KR970703303A - N-Z-보호된 N-알킬화 아미노산의 제조 방법(Process for Producing N-Z Protected N-Alkylated Amino Acids) - Google Patents

N-Z-보호된 N-알킬화 아미노산의 제조 방법(Process for Producing N-Z Protected N-Alkylated Amino Acids)

Info

Publication number
KR970703303A
KR970703303A KR1019960706542A KR19960706542A KR970703303A KR 970703303 A KR970703303 A KR 970703303A KR 1019960706542 A KR1019960706542 A KR 1019960706542A KR 19960706542 A KR19960706542 A KR 19960706542A KR 970703303 A KR970703303 A KR 970703303A
Authority
KR
South Korea
Prior art keywords
protected
amino acids
formula
alkylated amino
alkyl
Prior art date
Application number
KR1019960706542A
Other languages
English (en)
Inventor
울리히 칼
쉬테판 뮐러
베른트 데포츠올리
Original Assignee
스타르크, 카르크
바스프 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스타르크, 카르크, 바스프 악티엔게젤샤프트 filed Critical 스타르크, 카르크
Publication of KR970703303A publication Critical patent/KR970703303A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

하기 화학식(I)의 N-보호된 N-알킬화 아미노산의 제조 방법이 개시되어 있으며, 식 중 성분들의 의미는 명세서에 기재되어 있다. 이 방법에서, 화학식(II)의 화합물의 비양성자성 유기 용매 중 포타슘 tert-부탄올레이트의 용액을 첨가하고, 이어서 C1-2-알킬 할라이드를 첨가한다.

Description

N-Z-보호된 N-알킬화 아미노산의 제조 방법(Process for Producing N-Z Protected N-Alkylated Amino Acids)
[도면의 간단한 설명]
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 화학식(II)의 화합물을 비양성자성 유기 용매 중에서 포타슘 tert-부탄올레이트의 용액과 혼합하고, 이어서 C1-2-알킬 할라이드를 첨가하는 것으로 이루어지는 하기 화학식(I)의 N-보호된 N-알킬화 아미노산의 제조 방법.
    식 중, Rs는 펩티드 합성에서의 통상적인 보호기이고, R1은 단백질 생성 아미노산의 측쇄 또는 그의 유도체이며, R2는 수소, 알킬, 알케닐, 알키닐, 아릴 또는 헤타릴이고, R3은 C1-2-알킬이다.
  2. 제1항에 있어서, 포타슘 tert-부탄올레이트를 염기로서 사용하고, 메틸 요오다이드 또는 브로마이드를 알킬화제로서 사용하는 방법.
  3. 제1 또는 2항에 있어서, RS가 치환된 카르보벤즈옥시 라디칼인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960706542A 1994-05-19 1995-05-09 N-Z-보호된 N-알킬화 아미노산의 제조 방법(Process for Producing N-Z Protected N-Alkylated Amino Acids) KR970703303A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4417478A DE4417478A1 (de) 1994-05-19 1994-05-19 Verfahren zur Herstellung N-Z-geschützter N-methylierter Aminosäuren
DEP4417478.0 1994-05-19
PCT/EP1995/001752 WO1995032180A1 (de) 1994-05-19 1995-05-09 Verfahren zur herstellung n-z-geschützter n-alkylierter aminosäuren

Publications (1)

Publication Number Publication Date
KR970703303A true KR970703303A (ko) 1997-07-03

Family

ID=6518436

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960706542A KR970703303A (ko) 1994-05-19 1995-05-09 N-Z-보호된 N-알킬화 아미노산의 제조 방법(Process for Producing N-Z Protected N-Alkylated Amino Acids)

Country Status (14)

Country Link
US (1) US6218572B1 (ko)
EP (1) EP0759901B1 (ko)
JP (1) JPH10500416A (ko)
KR (1) KR970703303A (ko)
AT (1) ATE183994T1 (ko)
AU (1) AU2562695A (ko)
CA (1) CA2190656A1 (ko)
DE (2) DE4417478A1 (ko)
DK (1) DK0759901T3 (ko)
ES (1) ES2136856T3 (ko)
FI (1) FI964607A (ko)
GR (1) GR3031456T3 (ko)
HU (1) HU221596B (ko)
WO (1) WO1995032180A1 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2043038A1 (en) 2007-05-08 2009-04-01 Ruben Pais Method and instruments for sale of personal care products

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1108125A (en) 1977-12-23 1981-09-01 Frank R. Atherton Olgiopeptide derivatives of phosphonic acid
AU4665289A (en) * 1988-12-22 1990-07-10 Upjohn Company, The N-alkylation of n-alpha-boc-protected amino acids
DE4337331A1 (de) * 1993-11-02 1995-05-04 Basf Ag Verfahren zur Herstellung N-geschützter N-alkylierter Aminosäuren

Also Published As

Publication number Publication date
WO1995032180A1 (de) 1995-11-30
GR3031456T3 (en) 2000-01-31
AU2562695A (en) 1995-12-18
DK0759901T3 (da) 1999-12-13
ES2136856T3 (es) 1999-12-01
JPH10500416A (ja) 1998-01-13
US6218572B1 (en) 2001-04-17
MX9605640A (es) 1998-03-31
HUT75707A (en) 1997-05-28
DE4417478A1 (de) 1995-11-23
ATE183994T1 (de) 1999-09-15
FI964607A0 (fi) 1996-11-18
FI964607A (fi) 1997-01-16
DE59506734D1 (de) 1999-10-07
EP0759901A1 (de) 1997-03-05
CA2190656A1 (en) 1995-11-30
EP0759901B1 (de) 1999-09-01
HU9603189D0 (en) 1997-01-28
HU221596B (hu) 2002-11-28

Similar Documents

Publication Publication Date Title
KR920004338A (ko) 치환된 발린아미드 유도체
KR860003210A (ko) 알킬설폰 아미도 페닐알킬 아민의 제조 방법
KR840006978A (ko) 1,4-벤조디아제핀 유도체의 제조방법
KR870007163A (ko) 질소함유 융합 헤테로 사이클릭 화합물의 제조방법
ES2098735T3 (es) N-acilacion selectiva de amino-alcoholes.
KR880001282A (ko) 옥사자포스포린 용액 및 이의 제조방법
KR920008018A (ko) 피페라진 유도체의 제조방법
MY109628A (en) An improved proces for the preparation of substituted indoline derivatives
KR970703303A (ko) N-Z-보호된 N-알킬화 아미노산의 제조 방법(Process for Producing N-Z Protected N-Alkylated Amino Acids)
KR840006206A (ko) 이소퀴놀린 유도체의 제조방법
KR870004027A (ko) 디하이드로리제르그산의 n-알킬화 방법
KR870000296A (ko) 신규한 이사틴 화합물의 제조방법
DE59712632D1 (de) Verfahren zur herstellung von 3-pyrrolin-2-carbonsäure-derivaten
KR850004460A (ko) 인돌의 제조방법
KR850001194A (ko) 화합물
KR960703109A (ko) N-보호된 N-알킬 아미노산의 제조 방법(Process for Producing N-Protected N-Alkylated Amino Acids)
KR850006180A (ko) 디아미노피리딘의 제조방법
KR850003388A (ko) 벤조일우레아 유도체의 제조방법
KR840006012A (ko) 포스페이트 유도체의 제조방법
JPS5585551A (en) New tricycloundecane amino acid amide
KR910011861A (ko) 신규한 2-(티아졸-4-일)티아졸로 [3,2-a)]벤즈이미다졸 유도체
KR840001123A (ko) 불소화된 디아미노알켄 유도체의 제조방법
KR840009080A (ko) 트리클로로아크릴로일우레아 유도체의 제조방법
KR900016195A (ko) 이미다졸 유도체의 제조방법
KR880001619A (ko) N₁-치환된 1h-벤조트리아졸 하이드록시에틸 설폰 화합물, 이의 제조방법 및 염료의 제조를 위한 이의 용도

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application