KR930019223A - 골다공증의 치료를 위한 방법 및 조성물 - Google Patents
골다공증의 치료를 위한 방법 및 조성물 Download PDFInfo
- Publication number
- KR930019223A KR930019223A KR1019930003607A KR930003607A KR930019223A KR 930019223 A KR930019223 A KR 930019223A KR 1019930003607 A KR1019930003607 A KR 1019930003607A KR 930003607 A KR930003607 A KR 930003607A KR 930019223 A KR930019223 A KR 930019223A
- Authority
- KR
- South Korea
- Prior art keywords
- mammal
- mineral density
- cortical bone
- bone mineral
- igf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims abstract 22
- 208000001132 Osteoporosis Diseases 0.000 title claims abstract 7
- 239000000203 mixture Substances 0.000 title claims abstract 4
- 241000124008 Mammalia Species 0.000 claims abstract 15
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims abstract 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims abstract 8
- 210000000988 bone and bone Anatomy 0.000 claims 8
- 230000001054 cortical effect Effects 0.000 claims 8
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 8
- 239000011707 mineral Substances 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- 230000000123 anti-resoprtive effect Effects 0.000 claims 5
- 239000013543 active substance Substances 0.000 claims 3
- 238000001739 density measurement Methods 0.000 claims 3
- 241000894007 species Species 0.000 claims 3
- 102000055006 Calcitonin Human genes 0.000 claims 2
- 108060001064 Calcitonin Proteins 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 2
- 229960004015 calcitonin Drugs 0.000 claims 2
- 229940011871 estrogen Drugs 0.000 claims 2
- 239000000262 estrogen Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- 229940122361 Bisphosphonate Drugs 0.000 claims 1
- 208000006386 Bone Resorption Diseases 0.000 claims 1
- 101000741445 Homo sapiens Calcitonin Proteins 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 230000024279 bone resorption Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940035811 conjugated estrogen Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- QTTMOCOWZLSYSV-QWAPEVOJSA-M equilin sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 QTTMOCOWZLSYSV-QWAPEVOJSA-M 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 229940045644 human calcitonin Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000002265 prevention Effects 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85054592A | 1992-03-13 | 1992-03-13 | |
| US07/850,545 | 1992-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930019223A true KR930019223A (ko) | 1993-10-18 |
Family
ID=25308435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930003607A Ceased KR930019223A (ko) | 1992-03-13 | 1993-03-11 | 골다공증의 치료를 위한 방법 및 조성물 |
Country Status (11)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712249A (en) * | 1994-09-08 | 1998-01-27 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
| JPH10504971A (ja) * | 1994-09-08 | 1998-05-19 | カイロン コーポレイション | インスリン様増殖因子の改善された生産方法 |
| US6025368A (en) * | 1997-02-25 | 2000-02-15 | Celtrix Pharmaceuticals, Inc. | Method for treating the symptoms of chronic stress-related disorders using IGF |
| US6514937B1 (en) | 1997-02-25 | 2003-02-04 | Celtrix Pharmaceuticals, Inc. | Method of treating psychological and metabolic disorders using IGF or IGF/IGFBP-3 |
| US6015786A (en) * | 1997-02-25 | 2000-01-18 | Celtrix Pharmaceuticals, Inc. | Method for increasing sex steroid levels using IGF or IGF/IGFBP-3 |
| ES2234560T3 (es) | 1999-01-06 | 2005-07-01 | Genentech, Inc. | Variante mutante del factor de crecimiento de tipo insulina (igf-i). |
| EP1265630B1 (en) | 2000-03-24 | 2006-06-07 | Genentech, Inc. | Use of insulin for the treatment of cartilagenous disorders |
| ATE389416T1 (de) | 2000-05-16 | 2008-04-15 | Genentech Inc | Behandlung von knorpelerkrankungen |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| WO2006130769A2 (en) * | 2005-06-02 | 2006-12-07 | Tercica, Inc. | Methods for treatment of growth disorders |
