KR950701219A - 치환된 인돌리지노[1,2-b]퀴놀리논(SUBSTITUTED INDOLIZINO [1,2-b]QUINOLINONES) - Google Patents
치환된 인돌리지노[1,2-b]퀴놀리논(SUBSTITUTED INDOLIZINO [1,2-b]QUINOLINONES)Info
- Publication number
- KR950701219A KR950701219A KR1019940703719A KR19940703719A KR950701219A KR 950701219 A KR950701219 A KR 950701219A KR 1019940703719 A KR1019940703719 A KR 1019940703719A KR 19940703719 A KR19940703719 A KR 19940703719A KR 950701219 A KR950701219 A KR 950701219A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- oxy
- propyl
- lower alkyl
- nch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title abstract 2
- 229930185107 quinolinone Natural products 0.000 title 2
- 238000000034 method Methods 0.000 claims abstract 29
- 208000036142 Viral infection Diseases 0.000 claims abstract 4
- 230000009385 viral infection Effects 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims 65
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 11
- -1 2-pyrrolidinylcarbonyl Chemical group 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical group CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 claims 3
- NZNUDBVXWDYNEN-UHFFFAOYSA-N 1-(12-cyano-8-methyl-9-oxo-11h-indolizino[1,2-b]quinolin-7-yl)propyl 2-aminoacetate Chemical compound C1=CC=C2C(C#N)=C(CN3C4=CC(=C(C3=O)C)C(OC(=O)CN)CC)C4=NC2=C1 NZNUDBVXWDYNEN-UHFFFAOYSA-N 0.000 claims 2
- RVWPSIYNXOHDGG-UHFFFAOYSA-N 1-(2-cyano-8-methyl-9-oxo-11h-indolizino[1,2-b]quinolin-7-yl)propyl 2-aminoacetate Chemical compound C1=C(C#N)C=C2C=C(CN3C4=CC(=C(C3=O)C)C(OC(=O)CN)CC)C4=NC2=C1 RVWPSIYNXOHDGG-UHFFFAOYSA-N 0.000 claims 2
- CYLKLPDYCVLODG-UHFFFAOYSA-N 1-(8-methyl-9-oxo-11h-indolizino[1,2-b]quinolin-7-yl)propyl 2-aminoacetate Chemical compound C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)C(OC(=O)CN)CC)C4=NC2=C1 CYLKLPDYCVLODG-UHFFFAOYSA-N 0.000 claims 2
- LEVQPAPUQREIEZ-UHFFFAOYSA-N 1-(8-methyl-9-oxo-11h-indolizino[1,2-b]quinolin-7-yl)propyl 2-morpholin-4-ylacetate Chemical compound C1=C2C3=NC4=CC=CC=C4C=C3CN2C(=O)C(C)=C1C(CC)OC(=O)CN1CCOCC1 LEVQPAPUQREIEZ-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- DXASQZJWWGZNSF-UHFFFAOYSA-N n,n-dimethylmethanamine;sulfur trioxide Chemical group CN(C)C.O=S(=O)=O DXASQZJWWGZNSF-UHFFFAOYSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- PABQHVNMQAWSRO-UHFFFAOYSA-N 1-(8-methyl-9-oxo-11h-indolizino[1,2-b]quinolin-7-yl)propyl 3-aminopropanoate Chemical compound C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)C(OC(=O)CCN)CC)C4=NC2=C1 PABQHVNMQAWSRO-UHFFFAOYSA-N 0.000 claims 1
- YJSPDKPPDSKBQZ-UHFFFAOYSA-N 11h-indolizino[1,2-b]quinolin-9-one Chemical compound C1=CC=C2C=C(CN3C(=O)C=CC=C33)C3=NC2=C1 YJSPDKPPDSKBQZ-UHFFFAOYSA-N 0.000 claims 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 150000003018 phosphorus compounds Chemical group 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87064992A | 1992-04-17 | 1992-04-17 | |
| US7/870,649 | 1992-04-17 | ||
| PCT/US1993/003596 WO1993020818A1 (en) | 1990-10-31 | 1993-04-15 | SUBSTITUTED INDOLIZINO[1,2-b]QUINOLINONES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950701219A true KR950701219A (ko) | 1995-03-23 |
Family
ID=25355849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940703719A Withdrawn KR950701219A (ko) | 1992-04-17 | 1993-04-15 | 치환된 인돌리지노[1,2-b]퀴놀리논(SUBSTITUTED INDOLIZINO [1,2-b]QUINOLINONES) |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0637960A4 (enrdf_load_stackoverflow) |
| JP (1) | JPH07506099A (enrdf_load_stackoverflow) |
| KR (1) | KR950701219A (enrdf_load_stackoverflow) |
| CN (1) | CN1083064A (enrdf_load_stackoverflow) |
| AU (1) | AU4288893A (enrdf_load_stackoverflow) |
| CA (1) | CA2118324A1 (enrdf_load_stackoverflow) |
| TW (1) | TW264471B (enrdf_load_stackoverflow) |
| ZA (1) | ZA932721B (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102093358B (zh) * | 2011-02-21 | 2012-09-05 | 中山大学 | 溴代中氮茚并喹啉二酮类衍生物及其在制备抗菌药物中的应用 |
| CN104398514B (zh) * | 2014-10-28 | 2017-04-19 | 中山大学 | 氯喹在制备抗疱疹病毒药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422344A (en) * | 1990-05-08 | 1995-06-06 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Method of treating retroviral infections in mammals |
| US5155225A (en) * | 1990-09-28 | 1992-10-13 | Smithkline Beecham Corporation | Method for making certain pyrano[3',4':6,7]indolizino-[1,2-B]quinolinones |
| AU8940491A (en) * | 1990-10-31 | 1992-05-26 | Smithkline Beecham Corporation | Substituted indolizino(1,2-b)quinolinones |
-
1993
- 1993-04-15 CA CA002118324A patent/CA2118324A1/en not_active Abandoned
- 1993-04-15 EP EP93912281A patent/EP0637960A4/en not_active Withdrawn
- 1993-04-15 KR KR1019940703719A patent/KR950701219A/ko not_active Withdrawn
- 1993-04-15 JP JP5518629A patent/JPH07506099A/ja active Pending
- 1993-04-15 AU AU42888/93A patent/AU4288893A/en not_active Abandoned
- 1993-04-17 CN CN93105930A patent/CN1083064A/zh active Pending
- 1993-04-19 ZA ZA932721A patent/ZA932721B/xx unknown
- 1993-05-29 TW TW082104275A patent/TW264471B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2118324A1 (en) | 1993-10-28 |
| CN1083064A (zh) | 1994-03-02 |
| AU4288893A (en) | 1993-11-18 |
| ZA932721B (en) | 1993-11-29 |
| TW264471B (enrdf_load_stackoverflow) | 1995-12-01 |
| EP0637960A1 (en) | 1995-02-15 |
| EP0637960A4 (en) | 1995-06-07 |
| JPH07506099A (ja) | 1995-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 19941017 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |