LT3494229T - Ląstelėmis paremta didelio našumo aptamerų atranka - Google Patents
Ląstelėmis paremta didelio našumo aptamerų atrankaInfo
- Publication number
- LT3494229T LT3494229T LTEPPCT/IB2017/001113T LTIB2017001113T LT3494229T LT 3494229 T LT3494229 T LT 3494229T LT IB2017001113 T LTIB2017001113 T LT IB2017001113T LT 3494229 T LT3494229 T LT 3494229T
- Authority
- LT
- Lithuania
- Prior art keywords
- aptamers
- high throughput
- based screening
- throughput cell
- cell
- Prior art date
Links
- 108091023037 Aptamer Proteins 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1048—SELEX
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
- C12N2330/31—Libraries, arrays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/30—Oligonucleotides characterised by their secondary structure
- C12Q2525/301—Hairpin oligonucleotides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370599P | 2016-08-03 | 2016-08-03 | |
| PCT/IB2017/001113 WO2018025085A2 (en) | 2016-08-03 | 2017-08-03 | High throughput cell-based screening for aptamers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3494229T true LT3494229T (lt) | 2024-02-12 |
Family
ID=60182820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/IB2017/001113T LT3494229T (lt) | 2016-08-03 | 2017-08-03 | Ląstelėmis paremta didelio našumo aptamerų atranka |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11371077B2 (lt) |
| EP (1) | EP3494229B1 (lt) |
| JP (2) | JP7089502B2 (lt) |
| KR (1) | KR102491566B1 (lt) |
| CN (1) | CN110199030B (lt) |
| AU (2) | AU2017306657B2 (lt) |
| BR (1) | BR112019002085A2 (lt) |
| CA (1) | CA3066654C (lt) |
| DK (1) | DK3494229T3 (lt) |
| EA (1) | EA201990423A1 (lt) |
| FI (1) | FI3494229T3 (lt) |
| HR (1) | HRP20240183T1 (lt) |
| IL (1) | IL264490B1 (lt) |
| LT (1) | LT3494229T (lt) |
| MX (1) | MX2019001239A (lt) |
| MY (1) | MY196527A (lt) |
| PH (1) | PH12019500239A1 (lt) |
| PL (1) | PL3494229T3 (lt) |
| PT (1) | PT3494229T (lt) |
| RS (1) | RS65228B1 (lt) |
| SG (1) | SG11201900851QA (lt) |
| WO (1) | WO2018025085A2 (lt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11083444B2 (en) | 2010-03-11 | 2021-08-10 | Globus Medical, Inc. | Tissue retractor and methods of use |
| MX2018009370A (es) * | 2016-02-02 | 2018-11-12 | Meiragtx Uk Ii Ltd | Regulacion de expresion genica a través de poliadenilacion modulada por aptámeros. |
| CN110636868B (zh) | 2017-02-21 | 2024-03-15 | 梅里特斯英国第二有限公司 | 通过适体-介导的多腺苷酸化信号可及性来调控基因表达 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580737A (en) | 1990-06-11 | 1996-12-03 | Nexstar Pharmaceuticals, Inc. | High-affinity nucleic acid ligands that discriminate between theophylline and caffeine |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| ATE318832T1 (de) | 1990-06-11 | 2006-03-15 | Gilead Sciences Inc | Verfahren zur vervendung von nukleinsäureliganden |
| US6423493B1 (en) * | 1998-10-26 | 2002-07-23 | Board Of Regents The University Of Texas System | Combinatorial selection of oligonucleotide aptamers |
| US8008071B2 (en) * | 1999-11-08 | 2011-08-30 | University Of South Florida | Compositions and methods for detecting intracellular glucose and analogs thereof |
| US20040126882A1 (en) | 2000-06-15 | 2004-07-01 | Ellington Andrew D | Regulatable, catalytically active nucleic acids |