| US8202546B2 (en) | 2005-08-04 | 2012-06-19 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for use under physiologically stressful conditions |
| US7998500B2 (en) | 2005-08-04 | 2011-08-16 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for women |
| US8263137B2 (en) | 2005-08-04 | 2012-09-11 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for women |
| US7901710B2 (en) | 2005-08-04 | 2011-03-08 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for use under physiologically stressful conditions |
| WO2007093220A1 (en) * | 2006-02-17 | 2007-08-23 | Associazione Foresta Per La Ricerca Nella Riproduzione Umana | Use of insulin-like factor 3 for treating osteoporosis and bone disorders |
| US20080200425A1 (en) * | 2007-02-16 | 2008-08-21 | Kurtz Seymour J | Methods and compositions for regulating bone mineral density |
| KR102795415B1 (ko) * | 2017-05-21 | 2025-04-14 | 아이쥐에프 온콜로지, 엘엘씨 | 골수이형성 증후군을 치료하기 위한 인슐린양 성장 인자-화학치료학적 접합체 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
| ATE220101T1 (de) | 1983-04-25 | 2002-07-15 | Chiron Corp | Hybrid-dns-synthesis von reifen insulinähnlichen wachstumsfaktoren |
| CA1322714C (en) * | 1986-11-14 | 1993-10-05 | Harry N. Antoniades | Wound healing and bone regeneration |
| EP0289314B1 (en) | 1987-04-28 | 1994-10-12 | Roche Diagnostics GmbH | Use of IGF-II in the treatment of bone disorders |
| JPH0649655B2 (ja) | 1987-11-12 | 1994-06-29 | シェリング・コーポレーション | Ｇｍ‐ｃｓｆによる骨形成の促進 |
| ZA9010332B (en) | 1989-12-22 | 1991-08-28 | Ciba Geigy | Method of reducing or preventing adverse effect of steroid therapy and compositions therefor |
| NZ236618A (en) * | 1990-01-03 | 1997-06-24 | Ciba Geigy Ag | Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound |
| JPH0818999B2 (ja) * | 1990-01-05 | 1996-02-28 | 藤沢薬品工業株式会社 | インシュリン様成長因子ｉの乾燥製剤 |
| US5118667A (en) * | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
-
1993
- 1993-02-22 TW TW082101222A patent/TW267102B/zh active
- 1993-03-04 IL IL104940A patent/IL104940A0/xx unknown
- 1993-03-04 EP EP93810161A patent/EP0560723A1/en not_active Ceased
- 1993-03-09 AU AU34068/93A patent/AU666514B2/en not_active Ceased
- 1993-03-11 NZ NZ247123A patent/NZ247123A/xx unknown
- 1993-03-11 KR KR1019930003607A patent/KR930019223A/ko not_active Ceased
- 1993-03-11 CA CA002091534A patent/CA2091534A1/en not_active Abandoned
- 1993-03-12 JP JP05172793A patent/JP3771280B2/ja not_active Expired - Fee Related
- 1993-03-12 ZA ZA931778A patent/ZA931778B/xx unknown
- 1993-03-12 MX MX9301387A patent/MX9301387A/es unknown
-
1994
- 1994-06-01 US US08/243,520 patent/US6300309B1/en not_active Expired - Fee Related
-
2000
- 2000-11-01 US US09/703,853 patent/US6358925B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0560723A1 (en) | 1993-09-15 |
| US6300309B1 (en) | 2001-10-09 |
| JPH069429A (ja) | 1994-01-18 |
| ZA931778B (en) | 1993-09-13 |
| AU666514B2 (en) | 1996-02-15 |
| CA2091534A1 (en) | 1993-09-14 |
| AU3406893A (en) | 1993-09-16 |
| TW267102B (enrdf_load_html_response) | 1996-01-01 |
| IL104940A0 (en) | 1993-07-08 |
| MX9301387A (es) | 1994-08-31 |
| JP3771280B2 (ja) | 2006-04-26 |
| NZ247123A (en) | 1997-08-22 |
| US6358925B1 (en) | 2002-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19930311 |
|
| PG1501 | Laying open of application | ||
| N231 | Notification of change of applicant | ||
| PN2301 | Change of applicant |
Patent event date: 19970731 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D |
|
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19980311 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19930311 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20000222 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20000509 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20000222 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |