KR960700710A - 항종양 조성물 및 치료방법(antitumor compositions and methods of treatment) - Google Patents
항종양 조성물 및 치료방법(antitumor compositions and methods of treatment) Download PDFInfo
- Publication number
- KR960700710A KR960700710A KR1019950703798A KR19950703798A KR960700710A KR 960700710 A KR960700710 A KR 960700710A KR 1019950703798 A KR1019950703798 A KR 1019950703798A KR 19950703798 A KR19950703798 A KR 19950703798A KR 960700710 A KR960700710 A KR 960700710A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- alkyl
- pharmaceutically acceptable
- hydrogen
- nco
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
본 발명은 특정 인돌린설폰아미드 및 치환된-인돌설폰아미드 유도체 및 포유동물에서의 감수성 종양을 치료하는데 이들을 사용하는 방법을 제공한다. 또한 담체, 부형제 또는 희석제와 혼합 형태로 이러한 인돌린설폰아미드 및 치환된-인돌린설폰아미드 유도체를 사용하는 특정 신규한 약학 제형을 제공한다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 하기 일반식의 화합물 또는 그의 약학적으로 허용되는 염 또는 용매화물 :R1은 C1-C6알킬이며; R2및 R3는 수소, 할로, C1-C6알킬, 및 트리플루오로메틸로 이루어진 그룹중에서 독립적으로 선택되나, 단 R2및 R3중 하나만이 수소일 수 있다.
- 제1항에 있어서, 상기 A가화합물.
- 제2항에 있어서, N-[[3,4-디클로로페닐)아미노]카보닐]-1-메틸-1H-인돌-5-설폰아미드 또는 그의 약학적으로 허용되는 염 또는 용매화물인 화합물.
- 제1항에 있어서, 상기 A가화합물.
- 제4항에 있어서, N-[[3,4-디클로로페닐)아미노]카보닐]-2,3-디하이드로-1H-인돌-5-설폰아미드, N-[[4-클로로페닐)아미노]카보닐]-2,3-디하이드로-1H-인돌-5-설폰아미드 또는 그의 약학적으로 허용되는 염 또는 용매화물인 화합물.
- 활성 성분으로서 제1 내지 제5항중 어느 한항에 청구된 화합물 또는 그의 약학적으로 허용되는 염 또는 용매화물을 이를 위한 하나 이상의 약학적으로 허용되는 담체, 희석제 또는 부형제와 함께 포함하는 약학 제형.
- 항암제로서 사용하기 위한 제1 내지 제5항중 어느 한항에 청구된 화합물 또는 그의 약학적으로 허용되는 염 또는 용매화물.
- 하기 일반식(1) 화합물과 하기 일반식(2)의 설포닐 화합물을 반응시킴을 포함하는, 제1 내지 제5항중 어느 한항에 청구된 바와 같은 설포닐우레아의 제조 방법 :R1은 C1-C6알킬이며; R2및 R3는 수소, 할로, C1-C6알킬, 및 트리플루오로메틸로 이루어진 그룹중에서 독립적으로 선택되나, 단 R2및 R3중 하나만이 수소일 수 있고; X는 -NCO, -NH2또는 -NH-COORaC1-C6알킬이다)이나 단, X가 -NCO 또는 -NH-COORa이면, Y는 -NH2이고, X가 -NH2이면 Y는 -NCO이며; Y는 -NH2또는 -NCO이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2909593A | 1993-03-10 | 1993-03-10 | |
US08/029,095 | 1993-03-10 | ||
PCT/US1994/002606 WO1994020101A1 (en) | 1993-03-10 | 1994-03-10 | Antitumor compositions and methods of treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960700710A true KR960700710A (ko) | 1996-02-24 |
Family
ID=21847185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950703798A KR960700710A (ko) | 1993-03-10 | 1994-03-10 | 항종양 조성물 및 치료방법(antitumor compositions and methods of treatment) |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0614887B1 (ko) |
JP (1) | JPH08507532A (ko) |
KR (1) | KR960700710A (ko) |
AT (1) | ATE154345T1 (ko) |
AU (1) | AU687042B2 (ko) |
BR (1) | BR9405997A (ko) |
CA (1) | CA2157801A1 (ko) |
CZ (1) | CZ232695A3 (ko) |
DE (1) | DE69403695T2 (ko) |
DK (1) | DK0614887T3 (ko) |
ES (1) | ES2102774T3 (ko) |
FI (1) | FI954213A (ko) |
GR (1) | GR3023827T3 (ko) |
HU (1) | HU218660B (ko) |
NO (1) | NO953557L (ko) |
NZ (1) | NZ263080A (ko) |
PL (1) | PL310558A1 (ko) |
RU (1) | RU2127259C1 (ko) |
WO (1) | WO1994020101A1 (ko) |
ZA (1) | ZA941500B (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69708340T2 (de) * | 1996-08-22 | 2002-05-16 | Dong Wha Pharm Ind Co Ltd | Arylsulfonylimidazolon-derivate als antitumormittel |
DE19919793A1 (de) | 1999-04-30 | 2000-11-02 | Bayer Ag | Neue Sulfonamide |
