LT2758432T - Neutralizuojantys antikūnai prieš clostridium difficile tcda ir tcdb ekzotoksinus - Google Patents

Neutralizuojantys antikūnai prieš clostridium difficile tcda ir tcdb ekzotoksinus

Info

Publication number
LT2758432T
LT2758432T LTEP12761789.2T LT12761789T LT2758432T LT 2758432 T LT2758432 T LT 2758432T LT 12761789 T LT12761789 T LT 12761789T LT 2758432 T LT2758432 T LT 2758432T
Authority
LT
Lithuania
Prior art keywords
tcdb
clostridium difficile
neutralising antibodies
tcda
major
Prior art date
Application number
LTEP12761789.2T
Other languages
English (en)
Lithuanian (lt)
Inventor
David Paul Humphreys
Daniel John Lightwood
Kerry Louise Tyson
David Edward Ormonde KNIGHT
Karine Jeannine Madeleine HERVÉ
Joanne Elizabeth COMPSON
Matthew Jon Timothy PAGE
Andrew Charles Payne
Nicola Louise FISHER
Brendon MACKENZIE
Matthew Cox
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46881094&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2758432(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of LT2758432T publication Critical patent/LT2758432T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91097—Hexosyltransferases (general) (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
LTEP12761789.2T 2011-09-16 2012-09-10 Neutralizuojantys antikūnai prieš clostridium difficile tcda ir tcdb ekzotoksinus LT2758432T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161535532P 2011-09-16 2011-09-16
US201261638731P 2012-04-26 2012-04-26
PCT/GB2012/052222 WO2013038156A1 (en) 2011-09-16 2012-09-10 Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile

Publications (1)

Publication Number Publication Date
LT2758432T true LT2758432T (lt) 2019-06-10

Family

ID=46881094

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP12761789.2T LT2758432T (lt) 2011-09-16 2012-09-10 Neutralizuojantys antikūnai prieš clostridium difficile tcda ir tcdb ekzotoksinus

Country Status (30)

Country Link
US (2) US10752676B2 (en:Method)
EP (2) EP2758432B1 (en:Method)
JP (3) JP6152107B2 (en:Method)
KR (1) KR20140063825A (en:Method)
CN (2) CN103958544B (en:Method)
AU (1) AU2012307157B2 (en:Method)
BR (1) BR112014006175B1 (en:Method)
CA (1) CA2848611A1 (en:Method)
CL (1) CL2014000491A1 (en:Method)
CO (1) CO6930310A2 (en:Method)
CY (1) CY1121673T1 (en:Method)
DK (1) DK2758432T3 (en:Method)
EA (1) EA032475B1 (en:Method)
EC (1) ECSP14013316A (en:Method)
ES (1) ES2729278T3 (en:Method)
HK (1) HK1199463A1 (en:Method)
HR (1) HRP20190917T1 (en:Method)
HU (1) HUE043661T2 (en:Method)
IL (1) IL231167A0 (en:Method)
LT (1) LT2758432T (en:Method)
MX (1) MX2014002769A (en:Method)
PE (1) PE20141547A1 (en:Method)
PH (1) PH12014500456A1 (en:Method)
PL (1) PL2758432T3 (en:Method)
PT (1) PT2758432T (en:Method)
SG (2) SG11201400193SA (en:Method)
SI (1) SI2758432T1 (en:Method)
TN (1) TN2014000101A1 (en:Method)
WO (1) WO2013038156A1 (en:Method)
ZA (1) ZA201402760B (en:Method)

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LT2758432T (lt) * 2011-09-16 2019-06-10 Ucb Biopharma Sprl Neutralizuojantys antikūnai prieš clostridium difficile tcda ir tcdb ekzotoksinus
JP2016501877A (ja) * 2012-11-28 2016-01-21 シーエヌジェー ホールディングス，インコーポレイテッド クロストリジウム・ディフィシルに対する抗体
CN105451762A (zh) * 2013-04-22 2016-03-30 俄克拉荷马州大学评议会 艰难梭菌疫苗及使用方法
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CN110088300A (zh) * 2016-12-14 2019-08-02 默沙东公司 与对靶向艰难梭菌毒素b的治疗的响应相关的人类遗传标志物
CN110607314B (zh) * 2019-10-31 2022-09-23 四川农业大学 一种TcdB RBD基因、重组RBD蛋白和应用
CN111763263A (zh) * 2020-07-09 2020-10-13 宁夏医科大学 一种艰难梭菌抗原及多克隆抗体的制备方法和检测试剂盒
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Also Published As

Publication number Publication date
EA032475B1 (ru) 2019-06-28
US10752676B2 (en) 2020-08-25
ES2729278T3 (es) 2019-10-31
EP2758432B1 (en) 2019-03-06
CN103958544B (zh) 2018-04-24
MX2014002769A (es) 2014-06-11
JP6152107B2 (ja) 2017-06-21
US20200377578A1 (en) 2020-12-03
CA2848611A1 (en) 2013-03-21
PH12014500456A1 (en) 2014-04-14
JP2015501286A (ja) 2015-01-15
PE20141547A1 (es) 2014-10-25
EP3617227A3 (en) 2020-06-03
BR112014006175A2 (pt) 2017-04-04
CN103958544A (zh) 2014-07-30
AU2012307157A1 (en) 2014-04-24
SG11201400193SA (en) 2014-05-29
JP2020037555A (ja) 2020-03-12
HUE043661T2 (hu) 2019-08-28
EP3617227A2 (en) 2020-03-04
JP2017149773A (ja) 2017-08-31
EP2758432A1 (en) 2014-07-30
CY1121673T1 (el) 2020-07-31
SG10201701055WA (en) 2017-03-30
ECSP14013316A (es) 2014-08-29
CO6930310A2 (es) 2014-04-28
NZ623293A (en) 2016-05-27
PT2758432T (pt) 2019-06-14
CL2014000491A1 (es) 2014-12-26
JP6603685B2 (ja) 2019-11-06
BR112014006175B1 (pt) 2020-02-11
TN2014000101A1 (en) 2015-07-01
PL2758432T3 (pl) 2019-08-30
US20140348844A1 (en) 2014-11-27
CN108424449A (zh) 2018-08-21
WO2013038156A1 (en) 2013-03-21
ZA201402760B (en) 2016-03-30
AU2012307157B2 (en) 2017-08-03
KR20140063825A (ko) 2014-05-27
DK2758432T3 (da) 2019-06-03
HRP20190917T1 (hr) 2019-07-26
SI2758432T1 (sl) 2019-07-31
EA201400345A1 (ru) 2014-09-30
HK1199463A1 (en) 2015-07-03
IL231167A0 (en) 2014-04-30

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