no) 1991-12-20
PL285752A1 (en) 1991-03-11
AU5836990A (en) 1991-01-08
JPH04505923A (ja) 1992-10-15
JP3064411B2 (ja) 2000-07-12
SI9011223A (en) 1997-10-31
PL167761B1 (pl) 1995-10-31
DK0409410T3 (da) 1996-04-29
ATE135688T1 (de) 1996-04-15
AU644084B2 (en) 1993-12-02
IL94830A (en) 1996-07-23
PT94468A (pt) 1991-02-08
IS3590A7 (is) 1990-12-23
ES2084660T3 (es) 1996-05-16
NO177932B (no) 1995-09-11
LV10253B (en) 1995-04-20
RO111573B1 (ro) 1996-11-29
KR920702679A (ko) 1992-10-06
IE74682B1 (en) 1997-07-30
BG60317B2 (bg) 1994-07-25
LTIP912A (en) 1995-03-27
IE902247L (en) 1990-12-22
RU2104270C1 (ru) 1998-02-10
CA2060897A1 (en) 1990-12-23
NO915049L (no) 1992-02-21
WO1990015799A1 (en) 1990-12-27
FI100800B (fi) 1998-02-27
DE69025998T2 (de) 1996-08-08
EP0409410A1 (en) 1991-01-23
FI915999A0 (fi) 1991-12-19
IE902247A1 (en) 1991-01-16
HRP920903A2 (hr) 1994-04-30
EP0409410B1 (en) 1996-03-20
NO177932C (no) 1995-12-20
NZ234175A (en) 1992-12-23
PT94468B (pt) 1997-12-31
DE69025998D1 (de) 1996-04-25

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Effective date: 19980830