US7282595B2 (en) | 2002-11-22 | 2007-10-16 | Eli Lilly And Company | Antitumor benzoylsulfonamides |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1240866B (de) * | 1961-06-29 | 1967-05-24 | Heyden Chem Fab | Verfahren zur Herstellung von Indolin-6-sulfonylharnstoffen |
US5116874A (en) * | 1985-09-23 | 1992-05-26 | Eli Lilly And Company | Anti-tumor method and compounds |
IL80032A (en) * | 1985-09-23 | 1992-07-15 | Lilly Co Eli | Anti-tumor phenyl-aminocarbonylsulfonamides,their preparation and pharmaceutical compositions containing them |
CA1331464C (en) * | 1987-05-12 | 1994-08-16 | Eli Lilly And Company | Anti-tumor method and compounds |
IL98784A0 (en) * | 1990-07-17 | 1992-07-15 | Lilly Co Eli | Heterocyclyl sulfonamide derivatives,process for their preparation and pharmaceutical compositions containing them |
US5169860A (en) * | 1992-03-13 | 1992-12-08 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
-
1994
- 1994-03-03 ZA ZA941500A patent/ZA941500B/xx unknown
- 1994-03-09 EP EP94301671A patent/EP0614887B1/en not_active Expired - Lifetime
- 1994-03-09 DE DE69403695T patent/DE69403695T2/de not_active Expired - Fee Related
- 1994-03-09 ES ES94301671T patent/ES2102774T3/es not_active Expired - Lifetime
- 1994-03-09 AT AT94301671T patent/ATE154345T1/de not_active IP Right Cessation
- 1994-03-09 DK DK94301671.7T patent/DK0614887T3/da active
- 1994-03-10 CZ CZ952326A patent/CZ232695A3/cs unknown
- 1994-03-10 BR BR9405997A patent/BR9405997A/pt not_active Application Discontinuation
- 1994-03-10 WO PCT/US1994/002606 patent/WO1994020101A1/en not_active Application Discontinuation
- 1994-03-10 NZ NZ263080A patent/NZ263080A/en unknown
- 1994-03-10 JP JP6520310A patent/JPH08507532A/ja active Pending
- 1994-03-10 RU RU95122639A patent/RU2127259C1/ru active
- 1994-03-10 KR KR1019950703798A patent/KR960700710A/ko not_active Application Discontinuation
- 1994-03-10 AU AU63638/94A patent/AU687042B2/en not_active Ceased
- 1994-03-10 PL PL94310558A patent/PL310558A1/xx unknown
- 1994-03-10 HU HU9502627A patent/HU218660B/hu not_active IP Right Cessation
- 1994-03-10 CA CA002157801A patent/CA2157801A1/en not_active Abandoned
-
1995
- 1995-09-08 NO NO953557A patent/NO953557L/no unknown
- 1995-09-08 FI FI954213A patent/FI954213A/fi unknown
-
1997
- 1997-06-19 GR GR970401465T patent/GR3023827T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
HUT72897A (en) | 1996-06-28 |
EP0614887A1 (en) | 1994-09-14 |
FI954213A0 (fi) | 1995-09-08 |
CA2157801A1 (en) | 1994-09-15 |
BR9405997A (pt) | 1995-12-19 |
RU2127259C1 (ru) | 1999-03-10 |
PL310558A1 (en) | 1995-12-27 |
FI954213A (fi) | 1995-10-11 |
WO1994020101A1 (en) | 1994-09-15 |
AU687042B2 (en) | 1998-02-19 |
NO953557L (no) | 1995-11-02 |
NO953557D0 (no) | 1995-09-08 |
NZ263080A (en) | 1996-12-20 |
ZA941500B (en) | 1995-09-04 |
ES2102774T3 (es) | 1997-08-01 |
ATE154345T1 (de) | 1997-06-15 |
DE69403695D1 (de) | 1997-07-17 |
JPH08507532A (ja) | 1996-08-13 |
EP0614887B1 (en) | 1997-06-11 |
DK0614887T3 (da) | 1997-10-20 |
HU218660B (hu) | 2000-10-28 |
GR3023827T3 (en) | 1997-09-30 |
DE69403695T2 (de) | 1997-10-30 |
AU6363894A (en) | 1994-09-26 |
CZ232695A3 (en) | 1996-01-17 |
HU9502627D0 (en) | 1995-11-28 |
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