KR950032254A - 당지질 동족체 - Google Patents

당지질 동족체 Download PDF

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Publication number
KR950032254A
KR950032254A KR1019950014691A KR19950014691A KR950032254A KR 950032254 A KR950032254 A KR 950032254A KR 1019950014691 A KR1019950014691 A KR 1019950014691A KR 19950014691 A KR19950014691 A KR 19950014691A KR 950032254 A KR950032254 A KR 950032254A
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KR
South Korea
Prior art keywords
integer
glycolipid
homologue
amino
inhibitory activity
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KR1019950014691A
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English (en)
Inventor
세이이치로 오가와
히데토시 쓰노다
진이치 이노쿠치
Original Assignee
야마다니 와다루
세이카가쿠고교 가부시키가이샤
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Application filed by 야마다니 와다루, 세이카가쿠고교 가부시키가이샤 filed Critical 야마다니 와다루
Publication of KR950032254A publication Critical patent/KR950032254A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

본 발명은 강력한 글리코시다제 억제 활성을 나타내며 강력한 생리학적 활성, 예를 들면 바이러스 억제 활성을 지니는 일반식(1)의 신규 규조를 당지질 동족체인 화합물을 제공한다.
상기식에서, Z는 이미노 그룹, 산소원자 또는 황원자이고; m은 3 내지 12의 정수이며; n은 4 내지 22의 정수이다.
본 발명은 또한 활성 성분으로서 상기 당지질 동족체를 포함하는 글리코시다제 억제제를 제공한다.

Description

당지질 동족체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 HIV에 새로이 감염된 PHA-활성화 PBMC에 의한 HIV생성에 대한 본 발명의 당지질 동족체의 효과를 도시한 것이다. 제2도는 공-배양된 Molt-4/c18과 Molt-4/IIIB의 합포체 형성에 대한 본 발명의 당지질 동족체의 효과를 도시한 것이다.

Claims (9)

  1. 하기 일반식(1)의 당지질 동족체,
    상기 식에서, Z는 이미노 그룹, 산소원자 또는 황원자이고; m은 3 내지 12의 정수이며; n은 4 내지 22의 정수이다.
  2. 제1항에 있어서, Z가 아미노 그룹이고 n이 4 내지 16의 정수인 당지질 동족체.
  3. 제1항에 있어서, 하기 일반식(1a) 또는 (1b)의 당지질 동족체.
    상기식에서, Z는 이미노 그룹이고; X 및 Y는 서로 상이하며 각각 수소원자 또는 하이드록실 그룹이고; m은 3 내지 12의 정수이며; n은 4 내지 16의 정수이다.
  4. 제1항에 있어서, (2S, 3R, 4E)-1-[(5a-카르바-β-D-크실로-헥스-5-에노피라노실)아미노]-2-(헥사데카노일아미노)-4-옥타데덴-3-올,(2S, 3R, 4Z)-1-[(5a-카르바-β-D-크실로-헥스-5-에노피라노실)아미노]-2-헥사데카노일아미노)-4-옥타데덴-3-올,(2S, 3R, 4E)-1-[(5a-카르바-α-L-아라비노-헥스-5-에노피라노실)아미노]-2-(헥사데카노일아미노)-4-옥타데센-3-올 및 (2S, 3R, 4Z)-1-[(5a-카르바-α-L-아라비노-헥스-5-에노피라노실)아미노]-2-(헥사데카노일아미노)-4-옥타데센-3-올로 이루어진 그룹으로부터 선택된 당지질 동족체.
  5. 활성 성분으로서의 제1항에 따르는 당지질 동족체와 약제학적으로 또는 생화학적으로 허용되는 담체를 포함하는 글리코시다제 억제제.
  6. 제5항에 있어서, 글리코세레브로시다제 억제제인 글리코시다제 억제제.
  7. 제6항에 있어서, 적어도 글리코세레브로시다제 억제 활성 또는 갈락토세레브로시다제 억제 활성을 나타내는 글리코시다제 억제제.
  8. 제7항에 있어서, β-글루코세레브로시다제 억제 활성이 있고, 활성 성분이 하기 일반식(1a) 또는 (1b)로 표시되는 글리코시다제 억제제.
    상기식에서, Z는 이미노 그룹, 산소원자 또는 황원자를 나타내고; m은 3 내지 12의 정수이며; n은 4 내지 22의 정수이고; X는 수소원자를 나타내며; Y는 하이드록실 그룹을 나타낸다.
  9. 제7항에 있어서, β-글루코세레브로시다제 억제 활성이 있고, 활성 성분이 하기 일반식(1a) 또는 (1b)로 표시되는 글리코시다제 억제제.
    상기식에서, Z는 이미노 그룹, 산소원자 또는 황원자를 나타내고; m은 3 내지 12의 정수이며; n은 4 내지 22의 정수이고; X는 하이드록실 그룹을 나타내며; Y는 수소원자를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950014691A 1994-05-31 1995-05-31 당지질 동족체 KR950032254A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14118794 1994-05-31
JP94-141187 1994-05-31

Publications (1)

Publication Number Publication Date
KR950032254A true KR950032254A (ko) 1995-12-20

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ID=15286190

Family Applications (1)

Application Number Title Priority Date Filing Date
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US (1) US5861520A (ko)
EP (1) EP0685458B1 (ko)
KR (1) KR950032254A (ko)
CN (1) CN1058498C (ko)
CA (1) CA2150613A1 (ko)
DE (1) DE69504134T2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001080848A1 (fr) * 2000-04-25 2001-11-01 Hokko Chemical Industry Co., Ltd. Compositions destinees a inhiber la proliferation du virus d'immunodeficience humaine et methode d'inhibition de la proliferation de ce virus
KR100880063B1 (ko) * 2001-08-16 2009-01-22 아스비오파마 가부시키가이샤 신규한 당지질 및 이것을 유효성분으로 하는 자기면역질환 치료약
EP1433776B1 (en) * 2001-09-07 2011-01-19 Seikagaku Corporation Carba-sugar amine derivatives and treatments for disorder of glycolipid metabolism containing the same as the active ingredient
US20040121406A1 (en) * 2002-05-23 2004-06-24 Wilson Constance Neely Methods and formulations for increasing the affinity of a1 adenosine receptor ligands for the a1 adenosine receptor
WO2005032462A2 (en) 2003-02-27 2005-04-14 Enzo Therapeutics, Inc. Glucocerebroside treatment of disease
US20040171522A1 (en) * 2003-02-27 2004-09-02 Yaron Ilan Regulation of immune responses by manipulation of intermediary metabolite levels
US9717754B2 (en) 2003-02-27 2017-08-01 Enzo Therapeutics, Inc. Glucocerebroside treatment of disease
WO2005120574A1 (ja) * 2004-06-11 2005-12-22 Riken 調節性細胞リガンドをリポソームに含有させてなる医薬
EP2411526A4 (en) * 2009-03-27 2012-09-19 Zacharon Pharmaceuticals Inc MODULATORS OF GANGLIOSID BIOSYNTHESIS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095119A (en) * 1990-03-08 1992-03-10 American Home Products Corporation Renin inhibitors

Also Published As

Publication number Publication date
CN1117496A (zh) 1996-02-28
US5861520A (en) 1999-01-19
AU2040095A (en) 1995-11-09
EP0685458B1 (en) 1998-08-19
CN1058498C (zh) 2000-11-15
DE69504134D1 (de) 1998-09-24
EP0685458A1 (en) 1995-12-06
CA2150613A1 (en) 1995-12-01
DE69504134T2 (de) 1999-02-04
AU695597B2 (en) 1998-08-20

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