LT3157527T - Ezh2 inhibitoriai, skirti limfomos gydymui - Google Patents

Ezh2 inhibitoriai, skirti limfomos gydymui

Info

Publication number
LT3157527T
LT3157527T LTEPPCT/US2015/036310T LT15036310T LT3157527T LT 3157527 T LT3157527 T LT 3157527T LT 15036310 T LT15036310 T LT 15036310T LT 3157527 T LT3157527 T LT 3157527T
Authority
LT
Lithuania
Prior art keywords
ezh2 inhibitors
treating lymphoma
lymphoma
treating
ezh2
Prior art date
Application number
LTEPPCT/US2015/036310T
Other languages
English (en)
Lithuanian (lt)
Inventor
Heike KEILHACK
Lone Ottesen
Larisa Reyderman
L. Danielle JOHNSTON
Sarah K. Knutson
Original Assignee
Epizyme, Inc.
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme, Inc., Eisai R&D Management Co., Ltd. filed Critical Epizyme, Inc.
Publication of LT3157527T publication Critical patent/LT3157527T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LTEPPCT/US2015/036310T 2014-06-17 2015-06-17 Ezh2 inhibitoriai, skirti limfomos gydymui LT3157527T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462013522P 2014-06-17 2014-06-17
US201462036265P 2014-08-12 2014-08-12
PCT/US2015/036310 WO2015195848A1 (en) 2014-06-17 2015-06-17 Ezh2 inhibitors for treating lymphoma

Publications (1)

Publication Number Publication Date
LT3157527T true LT3157527T (lt) 2023-07-25

Family

ID=54936086

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2015/036310T LT3157527T (lt) 2014-06-17 2015-06-17 Ezh2 inhibitoriai, skirti limfomos gydymui

Country Status (21)

Country Link
US (5) US10166238B2 (cg-RX-API-DMAC10.html)
EP (2) EP4252851A3 (cg-RX-API-DMAC10.html)
JP (1) JP6779793B2 (cg-RX-API-DMAC10.html)
KR (2) KR20230031963A (cg-RX-API-DMAC10.html)
CN (2) CN106999498B (cg-RX-API-DMAC10.html)
AU (3) AU2015277139A1 (cg-RX-API-DMAC10.html)
BR (1) BR112016029492A2 (cg-RX-API-DMAC10.html)
CA (1) CA2952074C (cg-RX-API-DMAC10.html)
DK (1) DK3157527T3 (cg-RX-API-DMAC10.html)
EA (1) EA038337B1 (cg-RX-API-DMAC10.html)
ES (1) ES2948442T3 (cg-RX-API-DMAC10.html)
FI (1) FI3157527T3 (cg-RX-API-DMAC10.html)
HU (1) HUE062158T2 (cg-RX-API-DMAC10.html)
IL (3) IL285201B2 (cg-RX-API-DMAC10.html)
LT (1) LT3157527T (cg-RX-API-DMAC10.html)
MX (2) MX383866B (cg-RX-API-DMAC10.html)
PL (1) PL3157527T3 (cg-RX-API-DMAC10.html)
PT (1) PT3157527T (cg-RX-API-DMAC10.html)
SG (2) SG10201811128RA (cg-RX-API-DMAC10.html)
SI (1) SI3157527T1 (cg-RX-API-DMAC10.html)
WO (1) WO2015195848A1 (cg-RX-API-DMAC10.html)

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IL308613A (en) 2012-10-15 2024-01-01 Epizyme Inc Cancer treatment methods
CN116019921A (zh) 2013-12-06 2023-04-28 Epizyme股份有限公司 用于治疗癌症的组合疗法
LT3157527T (lt) 2014-06-17 2023-07-25 Epizyme, Inc. Ezh2 inhibitoriai, skirti limfomos gydymui
CA2963149A1 (en) 2014-10-16 2016-04-21 Epizyme, Inc. Method for treating cancer
MX383484B (es) * 2014-11-17 2025-03-11 Epizyme Inc Método para tratar el cáncer.
AR102767A1 (es) 2014-12-05 2017-03-22 Lilly Co Eli Inhibidores de ezh2
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CN116019921A (zh) 2013-12-06 2023-04-28 Epizyme股份有限公司 用于治疗癌症的组合疗法
LT3157527T (lt) 2014-06-17 2023-07-25 Epizyme, Inc. Ezh2 inhibitoriai, skirti limfomos gydymui
BR112017009440A2 (pt) 2014-11-06 2017-12-19 Dana Farber Cancer Inst Inc uso de composições que modulam a estrutura de cromatina quanto à doença do enxerto versus hospedeiro (gvhd)
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Also Published As

Publication number Publication date
US20200323866A1 (en) 2020-10-15
WO2015195848A1 (en) 2015-12-23
EP3157527B1 (en) 2023-05-24
KR102497728B1 (ko) 2023-02-09
AU2015277139A1 (en) 2016-12-22
EP4252851A2 (en) 2023-10-04
EP4252851A3 (en) 2023-11-22
US11642347B2 (en) 2023-05-09
WO2015195848A8 (en) 2016-07-07
SG11201610273VA (en) 2017-01-27
CN113289022A (zh) 2021-08-24
MX2016016744A (es) 2017-11-30
DK3157527T3 (da) 2023-07-03
KR20170052558A (ko) 2017-05-12
NZ727108A (en) 2023-09-29
HUE062158T2 (hu) 2023-10-28
AU2020244382B2 (en) 2022-08-04
EA201692285A1 (ru) 2017-06-30
PL3157527T3 (pl) 2023-08-07
SI3157527T1 (sl) 2023-09-29
IL249438A0 (en) 2017-02-28
IL309539A (en) 2024-02-01
AU2020244382A1 (en) 2020-10-29
MX383866B (es) 2025-03-14
EA038337B1 (ru) 2021-08-11
EP3157527A4 (en) 2018-05-23
MX2021007651A (es) 2021-08-11
CA2952074A1 (en) 2015-12-23
AU2022263523A1 (en) 2022-12-08
JP2017518334A (ja) 2017-07-06
US20170216300A1 (en) 2017-08-03
US20200022987A1 (en) 2020-01-23
CA2952074C (en) 2022-08-30
IL285201B1 (en) 2024-01-01
BR112016029492A2 (pt) 2017-10-17
US10166238B2 (en) 2019-01-01
FI3157527T3 (fi) 2023-07-25
CN106999498A (zh) 2017-08-01
US20190175604A1 (en) 2019-06-13
ES2948442T3 (es) 2023-09-12
KR20230031963A (ko) 2023-03-07
SG10201811128RA (en) 2019-01-30
IL285201B2 (en) 2024-05-01
CN106999498B (zh) 2021-06-08
PT3157527T (pt) 2023-06-30
US20240058348A1 (en) 2024-02-22
EP3157527A1 (en) 2017-04-26
IL285201A (en) 2021-08-31
EA201692285A8 (ru) 2018-01-31
JP6779793B2 (ja) 2020-11-04

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