KR930003853B1 - 2, 5, 6, 7-테트라노르-18, 18, 19, 19-테트라데히드로-4, 8-인터-m-페닐렌 PGI₂유도체 - Google Patents

2, 5, 6, 7-테트라노르-18, 18, 19, 19-테트라데히드로-4, 8-인터-m-페닐렌 PGI₂유도체 Download PDF

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Publication number
KR930003853B1
KR930003853B1 KR1019870014231A KR870014231A KR930003853B1 KR 930003853 B1 KR930003853 B1 KR 930003853B1 KR 1019870014231 A KR1019870014231 A KR 1019870014231A KR 870014231 A KR870014231 A KR 870014231A KR 930003853 B1 KR930003853 B1 KR 930003853B1
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KR
South Korea
Prior art keywords
general formula
added
mmol
inter
tetranor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019870014231A
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English (en)
Korean (ko)
Other versions
KR880007453A (ko
Inventor
기요따까 오노
도시야 다까하시
신따로 니시오
Original Assignee
도레이 가부시끼가이샤
나까가와 다로
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Publication date
Application filed by 도레이 가부시끼가이샤, 나까가와 다로 filed Critical 도레이 가부시끼가이샤
Publication of KR880007453A publication Critical patent/KR880007453A/ko
Application granted granted Critical
Publication of KR930003853B1 publication Critical patent/KR930003853B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
KR1019870014231A 1986-12-11 1987-12-11 2, 5, 6, 7-테트라노르-18, 18, 19, 19-테트라데히드로-4, 8-인터-m-페닐렌 PGI₂유도체 Expired - Fee Related KR930003853B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP29536786 1986-12-11
JP61-295367 1986-12-11
JP295367 1986-12-11

Publications (2)

Publication Number Publication Date
KR880007453A KR880007453A (ko) 1988-08-27
KR930003853B1 true KR930003853B1 (ko) 1993-05-14

Family

ID=17819706

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870014231A Expired - Fee Related KR930003853B1 (ko) 1986-12-11 1987-12-11 2, 5, 6, 7-테트라노르-18, 18, 19, 19-테트라데히드로-4, 8-인터-m-페닐렌 PGI₂유도체

Country Status (10)

Country Link
US (1) US4880939A (https=)
EP (1) EP0274064B1 (https=)
JP (1) JPS63264475A (https=)
KR (1) KR930003853B1 (https=)
AT (1) ATE73768T1 (https=)
AU (1) AU600054B2 (https=)
CA (1) CA1291131C (https=)
DE (1) DE3777590D1 (https=)
ES (1) ES2032427T3 (https=)
ZA (1) ZA879186B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0365678B1 (en) * 1987-10-16 1994-01-05 Toray Industries, Inc. 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF
DE69008851T2 (de) * 1989-02-27 1994-08-18 Toray Industries VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen.
DE69005006T2 (de) * 1989-03-14 1994-05-11 Toray Industries 2,5,6,7-Tetranor-4,8-inter-m-phenylen-PGI2-Derivate.
US5233059A (en) * 1991-07-25 1993-08-03 Iowa State University Research Foundation, Inc. Synthesis of benzoprostacyclins using palladium catalysis
CA2254925A1 (en) * 1997-03-13 1998-09-17 Shigeyasu Annoh Drugs for relieving diabetic vascular lesion
WO1999013881A1 (en) * 1997-09-17 1999-03-25 Toray Industries, Inc. Cervical maturing agent
CN103717585B (zh) 2011-06-16 2015-11-25 琅歌生物技术股份有限公司 贝前列素的生产方法
US9388154B2 (en) * 2011-09-12 2016-07-12 Lund Biotechnology PBC Process for preparing synthetic prostacyclins
KR101986966B1 (ko) 2015-08-12 2019-06-07 유나이티드 쎄러퓨틱스 코포레이션 베라프로스트의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
DE3041601A1 (de) * 1980-10-31 1982-06-16 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3147714A1 (de) * 1981-11-27 1983-06-01 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacycline und verfahren zu ihrer herstellung
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体

Also Published As

Publication number Publication date
AU600054B2 (en) 1990-08-02
EP0274064A2 (en) 1988-07-13
ZA879186B (en) 1988-06-06
US4880939A (en) 1989-11-14
EP0274064A3 (en) 1988-07-27
JPS63264475A (ja) 1988-11-01
ATE73768T1 (de) 1992-04-15
KR880007453A (ko) 1988-08-27
JPH0571592B2 (https=) 1993-10-07
EP0274064B1 (en) 1992-03-18
CA1291131C (en) 1991-10-22
ES2032427T3 (es) 1993-02-16
AU8242087A (en) 1988-06-16
DE3777590D1 (de) 1992-04-23

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