KR950703335A - 항시토메갈로비루스제로서의 폴리아민 유도체(Polyamine Derivatives as Anti-Cytomegaloviral Agents) - Google Patents
항시토메갈로비루스제로서의 폴리아민 유도체(Polyamine Derivatives as Anti-Cytomegaloviral Agents) Download PDFInfo
- Publication number
- KR950703335A KR950703335A KR1019950701292A KR19950701292A KR950703335A KR 950703335 A KR950703335 A KR 950703335A KR 1019950701292 A KR1019950701292 A KR 1019950701292A KR 19950701292 A KR19950701292 A KR 19950701292A KR 950703335 A KR950703335 A KR 950703335A
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- KR
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- Prior art keywords
- compound
- bis
- ethylamino
- propyl
- phenyl
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
본 발명은 하기식(Ⅰ)의 폴리아민 화합물로 CMV 감염을 치료하는 거세 관한 것이다.
상기 식에서, Z1은 포화 또는 분지쇄(C2-C6) 알킬렌 잔기이고, m은 7또는 8이며, R기는 각각 독립적으로 수소, C1-C6포화 또는 블록화 히드로카 빌, 또는 -(CH2)x-(Ar)-X[여기서, Ar는 페닐 도는 나프틸이고, X는 H, C1-C6알콕시, 할로겐, C1-C4알킬이며, x는 정수 0, 1 또는 2임]이고, 단 R기는 둘다 수소일 수 없다. 식(Ⅰ)의 화합물의 그의 약제학적으로 허용 가능한 산부가염일 수 있다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 항비루스 유효량의 하기식의 화합물 또는 그의 약제학적으로 허용 가능한 산부가염을 시토메갈로비루스 감염 억제를 필요로 하는 환자에게 투여하는 것으로 이루어지는 시토메갈로비루스 감염의 억제방법.상기 식에서 Z1은 분지쇄(C2-C6)알킬렌 잔기이고, m은 7 또는 8이며, R기는 각각 독립적으로 수소, C1-C6포화 또는 불포화 히드로카르빌, 또는 -(CH2)x-(Ar)-X[여기서, Ar는 페닐 또는 나프틸이고, X는 H, C1-C6알킬이며, x는 정수 0, 1 또는 2임]이고, 단, R기는 둘다 수소일 수 없다.
- 제1항에 있어서, N,N1-비스(3-(에틸아미노)프로필)-1,8-옥탄디민인 화합물.
- 제1항에 있어서, 1,18-비스[(페닐)메틸]1,5,14,18-테트라아자옥타데칸인 화합물.
- 제6항에 있어서, N,N1-비스(3-(에틸아미노)프로필)-1,7-헵탄디아민인 화합물.
- 제6항에 있어서, N,N1-비스[3-(에틸아미노)프로필]-1,7-디아미노헵탄인 화합물.
- 제4항에 있어서, 부가 성분으로써 유효량이 폴리아민 옥시다제 억제제를 추가로 함유하는 약제학적 조성물.
- 치료유효량의 하기식의 화합물 또는 그의 약제학적으로 허용 가능한 산부가염을 CMV 질환 치료를 필요로 하는 환자에게 투여하는 것으로 이루어지는 CMV 질병 상태로 고생하는 환자의 치료방법.상기 식에서 Z2은 포화쇄(C2-C6)알킬렌 잔기이고, m은 7 또는 8이며, R기는 각각 독립적으로 수소, C1-C6포화 또는 불포화 히드로카르빌, 또는 -(CH2)x-(Ar)-X[여기서, Ar는 페닐 또는 나프틸이고, X는 H, C1-C6알콕시, 할로겐, C1-C4알킬이며, x는 정수 0, 1 또는 2임]이고, 단, R기는 둘다 수소일 수 없다.
- 제1항에 있어서, N,N1-비스(3-(에틸아미노)프로필)-1,8-옥탄디아민인 화합물.
- 제1항에 있어서, 1,18-비스[(페닐)메틸]1,5,14,18-테트라아자옥타데칸인 화합물.
