KR930703241A - 6 내지 12개의 탄소원자들을 가지는 디카르복실산의 유도체와 장용성의 및 비경구적 영양분에 대한 약제적 조성물의 조제에 있어서 단지 이 유도체 및 디카르복실산의 이용 - Google Patents
6 내지 12개의 탄소원자들을 가지는 디카르복실산의 유도체와 장용성의 및 비경구적 영양분에 대한 약제적 조성물의 조제에 있어서 단지 이 유도체 및 디카르복실산의 이용Info
- Publication number
- KR930703241A KR930703241A KR1019930702198A KR930702198A KR930703241A KR 930703241 A KR930703241 A KR 930703241A KR 1019930702198 A KR1019930702198 A KR 1019930702198A KR 930702198 A KR930702198 A KR 930702198A KR 930703241 A KR930703241 A KR 930703241A
- Authority
- KR
- South Korea
- Prior art keywords
- dicarboxylic acids
- linear chain
- chain dicarboxylic
- pharmacologically
- water soluble
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 8
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- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 2
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- 230000000144 pharmacologic effect Effects 0.000 claims 2
- 229920002647 polyamide Polymers 0.000 claims 2
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- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
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- 239000004380 Cholic acid Substances 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
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- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 1
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- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
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- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
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- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
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- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 1
- 229960002471 cholic acid Drugs 0.000 claims 1
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- 150000004985 diamines Chemical class 0.000 claims 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 1
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- 159000000001 potassium salts Chemical class 0.000 claims 1
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Classifications
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- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
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- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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Abstract
천연 아미노산들을 가지는 아미드를 및 답즙산들을 가지는 에스테르를 같은 6 내지 12의 탄소원자들을 가지는 선형 사슬 디카르복실산들 및 이것의 새로운 유도체들은 장용성의 또는 비경구적 투약을 위해 적당한 약제적 조성물들의 조합물로 유용하다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (21)
- (ⅰ)글리신, 아라닌, 발린, 류신, 이소류신, 프롤린, 리신, 아르기닌, 아스파라긴, 글루타민, 시스테인, 매타오닌, 세린, 트레오닌, 및 히도록시 프롤린을 포함하는 군으로부터 선택된 아미노산들.
- (ⅱ) 지방족 모노- 및 디-아민들을 가지는 탄소원자 수가 6 내지 12의 범위인 선형 사슬 디카르복실산들의 아미드들 및 약리학적으로 이것의 수영성 염들.
- 세린, 트레오닌 및 히드록시프롤린을 갖는 C6 내지 C12의 선형 사슬 디카르복실산들의 에스테르들 및 약리학적으로 이것의 수용성 염들.
- L-카르니틴을 갖는 C6내지 C12의 선형 사슬 디카르복실산들의 에스테르들 및 약리학적으로 이것의 수용성 염들.
- 자유형 또는 타우로-또는 글리코-결합된 형태중의 어느 하나에서 콜산, 디옥시콜산 또는 리토콜산을 갖는 C6 내지 C12의 선형 사슬 디카르복실산들의 에스테르들 및 약리학적으로 이것의 수용성 염들.
- 지방족 제1의, 제2의 또는 제3의 알코올들을 갖는 C6 내지 C12의 선형 사슬 디카르복실산들의 에스테르들 및 약리학적으로 이것의 수용성 염들.
- C6 내지 C12의 선형 사슬 디카르복실산들의 트리글리세리드들 및 세바스산의 트리글리 세리드 및 약리학적으로 이것의 수용성 염들이 배제된 약리학적으로 이것의 수용성 염들.
- 제1항 내지 제6항에 있어서, 나트륨 염들 또는 칼륨 염들의 형태인 화합물들.
- 장용성의 및 비경구적 영양분을 위해 약제적 조성물들의 생성을 위한 세바스산이 배제된 C6 내지 C12의 선형 사슬 디카르복실산들 및 약리학적으로 이것의 수용성 염들의 이용.
- 제1항 내지 제7항에 있어서, 장용성 및 비경구적 영양분을 위한 약제적 조성물들을 생성하기 위한 화합물들의 이용.
