KR960016889A - 뇌기능 개선제 - Google Patents
뇌기능 개선제 Download PDFInfo
- Publication number
- KR960016889A KR960016889A KR1019950039253A KR19950039253A KR960016889A KR 960016889 A KR960016889 A KR 960016889A KR 1019950039253 A KR1019950039253 A KR 1019950039253A KR 19950039253 A KR19950039253 A KR 19950039253A KR 960016889 A KR960016889 A KR 960016889A
- Authority
- KR
- South Korea
- Prior art keywords
- lecithin
- celine
- fatty acid
- phosphatidyl
- acid ring
- Prior art date
Links
- 230000003925 brain function Effects 0.000 title claims abstract 6
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract 11
- 229940067606 lecithin Drugs 0.000 claims abstract 11
- 235000010445 lecithin Nutrition 0.000 claims abstract 11
- 239000000787 lecithin Substances 0.000 claims abstract 11
- 239000000470 constituent Substances 0.000 claims abstract 7
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 claims abstract 5
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims abstract 5
- 239000004480 active ingredient Substances 0.000 claims abstract 5
- 239000002994 raw material Substances 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 239000003795 chemical substances by application Substances 0.000 claims abstract 3
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims abstract 2
- 239000008347 soybean phospholipid Substances 0.000 claims abstract 2
- 150000004665 fatty acids Chemical class 0.000 claims 8
- 240000002791 Brassica napus Species 0.000 claims 4
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims 3
- 125000005471 saturated fatty acid group Chemical group 0.000 claims 3
- 229940083466 soybean lecithin Drugs 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 210000004556 brain Anatomy 0.000 abstract 2
- 125000005313 fatty acid group Chemical group 0.000 abstract 2
- 244000188595 Brassica sinapistrum Species 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 125000001095 phosphatidyl group Chemical group 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000006276 transfer reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
뇌내글루코오스의 농도를 증가시키는 현저한 작용을 나타내고, 그 투여를 받은 피검체의 뇌기능을 개선하는 효과를 가지는 뇌기능 개선제, 포스타티딜-L-셀린 또는 그 α위치 또는 β위치의 지방산고리를 절재해서 얻어지는 리소포스파티딜-L-셀린, 혹은 그들의 염을 유효성분으로서 함유한다.
이 포스타티딜-L-셀린은, 대두레시틴, 채종레시틴, 및 난황레시틴으로 이루어지는 군에서 선발된 적어도 1종의 원료레시틴에 유래하는 구성지방산고리를 보유한다.
포스타티딜-L-셀린은, 원료레시틴을 기질에 사용하여 포스파티딜기 전이반응을 이용해 제조된다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 포스타티딜-L-셀린 또는 그 염을 유효성분에 함유하고, 상기한 포스파티딜-L-셀린은, 대두레시틴, 채종레시틴 및 난황레시틴으로 이루어지는 군에서 선발된 적어도 1종의 원료레시틴에 유래하는 구성지방산고리를 가지고 있는 것을 특징으로 하는 뇌기능 개선제.
- 포스타티딜-L-셀린 또는 그 염을 유효성분에 함유하고, 상기한 포스파티딜-L-셀린은, 대두레시틴, 채종레시틴 및 난황레시틴으로 이루어지는 군에서 선발된 적어도 1종의 원료레시틴에 유래하는 구성지방산고리를 보유하고, 이 구성지방산고리는 수소첨가처리된 포화지방산고리인 것을 특징으로 하는 뇌기능 개선제.
- 리소포스파타딜-L-셀린 또는 그 염을 유효성분에 함유하고, 상기한 리소포스파타딜-L-셀린은, α위치 또는 β위치의 지방산고리가 절제된 포스파티딜-L-셀린으로 이루어지고, 상기한 포스파티딜-L-셀린 은 대두레시틴, 채종레시틴 및 난황레시틴으로 이루어지는 군에서 선발된 적어도 1종의 원료레시틴에 유래하는 구성지방산고리를 가지고 있는 것을 특징으로 하는 뇌기능 개선제.
