KR970703137A - 배뇨장해 치료용 경피투여제제(percutaneously administrable preparation for treating urination disorder) - Google Patents

배뇨장해 치료용 경피투여제제(percutaneously administrable preparation for treating urination disorder) Download PDF

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Publication number
KR970703137A
KR970703137A KR1019960706510A KR19960706510A KR970703137A KR 970703137 A KR970703137 A KR 970703137A KR 1019960706510 A KR1019960706510 A KR 1019960706510A KR 19960706510 A KR19960706510 A KR 19960706510A KR 970703137 A KR970703137 A KR 970703137A
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South Korea
Prior art keywords
molecular weight
drug
transdermal
urination
agent
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KR1019960706510A
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English (en)
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가츠히로 나카무라
노부유키 고가
Original Assignee
나카토미 히로타카
히사미츠 세이야쿠 가부시키가이샤
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Publication of KR970703137A publication Critical patent/KR970703137A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

배뇨장해치료약을 저분자량 폴리이소부틸렌, 고분자량 폴리이소부틸렌 및 유지를 주기제로 함유하는 점착제 중에 함유시켜서 구성되는 배뇨장해치료용 경피투여제제이다. 또, 배뇨장해 치료약은 저분자량 폴리이소부틸렌, 고분자량 폴리이소부틸렌, 유지 및 스티렌이소프렌스티렌블록 공중합체를 주기제로 함유하는 점착제중에 함유시켜서 구성되는 배뇨장해치료용 경피투여제제이다. 본 발명의 배뇨장해치료용 경피투여제제는 이와 같은 특정 기제성분을 사용함으로써 경시적 안정성이 우수하고, 피부에 대해여 저자극성이고, 게다가 경피흡수성에도 우수하다.

Description

배뇨장해 치료용 경피투여제제(PERCUTANEOUSLY ADMINISTRABLBLE PREPARATION FOR TREATING URINATION DISORDER)
[도면의 간단한 설명]
제1도는 래트에 의한 경피흡수시험결과를 도시한다,
제2도는 사람 피부에 의한 경피흡수시험결과를 도시한다,
제1도 및 제2도에 있어서, ○은 하기의 실시예 1의 제제, ●은 하기 실시예 2의 제제, □은 하기 실시예 3의 제제, ■은 하기 실시예 4의 제제, ◇은 하기 실시예 5의 제제, ×는 하기 실시예 6의 제제,은 하기 실시예 7의 제제, ◆은 하기 비교예 1의 제제, △은 하기 비교예 2의 제제, □은 하기 비교예 3의 제제, |은 하기 비교예 4의 제제,은 하기 비교예 19의 제제,비교예 20의 제제의 결과를 나타낸다.
제3도는 래트에 의한 시스토메트리법에 의한 약효 평가시험 결과를 도시한다.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 배뇨장해 치료약을 저분자량 폴리이소부틸렌, 고분자량 폴리이소부틸렌 및 유지를 주기제로서 함유하는 점착제중에 함유시켜서 구성되는 배뇨장해 치료용 경피투여제제.
  2. 제1항에 있어서, 상기 점착제의 전체중량에 의거하여, 상기 배뇨장해치료약 0.01∼50중량부를 상기 저분자량 폴리이소부틸렌 1∼60중량부, 상기 고분자량 폴리이소부틸렌 0.1∼40중량부 및 상기 유지 10∼60중량부를 주기제로서 함유하는 점착제중에 함유시켜서 구성되는 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  3. 배뇨장해치료약을 저분자량 폴리이소부틸렌, 고분자량 폴리이소부틸렌, 유지 및 스티렌이소프렌스티렌블록 공중합체를 주기제로 함유하는 점착제중에 함유시켜서 구성되는 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  4. 제3항에 있어서, 상기 점착제의 전체중량에 의거하여, 상기 배뇨장해치료약 0.01∼50중량부를 상기 저분자량 폴리이소부틸렌 1∼60중량부, 상기 고분자량 폴리이소부틸렌 0.1∼40중량부, 상기 유지 10∼60중량부 및 상기 스티렌이소프렌스티렌블록 공중합체 5∼50중량부를 주기제로 함유하는 점착제중에 함유시켜서 구성되는 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  5. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 배뇨장해치료약이 요실금치료약, 배뇨곤란치료약, 빈뇨치료약 또는 배뇨통 치료약인 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  6. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 배뇨장해치료약이 요실금치료약인 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  7. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 저분자량 폴리이소부틸렌의 점도평균 분자량이 10,000∼100,000이고, 상기 고분자량 폴리이소부틸렌의 점도평균 분자량이 500,000∼2,500,000인 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  8. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 유지가 점도 5∼100mm2/S의 유동 파라핀, 천연 및 합성 스쿠알렌 및 스쿠알란으로 이루어지는 군에서 선택된 적어도 1종인 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  9. 제l항 내지 제8항 중 어느 한 항에 있어서, 경피흡수촉진제를 더 포함하는 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960706510A 1994-05-18 1995-05-18 배뇨장해 치료용 경피투여제제(percutaneously administrable preparation for treating urination disorder) KR970703137A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP94-128162 1994-05-18
JP12816294 1994-05-18
PCT/JP1995/000946 WO1995031190A1 (fr) 1994-05-18 1995-05-18 Preparation administrable par voie percutanee pour le traitement des troubles de la miction

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KR970703137A true KR970703137A (ko) 1997-07-03

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US (1) US5770221A (ko)
EP (1) EP0760238B1 (ko)
KR (1) KR970703137A (ko)
AU (1) AU2454495A (ko)
DE (1) DE69526437T2 (ko)
DK (1) DK0760238T3 (ko)
ES (1) ES2172584T3 (ko)
WO (1) WO1995031190A1 (ko)

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Publication number Publication date
WO1995031190A1 (fr) 1995-11-23
DE69526437T2 (de) 2002-10-31
EP0760238B1 (en) 2002-04-17
DK0760238T3 (da) 2002-07-22
DE69526437D1 (de) 2002-05-23
AU2454495A (en) 1995-12-05
US5770221A (en) 1998-06-23
ES2172584T3 (es) 2002-10-01
EP0760238A1 (en) 1997-03-05
EP0760238A4 (en) 1998-06-03

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