LT2002103A - (e)-n-(6,6-dimetil-2-hepten-4-inil)-n-metil-1-naftalenometanamino (terbinafino) gamybos būdas - Google Patents

(e)-n-(6,6-dimetil-2-hepten-4-inil)-n-metil-1-naftalenometanamino (terbinafino) gamybos būdas

Info

Publication number
LT2002103A
LT2002103A LT2002103A LT2002103A LT2002103A LT 2002103 A LT2002103 A LT 2002103A LT 2002103 A LT2002103 A LT 2002103A LT 2002103 A LT2002103 A LT 2002103A LT 2002103 A LT2002103 A LT 2002103A
Authority
LT
Lithuania
Prior art keywords
naphthalenemethanamine
methyl
hepten
terbinafine
ynyl
Prior art date
Application number
LT2002103A
Other languages
English (en)
Other versions
LT5051B (lt
Inventor
Ivan Kakalik
Vladimir Oremus
Vendel MAHOVSKY
Vladislav �NUPAREK
Du�an VANDAK
Ivan Varga
Ladislav JE�EK
Marian Zemanek
Valdemar �TALMACH
Original Assignee
Slovakofarma, A. S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slovakofarma, A. S. filed Critical Slovakofarma, A. S.
Publication of LT2002103A publication Critical patent/LT2002103A/lt
Publication of LT5051B publication Critical patent/LT5051B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

(E) -N-(6,6-dimetil-2-hepten-4-inil)-n-metil-1-naftalenmetanamino (terbinafino) pagaminimo būdas iš n-metil-1-naftalenmetanamino ir (E) -1,3-dichlorpropeno ir po to veikiant 3,3-dimetilbut-1-inu, besiskiriantis tuo, kad reakcijų seka yra vykdoma neišskiriant tarpinių junginių. Visos viena po kitos einančios reakcijos yra vykdomos tirpiklių sistemoje, kuri yra bendra visai reakcijų sekai ir yra inertiška procese esantiems reagentams ir tarpiniams junginiams. Šio išradimo būdas taip pat gali turėti ir papildomas gryninimo stadijas.ą
LT2002103A 2000-04-07 2002-09-19 (e)-n-(6,6-dimetil-2-hepten-4-inil)-n-metil-1-naftalenometanamino (terbinafino) gamybos būdas LT5051B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SK520-2000A SK5202000A3 (en) 2000-04-07 2000-04-07 Method for the preparation of (e)-n-(6,6-dimethyl-2-hepten-4- inyl)-n-methyl-1-naphthalenemethylamine (terbinaphin)

Publications (2)

Publication Number Publication Date
LT2002103A true LT2002103A (lt) 2003-05-26
LT5051B LT5051B (lt) 2003-08-25

Family

ID=20435846

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2002103A LT5051B (lt) 2000-04-07 2002-09-19 (e)-n-(6,6-dimetil-2-hepten-4-inil)-n-metil-1-naftalenometanamino (terbinafino) gamybos būdas

Country Status (7)

Country Link
AU (1) AU2001248998A1 (lt)
EE (1) EE200200583A (lt)
HU (1) HUP0302919A3 (lt)
LT (1) LT5051B (lt)
LV (1) LV12955B (lt)
SK (1) SK5202000A3 (lt)
WO (1) WO2001077064A1 (lt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100459275B1 (ko) * 2001-12-28 2004-12-03 주식회사유한양행 터비나핀 또는 그의 염산염의 제조방법
KR20030066186A (ko) * 2002-02-05 2003-08-09 한솔케미언스 주식회사 (ｅ)-터비나핀 또는 이의 염산염의 제조방법
ITMI20022534A1 (it) 2002-11-29 2004-05-30 Dinamite Dipharma S P A Procedimento per la preparazione di terbinafina mediante l'uso di platino come catalizzatore.
DK1951699T3 (da) * 2005-10-31 2013-01-14 Janssen Pharmaceutica Nv Fremgangsmåder til fremstilling af cyclopropylamidderivater
EA014905B1 (ru) * 2005-10-31 2011-02-28 Янссен Фармацевтика Н.В. Новый способ получения пиперазинильных производных бензамида
CN101624328B (zh) * 2009-07-31 2011-12-14 山东铂源化学有限公司 (e)-1-氯-6,6-二甲基-2-庚烯-4-炔的合成方法
CN104725240B (zh) * 2015-02-12 2017-05-24 吉林修正药业新药开发有限公司 一种盐酸特比萘芬z型异构体的制备方法
CN105016966A (zh) * 2015-07-31 2015-11-04 江苏恒润制药有限公司 一种（e）-1-氯-6,6-二甲基-2-庚烯-4-炔的制备方法
CN111153807B (zh) * 2020-01-16 2023-01-06 河南豫辰药业股份有限公司 一种n,n-二甲氨基氯丙烷盐酸盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1410A (en) 1979-08-22 1988-04-22 Sandoz Ag Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
CH678527A5 (en) 1989-06-22 1991-09-30 Sandoz Ag Trans(E)-N-(1-naphthyl:methyl)-heptenyl-amine prepn. - by simultaneously converting crude mixt. contg. cis and trans isomers to salt and precipitating trans isomer
JP3116364B2 (ja) 1989-10-02 2000-12-11 萬有製薬株式会社 エンイン誘導体の製造法
NZ280065A (en) 1995-09-20 1998-04-27 Apotex Inc Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives

Also Published As

Publication number Publication date
HUP0302919A2 (hu) 2003-12-29
WO2001077064A1 (en) 2001-10-18
LT5051B (lt) 2003-08-25
HUP0302919A3 (en) 2004-09-28
EE200200583A (et) 2004-04-15
WO2001077064A8 (en) 2002-01-03
LV12955B (en) 2003-04-20
AU2001248998A1 (en) 2001-10-23
SK5202000A3 (en) 2001-12-03

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Effective date: 20040405