LT3151B - Novel selective aromatase inhibiting compounds - Google Patents

Novel selective aromatase inhibiting compounds Download PDF

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Publication number
LT3151B
LT3151B LTIP1524A LTIP1524A LT3151B LT 3151 B LT3151 B LT 3151B LT IP1524 A LTIP1524 A LT IP1524A LT IP1524 A LTIP1524 A LT IP1524A LT 3151 B LT3151 B LT 3151B
Authority
LT
Lithuania
Prior art keywords
cyanophenyl
fluorophenyl
compound
pharmaceutically acceptable
triazole
Prior art date
Application number
LTIP1524A
Other languages
English (en)
Lithuanian (lt)
Inventor
Arto Johannes Karjalainen
Marja-Liisa Soedervall
Arja Marketta Kalapudas
Reino Olavi Pelkonen
Aire Marja Laine
Risto Arvo Sakari Lammintausta
Jarmo Sakari Salonen
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of LTIP1524A publication Critical patent/LTIP1524A/xx
Publication of LT3151B publication Critical patent/LT3151B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
LTIP1524A 1992-12-16 1993-12-03 Novel selective aromatase inhibiting compounds LT3151B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9226209A GB2273704B (en) 1992-12-16 1992-12-16 Triazolyl diaryl selective aromatase inhibiting compounds

Publications (2)

Publication Number Publication Date
LTIP1524A LTIP1524A (en) 1994-07-15
LT3151B true LT3151B (en) 1995-01-31

Family

ID=10726697

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1524A LT3151B (en) 1992-12-16 1993-12-03 Novel selective aromatase inhibiting compounds

Country Status (31)

Country Link
US (2) US5703109A (de)
EP (1) EP0674626B1 (de)
JP (1) JP3186771B2 (de)
KR (1) KR100347639B1 (de)
CN (1) CN1056835C (de)
AT (1) ATE194833T1 (de)
AU (1) AU682332B2 (de)
BG (1) BG62930B1 (de)
CA (1) CA2150904A1 (de)
CZ (1) CZ283043B6 (de)
DE (1) DE69329072T2 (de)
DK (1) DK0674626T3 (de)
EE (1) EE03155B1 (de)
ES (1) ES2148312T3 (de)
FI (1) FI952867A (de)
GB (1) GB2273704B (de)
GR (1) GR3034618T3 (de)
HR (1) HRP931494B1 (de)
IL (1) IL107714A (de)
LT (1) LT3151B (de)
NO (1) NO310237B1 (de)
NZ (1) NZ258588A (de)
PL (1) PL176413B1 (de)
PT (1) PT674626E (de)
RO (1) RO113986B1 (de)
RU (1) RU2131418C1 (de)
SI (1) SI9300663B (de)
SK (1) SK281667B6 (de)
TW (1) TW327169B (de)
WO (1) WO1994013645A1 (de)
ZA (1) ZA938717B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0891334A1 (de) * 1996-04-03 1999-01-20 Merck & Co., Inc. Inhibitoren von farnesylprotein-transferase
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5972921A (en) * 1997-12-12 1999-10-26 Hormos Medical Oy Ltd. Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
EP1303270B1 (de) * 2000-07-10 2006-03-29 Hormos Medical Ltd. Methoden zur behandlung des kryptorchysmus
FI20010905A0 (fi) * 2001-05-02 2001-05-02 Vetcare Oy Uusi eläinlääke
JP2005515207A (ja) * 2001-12-11 2005-05-26 エモリー ユニバーシティ 乳癌の予防において使用するためのビス（シアノフェニル）メチル−トリアゾール
EP1431292A1 (de) * 2002-12-16 2004-06-23 Laboratoire Theramex 1-N-Phenylamino-1H-imidazolderivate und deren Verwendung als aromatase Inhibitoren
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
US7345073B2 (en) 2003-02-07 2008-03-18 Hormos Medical Ltd. Method for treating cryptorchidism
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
CA2549603A1 (en) * 2003-12-15 2005-06-30 Laboratoire Theramex 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them
MX2008014825A (es) * 2006-05-22 2008-12-01 Hormos Medical Ltd Moduladores selectivos del receptor de estrogeno o inhibidores de aromatasa para tratar prostatitis cronica no bacteriana.
GB0914767D0 (en) * 2009-08-24 2009-09-30 Sterix Ltd Compound
WO2011127232A2 (en) 2010-04-08 2011-10-13 Emory University Substituted androst-4-ene diones
JP5870093B2 (ja) * 2010-05-27 2016-02-24 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 殺菌剤としてのヘテロ環式アルカノール誘導体
KR101583521B1 (ko) 2015-07-31 2016-01-08 (주) 엘림비엠에스 내오염, 내마모 성능과 시공 작업성 및 광도 성능이 개선된 피브이씨 타일 바닥의 코팅방법
US10905253B2 (en) 2018-04-19 2021-02-02 Wonderland Switzerland Ag Child carrier