- 제6항에 있어서, N,N1-비스(3-(에틸아미노)프로필)-1,7-헵탄디아민인 화합물.
- 제6항에 있어서, N,N1-비스[3-(에틸아미노)프로필]-1,7-디아미노헵탄인 화합물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929220921A GB9220921D0 (en) | 1992-10-05 | 1992-10-05 | Polyamine derivatives as anticytomegaloviral agents |
GB9220921.2 | 1992-10-05 | ||
PCT/US1993/008517 WO1994007480A1 (en) | 1992-10-05 | 1993-09-10 | Polyamine derivatives as anti-cytomegaloviral agents |
Publications (1)
Publication Number | Publication Date |
---|---|
KR950703335A true KR950703335A (ko) | 1995-09-20 |
Family
ID=10722983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950701292A KR950703335A (ko) | 1992-10-05 | 1993-09-10 | 항시토메갈로비루스제로서의 폴리아민 유도체(Polyamine Derivatives as Anti-Cytomegaloviral Agents) |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0662829A1 (ko) |
JP (1) | JPH08512279A (ko) |
KR (1) | KR950703335A (ko) |
AU (1) | AU4854793A (ko) |
CA (1) | CA2146319A1 (ko) |
GB (1) | GB9220921D0 (ko) |
HU (1) | HUT72663A (ko) |
NZ (1) | NZ256254A (ko) |
WO (1) | WO1994007480A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5831001A (en) * | 1990-10-24 | 1998-11-03 | Allelix Biopharmaceuticals Inc. | Treatment of herpesvirus infection |
WO1995009832A1 (en) * | 1993-10-07 | 1995-04-13 | Merrell Dow Pharmaceuticals Inc. | Novel process for preparing polyamine derivatives and intermediates thereof |
FR2749845B1 (fr) * | 1996-06-18 | 1998-08-21 | Oreal | Nouveaux derives benzyl substitue(s) de polyalkylene-polyamines et leur utilisation dans des compositions cosmetiques et pharmaceutiques |
US7045550B2 (en) | 2001-08-07 | 2006-05-16 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
CA2463771A1 (en) | 2001-10-16 | 2003-04-24 | Slil Biomedical Corporation | Oligoamine compounds and derivatives thereof for cancer therapy |
WO2019152373A1 (en) * | 2018-01-30 | 2019-08-08 | Sun Biopharma, Inc. | Methods for producing (6s,15s)-3,8,13,18-tetraazaicosane-6,15-diol |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU628174B2 (en) * | 1989-05-23 | 1992-09-10 | Merrell Dow Pharmaceuticals Inc. | A method of potentiating cell-mediated immunity utilizing polyamine derivatives |
-
1992
- 1992-10-05 GB GB929220921A patent/GB9220921D0/en active Pending
-
1993
- 1993-09-10 EP EP93921461A patent/EP0662829A1/en not_active Ceased
- 1993-09-10 HU HU9500982A patent/HUT72663A/hu unknown
- 1993-09-10 WO PCT/US1993/008517 patent/WO1994007480A1/en not_active Application Discontinuation
- 1993-09-10 CA CA002146319A patent/CA2146319A1/en not_active Abandoned
- 1993-09-10 JP JP6509077A patent/JPH08512279A/ja active Pending
- 1993-09-10 KR KR1019950701292A patent/KR950703335A/ko not_active Application Discontinuation
- 1993-09-10 NZ NZ256254A patent/NZ256254A/en unknown
- 1993-09-10 AU AU48547/93A patent/AU4854793A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0662829A1 (en) | 1995-07-19 |
AU4854793A (en) | 1994-04-26 |
HU9500982D0 (en) | 1995-06-28 |
CA2146319A1 (en) | 1994-04-14 |
JPH08512279A (ja) | 1996-12-24 |
NZ256254A (en) | 1997-04-24 |
GB9220921D0 (en) | 1992-11-18 |
HUT72663A (en) | 1996-05-28 |
WO1994007480A1 (en) | 1994-04-14 |
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