KR940703635A - 이식용 뼈의 제조(preparation of bone for transplanta-tion) - Google Patents

이식용 뼈의 제조(preparation of bone for transplanta-tion)

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Publication number
KR940703635A
KR940703635A KR1019940702289A KR19940702289A KR940703635A KR 940703635 A KR940703635 A KR 940703635A KR 1019940702289 A KR1019940702289 A KR 1019940702289A KR 19940702289 A KR19940702289 A KR 19940702289A KR 940703635 A KR940703635 A KR 940703635A
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bone
spherical
contacting
decontaminant
cleaning
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KR1019940702289A
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모스 브렌다
샨브롬 에드워드
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로버트 티. 맥낼리
크리오라이프, 인코오포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2825—Femur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2825—Femur
    • A61F2002/2828—Femoral head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A61F2002/2839—Bone plugs or bone graft dowels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4646—Devices for cleaning bone graft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic
    • Y10S623/923—Bone

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  • Apparatus For Disinfection Or Sterilisation (AREA)
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Abstract

본 발명은; a) 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염 제거제와 뼈를 접촉시키고; b) 이 뼈를 세정하고; c) 세정된 뼈를 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염 제거제와 접촉시킴으로써 뼈의 오염물을 최종적으로 제거하는 단계를 포함하여, 뼈를 처리하고 이식하기에 적합하도록 뼈를 제조하는 간단하고 안전하며 효과적인 방법을 제공하고 있다.
본 발명은 또한 전술한 방법의 단계 b)에서 사용할 수 있는 뼈의 세정방법을 제공하며, 승온의 고압세척 조건하에서 상기 뼈를 세정제와 접촉시키는 단계를 포함한다.

Description

이식용 뼈의 제조(PREPARATION OF BONE FOR TRANSPLANTATION)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
본 발명을 설명함에 있어서, 실시예 5에 기술한 바와 같은 세정된 대퇴부 두(head)를 비교하는 사진인 제1도를 참고로 한다. 좌측의 대퇴부 두는 표준방법으로 세정한 반면, 우측의 대퇴부 두는 고압/승온하에서의 세정방법으로 세정한 것이다. 대퇴부 두를 분할하여, 본 발명의 세정과정 전부를 밝힌다.

Claims (64)

  1. a) 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염 제거제와 뼈를 접촉시키고; b) 이 뼈를 세정하고; c) 세정된 뼈를 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염 제거제와 접촉시킴으로써 뼈의 오염물을 최종적으로 제거하는 단계를 포함하여, 뼈를 처리하고 이식하기에 적합하도록 뼈를 제조하는 방법.
  2. 제1항에 있어서, 구형 오염제거제가 요오드포어(Iodophor)인 방법.
  3. 제2항에 있어서, 구형 오염제거제가 폴리비닐피롤리돈 요오드인 방법.
  4. 제3항에 있어서, 폴리비닐피롤리돈 요오드의 분자량이 약 20,000이하인 방법.
  5. 제1항에 있어서, 폴리비닐퍼롤리돈 요오드 용액의 농도가 0.5 내지 10%인 방법.
  6. 제1항에 있어서, 초기의 오염제거를 위한 접촉시간이 적어도 약 2분 이상인 방법.
  7. 제1항에 있어서, 초기의 오염제거를 위한 접촉시간이 적어도 약 10분 이상인 방법.
  8. 제1항에 있어서, 초기의 오염제거를 위한 접촉시간이 적어도 약 1시간 이상인 방법.
  9. 제1항에 있어서, 최종의 오염제거를 위한 접촉시간이 적어도 약 2분 이상인 방법
  10. 제1항에 있어서, 최종의 오염제거를 위한 접촉시간이 적어도 약 10분 이상인 방법.
  11. 제1항에 있어서, 최종의 오염제거를 위한 접촉시간이 적어도 약 30 내지 60분 이상인 방법.
  12. 제1항에 있어서, 단계 a)의 구형 오염 제거제에 세정제를 첨가하는 방법.
  13. 제12항에 있어서, 세정제가 비-이온계 세정제인 방법..
  14. 제13항에 있어서, 비-이온계 세정제가 옥틸페녹시폴리에톡시에탄올인 방법.
  15. 제1항에 있어서, 뼈는 결합조직이 붙어 있는 뼈조직괴(bone block)인 방법.
  16. 제1항에 있어서, 최종의 오염제거 단계전에 뼈를 분말화 시키는 방법.
  17. 제1항에 있어서, 세정 단계는 뼈를 세정제로 세척하는 단계를 포함하는 방법
  18. 제17항에 있어서, 세정제가 비-이온계 세정제인 방법.
  19. 제18항에 있어서, 비-이온계 세정제가 옥틸페녹시폴리에톡시에탄올인 방법.
  20. 제17항에 있어서, 구형 오염제거제를 세정제에 첨가하는 방법.
  21. 제20항에 있어서, 구형 오염제거제가 요오드포어인 방법.
  22. 제21항에 있어서, 요오드포어가 폴리비닐피로리돈 요오드인 방법.
  23. 제1항에 있어서, 단계 b)의 세정 단계는 뼈를 과산화수소와 접촉시키는 단계를 포함하는 방법.
  24. a) 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염 제거제와 뼈를 접촉시키고; b) 이 뼈를 세정하고; c) 세정된 뼈를 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염 제거제와 접촉시킴으로써 뼈의 오염물을 최종적으로 제거하고; d) 최종의 구형 오염 제거제를 비활성화시키는 단계를 포함하여, 뼈를 처리하고 이식하기에 적합하도록 뼈를 제조하는 방법.
  25. 제24항에 있어서, 최종의 구형 오염제거제가 요오드포어인 방법.
  26. 제25항에 있어서, 요오드포어가 폴리비닐피롤리돈 요오드인 방법.
  27. 제25항에 있어서, 요오드포어를 환원제와 반응시켜 비활성화시키는 방법.
  28. 제27항에 있어서, 환원제가 아스코브산 또는 이의 염인 방법.
  29. 제28항에 있어서, 아스코브산의 염이 나트륨 아스코브베이트인 방법.
  30. a) 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염 제거제와 뼈를 접촉시키고; b) 이 뼈를 세정하고; c) 세정된 뼈를 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염제거제와 접촉시킴으로써 뼈의 오염물을 최종적으로 제거하고; d) 세정되고 오염물 제거된 뼈를 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염 제거제로 피복시키는 단계를 포함하여, 이식하기에 적합한, 구형오염제거제-피복된 뼈를 제조하는 방법.
  31. 제30항에 있어서, 단계 c)의 최종적 구형 오염제거제가 피복물을 형성하는 방법.
  32. 제30항에 있어서, 단계 d)의 구형 오염제거체 피복물이 폴리비닐피롤리돈 요오드인 방법.
  33. 제30항의 방법으로 제조한, 구형 오염제거제-피복된 뼈.
  34. 제33항에 있어서, 구형 오염제거제 피복물이 폴리비필피롤리돈 요오드인, 구형 오염제거제-피복된 뼈.
  35. 이식하기에 적합한 폴리비닐퍼롤리돈-피복된 뼈.
  36. 고압의 세척조건하에서 뼈를 세정제와 접촉시키는 단계를 포함하여 뼈를 세정하는 방법.
  37. 제36항에 있어서, 고압의 세척조건은 세정제가 뼈내부의 세포간질속으로 들어가도록 하기에 충분한 격렬한 교반단계를 포함하는 방법.