- 리소포스파타딜-L-셀린 또는 그 염을 유효성분에 함유하고, 상기한 리소포스파타딜-L-셀린은, α위치 또는 β위치의 지방산고리가 절제된 포스파티딜-L-셀린으로 부터 나고, 상기 포스파티딜-L-셀린은 대두레시틴, 채종레시틴 및 난황레시틴으로 이루어지는 군에서 선발된 적어도 1종의 원료레시틴에 유래하는 구성지방산고리를 보유하고, 이 구성지방산고리를 수소첨가처리된 포화지방산고리인 것을 특징으로 하는 뇌기능 개선제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6297998A JP3053537B2 (ja) | 1994-11-08 | 1994-11-08 | 脳機能改善剤 |
JP94-297998 | 1994-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960016889A true KR960016889A (ko) | 1996-06-17 |
Family
ID=17853809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950039253A KR960016889A (ko) | 1994-11-08 | 1995-11-01 | 뇌기능 개선제 |
Country Status (7)
Country | Link |
---|---|
US (2) | US5900409A (ko) |
EP (1) | EP0711559B1 (ko) |
JP (1) | JP3053537B2 (ko) |
KR (1) | KR960016889A (ko) |
CA (1) | CA2162232C (ko) |
DE (1) | DE69534002T2 (ko) |
ES (1) | ES2237756T3 (ko) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7226916B1 (en) | 2000-05-08 | 2007-06-05 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
JP4298902B2 (ja) | 2000-08-09 | 2009-07-22 | 株式会社ヤクルト本社 | リン脂質の製造法 |
US6733797B1 (en) | 2000-11-15 | 2004-05-11 | William K. Summers | Neuroceutical for improving memory and cognitive abilities |
US6896776B2 (en) | 2000-12-18 | 2005-05-24 | Applied Materials Inc. | Method and apparatus for electro-chemical processing |
US6635456B2 (en) | 2001-02-09 | 2003-10-21 | Fidia Farmaceutici S.P.A. | Procedure for the preparation of pure phosphatides with phospholipase D |
US7160432B2 (en) * | 2001-03-14 | 2007-01-09 | Applied Materials, Inc. | Method and composition for polishing a substrate |
US6899804B2 (en) | 2001-12-21 | 2005-05-31 | Applied Materials, Inc. | Electrolyte composition and treatment for electrolytic chemical mechanical polishing |
US7232514B2 (en) * | 2001-03-14 | 2007-06-19 | Applied Materials, Inc. | Method and composition for polishing a substrate |
US7323416B2 (en) | 2001-03-14 | 2008-01-29 | Applied Materials, Inc. | Method and composition for polishing a substrate |
US7128825B2 (en) | 2001-03-14 | 2006-10-31 | Applied Materials, Inc. | Method and composition for polishing a substrate |
US6811680B2 (en) | 2001-03-14 | 2004-11-02 | Applied Materials Inc. | Planarization of substrates using electrochemical mechanical polishing |
US7582564B2 (en) | 2001-03-14 | 2009-09-01 | Applied Materials, Inc. | Process and composition for conductive material removal by electrochemical mechanical polishing |
ES2227479T3 (es) * | 2001-03-26 | 2005-04-01 | Giventis Gmbh | Alimento destinado a aumentar la capacidad cognitiva. |
WO2003003981A2 (en) * | 2001-07-05 | 2003-01-16 | Vital Basics, Inc. | Compositions for improving mental performance |
CN1625406A (zh) * | 2001-08-09 | 2005-06-08 | 底古萨食品配料有限公司 | 用于预防和治疗温血动物的应激状态的含有溶血磷脂酰丝氨酸的制剂 |
IL150240A (en) * | 2002-06-16 | 2005-07-25 | Lipogen Ltd | Infant formula supplemented with phospholipids |
US20050129738A1 (en) * | 2002-06-16 | 2005-06-16 | Lipogen Ltd. | Infant formula supplemented with phospholipids |
US6878532B1 (en) | 2003-04-28 | 2005-04-12 | Sioux Biochemical, Inc. | Method of producing phosphatidylserine |
US7390429B2 (en) | 2003-06-06 | 2008-06-24 | Applied Materials, Inc. | Method and composition for electrochemical mechanical polishing processing |
