KR930000529A - 백금(ii)착체 및 종양치료제 - Google Patents

백금(ii)착체 및 종양치료제 Download PDF

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Publication number
KR930000529A
KR930000529A KR1019920009851A KR920009851A KR930000529A KR 930000529 A KR930000529 A KR 930000529A KR 1019920009851 A KR1019920009851 A KR 1019920009851A KR 920009851 A KR920009851 A KR 920009851A KR 930000529 A KR930000529 A KR 930000529A
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methyl
hydrogen
complex
platinum
cycloalkyl
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KR1019920009851A
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KR960010017B1 (ko
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고 하타
다쓰야 가네코
히데키 가와이
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마에다 가쓰노스케
도레이 가부시키가이샤
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Publication of KR930000529A publication Critical patent/KR930000529A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

백금(∥)착체 및 종양치료제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 마우스에 이식된 콜론-26세포에 대해 실시예 1에서 수득한 화합물 1의 종양치료 효과를 도시한 것이다.
제2도는 마우스에 이식된 콜론 -26세포에 대해 실시예 2에서 수득한 화합물 2의 종양치료 효과를 도시한 것이다.
제3도는 마우스에 이식된 콜론-26세포에 대해 실시예 4에서 수득한 화합물 4의 종양치료 효과를 도시한 것이다.

Claims (11)

  1. 하기 일반식(A)의 백금(Ⅱ)착체.
    상기식에서, R1은 C1-10탄화수소 라디칼이고, R2및 R3은 각각 수소 원자 또는 C1-10탄화수소 라디칼이거나, R2와 R3은 함께 -(CH2)4-또는 -(CH2)5-를 형성할 수 있으며, X 및 Y는 각각 암모니아 분자 또는 C1-7한자리 아민이거나, X와 Y는 함께 C2-C10두자리 디아민을 형성할 수 있다.
  2. 제1항에 있어서, R1이 알킬, 알케닐, 사이클로알킬, 사이클로알킬-알킬아릴 또는 아르알킬이고 R2및 R3이 독립적으로 수소, 알킬, 알케닐, 사이클로알킬, 사이클로알킬-알킬, 아릴 또는 아르알킬인 착체.
  3. 제1항 또는 제2항에 있어서, R1이 메틸인 착체.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, R2가 수소 또는 메틸인 착체.
  5. 제1항 내지 제4항중 어느 한 항에 있어서, R3이 수소 또는 메틸인 착체.
  6. 제1항 내지 제5항중 어느 한 항에 있어서, X 및 Y가 각각 암모니아 분자이거나, 함께 일반식
    [여기서, R4및 R5는 각각 수소 원자 또는 C1-6탄화수소 라디칼이거나, R4와 R5는 함께 -(CH2)ℓ-(여기서, ℓ은 3내지 5의 정수이다)또는 -(CH2)2-O-(CH2)2-를 형성할 수 있고, m은 1 또는 2이다]의 분자를 형성할 수 있는 착체.
  7. 제1항에서 정의한 백금(Ⅱ)착체 유효량을 포함하는 종양 치료제.
  8. 제7항에 있어서, R1이 메틸인 종양 치료제.
  9. 제7항 또는 제8항에 있어서, R2가 수소 또는 메틸인 종양 치료제.
  10. 제7항 내지 제9항중 어느 한 항에 있어서, R3이 수소 또는 메틸인 종양 치료제.
  11. 제7항 내지 제10항중 어느 한 항에 있어서, X 및 Y가 각각 암모니아 분자이거나, 함께 일반식
    [여기서, R4및 R5는 각각 수소 원자 또는 C1-6탄화수소 라디칼이거나, R4와 R5는 함께 -(CH2)ℓ-(여기서, ℓ은 3내지 5의 정수이다)또는 -(CH2)2-O-(CH2)2-를 형성할 수 있고 m은 1 또는 2이다]의 분자를 형성할 수 있는 종양 치료제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920009851A 1991-06-10 1992-06-08 백금(ⅱ) 착체 및 종양 치료제 KR960010017B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP91-138029 1991-06-10
JP13802991 1991-06-10

Publications (2)

Publication Number Publication Date
KR930000529A true KR930000529A (ko) 1993-01-15
KR960010017B1 KR960010017B1 (ko) 1996-07-25

Family

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KR1019920009851A KR960010017B1 (ko) 1991-06-10 1992-06-08 백금(ⅱ) 착체 및 종양 치료제

Country Status (11)

Country Link
US (1) US5348950A (ko)
EP (1) EP0518645B1 (ko)
JP (1) JPH05178873A (ko)
KR (1) KR960010017B1 (ko)
AT (1) ATE147747T1 (ko)
CA (1) CA2070497C (ko)
DE (1) DE69216693T2 (ko)
DK (1) DK0518645T3 (ko)
ES (1) ES2096721T3 (ko)
GR (1) GR3022607T3 (ko)
TW (1) TW221443B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0704453A4 (en) * 1994-04-19 1998-07-29 Toray Industries NEW PLATINUM (II) COMPLEX AND MEDICINE AGAINST MALIGNE TUMORS
US6316652B1 (en) * 1995-06-06 2001-11-13 Kosta Steliou Drug mitochondrial targeting agents
US8048870B2 (en) * 2005-01-11 2011-11-01 Batarseh Kareem I Apoptosis-inducing antineoplastic silver (I) coordination complexes
DE102005047308A1 (de) * 2005-09-30 2007-04-05 Martin-Luther-Universität Halle-Wittenberg Platin(II)Verbindungen aus 2-substituierten Propan-1,3-diaminen zur Verwendung als Chemotherapeutikum

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980347A (en) * 1986-10-15 1990-12-25 Toray Industries Platinum complex, process for preparing same and antitumor agent
US4912100A (en) * 1986-10-15 1990-03-27 Toray Industries, Inc. Platinum complex, process for preparing same and antitumor agent
EP0341318A4 (en) * 1987-11-11 1990-10-10 Toray Industries, Inc. Novel platinum (ii) complex, process for preparing the same, and therapeutic agent for malignant tumor
EP0345356A4 (en) * 1987-11-11 1990-10-10 Toray Industries, Inc. Platinum complex and therapeutic agent for malignant tumor
JPH01313488A (ja) * 1988-06-13 1989-12-18 Toray Ind Inc 新規白金含有化合物および悪性腫瘍治療剤
EP0457921B1 (en) * 1989-12-12 1996-10-09 Toray Industries, Inc. Novel platinum (ii) complex and drug for treating malignant tumor

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DK0518645T3 (da) 1997-02-03
ES2096721T3 (es) 1997-03-16
EP0518645A1 (en) 1992-12-16
CA2070497A1 (en) 1992-12-11
US5348950A (en) 1994-09-20
EP0518645B1 (en) 1997-01-15
TW221443B (ko) 1994-03-01
DE69216693T2 (de) 1997-05-07
KR960010017B1 (ko) 1996-07-25
DE69216693D1 (de) 1997-02-27
ATE147747T1 (de) 1997-02-15
CA2070497C (en) 1999-05-25
JPH05178873A (ja) 1993-07-20
GR3022607T3 (en) 1997-05-31

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