LT2944688T - Stromos kamieninių ląstelių, kilusių iš riebalinio audinio, panaudojimas fistulės gydymui - Google Patents

Stromos kamieninių ląstelių, kilusių iš riebalinio audinio, panaudojimas fistulės gydymui

Info

Publication number
LT2944688T
LT2944688T LTEP15158571.8T LT15158571T LT2944688T LT 2944688 T LT2944688 T LT 2944688T LT 15158571 T LT15158571 T LT 15158571T LT 2944688 T LT2944688 T LT 2944688T
Authority
LT
Lithuania
Prior art keywords
stem cells
adipose tissue
derived stromal
stromal stem
treating fistula
Prior art date
Application number
LTEP15158571.8T
Other languages
English (en)
Lithuanian (lt)
Inventor
Maria Gema Fernandez Miguel
Manuel Angel Gonzalez De La Pena
Rosa Ana Garcia Castro
Mariano Garcia Arranz
Damian Garcia Olmo
Original Assignee
Tigenix, S.A.U.
Universidad Autonoma De Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37116048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2944688(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tigenix, S.A.U., Universidad Autonoma De Madrid filed Critical Tigenix, S.A.U.
Publication of LT2944688T publication Critical patent/LT2944688T/lt

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    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/106Fibrin; Fibrinogen
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    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
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    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
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    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/3895Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
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    • A61B2017/320008Scrapers
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64Animal cells
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
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  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Botany (AREA)
  • Transplantation (AREA)
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  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
LTEP15158571.8T 2005-06-24 2006-05-16 Stromos kamieninių ląstelių, kilusių iš riebalinio audinio, panaudojimas fistulės gydymui LT2944688T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/167,061 US20060045872A1 (en) 2004-08-25 2005-06-24 Use of adipose tissue-derived stromal stem cells in treating fistula

Publications (1)

Publication Number Publication Date
LT2944688T true LT2944688T (lt) 2018-02-26

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ID=37116048

Family Applications (3)

Application Number Title Priority Date Filing Date
LTEP17150455.8T LT3176255T (lt) 2005-06-24 2006-05-16 Stromos kamieninių ląstelių, kilusių iš riebalinio audinio, panaudojimas fistulės gydymui
LTEP15158571.8T LT2944688T (lt) 2005-06-24 2006-05-16 Stromos kamieninių ląstelių, kilusių iš riebalinio audinio, panaudojimas fistulės gydymui
LTPA2018514C LTC2292737I2 (lt) 2005-06-24 2018-09-18 Panaudojimas iš adipozinio audinio kilusių stromos kamieninių ląstelių fistulų gydyme

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP17150455.8T LT3176255T (lt) 2005-06-24 2006-05-16 Stromos kamieninių ląstelių, kilusių iš riebalinio audinio, panaudojimas fistulės gydymui

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTPA2018514C LTC2292737I2 (lt) 2005-06-24 2018-09-18 Panaudojimas iš adipozinio audinio kilusių stromos kamieninių ląstelių fistulų gydyme

Country Status (23)

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US (10) US20060045872A1 (OSRAM)
EP (7) EP3176255B1 (OSRAM)
JP (5) JP2008546397A (OSRAM)
KR (1) KR20080036588A (OSRAM)
CN (2) CN103143055A (OSRAM)
AU (1) AU2006261383B2 (OSRAM)
BR (1) BRPI0613811B8 (OSRAM)
CA (1) CA2613457C (OSRAM)
CY (3) CY1116764T1 (OSRAM)
DK (4) DK3176255T3 (OSRAM)
ES (6) ES2696535T3 (OSRAM)
HU (3) HUE025338T2 (OSRAM)
IL (1) IL188378A (OSRAM)
LT (3) LT3176255T (OSRAM)
LU (1) LUC00085I2 (OSRAM)
NL (1) NL300953I2 (OSRAM)
NZ (2) NZ594848A (OSRAM)
PL (3) PL2944688T3 (OSRAM)
PT (3) PT3176255T (OSRAM)
RU (3) RU2435846C2 (OSRAM)
SG (1) SG166770A1 (OSRAM)
SI (3) SI2292737T2 (OSRAM)
WO (1) WO2006136244A2 (OSRAM)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7803787B2 (en) * 2002-10-16 2010-09-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage by transmucosal administration
US8455458B2 (en) 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
AU2006244479B2 (en) 2005-05-05 2012-08-09 Nyse Group, Inc. Unpriced order auction and routing
US20070027543A1 (en) * 2005-08-01 2007-02-01 Gimble Jeffrey M Use of adipose tissue-derived stromal cells in spinal fusion
DK1926813T4 (da) 2005-09-23 2019-08-19 Tigenix S A U Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser
US20100322906A1 (en) * 2005-10-05 2010-12-23 Osaka University Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells
US20070129757A1 (en) * 2005-12-02 2007-06-07 Cook Incorporated Devices, systems, and methods for occluding a defect
US20090209031A1 (en) * 2006-01-26 2009-08-20 Tyco Healthcare Group Lp Medical device package
US8592209B2 (en) * 2006-01-30 2013-11-26 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
US20070224173A1 (en) * 2006-03-21 2007-09-27 Koullick Edouard A Nonexpansion Protocol for Autologous Cell-Based Therapies
WO2008024996A2 (en) * 2006-08-24 2008-02-28 Johnstone Brian H Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith
WO2008060374A2 (en) * 2006-10-06 2008-05-22 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
KR20080103637A (ko) * 2007-05-25 2008-11-28 주식회사 알앤엘바이오 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의세포치료용 조성물
US9186375B2 (en) 2007-06-21 2015-11-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan compositions in combination with stem cells
AU2014227541B2 (en) * 2007-09-19 2015-10-01 Pluristem Ltd. Methods of Treating Inflammatory Colon Diseases
CA2725637A1 (en) * 2008-05-27 2009-12-03 Pluristem Ltd. Methods of treating inflammatory colon diseases
US9144584B2 (en) * 2008-06-11 2015-09-29 Cell4Vet Corporation Adipose tissue-derived stem cells for veterinary use
US8876864B2 (en) * 2008-06-24 2014-11-04 Bioactive Surgical, Inc Surgical sutures incorporated with stem cells or other bioactive materials
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
US20100112696A1 (en) * 2008-11-03 2010-05-06 Baxter International Inc. Apparatus And Methods For Processing Tissue To Release Cells
US8309343B2 (en) * 2008-12-01 2012-11-13 Baxter International Inc. Apparatus and method for processing biological material
DK2425844T3 (da) * 2009-04-28 2014-06-16 Anterogen Co Ltd Autolog og allogen stromastamcellesammensætning, der stammer fra fedtvæv, til behandling af fistler
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9669200B2 (en) 2010-08-06 2017-06-06 Boston Scientific Scimed, Inc. Systems and methods for the treatment of pelvic disorders including magnetic particulates
EP4663241A2 (en) 2010-10-08 2025-12-17 Mesoblast International Sàrl Enhanced msc preparations
US9180172B2 (en) 2010-12-15 2015-11-10 Ams Research Corporation Treatment of Peyronies disease
US8979797B2 (en) 2010-12-16 2015-03-17 Ams Research Corporation High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics
KR101900664B1 (ko) 2011-01-12 2018-09-21 타이제닉스, 에스.에이.유. 자가면역 및 염증성 질환에서 림프내 투여를 위한 지방-유래 중간엽 줄기 세포
EP2683813A1 (en) * 2011-03-11 2014-01-15 TiGenix, S.A.U. Cell populations having immunoregulatory activity, method for isolation and uses
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
CL2011001904A1 (es) * 2011-08-08 2012-03-09 Univ Pontificia Catolica Chile Formulacion farmaceutica que comprende celulas madres mesenquimales vivas suspendidas en un vehiculo farmaceuticamente aceptable, sistema de aplicacion topica en aerosol que las comprende; y su uso para tratar heridas.
US20130072903A1 (en) * 2011-09-20 2013-03-21 John Chapman Adipose Tissue Graft for Wound Healing
GB201202319D0 (en) * 2012-02-10 2012-03-28 Orbsen Therapeutics Ltd Stromal stem cells
US20140024011A1 (en) * 2012-07-23 2014-01-23 AdiCyte, Inc. Method for Preparing Adipose Tissue
EP3473276B1 (en) * 2012-10-18 2023-12-13 Mayo Foundation for Medical Education and Research Techniques for treatment of abscesses
WO2014186854A1 (pt) * 2013-05-24 2014-11-27 Universidade Estadual De Campinas - Unicamp Processo de obtenção de fio de sutura enriquecido com celulas-tronco, fios obtidos, kit de sutura e seus usos
MX2016001247A (es) 2013-07-30 2016-08-17 Musculoskeletal Transplant Foundation Matrices derivadas de tejido suave acelular y metodos para preparar las mismas.
EP3581585A1 (en) * 2014-11-26 2019-12-18 Millennium Pharmaceuticals, Inc. Vedolizumab for the treatment of fistulizing crohn's disease
RU2588835C1 (ru) * 2014-11-27 2016-07-10 Олег Германович Макеев Способ терапии повреждений кожи и биотрансплантат для его осуществления
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
SI3365432T1 (sl) 2015-10-23 2020-08-31 Rigshospitalet Terapija z matičnimi celicami, na osnovi matičnih celic iz adipoze
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
WO2018011192A1 (en) * 2016-07-12 2018-01-18 Centre National De La Recherche Scientifique Compositions useful for mucosal healing
IT201700043316A1 (it) * 2017-04-20 2018-10-20 Lipogems Int S P A Drug delivery system
JP6999918B2 (ja) * 2017-08-21 2022-02-04 学校法人慶應義塾 血小板表面抗原と間葉系細胞表面抗原を共発現する血小板様細胞を含む創傷治癒促進剤
WO2019102268A1 (en) 2017-11-22 2019-05-31 Mesoblast International Sarl Cellular compositions and methods of treatment i
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN111840645B (zh) * 2020-07-29 2022-04-01 沈阳细胞治疗工程技术研发中心有限公司 一种瘘洞修补制剂及其制备方法
CN115103696B (zh) * 2020-12-24 2024-07-09 罗基医疗保健公司 用于构建组织再生贴片的方法
CN114949361A (zh) * 2021-12-31 2022-08-30 浙江金时代生物技术有限公司 一种用于子宫内膜修复的聚乳酸-羟基乙酸共聚物支架与人脐带间充质干细胞复合物的制备方法
WO2024227193A2 (en) * 2023-04-28 2024-10-31 Angiocrine Bioscience, Inc. Endothelial cells for treatment of gastrointestinal fistula