- 활성물질로서 세바스산이 배제된 C6 내지 C12의 선형 사슬 디카르복실산들 또는 약리학적으로 이것의 수용성 염을 함유하는 장용성의 및 비경구적 투약을 위한 적당한 약제적 조성물.
- 활성물질로서 제1항 내지 제7항에 따른 화합물을 함유하는 장용성의 및 비경구적 투약을 위한 적당한 약제적 조성물.
- 제10항 내지 제11항에 있어서 수용액의 형태로 0.2 내지 1몰/리터의 활성물질을 함유하는 것을 특징으로 하는 조성물.
- 제10항 내지 제11항에 있어서, 단위투약량 형태로 0.5 내지 25g/ℓ의 활성물질을 함유하는 경구적 투약으로 적당한 조성물.
- 식이의 통합물 및/또는 효과적인 통합물로서 단위 투약량 형태로, 0.5 내지 25g의 제1항 내지 제7항에서 청구된 화합물들중의 하나 또는 C6 내지 C12의 선형 사슬 디카르복실산 산 또는 약리학적으로 이것의 수용성 염을 함유하는 경구로 투약할 수 있는 조성물.
- 담당의 결석들을 용해하기 위해 경구로 투약할 수 있는 약제적 조성물을 생성하기 위한 제4항의 에스테르들의 이용.
- 신경전달 및/또는 근육 운동성을 개선하려고 경구로 및 비경구로 투약할 수 있는 약제적 조성물을 생성하기 위해서 제1항 내지 제7항의 화합물들중의 하나 또는 C6 내지 C12의 선형 사슬 디카르복실산 또는 약리학적으로 이것의 수용성 염의 이용.
- 디아민을 갖는 C6 내지 C12의 선형 사슬 디카르복실산의 폴리아미드.
- 그리콜, 특히 에틸렌 또는 프로필렌 글리콜 또는 글리세롤을 갖는 C6 내지 C12의 선형 사슬 디카르복실산의 폴리에스테르.
- 외과의 또는 내과의 목적들을 위해 적당한 합성섬유들, 특히 섬유들을 생성하기 위해 제17항에 따른 폴리아미드 또는 제18항에 따른 폴리에스테르의 이용.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910070A IT1244645B (it) | 1991-01-29 | 1991-01-29 | Derivati degli acidi dicarbossilici aventi da sei a dodici atomi di carbonio ed impiego di tali derivati e degli acidi stessi per la preparazione di composizioni farmaceutiche atte all'alimentazione enterale parenterale. |
| ITRM91A00070 | 1991-01-29 | ||
| ITRM91A000070 | 1991-01-29 | ||
| PCT/IT1992/000006 WO1992012960A2 (en) | 1991-01-29 | 1992-01-28 | Derivatives of dicarboxylic acids having six to twelve carbon atoms and use of these derivatives and dicarboxylic acids alone in the preparation of pharmaceutical compositions for enteral and parenteral nutrition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR930703241A true KR930703241A (ko) | 1993-11-29 |
| KR100208498B1 KR100208498B1 (ko) | 1999-07-15 |
Family
ID=11399808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930702198A KR100208498B1 (ko) | 1991-01-29 | 1992-01-28 | 6 내지 12개의 탄소원자를 가지는 디카르복실산의 유도체와 장내 및 비경구적 영양을 위한 약제적 조성물의 제제에 단지 이 유도체와 디카르복실산의 사용 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0569393B1 (ko) |
| JP (1) | JP3011458B2 (ko) |
| KR (1) | KR100208498B1 (ko) |
| AT (1) | ATE129233T1 (ko) |
| CA (1) | CA2100868C (ko) |
| DE (1) | DE69205562T2 (ko) |
| DK (1) | DK0569393T3 (ko) |
| HK (1) | HK1006452A1 (ko) |
| IT (1) | IT1244645B (ko) |
| WO (1) | WO1992012960A2 (ko) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL107715A0 (en) * | 1992-11-25 | 1994-02-27 | Baxter Int | Water soluble non-immunogenic polyamide cross-linking agents |
| GB2303133B (en) * | 1994-05-04 | 1998-12-09 | Burwood Corp Ltd The | Amide and imide compounds and their use as lubricant oils |
| AU2350295A (en) * | 1994-05-04 | 1995-11-29 | Burwood Corporation Limited, The | Amide and imide compounds and their use as lubricant oils |