| US20040137472A1 (en) | 2002-09-27 | 2004-07-15 | Ryszard Kole | Methods and compositions for modification of splicing of pre-mRNA |
| AU2005306801B2 (en) * | 2004-11-08 | 2012-05-17 | The Regents Of The University Of Colorado | Structure-based compound design involving riboswitches |
| EP2186903A3 (en) * | 2005-02-09 | 2010-09-08 | BASF Plant Science GmbH | Expression cassettes for regulation of expression in monocotyledonous plants |
| EP1931803A2 (en) * | 2005-09-15 | 2008-06-18 | Duke University | Focused libraries, functional profiling, laser selex and deselex |
| JP2010521977A (ja) * | 2007-03-22 | 2010-07-01 | イェール ユニバーシティー | オルタナティブスプライシングを調節するリボスイッチに関する方法および組成物 |
| AU2008260089A1 (en) * | 2007-05-29 | 2008-12-11 | Yale University | Methods and compositions related to riboswitches that control alternative splicing and RNA processing |
| US8604176B2 (en) * | 2009-11-10 | 2013-12-10 | California Institute Of Technology | Protein-responsive RNA control devices and uses thereof |
| US9487767B2 (en) * | 2012-05-31 | 2016-11-08 | Novozymes A/S of Krogshoejvej 36 | Selection in fungi |
| LT2943579T (lt) * | 2013-01-10 | 2018-11-12 | Dharmacon, Inc. | Molekulių bibliotekos ir molekulių generavimo būdai |
| EA037120B1 (ru) | 2015-02-02 | 2021-02-09 | МЕИРЭДжТиЭкс ЮКей II ЛИМИТЕД | Регулирование экспрессии генов посредством аптамер-опосредованного модулирования альтернативного сплайсинга |
| GB201506440D0 (en) * | 2015-04-16 | 2015-06-03 | Univ Wageningen | Riboswitch-controlled screening and selection of desired biocatalysts |
| US10011870B2 (en) * | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
-
2017
- 2017-08-03 RS RS20240097A patent/RS65228B1/sr unknown
- 2017-08-03 FI FIEP17790843.1T patent/FI3494229T3/fi active
- 2017-08-03 SG SG11201900851QA patent/SG11201900851QA/en unknown
- 2017-08-03 DK DK17790843.1T patent/DK3494229T3/da active
- 2017-08-03 BR BR112019002085A patent/BR112019002085A2/pt unknown
- 2017-08-03 KR KR1020197005510A patent/KR102491566B1/ko active IP Right Grant
- 2017-08-03 PT PT177908431T patent/PT3494229T/pt unknown
- 2017-08-03 LT LTEPPCT/IB2017/001113T patent/LT3494229T/lt unknown
- 2017-08-03 JP JP2019505401A patent/JP7089502B2/ja active Active
- 2017-08-03 EP EP17790843.1A patent/EP3494229B1/en active Active
- 2017-08-03 MX MX2019001239A patent/MX2019001239A/es unknown
- 2017-08-03 MY MYPI2019000618A patent/MY196527A/en unknown
- 2017-08-03 PL PL17790843.1T patent/PL3494229T3/pl unknown
- 2017-08-03 WO PCT/IB2017/001113 patent/WO2018025085A2/en active Application Filing
- 2017-08-03 EA EA201990423A patent/EA201990423A1/ru unknown
- 2017-08-03 IL IL264490A patent/IL264490B1/en unknown
- 2017-08-03 CN CN201780061565.2A patent/CN110199030B/zh active Active
- 2017-08-03 US US16/322,865 patent/US11371077B2/en active Active
- 2017-08-03 CA CA3066654A patent/CA3066654C/en active Active
- 2017-08-03 AU AU2017306657A patent/AU2017306657B2/en active Active
- 2017-08-03 HR HRP20240183TT patent/HRP20240183T1/hr unknown
-
2019
- 2019-02-01 PH PH12019500239A patent/PH12019500239A1/en unknown
-
2022
- 2022-06-09 JP JP2022093742A patent/JP2022113773A/ja active Pending
- 2022-06-27 US US17/809,043 patent/US20230065720A1/en active Pending
-
2023
- 2023-03-08 AU AU2023201431A patent/AU2023201431A1/en active Pending
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