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298002A (en) 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5143842A (en) 1988-11-01 1992-09-01 The University Of Colorado Foundation, Inc. Media for normal human muscle satellite cells
US5145770A (en) * 1990-06-04 1992-09-08 Biosurface Technology, Inc. Cryopreservation of cultured epithelial sheets
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5733542A (en) 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US6010696A (en) * 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
WO1994008808A1 (de) 1992-10-10 1994-04-28 Hemscheidt Fahrwerktechnik Gmbh & Co. Kg Hydropneumatisches federungssystem
BR9307550A (pt) 1992-12-02 1999-05-25 Shell Int Research Composto fungicida processo para a preparação de um composto fungicida composição fungicida processo de combate aos fungos em um local e uso
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5578475A (en) 1993-07-12 1996-11-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
JPH10505250A (ja) * 1994-06-06 1998-05-26 ケース ウエスターン リザーブ ユニバーシティ 組織再生のためのバイオマトリックス
US6174333B1 (en) * 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
ATE285477T1 (de) 1995-06-07 2005-01-15 Inex Pharmaceutical Corp Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
EP0842266A4 (en) 1995-08-04 1999-07-21 Gen Hospital Corp TRANSGENIC PORK AND PORK CELLS HAVING HLA GENES OF MAN
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US5705308A (en) 1996-09-30 1998-01-06 Eastman Kodak Company Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element
US6541028B1 (en) * 1997-01-17 2003-04-01 Celadon Science, Llc Methods for promoting healing of corneal resurfacing wounds
DE69841850D1 (de) 1997-12-02 2010-09-30 Artecel Sciences Inc Differenzierung in osteoblasten der fettgewebe-stromalen zellen und ihre verwendungen
US6514513B1 (en) 1998-02-04 2003-02-04 The General Hospital Corporation Costimulatory blockade and mixed chimerism in transplantation
US6368636B1 (en) * 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US9585916B2 (en) 1999-03-26 2017-03-07 Northern Therapeutics Inc. Cell based therapy for the pulmonary system
DE69910362T2 (de) 1998-04-03 2004-06-24 Osiris Therapeutics, Inc. Anwendung der mesenchymalen stammzellen als immunsuppressiva
US6546105B1 (en) 1998-10-30 2003-04-08 Matsushita Electric Industrial Co., Ltd. Sound image localization device and sound image localization method
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US20050153442A1 (en) * 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
EP1165830B1 (en) 1999-03-10 2017-07-12 University of Pittsburgh of the Commonwealth System of Higher Education Adipose-derived stem cells and lattices
WO2000073418A2 (en) * 1999-05-28 2000-12-07 Pacgen Technologies Llc A method of using autologous fibroblasts to promote healing of wounds and fistulas
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
US7078232B2 (en) * 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
CA2392615A1 (en) 1999-12-06 2001-06-07 The General Hospital Corporation Pancreatic stem cells and their use in transplantation
CA2438904C (en) 2001-02-23 2012-09-04 The University Of Pittsburgh Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
AU2002356935A1 (en) 2001-11-09 2003-05-19 Artecel Sciences, Inc. Methods and compositions for the use of stromal cells to support embryonic and adult stem cells
WO2003047530A2 (en) * 2001-12-04 2003-06-12 Woolverton Christopher J Storage-stable fibrin sealant
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
EP1483371B1 (en) * 2002-02-19 2007-06-27 Medipost, Co., Ltd. Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood, and differentiation method of umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues
EP1499347A2 (en) 2002-03-15 2005-01-26 Department of Veterans Affairs, Rehabilitation R&D Service Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
DK1513877T3 (da) 2002-06-14 2008-06-02 Cartela Ab Markör for stamceller og dens anvendelse
CA2489596A1 (en) * 2002-06-14 2003-12-24 Dyax Corporation Protein analysis
US20040101959A1 (en) * 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
JP2004190976A (ja) * 2002-12-12 2004-07-08 Sony Corp 熱輸送装置及び電子デバイス
BRPI0407427A (pt) * 2003-02-13 2006-01-24 Anthrogenesis Corp Método para tratar um paciente e para tratar a mielodisplasia
CA2809195C (en) 2003-04-01 2014-05-20 United States Of America Department Of Veteran's Affairs Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
AU2004252568B2 (en) 2003-06-27 2011-06-30 Ethicon, Incorporated Regeneration and repair of neural tissue using postpartum-derived cells
US7645229B2 (en) * 2003-09-26 2010-01-12 Armstrong David N Instrument and method for endoscopic visualization and treatment of anorectal fistula
KR20060036933A (ko) 2003-10-07 2006-05-02 바이오마스터 인코포레이티드 지방-유래 전구세포의 세포 분화
JP4217262B2 (ja) 2003-11-04 2009-01-28 株式会社バイオマスター 脂肪組織から幹細胞を調製するための方法およびシステム
US7968126B2 (en) 2003-12-24 2011-06-28 The Trustees Of Columbia University In The City Of New York Creation of a biological atrioventricular bypass to compensate for atrioventricular block
US20080095749A1 (en) 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
EP2298863B1 (en) * 2004-03-22 2015-07-22 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
RU2252252C1 (ru) 2004-04-09 2005-05-20 Тепляшин Александр Сергеевич Способ выделения мезенхимальных стволовых клеток
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
ES2264862B8 (es) 2004-08-25 2017-01-20 Cellerix, S.L. Biomaterial para sutura.
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
WO2006029347A2 (en) 2004-09-03 2006-03-16 University Of Maryland, Baltimore Integrin cd18 is a novel stromal stem cell marker and functions to promote osteogenesis
US20060286089A1 (en) 2005-04-08 2006-12-21 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
DK1926813T4 (da) 2005-09-23 2019-08-19 Tigenix S A U Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
WO2008036374A2 (en) 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
WO2009031606A1 (ja) 2007-09-07 2009-03-12 Jcr Pharmaceuticals Co., Ltd. 関節炎治療及び予防剤
EP3103463B1 (en) 2007-09-19 2020-01-01 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
KR20100076031A (ko) 2007-10-17 2010-07-05 티엑셀 Tr1 세포, 중간엽 줄기 세포 및 이들의 용도
GB0814249D0 (en) 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells
ES2345867B1 (es) 2009-04-03 2011-07-28 Fundacion Instituto Mediterraneo Para La Biotecnologia Y La Investigacion Sanitaria (Imabis) Celulas madre multipotentes derivadas de estroma de mesenterio.
DK2425844T3 (da) 2009-04-28 2014-06-16 Anterogen Co Ltd Autolog og allogen stromastamcellesammensætning, der stammer fra fedtvæv, til behandling af fistler
CN107007626A (zh) 2009-07-09 2017-08-04 蒂盖尼克斯公司 用于细胞治疗的方法和组合物
KR101900664B1 (ko) 2011-01-12 2018-09-21 타이제닉스, 에스.에이.유. 자가면역 및 염증성 질환에서 림프내 투여를 위한 지방-유래 중간엽 줄기 세포
EP2683813A1 (en) 2011-03-11 2014-01-15 TiGenix, S.A.U. Cell populations having immunoregulatory activity, method for isolation and uses
US20140134140A1 (en) 2012-11-09 2014-05-15 Case Western Reserve University Mesenchymal stem cell compositions for the treatment of microbial infections
JP6567430B2 (ja) 2013-03-15 2019-08-28 ティゲニクス、エセ、ア、ウTiGenix,S.A.U. 細胞治療に対する臨床反応を決定するためのリンパ球バイオマーカー
US20160120910A1 (en) 2013-06-25 2016-05-05 Tigenix S.A.U. Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

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