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937250A (en) 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
EP0390558A1 (de) 1989-03-30 1990-10-03 Orion-Yhtymà„ Oy Aromatase inhibierende 4(5)-Imidazole
US4978672A (en) 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US5071861A (en) 1986-03-07 1991-12-10 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5073574A (en) 1989-07-14 1991-12-17 Ciba-Geigy Corporation Tetrazolyl substituted benzonitriles and anti-tumor use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1580535A (en) * 1976-08-27 1980-12-03 Ici Ltd Substituted ketones and their use as herbicides
US5112845A (en) * 1986-03-07 1992-05-12 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
GB9125924D0 (en) * 1991-06-18 1992-02-05 Orion Yhtymae Oy Stereoisomers of an imidazole derivative

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978672A (en) 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US5071861A (en) 1986-03-07 1991-12-10 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4937250A (en) 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
EP0390558A1 (de) 1989-03-30 1990-10-03 Orion-Yhtymà„ Oy Aromatase inhibierende 4(5)-Imidazole
US5073574A (en) 1989-07-14 1991-12-17 Ciba-Geigy Corporation Tetrazolyl substituted benzonitriles and anti-tumor use thereof

Also Published As

Publication number Publication date
FI952867A0 (fi) 1995-06-09
GB2273704A (en) 1994-06-29
AU5652394A (en) 1994-07-04
JP3186771B2 (ja) 2001-07-11
HRP931494A2 (en) 1996-08-31
DE69329072D1 (de) 2000-08-24
HRP931494B1 (en) 2001-06-30
NO952365D0 (no) 1995-06-15
NO952365L (no) 1995-06-15
NZ258588A (en) 1996-11-26
SI9300663B (sl) 2002-02-28
JPH08504424A (ja) 1996-05-14
SK281667B6 (sk) 2001-06-11
LTIP1524A (en) 1994-07-15
TW327169B (en) 1998-02-21
KR950704263A (ko) 1995-11-17
IL107714A (en) 2003-07-31
NO310237B1 (no) 2001-06-11
CZ153295A3 (en) 1995-11-15
KR100347639B1 (ko) 2002-11-29
CN1056835C (zh) 2000-09-27
PT674626E (pt) 2000-11-30
EP0674626B1 (de) 2000-07-19
RU2131418C1 (ru) 1999-06-10
ZA938717B (en) 1994-06-30
GB9226209D0 (en) 1993-02-10
CZ283043B6 (cs) 1997-12-17
FI952867A (fi) 1995-06-09
SK77895A3 (en) 1995-12-06
SI9300663A (en) 1994-09-30
ATE194833T1 (de) 2000-08-15
GB2273704B (en) 1997-01-22
DE69329072T2 (de) 2000-12-21
CN1093357A (zh) 1994-10-12
BG62930B1 (bg) 2000-11-30
PL176413B1 (pl) 1999-05-31
BG99699A (bg) 1996-04-30
RO113986B1 (ro) 1998-12-30
DK0674626T3 (da) 2000-11-13
EE03155B1 (et) 1999-02-15
WO1994013645A1 (en) 1994-06-23
CA2150904A1 (en) 1994-06-23
AU682332B2 (en) 1997-10-02
GR3034618T3 (en) 2001-01-31
ES2148312T3 (es) 2000-10-16
RU95114360A (ru) 1997-06-10
IL107714A0 (en) 1994-02-27
PL309350A1 (en) 1995-10-02
US5962495A (en) 1999-10-05
EP0674626A1 (de) 1995-10-04
US5703109A (en) 1997-12-30

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Legal Events

Date Code Title Description
PC9A Transfer of patents

Free format text: RISTO ARVO SAKARI LAMMINTAUSTA,MELTOISTENTIE, FIN-20900 TURKU,FI,980210

MM9A Lapsed patents

Effective date: 20031203