KR930000466A - 알킬 3-클로로안트라닐레이트의 제조방법 - Google Patents

알킬 3-클로로안트라닐레이트의 제조방법 Download PDF

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Publication number
KR930000466A
KR930000466A KR1019920010208A KR920010208A KR930000466A KR 930000466 A KR930000466 A KR 930000466A KR 1019920010208 A KR1019920010208 A KR 1019920010208A KR 920010208 A KR920010208 A KR 920010208A KR 930000466 A KR930000466 A KR 930000466A
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KR
South Korea
Prior art keywords
alkyl
chloroanthranilate
chloroanthranilates
chloro
separation
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KR1019920010208A
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English (en)
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KR100228368B1 (ko
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알. 페어슨 노만
Original Assignee
케네트 엘. 로어춰
다우 엘랑코
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Publication of KR930000466A publication Critical patent/KR930000466A/ko
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Publication of KR100228368B1 publication Critical patent/KR100228368B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

알킬 3-클로로안트라닐레이트의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 일반식(Ⅱ)의 안트라닐산의 알킬 에스테르를 불활성 용매중에서 1,3-디클로로-5,5-디메틸하이단토인과 0 내지 150℃ 온도에서 반응시키고, 혼합물로부터 알킬 3-클로로안트라닐레이트를 분리시킴을 특징으로 하여, 하기 일반식(Ⅰ)의 3-클로로안트라닐산의 알킬 에스테르를 제조하는 방법.
    상기 식에서, R은 탄소수 1 내지 4의 직쇄 또는 측쇄 알킬 그룹이다.
  2. 제1항에 있어서, 불활성 용매가 할로겐화된 탄화수소 용매인 방법.
  3. 알킬 3-클로로안트라닐레이트와 혼합된 5-클로로안트라닐레이트를 알킬 5-클로로안트라닐레이트의 당량당 아세트산 무수물 1.0 내지 1.2당량과 접촉시켜 알킬 N-아세틸-5-클로로 안트라닐레이트와 알킬 3-클로로안트라닐레이트의 혼합물을 수득하고 아세틸화되지 않은 3-클로로 이성질체로부터 아세틸화된 5-클로로 이성질체를 분리시킴을 특징으로 하여, 상응하는 5-클로로안트라닐레이트로부터 알킬 3-클로로안트라닐레이트를 분리하는 방법.
  4. 제3항에 있어서, 분리를 가용성의 차이를 기초로 하여 수행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019920010208A 1991-06-14 1992-06-12 알킬 3-클로로안트라닐레이트의 제조방법 KR100228368B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/715,514 US5118832A (en) 1991-06-14 1991-06-14 Process for the preparation of alkyl 3-chloroanthranilates
US7/715514 1991-06-14
US07/715514 1991-06-14

Publications (2)

Publication Number Publication Date
KR930000466A true KR930000466A (ko) 1993-01-15
KR100228368B1 KR100228368B1 (ko) 1999-11-01

Family

ID=24874341

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920010208A KR100228368B1 (ko) 1991-06-14 1992-06-12 알킬 3-클로로안트라닐레이트의 제조방법

Country Status (14)

Country Link
US (1) US5118832A (ko)
EP (1) EP0518374B1 (ko)
JP (1) JP3268825B2 (ko)
KR (1) KR100228368B1 (ko)
AT (1) ATE137492T1 (ko)
AU (1) AU641097B2 (ko)
CA (1) CA2071118C (ko)
DE (1) DE69210309T2 (ko)
DK (1) DK0518374T3 (ko)
ES (1) ES2086581T3 (ko)
HU (1) HU209738B (ko)
IL (1) IL102191A (ko)
RU (1) RU2026284C1 (ko)
TW (1) TW204335B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118832A (en) * 1991-06-14 1992-06-02 Dowelanco Process for the preparation of alkyl 3-chloroanthranilates
DE4313174A1 (de) * 1993-04-22 1994-10-27 Hoechst Ag Verfahren zur Herstellung von 3-Chloranthranilsäurealkylestern hoher Reinheit aus 3-Chloranthranilsäure
CN103193666B (zh) * 2013-04-09 2015-11-18 江苏省农用激素工程技术研究中心有限公司 2-氨基-3-氯苯甲酸甲酯的制备方法
EP3015453B1 (en) * 2014-10-28 2016-10-12 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of Clomiphene
EP3368506B1 (en) 2016-04-22 2023-09-06 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of enclomiphene citrate having needle shaped crystal habit.
CN107266324A (zh) * 2017-07-17 2017-10-20 常州大学 一种2‑氨基‑3‑氯苯甲酸甲酯的合成方法
CN108047069A (zh) * 2017-12-29 2018-05-18 南通泰禾化工股份有限公司 一种2-氨基-3-氯苯甲酸甲酯的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8006496A (nl) * 1979-12-19 1981-07-16 Upjohn Co Werkwijze voor het bereiden van arylpropionzuren.
US5118832A (en) * 1991-06-14 1992-06-02 Dowelanco Process for the preparation of alkyl 3-chloroanthranilates

Also Published As

Publication number Publication date
AU1813992A (en) 1992-12-17
HUT64010A (en) 1993-11-29
ATE137492T1 (de) 1996-05-15
CA2071118A1 (en) 1992-12-15
JPH05194341A (ja) 1993-08-03
EP0518374A3 (en) 1993-04-28
AU641097B2 (en) 1993-09-09
IL102191A0 (en) 1993-01-14
DK0518374T3 (da) 1996-08-26
TW204335B (ko) 1993-04-21
ES2086581T3 (es) 1996-07-01
CA2071118C (en) 1996-06-18
DE69210309T2 (de) 1996-09-12
IL102191A (en) 1996-10-31
HU209738B (en) 1994-10-28
KR100228368B1 (ko) 1999-11-01
HU9201972D0 (en) 1992-09-28
RU2026284C1 (ru) 1995-01-09
EP0518374A2 (en) 1992-12-16
DE69210309D1 (de) 1996-06-05
EP0518374B1 (en) 1996-05-01
JP3268825B2 (ja) 2002-03-25
US5118832A (en) 1992-06-02

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