  38. 제36항에 있어서, 고압의 세척조건은 뼈를 고압 액체 분류(liquid jet stream)와 접촉시키는 단계를 포함하는 방법.
  39. 제38항에 있어서, 고압액체분류의 압력이 약 100 내지 3,000psi인 방법.
  40. 제38항에 있어서, 고압액체분류의 압력이 약 500 내지 1,500psi인 방법.
  41. 제38항에 있어서, 액체가 세정제인 방법.
  42. 제36항에 있어서, 세정제가 비-이온계 세정제인 방법.
  43. 제42항에 있어서, 비-이온계 세정제가 옥틸페녹시폴리에톡시에탄올인 방법.
  44. 제42항에 있어서, 비-이온계 세정제가 폴리옥시에틸렌(20) 솔비탄 모노올레이트인 방법.
  45. 제36항에 있어서, 뼈를 추가로 과산화수소와 접촉시키는 방법.
  46. a) 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염제거제와 뼈를 접촉시키고; b) 이 뼈를 고압의 세척조건하에서 세정제와 겁촉시킴으로써 뼈를 세정하고; c) 세정된 뼈를 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염제거제와 접촉시킴으로써 뼈의 오염물을 최종적으로 제거하는 단계를 포함하여, 뼈를 처리하고 이식하기에 적합하도록 뼈를 제조하는 방법.
  47. 제46항에 있어서, 고압의 세척조건은 세정제가 뼈내부의 세포간질 속으로 들어가도록 하기에 충분한 격렬한 교반단계를 포함하는 방법.
  48. 제46항에 고압의 세척조건은 뼈를 고압액체 분류와 접촉시키는 단계를 포함하는 방법.
  49. 제48항에 있어서, 고압 액체 분류의 압력이 약 100 내지 3,000psi인 방법.
  50. 제48항에 있어서, 고압 액체 분류의 압력이 약 500 내지 1,500psi인 방법.
  51. 제48항에 있어서, 액체가 세정제인 방법.
  52. 제46항에 있어서, 세정제가 비-이온계 세정제인 방법.
  53. 제52항에 있어서, 비-이온계 세정제가 옥틸페녹시폴리에톡시에탄올인 방법.
  54. 제46항에 있어서, 뼈를 추가로 과산화 수소와 접촉시키는 방법.
  55. 제1항의 산물을 인간에게 삽입하는 단계를 포함하여 제1항의 산물을 사용하는 방법.
  56. 제36항에 있어서, 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염제 거제와 뼈를 접촉시킴으로써 뼈의 오염물을 최종적으로 더 제거하는 방법.
  57. a) 뼈의 골수, 세포, 지방 및 기타 파편이 실질적으로 제거되도록 뼈를 세정하고; b) 세정된 뼈를 박테리아, 진균류, 비루스 및 기생충을 비활성화시키기에 효과적인 구형의 오염 제거제와 접촉시킴으로써 뼈의 오염물을 최종적으로 제거하는 단계를 포함하여, 뼈를 처리하고 이식하기에 적합하도록 뼈를 제조하는 방법.
  58. a) 뼈를 세정하고; b) 세정된 뼈를 폴리비닐피롤리돈 요오드와 접촉시킴으로써 뼈의 오염물을 최종적을 제거하는 단계를 포함하여, 뼈를 처리하고 이식하기에 적합하도록 뼈를 제조하는 방법.
  59. 제36항에 있어서, 세정단계를 승온에서 수행하는 방법.
  60. 제46항에 있어서, 세정단계를 승온에서 수행하는 방법.
  61. 제59항에 있어서, 승온의 밤위가 약 37 내지 80℃인 방법.
  62. 제59항에 있어서, 승온의 범위가 약 37 내지 60℃인 방법.
  63. 제60항에 있어서, 승온의 범위가 약 37 내지 80℃인 방법.
  64. 제60항에 있어서, 승온의 범위가 약 37 내지 60℃인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940702289A 1991-12-31 1992-12-22 이식용 뼈의 제조(preparation of bone for transplanta-tion) KR940703635A (ko)

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US07/815,394 US5333626A (en) 1991-12-31 1991-12-31 Preparation of bone for transplantation
US07/815,394 1991-12-31
PCT/US1992/011046 WO1993012731A1 (en) 1991-12-31 1992-12-22 Preparation of bone for transplantation

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EP0619722A1 (en) 1994-10-19
HK1011605A1 (en) 1999-07-16
DE69231967T2 (de) 2002-04-04
DE69231967D1 (de) 2001-08-30
JPH07502442A (ja) 1995-03-16
US5333626A (en) 1994-08-02

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