DE10340740A1 (de) * | 2003-09-04 | 2005-03-31 | Degussa Food Ingredients Gmbh | Physiologisch aktive Zusammensetzung auf Phosphatidylserin-Basis |
US7935365B2 (en) * | 2003-10-22 | 2011-05-03 | Enzymotec, Ltd. | Glycerophospholipids for the improvement of cognitive functions |
US7390744B2 (en) | 2004-01-29 | 2008-06-24 | Applied Materials, Inc. | Method and composition for polishing a substrate |
DE102005003865A1 (de) * | 2005-01-27 | 2007-05-10 | Bioghurt Biogarde Gmbh & Co. Kg | Phosphatidylserin-basierte Zusammensetzung zur Steigerung der Gehirnfunktion |
ITPD20050164A1 (it) | 2005-05-30 | 2006-11-30 | Fidia Farmaceutici | Processo per la preparazione e l'isolamento di fosfatidi |
US20070151866A1 (en) * | 2006-01-05 | 2007-07-05 | Applied Materials, Inc. | Substrate polishing with surface pretreatment |
JP6831558B2 (ja) * | 2016-08-23 | 2021-02-17 | 株式会社Hbcフナト | 脳機能改善組成物 |
CN112566633A (zh) * | 2018-06-08 | 2021-03-26 | 民族医学研究所 | 增强中枢神经系统中葡萄糖水平的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4385053A (en) * | 1981-03-11 | 1983-05-24 | Barry Reisberg | Treatment for human memory impairment associated with aging |
JPS63245684A (ja) | 1987-03-31 | 1988-10-12 | Japanese Res & Dev Assoc Bio Reactor Syst Food Ind | ホスフアチジン酸誘導体の製造法 |
JPS63245685A (ja) * | 1987-03-31 | 1988-10-12 | Japanese Res & Dev Assoc Bio Reactor Syst Food Ind | リン脂質にホスホリパーゼを作用させる方法 |
JPH01135720A (ja) * | 1987-11-20 | 1989-05-29 | Eisai Co Ltd | 神経線維再生剤 |
US5001117A (en) * | 1989-03-07 | 1991-03-19 | Pharmacaps, Inc. | Use of lecithin to restore olfaction and taste |
IT1230140B (it) * | 1989-05-03 | 1991-10-14 | Fidia Spa | Derivati della serina, loro processo di preparazione e impiego in terapia umana |
DE4117629A1 (de) * | 1991-05-29 | 1992-12-03 | Max Planck Gesellschaft | Phospatidylserine |
JPH0717855A (ja) * | 1992-09-02 | 1995-01-20 | Maruha Corp | 脳機能改善組成物、学習能力増強剤、記憶力増強剤、痴呆予防剤、痴呆治療剤、または脳機能改善効果を有する機能性食品 |
JP3467794B2 (ja) * | 1993-03-09 | 2003-11-17 | 日本油脂株式会社 | 学習能向上剤 |
JPH06279311A (ja) * | 1993-03-26 | 1994-10-04 | Sagami Chem Res Center | プロテインキナーゼcアイソザイムの活性化剤 |
JP3194652B2 (ja) * | 1993-07-23 | 2001-07-30 | 東芝キヤリア株式会社 | 空気調和機 |
-
1994
- 1994-11-08 JP JP6297998A patent/JP3053537B2/ja not_active Expired - Lifetime
-
1995
- 1995-11-01 KR KR1019950039253A patent/KR960016889A/ko not_active IP Right Cessation
- 1995-11-02 US US08/556,862 patent/US5900409A/en not_active Expired - Lifetime
- 1995-11-06 CA CA002162232A patent/CA2162232C/en not_active Expired - Lifetime
- 1995-11-07 EP EP95402484A patent/EP0711559B1/en not_active Expired - Lifetime
- 1995-11-07 ES ES95402484T patent/ES2237756T3/es not_active Expired - Lifetime
- 1995-11-07 DE DE69534002T patent/DE69534002T2/de not_active Expired - Lifetime
-
1999
- 1999-01-12 US US09/228,938 patent/US6117853A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0711559A2 (en) | 1996-05-15 |
US5900409A (en) | 1999-05-04 |
DE69534002D1 (de) | 2005-03-17 |
US6117853A (en) | 2000-09-12 |
JPH08133984A (ja) | 1996-05-28 |
DE69534002T2 (de) | 2006-01-12 |
ES2237756T3 (es) | 2005-08-01 |
EP0711559B1 (en) | 2005-02-09 |
JP3053537B2 (ja) | 2000-06-19 |
EP0711559A3 (en) | 1997-01-15 |
CA2162232C (en) | 2007-05-22 |
CA2162232A1 (en) | 1996-05-09 |
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