KR970006296A - 4-메틸-7-히드록시쿠마린의 상업적 제조방법 - Google Patents

4-메틸-7-히드록시쿠마린의 상업적 제조방법 Download PDF

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Publication number
KR970006296A
KR970006296A KR1019950021181A KR19950021181A KR970006296A KR 970006296 A KR970006296 A KR 970006296A KR 1019950021181 A KR1019950021181 A KR 1019950021181A KR 19950021181 A KR19950021181 A KR 19950021181A KR 970006296 A KR970006296 A KR 970006296A
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KR
South Korea
Prior art keywords
formula
hydroxycoumarin
methyl
alkali metal
alkoxide
Prior art date
Application number
KR1019950021181A
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English (en)
Other versions
KR0157368B1 (ko
Inventor
박인수
김윤철
Original Assignee
이웅열
주식회사 코오롱
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 이웅열, 주식회사 코오롱 filed Critical 이웅열
Priority to KR1019950021181A priority Critical patent/KR0157368B1/ko
Publication of KR970006296A publication Critical patent/KR970006296A/ko
Application granted granted Critical
Publication of KR0157368B1 publication Critical patent/KR0157368B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/04—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
    • B01J20/041—Oxides or hydroxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 제소시놀과 알킬(또는 아릴)아세토아세테이트를 반응시켜서 구조식(Ⅰ)의 4-메틸-7-히드록시쿠마린을 제조함에 있어서, 알칼리금속의 알콕사이드촉매존재하에 반응시키고 반응물질을 산성화시켜서 구조식(Ⅰ)의 화합물을 제조하는 방법에 관한 것이며, 본 발명의 방법에 의하여 단시간내에 고순도로 목적화합물을 제조할 수 있다.
상기 식에서 R은 탄소수 1~9의 저급알킬 또는 아릴기이다.

Description

4-메틸-7-히드록시쿠마린의 상업적 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 구조식(Ⅱ)의 레소시놀과 구조식(Ⅲ)의 알킬(또는 아릴)아세토아세테이트를 알칼리금속의 알콕사이드 촉매존재하에 반응시키고 반응물을 산성화하여 얻어진 침전물을 여과하여 구조식(Ⅰ)의 4-메틸-7-히드록시쿠마린을 제조하는 방법.
    상기 식에서 R은 탄소수 1~9의 저급알킬 또는 아릴기이다.
  2. 제1항에 있어서, 알칼리금속의 알콕사이드로 탄소수 1~5의 저급알카놀의 소듐, 칼륨 및 리튬에서 선택된 알칼리금속의 알콕사이드인 방법.
  3. 제1항 또는 제2항에 있어서, 염산 또는 황산으로 산성화하여 구조식(Ⅰ)의 화합물을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950021181A 1995-07-19 1995-07-19 4-메틸-7-히드록시쿠마린의 상업적 제조방법 KR0157368B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950021181A KR0157368B1 (ko) 1995-07-19 1995-07-19 4-메틸-7-히드록시쿠마린의 상업적 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950021181A KR0157368B1 (ko) 1995-07-19 1995-07-19 4-메틸-7-히드록시쿠마린의 상업적 제조방법

Publications (2)

Publication Number Publication Date
KR970006296A true KR970006296A (ko) 1997-02-19
KR0157368B1 KR0157368B1 (ko) 1998-11-16

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ID=19420913

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950021181A KR0157368B1 (ko) 1995-07-19 1995-07-19 4-메틸-7-히드록시쿠마린의 상업적 제조방법

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Publication number Publication date
KR0157368B1 (ko) 1998-11-16

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