| IT1291919B1 (it) | 1997-05-30 | 1999-01-21 | Sigma Tau Ind Farmaceuti | Sali idrosolubili dell'acido dodecandioico e composizioni farmaceutiche e nutrizionali contenenti tali sali |
| ITMI20041567A1 (it) * | 2004-07-30 | 2004-10-30 | Maycos Italiana Di Comini Miro | "derivati n-acilati di acidi bicarbossilici con amminoacidi e con idrolizzati proteici vegetali e loro applicazione in prodotti cosmetici, dermofarmaceutici e farmaceutici" |
| ITMI20070953A1 (it) * | 2007-05-10 | 2008-11-11 | Novamont Spa | Processo di scissione catalitica di oli vegetali |
| KR101996124B1 (ko) * | 2017-01-06 | 2019-07-03 | 연세대학교 산학협력단 | 수베르산 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 근육 질환 예방 또는 치료용 조성물 |
| US11931330B2 (en) * | 2018-02-20 | 2024-03-19 | Korea University Research And Business Foundation | Composition for promoting skeletal muscle activity via induction of mitochondrial biogenesis comprising of azelaic acid as an active ingredient |
| KR102173179B1 (ko) * | 2018-10-18 | 2020-11-02 | 연세대학교 산학협력단 | 아젤라익산을 유효성분으로 함유하는 근력강화, 근육증강, 근육분화, 근육재생, 근감소증 억제효과를 갖는 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE854357C (de) * | 1944-12-05 | 1952-11-04 | Basf Ag | Verfahren zur Herstellung von N-alkylierten Halbamiden aliphatischer Dicarbonsaeuren |
| US4999417A (en) * | 1989-03-30 | 1991-03-12 | Nova Pharmaceutical Corporation | Biodegradable polymer compositions |
-
1991
- 1991-01-29 IT ITRM910070A patent/IT1244645B/it active IP Right Grant
-
1992
- 1992-01-28 AT AT92902884T patent/ATE129233T1/de not_active IP Right Cessation
- 1992-01-28 JP JP4503593A patent/JP3011458B2/ja not_active Expired - Fee Related
- 1992-01-28 WO PCT/IT1992/000006 patent/WO1992012960A2/en active IP Right Grant
- 1992-01-28 CA CA002100868A patent/CA2100868C/en not_active Expired - Fee Related
- 1992-01-28 DK DK92902884.3T patent/DK0569393T3/da active
- 1992-01-28 KR KR1019930702198A patent/KR100208498B1/ko not_active IP Right Cessation
- 1992-01-28 EP EP92902884A patent/EP0569393B1/en not_active Expired - Lifetime
- 1992-01-28 DE DE69205562T patent/DE69205562T2/de not_active Expired - Fee Related
-
1998
- 1998-06-18 HK HK98105618A patent/HK1006452A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06504996A (ja) | 1994-06-09 |
| IT1244645B (it) | 1994-08-08 |
| JP3011458B2 (ja) | 2000-02-21 |
| KR100208498B1 (ko) | 1999-07-15 |
| ITRM910070A0 (it) | 1991-01-29 |
| HK1006452A1 (en) | 1999-02-26 |
| EP0569393B1 (en) | 1995-10-18 |
| WO1992012960A3 (en) | 1992-09-17 |
| EP0569393A1 (en) | 1993-11-18 |
| DE69205562T2 (de) | 1996-06-20 |
| CA2100868C (en) | 2001-08-21 |
| WO1992012960A2 (en) | 1992-08-06 |
| ITRM910070A1 (it) | 1992-07-29 |
| ATE129233T1 (de) | 1995-11-15 |
| CA2100868A1 (en) | 1992-07-30 |
| DK0569393T3 (da) | 1996-02-26 |
| DE69205562D1 (de) | 1995-11-23 |
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